Study on the antitumor effect of vitamin B6
| Project/Area Number |
21380083
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Food science
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
KATO Norihisa 広島大学, 大学院・生物圏科学研究科, 教授 (20144892)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YANAKA Noriyuki 広島大学, 大学院・生物圏科学研究科, 准教授 (70346526)
MATSUBARA Kiminori 広島大学, 教育学研究科, 准教授 (90254565)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
|
|---|
| Keywords | ビタミンB6 / 抗腫瘍作用 / 遺伝子発現 / オートファジー / 炎症 / 大腸 / 大腸がん / インフラマソーム / Cystatin A / NOX-1 / リンパ管新生 / HSP / DNA microarray / SPI-3 |
|---|
| Research Abstract |
This study was performed to examine why the anti-tumor effect of vitamin B6 is profound in the colon. This reason was explained by indicating the higher sensitivity of colon levels of B6-vitamers to dietary supplemental vitamin B6. Further study with animals and colon cancer cells was conducted to examine the gene expression in response to vitamin B6. The results indicated the vitamin B6 altered the expression of genes relating to mast cells and cytotoxicT-cell activity and cytoprotection, which may lead to the anti-tumor effect
|
Report
(4 results)
Research Products
(32 results)
