Functions of gicerin, a cell adhesion molecule in development, memory and oncogenesis of animals

• Project/Area Number: 21380182
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: Kyoto Prefectural University
• Principal Investigator: TSUKAMOTO Yasuhiro 京都府立大学, 生命環境科学研究科, 教授 (90305657)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000); Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2009: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: 細胞接着分子 / 発生 / 記憶 / 腫瘍 / 獣医学

Research Abstract

In this study, the expression and functions of gicerin were examined in development, memory and oncogenesis of animals. Gicerin appeared in the skin dermal autografs of chickens and promoted the regeneration of epithelia of grafts. Furthermore, gicerin promoted the metastatic activities of tumor cells including colorectal cancer cells and marek's disease. Gicern knockout mice were totally lethal in development, thus its potential role in organogenesis and memory remains to be elucidated.

Research Products

• [Journal Article] Protection from avian influenza H5N1 virus infection with antibody-impregnated filters (2011)
  • Author(s): Kamiyama Y, Adachi K, Handharyani E, Soejoedono RD, Kusano T, Inai M, Tsukamoto M, Kashiwagi S, Tsukamoto Y.
  • Journal Title: Virology J Volume: 8 Pages: 54-54
• [Journal Article] Antibodies against swine influenza virus neutralize the pandemic influenza virus A/H1N1 (2011)
  • Author(s): Tsukamoto M, Hiroi S, Adachi K, Kato H, Inai M, Konishi I, Tanaka M, Yamamoto R, Sawa M, Handharyani E, Tsukamoto Y.
  • Journal Title: Mol Med Rep Volume: 4 Pages: 209-214
• [Journal Article] Ostrich produce cross-reactive neutralization antibodies against pandemic influenza virus A/H1N1 following immunization with a seasonal influenza vaccine (2011)
  • Author(s): Adachi K, Takama K, Tsukamoto M, Inai M, Handharyani E, Hiroi S, Tsukamoto Y.
  • Journal Title: Exp Ther Med Volume: 2 Pages: 41-45
• [Journal Article] Expression of SC1, a cell adhesion molecule, promotes the metastatic activities of the Gallus gallus lymphoblastoid cell line MDCC-MSB1 derived from Marek's disease (2011)
  • Author(s): Handharyani E, Tsukamoto M, Tsukamoto Y.
  • Journal Title: Avian Pathol Volume: 40 Pages: 111-115
• [Journal Article] Expression of SC1, a cell adhesion molecule, promotes the metastatic activities of the Gallus gallus lymphoblastoid cell line MDCC-MSB1 derived from Marek's disease. (2011)
  • Author(s): Handharyani E, Tsukarnoto M, Tsukamoto Y
  • Journal Title: Avian Pathology Volume: 40 Pages: 111-115
  • Peer Reviewed
• [Journal Article] Involvement of gicerin, a cell adhesion molecule, in the portal metastasis of rat colorectal adenocarcinoma cells (2010)
  • Author(s): Adachi K, Hattori M, Kato H, Inai M, Tsukamoto M, Handhartani E, Taira E, Tsukamoto Y.
  • Journal Title: Oncol Rep Volume: 24 Pages: 1427-1431
• [Journal Article] Involvement of gicerin, a cell adhesion molecule, in a dermal autograft chicken model (2010)
  • Author(s): Tsukamoto Y, Kataoka B, adachi K, Kato H, Inai M, Tsukamoto M, Handhartani E, Taira E.
  • Journal Title: Int J Mol Med Volume: 26 Pages: 661-666
• [Journal Article] Protecti on from avian influenza H5N1 virus infection with antibody-impregnated filters (2010)
  • Author(s): Kamiyama Y, Adachi K, Handharyani E, Soejoedono RD, Kusano T, Inai M, Tsukamoto M, Kashiwagi S, Tsukamoto Y.
  • Journal Title: Nature prec Volume: 4548 Pages: 1-1
• [Journal Article] Involvement of gicerin, a cell adhesion molecule, in a dermal autograft chicken model. (2010)
  • Author(s): Tsukamoto Y, Kataoka B, Adachi K, Kato H, Inai M, Tsukamoto M, Handharyani E, Taira E.
  • Journal Title: International Journal of Molecular Medicine Volume: 26 Pages: 661-666
  • Peer Reviewed
• [Journal Article] Involvement of gicerin, a cell adhesion molecule, in the portal metastasis of rat colorectal adenocazcinoma cells. (2010)
  • Author(s): Adachi K, Hattori M, Kato H, Inai M, Tsukamoto M, Handharyani E, Taira E, Tsukamoto Y
  • Journal Title: Oncology Reports Volume: 24 Pages: 1427-1431
  • Peer Reviewed
• [Presentation] 抗体担持エアフィルターを用いた高病原性鳥インフルエンザウイルスH5N1感染防御の試み (2010)
  • Author(s): 塚本康浩, 足立和英, 草野隆之, 上山洋一郎
  • Organizer: 日本ウイルス学会
  • Place of Presentation: 徳島
  • Year and Date: 2010-11-09
• [Presentation] 抗体担持エアフィルターを用いた高病原性鳥インフルエンザウイルスH5N1感染防御の試み
  • Author(s): 塚本康浩、足立和英、草野隆之、上山洋一郎
  • Organizer: 日本ウイルス学会2010年
  • Place of Presentation: 徳島
• [Patent(Industrial Property Rights)] エンドセリン受容体を標的とした高病原性鳥インフルエンザH5N1感染の治療薬 (2010)
  • Inventor(s): 塚本康浩
  • Industrial Property Rights Holder: 京都府立大学
  • Industrial Property Number: 2010-087975
  • Filing Date: 2010-04-06
• [Patent(Industrial Property Rights)] ダチョウを用いた抗体、及びその作製方法 (2010)
  • Inventor(s): 塚本康浩
  • Industrial Property Rights Holder: 府立大学、科学技術振興機構
  • Acquisition Date: 2010-04-09
• [Patent(Industrial Property Rights)] エンドセリン受容体を標的とした高病原性鳥インフルエンザH5N1感染の治療薬 (2010)
  • Inventor(s): 塚本康浩、足立和英、稲井まりえ
  • Industrial Property Rights Holder: 京都府立大学
  • Industrial Property Number: 2011-084676
  • Filing Date: 2010-04-07
• [Patent(Industrial Property Rights)] メラノーマ又は肺癌の検査のためのキット (2009)
  • Inventor(s): 塚本康浩
  • Industrial Property Rights Holder: 科学技術振興機構
  • Acquisition Date: 2009-07-31