| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2011: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2009: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Research Abstract |
Using a novel murine follicular dendritic cell line, FL-Y, I analyzed affinity maturation process of antibodies focusing on B cell selection in germinal centers(GCs). I found that FL-Y cells induced B cell death in the presence of a helper T cell cytokine, IL-21. The B cell death was shown to be dependent on PGE2 produced from FL-Y cells, The IL-21/PGE2-induced B cell death implicates a new negative selection mechanism of B cells in GCs.
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