Study on the function of the responsible gene for diet induced hypercholesterolemia identified by linkage analysis
| Project/Area Number |
21380084
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SATO Masao 九州大学, 大学院・農学研究院, 准教授 (90294909)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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| Keywords | 栄養化学 / コレステロール / エストロゲン / 連鎖解析 / ラットゲノム / Smek2 / HDL / ラット / 血清コレステロール濃度 |
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| Research Abstract |
The responsible genes for dietary induced hypercholesterolemia separately exist on 14^<th> and 5^<th> chromosomes of rats. The gene on the 14^<th> chromosome is SMEK2. SMEK2 affects on the triacylglycerol synthesis in the liver according to the data from a congenic strain of Ex. BN-Dihc2 rats and transcriptome analysis applied on the two strains. The number of candidate gene(s) on the 5^<th> chromosome is still 245 genes.
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Report
(4 results)
Research Products
(13 results)
