| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2010: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2009: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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| Research Abstract |
A new methodology for the conversion of racemic allyl alcohols into optically pure compounds was devised by the combined use of hydrolases and vanadium compounds. The results of this project present an innovative concept for the asymmetric synthesis of optically active compounds which is essential for the drug discovery research. It is noteworthy that in order to fulfill the original functions of the two highly reactive catalysts ; viz., enzymes and the oxovanadium compound, without mutual deactivation in a single reaction vessel, mesoporous silica was effectively employed to divide their work space.
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