Evaluation of nanoparticles exposure from surrounding environment and study on their disposition

• Project/Area Number: 21360253
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Civil and environmental engineering
• Research Institution: Kyoto University
• Principal Investigator: YONEDA Minoru 京都大学, 大学院・工学研究科, 教授 (40182852)
• Co-Investigator(Kenkyū-buntansha): NAKAYAMA Aki 京都大学, 大学院・工学研究科, 准教授 (10335200) ; SUGIMOTO Miki 京都大学, 大学院・農学研究科, 助教 (20243074) ; MIYOSHI Hirokazu 徳島大学, アイソトープ総合センター, 准教授 (90229906)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2009: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
• Keywords: ナノシリカ粒子 / 体内動態 / PBPPKモデル / 動物実験 / 空気中濃度 / PBPKモデル / 気管内投与 / 尾静脈投与 / 単回投与 / 連続投与 / リスク評価 / 静脈内投与 / 排泄経路 / 粒径分布 / ICR-マウス

Research Abstract

The biosafety of nano particles becomes a growing concern. Many experimental studies have shown that nano particles are able to penetrate deeply into the respiratory tract and translocate from the lungs into the systemic circulation. This study investigated the nano particles exposure from surrounding environment. Silica nano particles were selected as the target research particle. The disposition rate of silica nano particle in the air was determined using Low Pressure Impactor and ICP-AES. The results indicated that the silica nano particles concentration in the surrounding air was about 12. 7 ng/m3. The data was used in the disposition model to calculate the amount of silica nano particles in mice organs. The results of disposition model of mice showed that 0. 3 pg of silica nano particles was accumulated in liver. The results of disposition model of human showed that 1200 pg of silica nano particles was accumulated in lung.

Research Products

• [Journal Article] Whole-body distribution of 14C-labeled silica nanoparticles and submicron particles after intravenous injection into Mice (2012)
  • Author(s): Nobumitsu Sakai, Masato Takakura, Harutoshi Imamura, Miki Sugimoto, Yasuto Matsui, Hirokazu Miyoshi, Aki Nakayama, Minoru Yoneda
  • Journal Title: J Nanopart Res Volume: 14 Issue: 5 Pages: 849-849
  • DOI: 10.1007/s11051-012-0849-x
  • Peer Reviewed
• [Journal Article] Functional-dependent and size-dependent uptake of nanoparticles in PC12 (2011)
  • Author(s): N. Sakai, Y. Matsui, A. Nakayama, A. Tsuda, M. Yoneda
  • Journal Title: Journal of Physics : Conference Series Volume: Volume 304 Pages: 12049-12049
  • Peer Reviewed
• [Journal Article] 金属の体内輸送特性を考慮した生理学的薬物動態モデルの構築 (2011)
  • Author(s): 真見一樹, 北川英隆, 中村謙吾, 佐々木克典, 中山亜紀, 米田稔
  • Journal Title: 環境工学研究論文集
  • Peer Reviewed
• [Journal Article] ICRマウスにおける44nm^14C標識シリカナノ粒子を用いた体内動態評価モデルの構築 (2011)
  • Author(s): 今村治世, 高倉誠人, 坂井伸光, 中山亜紀, 佐々木克典, 真見一樹, 三好弘一, 杉本実紀, 米田稔
  • Journal Title: 環境工学研究論文集
  • Peer Reviewed
• [Journal Article] ICRマウスにおける44nm14C標識シリカナノ粒子を用いた体内動態評価モデルの構築 (2011)
  • Author(s): 今村治世, 高倉誠人, 坂井伸光, 中山亜紀, 佐々木克典, 真見一樹, 三好弘一, 杉本実紀, 米田稔
  • Journal Title: 環境工学研究論文集 Volume: III Pages: 223-232
  • Peer Reviewed
• [Journal Article] ICRマウスにおける14C標識シリカ微小粒子を用いた体内動態評価モデルの構築 (2010)
  • Author(s): 今村治世, 坂井伸光, 高倉誠人, 中山亜紀, 米田稔, 三好弘一, 杉本実紀, 佐々木克典, 真見一樹
  • Journal Title: 日本リスク研究学会第23回年次大会講演論文集 Volume: 23 Pages: 225-230
• [Presentation] ICRマウスにおける^14C標識シリカ微小粒子を用いた体内動態評価モデルの構築 (2010)
  • Author(s): 今村治世、坂井伸光、高倉誠人、中山亜紀、米田稔、三好弘一、杉本実紀、佐々木克典、真見一樹
  • Organizer: 日本リスク研究学会第23回年次大会講演論文集
  • Place of Presentation: 京都
  • Year and Date: 2010-11-28
• [Presentation] ICRマウスにおける14C標識シリカ微小粒子を用いた体内動態評価モデルの構築 (2010)
  • Author(s): 今村治世, 坂井伸光, 高倉誠人, 中山亜紀, 米田稔, 三好弘一, 杉本実紀, 佐々木克典, 真見一樹
  • Organizer: 日本リスク研究学会第23回年次大会講演論文集
  • Place of Presentation: 東京
  • Year and Date: 2010-11-27
• [Presentation] FUNCTIONAL-DEPENDENT AND SIZE-DEPENDENT UPTAKE OF NANOPARTICLES IN PC12, November 16-18, 2010, z (2010)
  • Author(s): Nobumitsu Sakai, Yasuto Matsui, Aki Nakayama, Akira Tsuda, Minoru Yoneda
  • Organizer: NANOSAFE 2010
  • Place of Presentation: 東京
  • Year and Date: 2010-11-27
• [Presentation] ICRマウスを用いた14C標識ナノシリカ粒子の体内動態に関する検討 (2010)
  • Author(s): 高倉誠人・坂井伸光・今村治世・中山亜紀・米田稔
  • Organizer: フォーラム:衛生薬学・環境トキシコロジー
  • Place of Presentation: 東京
  • Year and Date: 2010-09-10