Basic and Applied Research on Integrated Nutriomics Encompassing Various Aspects of Lifestyle

• Project/Area Number: 21380076
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Food science
• Research Institution: The University of Tokyo
• Principal Investigator: KATO Hisanori 東京大学, 総括プロジェクト機構, 特任教授 (40211164)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000); Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2009: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
• Keywords: ニュートリゲノミクス / 遺伝子発現 / 栄養 / 生活習慣 / 運動 / 日内リズム / トランスクリプトミクス / プロテオミクス / メタボロミクス / データベース / ポリフェノール / タンパク質栄養 / 統合オミクス / 胎児期栄養 / バイオインフォマティクス / DNAマイクロアレイ / カロリー制限 / タウリン / プロヒビチン / 生体リズム / 生活習慣病

Research Abstract

Methods for analyzing huge kinds of biological molecules, which are so called "omics" methods, were employed to exhaustively examine the response of animals to consumption of specific foods. Multiple exhaustive analyses including those for the levels of mRNA, proteins, and metabolites were combined. Efforts were made to improve a database and an analytical tool for the promotion of these types of researches, and their effectiveness was proved. The effects of factors relating to dietary habits, which include exercise and circadian rhythm were also examined.

Research Products

• [Journal Article] Role of the renin-angiotensin-aldosterone system in the enhancement of salt sensitivity caused by prenatal protein restriction in stroke-prone spontaneously hypertensive rats (2012)
  • Author(s): Otani, L., Sugimoto, N., Kaji, M., Murai, M., Chang, S.-J., Kato, H. and Murakami, T
  • Journal Title: J. Nutr. Biochem Volume: (印刷中) Issue: 8 Pages: 892-899
  • DOI: 10.1016/j.jnutbio.2011.04.014
  • Peer Reviewed
• [Journal Article] Omics and integrated omics for the promotion of food and nutrition science (2011)
  • Author(s): Kato, H., Takahashi, S. and Saito, K
  • Journal Title: J. Trad. Comp. Med Volume: 1 Pages: 25-30
• [Journal Article] Mild caloric restriction up-regulates the expression of prohibitin (2011)
  • Author(s): Takahashi, S., Masuda, J., Shimagami, H., Ohta, Y., Kanda, T., Saito, K. and Kato, H
  • Journal Title: A proteome study. Biochem. Biophys. Res. Commun Volume: 405 Issue: 3 Pages: 462-467
  • DOI: 10.1016/j.bbrc.2011.01.054
  • Peer Reviewed
• [Journal Article] Significant dissociation of expression patterns of the basic helix-loop-helix transcription factors Dec1 and Dec2 in rat kidney (2011)
  • Author(s): Wu, T., Ni, Y., Zhue, F., Sun, L., Xu, B., Kato, H., Fu, Z.
  • Journal Title: J.Exp.Biol. Volume: 214(Pt.8) Issue: 8 Pages: 1257-1263
  • DOI: 10.1242/jeb.052100
  • Peer Reviewed
• [Journal Article] Regulatory mechanism for the stimulatory action of genistein on glucose uptake in vitro and in vivo (2011)
  • Author(s): Ha, B.G., Nagaoka, M., Yonezawa, T., Tanabe, R., Woo, J.T., Kato, H., Chung, U.I., Yagasaki, K.
  • Journal Title: J.Nutr.Biochem. Volume: (印刷中) Issue: 5 Pages: 501-509
  • DOI: 10.1016/j.jnutbio.2011.02.007
  • Peer Reviewed
• [Journal Article] 分子栄養学-遺伝子の働きから探る食品機能 (2011)
  • Author(s): 加藤久典
  • Journal Title: バイオテクニシャン Volume: 19 Pages: 6-14
• [Journal Article] Mild caloric restriction up-regulates the expression of prohibitin : A proteome study. (2011)
  • Author(s): Takahashi, S., Masuda, J., Shimagami, H., Ohta, Y., Kanda, T., Saito, K., Kato, H.
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 405 Pages: 462-467
  • Peer Reviewed
• [Journal Article] Feeding-induced rapid resetting of the hepatic circadian clock is associated with acute induction of Per2 and Dec1 transcription in rats (2010)
  • Author(s): Wu, T., Ni, Y., Kato, H. and Fu, Z
  • Journal Title: Chronobiol. Int Volume: 27 Issue: 1 Pages: 1-18
  • DOI: 10.3109/07420520903398625
  • Peer Reviewed
• [Journal Article] Dietary iron deficiency induces a variety of metabolic changes and even apoptosis in rat liver : a DNA microarray study. (2010)
  • Author(s): Kamei, A., Watanabe, Y., Ishijima, T., Uehara, M., Arai, S., Kato, H., Nakai, Y. and Abe, K
  • Journal Title: Physiol. Genomics Volume: 42 Issue: 2 Pages: 149-156
  • DOI: 10.1152/physiolgenomics.00150.2009
  • Peer Reviewed
• [Journal Article] Regulation of circadian gene expression in the kidney by light and food cues in rats (2010)
  • Author(s): Wu, T., Ni, Y., Dong, Y., Kato, H. and Fu, Z. W
  • Journal Title: Am. J. Physiol. Regul. Integr. Comp. Physiol Volume: 298 Issue: 3 Pages: 635-641
  • DOI: 10.1152/ajpregu.00578.2009
  • Peer Reviewed
• [Journal Article] Effect of mild restriction of food intake on gene expression profile in the liver of young rats : reference data for in vivo nutrigenomics study. (2010)
  • Author(s): Saito, K., Ohta, Y., Sami, M., Kanda, T. and Kato, H
  • Journal Title: Brit. J. Nutr Volume: 104 Issue: 7 Pages: 941-950
  • DOI: 10.1017/s0007114510001625
  • Peer Reviewed
• [Journal Article] Dietary iron deficiency induces a variety of metabolic changes and even apoptosis in rat liver : a DNA microarray study. (2010)
  • Author(s): Kamei, A., Watanabe, Y., Ishijima, T., Uehara, M., Arai, S., Kato, H., Nakai, Y., Abe, K.
  • Journal Title: Physiol.Genomics Volume: 42 Pages: 149-156
  • Peer Reviewed
• [Journal Article] Feeding-induced rapid resetting of the hepatic circadian clock is associated with acute induction of Per2 and Dec1 transcription in rats. (2010)
  • Author(s): Wu, T., Ni, Y., Kato, H., Fu, Z.
  • Journal Title: Chronobiol.Int. Volume: 27 Pages: 1-18
  • Peer Reviewed
• [Journal Article] Dietary protein deprivation up-regulates insulin signaling and inhibits gluconeogenesis in rat liver. (2010)
  • Author(s): Toyoshima, Y, Tokita, R., Ohne, Y., Hakuno, F., Noguchi, T., Minami, S., Kato, H., Takahashi, S.I.
  • Journal Title: J.Mol.Endocrinol. Volume: 45 Pages: 329-340
  • Peer Reviewed
• [Journal Article] Effect of mild restriction of food intake on gene expression profile in the liver of young rats : reference data for in vivo nutrigenomics study. (2010)
  • Author(s): Saito, K., Ohta, Y., Sami, M., Kanda, T., Kato, H
  • Journal Title: Brit.J.Nutr. 103(印刷中)
  • Peer Reviewed
• [Journal Article] Regulation of circadian gene expression in the kidney by light and food cues in rats. (2010)
  • Author(s): Wu, T., Ni, Y., Dong, Y., Kato, H., Fu, Z.W.
  • Journal Title: Am.J.Physiol.Regul.Integr.Comp.Physiol. 298 Pages: 635-641
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): Abe, K., Kato, H., Yasuoka, A., Nakai, Y.
  • Journal Title: Genomics, proteomics, and metabolomics in nutraceuticals and functional foods.(Wiley-Blackwell) Pages: 127-154
• [Journal Article] (2010)
  • Author(s): 加藤久典
  • Journal Title: 食の安全科学の展開-食のリスク予測と制御に向けて(シーエムシー出版) Pages: 98-102
• [Presentation] 統合オミクス解析によるアミノ酸過剰摂取マーカーの探索 (2012)
  • Author(s): 加藤久典、今村渉
  • Organizer: 日本農芸化学会2012年大会
  • Place of Presentation: 京都女子大学(招待講演)
  • Year and Date: 2012-03-25
• [Presentation] セリン欠乏反応に関わるエピジェネティクス制御機構の解明 (2011)
  • Author(s): 仁木麻衣、佐矢野智子、加藤久典、古屋茂樹
  • Organizer: 日本アミノ酸学会第5回学術大会
  • Place of Presentation: 名古屋大学
  • Year and Date: 2011-11-05
• [Presentation] 胎児期低タンパク質暴露と高血圧 (2011)
  • Author(s): 加藤久典
  • Organizer: 第9回高付加価値食品開発のためのフォーラム
  • Place of Presentation: 三島市(招待講演)
  • Year and Date: 2011-09-02
• [Presentation] 統合オミクス技術と食品機能性解析第6回核酸 (2011)
  • Author(s): 加藤久典
  • Organizer: 核タンパク機能性研究会学術大会
  • Place of Presentation: 北海道恵庭市
  • Year and Date: 2011-08-08
• [Presentation] 統合オミクス技術と食品機能性解析 (2011)
  • Author(s): 加藤久典
  • Organizer: 第6回核酸・核タンパク機能性研究会学術大会
  • Place of Presentation: 恵庭市(招待講演)
  • Year and Date: 2011-08-08
• [Presentation] Mild caloric restriction up-regulates the expression of prohibitin : A proteome study (2011)
  • Author(s): Takahashi, S., Masuda, J., Shimagami, H., Ohta, Y., Kanda, T., Saito, K., Kato, H
  • Organizer: 11th Asian Congress of Nutrition
  • Place of Presentation: シンガポール
  • Year and Date: 2011-07-15
• [Presentation] Keggle : Web-based visualization tool of omics data for the promotion of nutri-omics study (2011)
  • Author(s): Saito, K. and Kato, H
  • Organizer: 11th Asian Congress of Nutrition
  • Place of Presentation: シンガポール
  • Year and Date: 2011-07-15
• [Presentation] Mild caloric restriction up-regulates the expression of prohibitin : A prot eome study (2011)
  • Author(s): Takahashi, S., Masuda, J., Shimagami, H., Ohta, Y., Kanda, T., Saito, K., Kato, H.
  • Organizer: 11th Asian Congress of Nutrition
  • Place of Presentation: シンガポール
  • Year and Date: 2011-07-15
• [Presentation] 網羅的解析技術による食品の機能性研究の現状 (2011)
  • Author(s): 加藤久典
  • Organizer: 第65回日本栄養・食糧学会大会
  • Place of Presentation: お茶の水女子大学
  • Year and Date: 2011-05-15
• [Presentation] 網羅的解析技術による食品の機能性研究の現状 (2011)
  • Author(s): 加藤久典
  • Organizer: 第65回 日本栄養・食糧学会大会
  • Place of Presentation: お茶の水女子大学(招待講演)
  • Year and Date: 2011-05-15
• [Presentation] コーヒー摂取による高脂肪食誘導性2型糖尿病の抑制 (2011)
  • Author(s): 江頭健二, 高橋祥子, 福島洋一, 阿部啓子, 加藤久典
  • Organizer: 第65回 日本栄養・食糧学会大会
  • Place of Presentation: お茶の水女子大学
  • Year and Date: 2011-05-15
• [Presentation] 網羅的手法を用いたロイシン過剰摂取時における毒性評価 (2011)
  • Author(s): 今村渉、高井まりえ、金本龍平、加藤久典
  • Organizer: 第65回 日本栄養・食糧学会大会
  • Place of Presentation: お茶の水女子大学
  • Year and Date: 2011-05-15
• [Presentation] 胎児期タンパク質制限モデルにおける血圧調節関連遺伝子のメチル化解析 (2011)
  • Author(s): 今門泰久, 大谷りら, 大鐘潤, 村上哲男, 加藤久典
  • Organizer: 第65回 日本栄養・食糧学会大会
  • Place of Presentation: お茶の水女子大学
  • Year and Date: 2011-05-15
• [Presentation] 穏やかなカロリー制限によるProhibitinの発現上昇 (2011)
  • Author(s): 高橋祥子、桝田旬子、島上洋、太田豊、神田智正、斉藤憲司、加藤久典
  • Organizer: 2011年日本農芸化学会大会
  • Place of Presentation: 京都女子大学(京都府)
  • Year and Date: 2011-03-26
• [Presentation] ニュートリオミクスがもたらす栄養学の新展開 (2010)
  • Author(s): 加藤久典
  • Organizer: 日本農芸化学会関東支部大会
  • Place of Presentation: 近畿大学(奈良県)
  • Year and Date: 2010-10-02
• [Presentation] 食品因子・運動負荷・薬剤がラット肝脂質代謝に与える影響のトランスクリプトーム解析 (2010)
  • Author(s): 斉藤憲司、小笠原由貴、加藤久典
  • Organizer: 第64回日本栄養・食糧学会大会
  • Place of Presentation: アスティ徳島(徳島県)
  • Year and Date: 2010-05-23
• [Presentation] SHRSPラットにおける胎児期の低タンパク質栄養に起因する食塩感受性亢進機構のトランスクリプトーム解析 (2010)
  • Author(s): 大谷りら、斉藤憲司、末安俊明、村上哲男、加藤久典
  • Organizer: 第64回日本栄養・食糧学会大会
  • Place of Presentation: アスティ徳島(徳島県)
  • Year and Date: 2010-05-23
• [Presentation] Functional study of an amino acid response element of the phosphoenolpyruvate carboxykinase 2(PEPCK2)gene. (2009)
  • Author(s): 石井駿介、小野絢香、斉藤憲司、加藤久典
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-12-12
• [Presentation] Transgenerational Effects of Maternal Protein Restriction During Pregnancy on Salt Sensitivity and Life Span in Stroke-Prone Spontaneously Hypertensive Rats(SHRSP) (2009)
  • Author(s): Otani, L., Murakami, T. and Kato, H
  • Organizer: 19th International Congress of Nutrition
  • Place of Presentation: BITEK(バンコク)
  • Year and Date: 2009-10-09
• [Presentation] Data Storage and Comparative Analysis of Gene Expression Profiles for Promotion of Nutrigenomics Study (2009)
  • Author(s): Saito, K., Ohta, Y., Sami, M., Kanda, T. and Kato, H
  • Organizer: 19th International Congress of Nutrition
  • Place of Presentation: BITEK(バンコク)
  • Year and Date: 2009-10-06
• [Book] 基礎栄養学 (2012)
  • Author(s): 佐藤隆一郎、加藤久典
  • Total Pages: 160
  • Publisher: 学文社
• [Book] 食べ物と健康 (2012)
  • Author(s): 佐藤隆一郎、加藤久典(編)
  • Total Pages: 245
  • Publisher: 学文社
• [Book] 基礎栄養学 (2012)
  • Author(s): 佐藤隆一郎、加藤久典(編)
  • Total Pages: 160
  • Publisher: 学文社
• [Book] バイオチップ実用化ハンドブック (2010)
  • Author(s): 加藤久典、斉藤憲司
  • Publisher: エヌ・ティー・エス
• [Book] Genomics, proteomics, and metabolomics in nutraceuticals and functional foods (2010)
  • Author(s): Abe, K., Kato, H., Yasuoka, A. and Nakai, Y.
  • Publisher: Wiley-Blackwell
• [Book] 食の安全科学の展開-食のリスク予測と制御に向けて (2010)
  • Author(s): 加藤久典
  • Publisher: シーエムシー出版
• [Remarks]
  • URL: http://www.nutrigenomics.jp
• [Remarks]
  • URL: http://www.keggle.jp
• [Remarks]
  • URL: http://www.nutrigenomics.jp
• [Remarks]
  • URL: http://www.a.u-tokyo.ac.jp/topics/topics110303.html
• [Remarks]
  • URL: http://www.nutrigenomics.jp
• [Remarks]
  • URL: http://www.keggle.jp