| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2009: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Research Abstract |
CytochromoeP450(CYP) is an enzyme that is involved in metabolism of chemicals derived from inside or outside of bodies. The variety of the enzymes is observed among different species, probably reflecting the difference in habitats or diets of species. To know biological mechanism for diversifying enzymes among species, we examined molecular evolution of CYP2D subfamily that is involved in drag metabolism、and CYP mRNA expression differences between primate species. The analysis shows the origin of the subfamily in an ancestor of amphibian and Amniota and the specific feature of evolution at amino acid substitutions at the substrate recognition sites of the enzyme.
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