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Iron acquisition mechanism of graminaceous plants by mugineic acids

Research Project

Project/Area Number 21310148
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Living organism molecular science
Research InstitutionSuntory Institute for Bioorganic Research

Principal Investigator

MURATA Yoshiko  公益財団法人サントリー生命科学財団, 生物有機科学研究所, 主席研究員 (60256047)

Co-Investigator(Kenkyū-buntansha) NAMBA Kosuke  北海道大学, 大学院・理学研究科, 准教授 (50414123)
Co-Investigator(Renkei-kenkyūsha) SUGASE Kenji  公益法人サントリー生命科学財団, 生物有機科学研究所, 主席研究員 (00300822)
YAMAGAKI Tohru  公益法人サントリー生命科学財団, 生物有機科学研究所, 主席研究員 (40313209)
MURATA Jun  公益法人サントリー生命科学財団, 生物有機科学研究所, 研究員 (90500794)
ARAKI Ryoichi  公益法人サントリー生命科学財団, 生物有機科学研究所, 研究員 (00530841)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Keywordsムギネ酸 / 鉄錯体 / イネ科植物 / トランスポーター / ファイトシデロフォア / ムギネ酸鉄錯体トランスポーター / 基質選択性 / イネ科食物 / オオムギ / 光親和標識体 / 鉄輸送 / 標識体
Research Abstract

Iron uptake from the soil in plants is a crucial event for all living creatures. Graminaceous plants have developed a specific strategy based on the phytosiderophores, mugineic acids. We identified transporters in barley and synthesis the mugineic acids derivatives as molecular probes. These studies are essential for further biological studies, and will hopefully lead to better crop production.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (33 results)

All 2011 2010 2009 Other

All Journal Article (8 results) (of which Peer Reviewed: 6 results) Presentation (20 results) Remarks (4 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] A novel barley yellow stripe 1-like transporter(HvYSL2) localized to the root endodermis transports metal-phytosiderophore complexes2011

    • Author(s)
      Araki, R., Murata, J. and Murata, Y.
    • Journal Title

      Plant Cell Physiol

      Volume: 52 Issue: 10 Pages: 1931-1940

    • DOI

      10.1093/pcp/pcp126

    • NAID

      10030305339

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mugineic acid derivatives as molecular probes for the mechanistic elucidation of iron acquisition in barley2010

    • Author(s)
      Namba, K., Kobayashi, K., Murata, Y., Hirakawa, H., Yamagaki, T., Iwashita, T., Nishizawa, M., Kusumoto, S. and Tanino, K.
    • Journal Title

      Angew. Chem. Int. Ed

      Volume: 49 Pages: 9956-9959

    • URL

      http://dx.doi.org/10.1002/anie.201004853

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Toward mechanistic elucidation of iron acquisition in barley : efficient synthesis of mugineic acids and their transport activities2010

    • Author(s)
      Namba, K., Murata, Y.
    • Journal Title

      The Chemical Record

      Volume: 10 Pages: 140-150

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ムギネ酸類によるイネ科植物の鉄取り込み機構2010

    • Author(s)
      村田佳子
    • Journal Title

      化学と生物

      Volume: 48 Pages: 528-534

    • NAID

      10026547064

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mugineic Acid Derivatives as Molecular Probes for the Mechanistic Elucidation of Iron Acquisition in Barley.2010

    • Author(s)
      Namba K., 他8名
    • Journal Title

      Angew Chem.Int.Ed.

      Volume: 49 Pages: 9956-9959

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toward Mechanistic Elucidation of Iron Acquisition in Barley : Efficient Synthesis of Mugineic Acids and Their transport Activities2010

    • Author(s)
      Namba K., Murata Y.
    • Journal Title

      The Chemical Record 10

      Pages: 140-150

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ムギネ酸によるイネ科植物の鉄取り込み機構の解明2009

    • Author(s)
      村田佳子、その他10名(1番目)
    • Journal Title

      SUNBOR ANNUAL REPORT

      Pages: 67-74

    • URL

      http://www.sunbor.or.jp

    • Related Report
      2011 Final Research Report
  • [Journal Article] ムギネ酸によるイネ科植物の鉄取り込み機構の解明2009

    • Author(s)
      村田佳子, 他10名
    • Journal Title

      SUNBOR ANNUAL REPORT

      Pages: 67-74

    • Related Report
      2009 Annual Research Report
  • [Presentation] 研究は他分野を経験するとよりおもしろい-有機化学から分子生物学へ-2011

    • Author(s)
      村田佳子
    • Organizer
      女性研究者による理工学部講演会
    • Place of Presentation
      関西学院大学理工学(兵庫)
    • Year and Date
      2011-05-28
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] オオムギのムギネ酸・鉄錯体トランスポーターHvYS1の基質選択性に関わるアミノ酸の解析2011

    • Author(s)
      村田佳子、向坂佳代子
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都国際会議場(京都)
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] IUPAC Workshop in Recent Advances of Natural Products. Iron acquisition mechanism of barley as explored by mugineic acids2011

    • Author(s)
      Murata, Y.
    • Organizer
      The 14th Asian Chemical Congress
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ムギネ酸類の実用的合成を基盤とする標識ムギネ酸の設計と合成2010

    • Author(s)
      小林香織、難波康祐、村田佳子、西沢麦夫、楠本正一、谷野圭持
    • Organizer
      第27回有機合成化学セミナー
    • Place of Presentation
      シーサイドホテル舞子ビラ神戸(兵庫)
    • Related Report
      2011 Final Research Report
  • [Presentation] オオムギのムギネ酸類・鉄錯体トランスポーターHvYS1における基質選択性に関与する膜外ループの解析2010

    • Author(s)
      村田佳子,原田英理砂、菅瀬謙治、岩下孝
    • Organizer
      第21回日本微量元素学会年会
    • Place of Presentation
      京都大学百周年時計台記念館(京都)
    • Related Report
      2011 Final Research Report
  • [Presentation] Analysis of transgenic petunia expressing phytosiderophore-iron(III) transporter, HvYS1 gene from barley2010

    • Author(s)
      Murata Y., Itoh Y., Namba K., Iwashita, T., Tanaka, Y.
    • Organizer
      XV International Symposium on Iron Nutrition and Interactions in Plants(ISINIP)
    • Place of Presentation
      ブタペスト(ハンガリー)
    • Related Report
      2011 Final Research Report
  • [Presentation] Characterization of a novel metalphytosiderophore transporter with broad substrate specificity from barley2010

    • Author(s)
      Araki, R., Murata, J., Kousaka, K., Murata Y.
    • Organizer
      XV International Symposium on Iron Nutrition and Interactions in Plants(ISINIP)
    • Place of Presentation
      ブタペスト(ハンガリー)
    • Related Report
      2011 Final Research Report
  • [Presentation] オオムギのムギネ酸類3価鉄錯体トランスポーターHvYS1を遺伝子導入したペチュニアの解析2010

    • Author(s)
      村田佳子、伊藤喜之、難波康祐、岩下孝、田中良和
    • Organizer
      第51日本植物生理学会年会
    • Place of Presentation
      熊本大学(熊本)
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Analysis of transgenic petunia expressing phytosiderophore-iron(III)transporter, HvYSI gene from barley.2010

    • Author(s)
      Murata Y, 他4名
    • Organizer
      XV International Symposium on Iron Nutrition and Interactions in Plants(IS-NIP)
    • Place of Presentation
      ブタペスト(ハンガリー)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Characterization of a novel metal-phytosiderophore transporter with broad substrate specificity from barley2010

    • Author(s)
      Araki R, 他3名
    • Organizer
      XV International Symposium on Iron Nutrition and Interactions in Plants(IS-NIP)
    • Place of Presentation
      ブタペスト(ハンガリー)
    • Related Report
      2010 Annual Research Report
  • [Presentation] オオムギのムギネ酸類・鉄錯体トランスポータ-HvYSIにおける基質選択性に関与する膜外ループの解析2010

    • Author(s)
      村田佳子, 他3名
    • Organizer
      第21回日本微量元素学会年会
    • Place of Presentation
      京都大学百周年時計台記念館(京都府)
    • Related Report
      2010 Annual Research Report
  • [Presentation] ムギネ酸類の実用的合成を基盤とする標識ムギネ酸の設計と合成2010

    • Author(s)
      小林香織, 他5名
    • Organizer
      第27回有機合成化学セミナー
    • Place of Presentation
      シーサイドホテル舞子ビラ神戸(兵庫県)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Structural analysis of an outer membrane loop responsible for substrate specificity of Fe(III)-phytosiderophore transpoerters2009

    • Author(s)
      原田英理砂、村田佳子、菅瀬謙治
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2011 Final Research Report
  • [Presentation] オオムギのムギネ酸類・3価鉄錯体トランスポーターHvYS1の基質特異性の解析2009

    • Author(s)
      村田佳子、原田英理砂、菅瀬謙治、岩下孝
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] ムギネ酸類を介したイネ科植物の鉄取り込み機構2009

    • Author(s)
      村田佳子、難波康祐、馬建鋒、菅瀬謙治、堀川学、岩下孝、楠本正一
    • Organizer
      第51回天然有機化合物討論会
    • Place of Presentation
      名古屋大学(名古屋)
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Synthesis and Its Iron Transport Activities of Labeled Mugineic Acid2009

    • Author(s)
      Namba, K., Kobayashi K., Murata, Y., Tanino, K.
    • Organizer
      5th Japan-Korea Young Scientists Meeting on Bioorganic and Natural Products Chemistry 2009
    • Place of Presentation
      Yugawara Training Institute(静岡)
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] ムギネ酸類3価鉄錯体トランスポーターHvYS1トランスジェニックペチュニアの鉄欠乏アルカリ培地における耐性2009

    • Author(s)
      村田佳子、伊藤喜之、難波康祐、岩下孝、田中良和
    • Organizer
      第20回日本微量元素学会
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2011 Final Research Report
  • [Presentation] オオムギのムギネ酸類3価鉄錯体トランスポーターHvYS1の基質特異性に関わる膜外ループの解析2009

    • Author(s)
      村田佳子,原田英理砂、菅瀬謙治、難波康祐、岩下孝
    • Organizer
      第4回トランスポーター研究会
    • Place of Presentation
      東京大学(東京)
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] ムギネ酸類3価鉄錯体トランスポーターHvYs1トランスジェニックペチュニアの鉄欠乏アルカリ培地における耐性2009

    • Author(s)
      村田佳子, 他4名
    • Organizer
      第20回日本微量元素学会
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Stracturel analysis of an outer membrane loop responsible for substrate specificity of Fe(III)-phytosiderophore transpoerters2009

    • Author(s)
      原田英里砂, 他2名
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://sunbor.or.jp

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.sunbor.or.jp

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.sunbor.or.ip

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.sunbor.or.jp

    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] ムギネ酸類金属錯体トランスポーター及びその用途2010

    • Inventor(s)
      村田佳子、荒木良一
    • Industrial Property Rights Holder
      サントリーホールディングス
    • Filing Date
      2010-06-22
    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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