Study on the antitumor effect of vitamin B6

• Project/Area Number: 21380083
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Food science
• Research Institution: Hiroshima University
• Principal Investigator: KATO Norihisa 広島大学, 大学院・生物圏科学研究科, 教授 (20144892)
• Co-Investigator(Kenkyū-buntansha): YANAKA Noriyuki 広島大学, 大学院・生物圏科学研究科, 准教授 (70346526) ; MATSUBARA Kiminori 広島大学, 教育学研究科, 准教授 (90254565)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000); Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
• Keywords: ビタミンB6 / 抗腫瘍作用 / 遺伝子発現 / オートファジー / 炎症 / 大腸 / 大腸がん / インフラマソーム / Cystatin A / NOX-1 / リンパ管新生 / HSP / DNA microarray / SPI-3

Research Abstract

This study was performed to examine why the anti-tumor effect of vitamin B6 is profound in the colon. This reason was explained by indicating the higher sensitivity of colon levels of B6-vitamers to dietary supplemental vitamin B6. Further study with animals and colon cancer cells was conducted to examine the gene expression in response to vitamin B6. The results indicated the vitamin B6 altered the expression of genes relating to mast cells and cytotoxicT-cell activity and cytoprotection, which may lead to the anti-tumor effect

Research Products

• [Journal Article] Regulation of colon geneexpression by vitamin B6 supplementation (2012)
  • Author(s): Toya Keigo, Hirata Atsuko, OhataTomomi, Sanada Yohei
  • Journal Title: Mol. Nutr. Food Res Volume: 56 Issue: 4 Pages: 641-652
  • DOI: 10.1002/mnfr.201100707
  • Peer Reviewed
• [Journal Article] Vitamin B6 suppressesserine protease inhibitor 3 expression inthe colon of rats and in TNF-α-stimulated HT-29 cells (2011)
  • Author(s): Noriyuki Yanaka, Tomomi Ohata, KeigoToya, Mayumi Kanda, Atsuko Hirata, Norihisa Kato
  • Journal Title: Mol. Nutr. Food Res. Volume: 55 Issue: 4 Pages: 635-645
  • DOI: 10.1002/mnfr.201000282
  • Peer Reviewed
• [Journal Article] Consumption of vitamin B6 reduces colonicdamage and protein expression of HSP70and HO-1 in rats exposed to1, 2-dimethylhydrazine (2011)
  • Author(s): Kayashima Tomoko, Tanaka Kenta, Okazaki Yukako, Matsubara Kiminori, Yanaka Noriyuki, Kato Norihisa
  • Journal Title: Oncol. Lett Volume: 2 Issue: 6 Pages: 1243-1246
  • DOI: 10.3892/ol.2011.370
  • Peer Reviewed
• [Journal Article] Vitamin B6 regulates mRNA expression of peroxisome proliferator-activatedreceptor-γtarget genes (2011)
  • Author(s): Yanaka Noriyuki, Kanda Mayumi, Toya Keigo, Suehiro Haruna, Kato Norihisa
  • Journal Title: Exp. Ther. Med Volume: 2 Issue: 3 Pages: 419-424
  • DOI: 10.3892/etm.2011.238
  • Peer Reviewed
• [Journal Article] Vitamin B6 suppresses serine protease inhibitor 3 expression in the colon of rats and in TNF-α-stimulated HT-29 cells (2011)
  • Author(s): Noriyuki Yanaka, Tomomi Ohata, Keigo Toya, Mayumi Kanda, Atsuko Hirata, Norihisa Kato
  • Journal Title: Molecular Nutrition and Food Research Volume: 55 Pages: 635-643
  • Peer Reviewed
• [Journal Article] ビタミンB6のがん予防研究の新展開 (2010)
  • Author(s): 加藤範久
  • Journal Title: ビタミン Volume: 84 Pages: 17-19
  • Peer Reviewed
• [Journal Article] ビタミンB6のがん予防研究の新展開 (2010)
  • Author(s): 加藤範久
  • Journal Title: ビタミン 84 Pages: 17-20
  • Peer Reviewed
• [Presentation] Inhibitory effect of vitamin B6, pyridoxal 5'-phosphate on lymphangiogenesis (2012)
  • Author(s): Matsubara Kiminori, Kato Norihisa
  • Organizer: Advances and Controversies in B-Vitaminsand Choline
  • Place of Presentation: Leipzig, Germany
  • Year and Date: 2012-03-06
• [Presentation] Consumption of Vitamin B6 Modulates Colonic Luminal Environment in Rats (2011)
  • Author(s): Sofya Suidasari, Yukako Okazaki, Utama Zaki, Aimi Ohsaki, Noriyuki Yanaka, Hiroyuki Tomotake, Norihisa Kato
  • Organizer: 2011 International Conference on Food Factors
  • Place of Presentation: 台北、台湾
  • Year and Date: 2011-11-22
• [Presentation] Effect of dietary vitamin B6 on colonic luminal environment in rats (2011)
  • Author(s): Sofya Suidasari, Okazaki Yukako, ZakiUtama, Zhang Peipei, Ohsaki Aimi, YanakaNoriyuki, Tomotake Hiroyuki, KatoNorihisa
  • Organizer: 2011International Conference on Food Factors
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2011-11-21
• [Presentation] Molecular mechanisms of anti-tumor effect of vitamin B6 (2011)
  • Author(s): Kato Norihisa
  • Organizer: 2011International Conference on Food Factors
  • Place of Presentation: Taipei, tqiwan
  • Year and Date: 2011-11-20
• [Presentation] Molecular Mechanisms of Anti-tumor Effect of Vitamin B6 (2011)
  • Author(s): Norihisa Kato
  • Organizer: 2011 International Conference on Food Factors
  • Place of Presentation: 台北、台湾
  • Year and Date: 2011-11-20
• [Presentation] ビタミンB6摂取に対する組織PLP,及びS1P濃度の応答 (2011)
  • Author(s): ソフィアスイダサリ, カボマシシ, 矢中規之, 加藤範久
  • Organizer: 第43回日本栄養・食糧学会中四国支部大会
  • Place of Presentation: 高知
  • Year and Date: 2011-11-07
• [Presentation] ビタミンB6による遺伝子発現変動の解析 (2011)
  • Author(s): 加藤範久
  • Organizer: 第426回ビタミンB研究協議会
  • Place of Presentation: 大津
  • Year and Date: 2011-11-05
• [Presentation] ビタミンB6による遺伝子発現変動の解析 (2011)
  • Author(s): 加藤範久
  • Organizer: ビタミンB研究委員会
  • Place of Presentation: 大津市
  • Year and Date: 2011-11-05
• [Presentation] Anti-tumor Effect of Dietary vitamin B6 and its me chanisms (2011)
  • Author(s): Kato Norihisa
  • Organizer: International Conference on Cofactors 03
  • Place of Presentation: Turku, Finland
  • Year and Date: 2011-07-14
• [Presentation] Anti-tumor Effect of Dietary Vitamin B6 and Its Mechanisms (2011)
  • Author(s): Norihisa Kato
  • Organizer: The Third International Conference on Cofactors 03
  • Place of Presentation: Turku, Finland
  • Year and Date: 2011-07-14
• [Presentation] Consumption of Vitamin B6 Modulates Colonic Luminal Environment in Rats Fed a High-fat Diet (2011)
  • Author(s): Yukako Okazaki, Noriyuki Yanaka, Norihisa Kato
  • Organizer: The Third International Conference on Cofactors 03
  • Place of Presentation: Turku, Finland
  • Year and Date: 2011-07-14
• [Presentation] Consumption of vtamin B6 modulates colonic luminal environment in rats fed a high-fat diet (2011)
  • Author(s): Okazaki Yukako, Zaki Utama, SofyaSuidasari, Zhang Peipei, Ohsaki Aimi, Yanaka Noriyuki, Tomotake Hiroyuki, Sakaguchi Ei, Kato Norihisa
  • Organizer: International Conference on Cofactors 03
  • Place of Presentation: Turku, Finland
  • Year and Date: 2011-07-13
• [Presentation] ビタミンB6摂取に応答する大腸遺伝子発現のDNA microarray解析 (2011)
  • Author(s): 加藤範久
  • Organizer: 第424回ビタミンB研究協議会
  • Place of Presentation: 広島
  • Year and Date: 2011-06-03
• [Presentation] ビタミンB6摂取が単球・マクロファージの白色脂肪組織への浸潤に与える影響 (2011)
  • Author(s): 久本高央、真田洋平、末廣春奈、加藤範久、矢中規之
  • Organizer: 日本農芸化学会中四国支部大会
  • Place of Presentation: 岡山市
  • Year and Date: 2011-05-21
• [Presentation] ビタミンB6摂取のラット腸内環境への影響 (2011)
  • Author(s): Sofya Suidasari、張培培、大崎愛美、矢中規之、岡崎由佳子、友竹浩之、坂口英、加藤範久
  • Organizer: 日本栄養・食糧学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-15
• [Presentation] ビタミンB6摂取量に対するマウス各臓器B6代謝物の応答の比較 (2011)
  • Author(s): Masisi Kabo, Sofya Suidasari, 矢中規之, 加藤範久
  • Organizer: 日本栄養・食糧学会大会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-14
• [Presentation] Viamin B6の摂取が脂肪組織の遺伝子発現に及ぼす影響 (2011)
  • Author(s): 真田洋平, 矢中規之, 末廣春奈, 久本高央, 平田敦子, 西村英紀, 加藤範久
  • Organizer: 2011年度日本農芸化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-03-27
• [Presentation] azoxymethane誘発大腸腫瘍モデルマウスの初期病変に関わる新規標的因子の同定,および抗癌活性を有するvitamin B6の予防効果に関する解析 (2010)
  • Author(s): 平田敦子, 真田洋平, 末廣春奈, 大畑智美, 矢中規之, 加藤範久
  • Organizer: 第33回日本分子生物学会年会第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-10
• [Presentation] ビタミンB6摂取に部する組織PLP、及びS1P濃度の応答 (2010)
  • Author(s): ソフィアスイダサリ、カボマシシ、矢中規之、加藤範久
  • Organizer: 第43回 日本栄養・食糧学会 中四国支部大会
  • Place of Presentation: 高知女子大学
  • Year and Date: 2010-11-07
• [Presentation] ビタミンB6摂取による大腸における遺伝子発現調節作用 (2010)
  • Author(s): 大畑智美, 矢中規之, 平田敦子, 真田洋平, 末廣春奈, 鳥家圭伍, 加藤範久
  • Organizer: 2010年度日本農芸化学会大会
  • Place of Presentation: 東京
  • Year and Date: 2010-03-29
• [Presentation] ヒタミンB6摂取による大腸における遺伝子発現調節作用 (2010)
  • Author(s): 矢中規之
  • Organizer: 日本農芸化学会2010年度大会
  • Place of Presentation: 東京大学駒場(東京都)
  • Year and Date: 2010-03-29
• [Book] Wageningen AcademicPublishers, Role of vitamin B6 in skin healthand diseases. Chapter 4 (2012)
  • Author(s): Kato Norihisa
  • Publisher: Handbook of diet, nutrition and the skin. ed. by Victor R. Reedy
• [Book] Role of vitamin B6 in skin health and diseases. Hand Book of diet, nutrition and the skin (2012)
  • Author(s): Norihisa Kato (edited by Victor R.Preedy)
  • Total Pages: 8
  • Publisher: Wageningen Academic Publishers
• [Book] ビタミン総合事典 (2010)
  • Author(s): 加藤範久,朝倉書店
  • Publisher: 朝倉書店
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/nutri/index.htm