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Development of Precise-controlled Magnetic Drug Delivery System

Research Project

Project/Area Number 21360133
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Power engineering/Power conversion/Electric machinery
Research InstitutionOsaka University

Principal Investigator

NISHIJIMA Shigehiro  大阪大学, 工学研究科, 教授 (00156069)

Co-Investigator(Kenkyū-buntansha) AKIYAMA Yoko  大阪大学, 工学研究科, 講師 (50452470)
NAKAGAWA Takashi  大阪大学, 工学研究科, 准教授 (70273589)
HUKUI Satoshi  新潟大学, 自然科学系, 准教授 (70293199)
Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Keywords超電気導バルク磁石 / 磁気薬剤配送システム / 強磁性粒子 / 変動磁場 / 粒子軌跡 / シミュレーション / 強磁性針 / 磁気力制御 / 低侵襲治療 / 磁気力 / 薬剤配送システム / 体内深部 / 回転磁場 / 薬剤配送システム(DDS) / 粒子軌跡シミュレーション / 温度感受性リポソーム / 非侵襲治療 / リポソーム / 動物実験
Research Abstract

The objective of this study is to construct the methods of MDDS (magnetic drug delivery system) to accumulate drugs in the local deep part of the body. Two methods; local accumulation of ferromagnetic drug with ferromagnetic needle in the external magnetic field and non-invasive accumulation by rotating MDDS were studied. As a result, the possibility of local accumulation of ferromagnetic drug in the deep part was shown

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (38 results)

All 2012 2011 2010 2009 Other

All Journal Article (17 results) (of which Peer Reviewed: 9 results) Presentation (19 results) Remarks (2 results)

  • [Journal Article] Study on Magnetic Drug Delivery System Using HTS Bulk Magnet2012

    • Author(s)
      K. Nakagawa, F. Mishima, Y. Akiyama, S. Nishijima
    • Journal Title

      IEEE TRANS.APPL.SUPERCOND, reviewed

      Volume: VOL. 22, NO. 3 Pages: 4903804-4903804

    • Related Report
      2012 Final Research Report
  • [Journal Article] Study on Magnetic Drug Delivery System Using HTS Bulk Magnet2012

    • Author(s)
      K. Nakagawa
    • Journal Title

      IEEE TRANS.APPL.SUPERCOND

      Volume: VOL. 22, NO. 3

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Drug accumulation by means of noninvasive magnetic drug delivery system2011

    • Author(s)
      M. Chuzawa, F. Mishima, Y. Akiyama, S. Nishijima
    • Journal Title

      Physica C: Superconductivity, reviewed

      Volume: Vol.471, Issue 21-22 Pages: 1538-1542

    • Related Report
      2012 Final Research Report
  • [Journal Article] Drug accumulation by means of noninvasive magnetic drug delivery system2011

    • Author(s)
      M.Chuzawa, F.Mishima, Y.Akiyama, S.Nishijima
    • Journal Title

      Physica C, Superconductivity

      Volume: 471 Issue: 21-22 Pages: 1538-1542

    • DOI

      10.1016/j.physc.2011.05.233

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A study on accumulation of magnetic drug in the capillary vessel of target organ using superconducting MDDS2010

    • Author(s)
      F. Mishima, Y. Akiyama, S. Nishijima
    • Journal Title

      Physica C: Superconductivity, reviewed

      Volume: Volume 470, Issue 20 Pages: 1837-1840

    • Related Report
      2012 Final Research Report
  • [Journal Article] Drug Delivery Using an Embedded Ferromagnetic Needle and External Magnets2010

    • Author(s)
      Y. Hirota, F. Mishima, Y. Akiyama, and S. Nishijima
    • Journal Title

      IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY, reviewed

      Volume: VOL. 20, NO.3 Pages: 826-828

    • Related Report
      2012 Final Research Report
  • [Journal Article] 超電導バルク磁石を用いた磁気薬剤配送システムに関する研究2010

    • Author(s)
      廣田友佳、忠澤充高、三島史人、秋山庸子、西嶋茂宏
    • Journal Title

      低温工学

      Volume: Vo . l4 5、No Pages: 298-303

    • NAID

      10026452707

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 磁気力薬剤配送システムの開発2010

    • Author(s)
      三島史人、西嶋茂宏
    • Journal Title

      日本AEM学会誌

      Volume: Vol. 18、No.1 Pages: 21-28

    • NAID

      110007619823

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Drug Delivery Using an Embedded Ferromagnetic Needle and External Magnets2010

    • Author(s)
      Y.Hirota, F.Mishima, Y.Akiyama, S.Nishijima
    • Journal Title

      IEEE Transactions on applied Superconductivity

      Volume: 20(3) Pages: 826-828

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A study on accumulation of magnetic drug in the capillary vessel of target organ using superconducting MDDS2010

    • Author(s)
      F.Mishima, Y.Akiyama, S.Nishijima
    • Journal Title

      Physica C : Superconductivity

      Volume: 470(20) Pages: 1837-1840

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Research and Development of Magnetic Drug Delivery System Using Bulk High Temperature Superconducting Magnet2009

    • Author(s)
      S. NishijimaF. Mishima, Y. Tabata, H. Iseki, Y.Muragaki, A. Sasaki, N. Saho
    • Journal Title

      IEEE Transactions on applied Superconductivity, reviewed

      Volume: Vol.19,No.3 Pages: 2257-2260

    • Related Report
      2012 Final Research Report
  • [Journal Article] Fundamental study for development magnetic drug delivery system2009

    • Author(s)
      Y. Hirota , Y.Akiyama , Y. Izumi, S . Nishijima
    • Journal Title

      Physica C: Superconductivity, reviewed

      Volume: Vol.469, 15-20 Pages: 1853-1856

    • NAID

      10024469086

    • Related Report
      2012 Final Research Report
  • [Journal Article] 磁気力誘導薬剤配送システム2009

    • Author(s)
      西嶋茂宏、三島史人
    • Journal Title

      まぐね/Magnetics Japan

      Volume: Vol. 4、No.11 Pages: 535-543

    • NAID

      10025570571

    • Related Report
      2012 Final Research Report
  • [Journal Article] Research and Development of Magnetic Drug Delivery System Using Bulk High Temperature2009

    • Author(s)
      S.Nishijima, F.Mishima, Y.Tabata, H.Iseki, Y.Muragaki, A.Sasaki, N.Saho
    • Journal Title

      IEEE Transactions on applied Superconductivity Vol19, No.3

      Pages: 2257-2260

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fundamental study for development magnetic drug delivery system2009

    • Author(s)
      Y.Hirota, Y.Akiyamaa, Y.Izumi, S.Nishijima,
    • Journal Title

      Physica C : Superconductivity, Vol.469, 15-20

      Pages: 1853-1856

    • NAID

      10024469086

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Study on magnetic separation of nanosized ferromagnetic particles2009

    • Author(s)
      R Nakao, Y Matuo, F Mishima, T Taquchi S Nishijima
    • Journal Title

      Phys.:Conf.Ser. 156

      Pages: 1-5

    • NAID

      10019981673

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 磁気力誘導薬剤配送システム2009

    • Author(s)
      西嶋茂宏、三島史人
    • Journal Title

      まぐね/Magnetics Jpan. Vol.4, No.11

      Pages: 535-543

    • NAID

      10025570571

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 超電導バルク磁石を用いた磁気力制御遺伝子導入のための研究2012

    • Author(s)
      中川公太、大阿久佳宏、玉田順也、三島史人、秋山庸子、大窄マリアナ今日美、中神啓徳、西嶋茂宏
    • Organizer
      第86回秋季低温工学・超電導学会
    • Place of Presentation
      いわて県民情報交流センター
    • Related Report
      2012 Final Research Report
  • [Presentation] Precise control of the drug kinetics by non-invasive magnetic drug delivery system2012

    • Author(s)
      F. Mishima, M. Chuzawa, Y. Akiyama, S. Nishijima
    • Organizer
      2012 Applied Superconductivity Conference
    • Place of Presentation
      Portland,U.S.A
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 超電導バルク磁石を用いた磁気力制御遺伝子導入のための研究2012

    • Author(s)
      中川公太
    • Organizer
      第86回 秋季低温工学・超電導学会
    • Place of Presentation
      いわて県民情報交流センター
    • Related Report
      2012 Annual Research Report
  • [Presentation] Study on Magnetic Drug Delivery System Using HTS Bulk Magnet2011

    • Author(s)
      K. Nakagawa, F. Mishima, Y. Akiyama, S. Nishijima
    • Organizer
      22nd International Conference on Magnet Technology
    • Place of Presentation
      Marseille, Franc
    • Related Report
      2012 Final Research Report
  • [Presentation] 非侵襲磁気力制御薬剤配送システムのための基礎的研究2011

    • Author(s)
      忠澤充高、三島史人、秋山庸子、西嶋茂宏
    • Organizer
      第10回2011年度磁気力制御・磁場応用夏の学校
    • Place of Presentation
      大阪市立長居ユースホステル
    • Related Report
      2012 Final Research Report
  • [Presentation] 温度感受性リポソームを用いた磁気力制御薬剤配送システムの基礎的研究2011

    • Author(s)
      中川公太、三島史人、秋山庸子、西嶋茂宏
    • Organizer
      第84回2011年度春季低温工学・超電導学会
    • Place of Presentation
      筑波NIMS
    • Related Report
      2012 Final Research Report
  • [Presentation] 温度感受性リポソームを用いた磁気力制御薬剤配送システムの基礎的研究2011

    • Author(s)
      中川公太、三島史人、秋山庸子、西嶋茂宏
    • Organizer
      平成23年電気学会全国大会
    • Place of Presentation
      大阪大学
    • Related Report
      2012 Final Research Report
  • [Presentation] Drug Accumulation by Means of Noninvasive Magnet Drug Delivery System2011

    • Author(s)
      M. Chuzawa, F. Mishima, Y. Akiyama, S. Nishijima
    • Organizer
      23rd Interantioanl Symoposium on Superconductivity
    • Place of Presentation
      Tsukuba, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] Study on Magnetic Drug Delivery System Using HTS Bulk Magnet2011

    • Author(s)
      K.Nakagawa, F.Mishima, Y.Akiyama, S.Nishijima
    • Organizer
      (MT-22) 22nd International Conference on Magnet Technology
    • Place of Presentation
      Marseille, France
    • Related Report
      2011 Annual Research Report
  • [Presentation] Precise Control of the Drug Kinetics by Means of Noninvasive Drug Delivery System2011

    • Author(s)
      M.Chuzawa, F.Mishima, Y.Akiyama, S.Nishijima
    • Organizer
      (ISS2011) 24rd International Symposium on Superconductivity
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 温度感受性リポソームを用いた磁気力制御薬剤配送システムの基礎的研究2011

    • Author(s)
      中川公太、三島史人、秋山庸子、西嶋茂宏
    • Organizer
      第84回2011年度春季低温工学・超電導学会
    • Place of Presentation
      物質・材料機構(筑波)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Drug accumulation by means of noninvasive magnetic drug delivery system2010

    • Author(s)
      M.Chuzawa, F.Mishima, Y.Akiyama, S.Nishijima
    • Organizer
      23^<rd> International Symposium on Superconductivity (ISS2010)
    • Place of Presentation
      Epochal Tsukuba, Tsukuba
    • Year and Date
      2010-11-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 磁気力制御薬剤配送システムによる精密集積制御の検討(1)-モデル系での検討-2010

    • Author(s)
      忠澤充高, 廣田友佳, 三島史人, 秋山庸子, 西嶋茂宏
    • Organizer
      2010年度春季低温工学・超電導学会
    • Place of Presentation
      川崎市産業振興会館, 川崎市
    • Year and Date
      2010-05-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] 磁気力制御薬剤配送システムによる精密集積制御の検討(2)-生体内での検討-2010

    • Author(s)
      三島史人, 忠澤充高, 廣田友佳, 秋山庸子, 西嶋茂宏
    • Organizer
      2010年度春季低温工学・超電導学会
    • Place of Presentation
      川崎市産業振興会館, 川崎市
    • Year and Date
      2010-05-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] 非侵襲の磁気分離薬剤配送システムの研究2010

    • Author(s)
      忠澤充高、三島史人、秋山庸子、西嶋茂宏
    • Organizer
      第9回2010 磁気力制御・磁場夏の学校
    • Place of Presentation
      国立オリンピック記念青少年総合センター
    • Related Report
      2012 Final Research Report
  • [Presentation] 磁気力制御薬剤配送システムによる精密集積制御の検討(1)~モデル系での検討~2010

    • Author(s)
      忠澤充高、廣田友佳、三島史人、秋山庸子、西嶋茂宏
    • Organizer
      第82回2010年度低温工学・超伝導学会
    • Place of Presentation
      川崎市産業振興会館
    • Related Report
      2012 Final Research Report
  • [Presentation] 磁気力制御薬剤配送システムによる精密集積制御の検討(2)~生体内での検討~2010

    • Author(s)
      三島史人、忠澤充高、廣田友佳、秋山庸子、西嶋茂宏
    • Organizer
      第82回2010年度低温工学・超伝導学会
    • Place of Presentation
      川崎市産業振興会館
    • Related Report
      2012 Final Research Report
  • [Presentation] 磁気薬剤配送システム(MDDS)に関する基礎的研究2009

    • Author(s)
      廣田友佳、三島史人、秋山庸子、西嶋茂宏
    • Organizer
      第81回2009年度低温工学・超伝導学
    • Place of Presentation
      岡山大学
    • Related Report
      2012 Final Research Report
  • [Presentation] Development of Magnetic Drug Delivery System2009

    • Author(s)
      Y. Hirota, F. Mishima, Y. Akiyama, S. Nishijima
    • Organizer
      21st International Conference on Magnet Technology
    • Place of Presentation
      Heifei, China
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.see.eng.osaka-u.ac.jp/seeqb/seeqb/main/import/mdds.html

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.see.eng.osaka-u.ac.jp/seeqb/seeqb/main/import/dds.html

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2019-07-29  

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