Development of the next generation of AIDS vaccine candidates based on the immune response of HIV-resistant individuals.
| Project/Area Number |
21390035
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
MISUMI Shogo 熊本大学, 大学院・生命科学研究部, 准教授 (40264311)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAMUNE Nobutoki 熊本大学, 大学院・生命科学研究部, 助教 (60322749)
SHOJI Shozo 熊本大学, 大学院・生命科学研究部, 名誉教授 (60040317)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Keywords | HIV / ワクチン / 粘膜 / 交叉免疫 / 経膣感染 / 感染モデル |
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| Research Abstract |
In this research, the following results were obtained.
1) The antibodies against viral ENV or CCR5 were induced in the vagina and mucosal surface.
2) The cross-reacting antigen for maintaining the titer level of antibodies against ENV or CCR5 was found.
3) To develop nonhuman primate models for vaginal HIV-1 infection in Japan, it resulted in the conclusion that the nonhuman primate model was inoculated with the mixture of 10000 TCID_<50>/ml of free SIV(1 ml), SIV-infected cells, and semen because cynomolgus monkey shows similar estrous cycle like women.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Targeted delivery of immunogen to primate M-cells with tetragalloyl lysine dendrimer2009
Author(s)
Misumi S, Masuyama M, Takamune N, Nakayama D, Mitsumata R, Matsumoto H, Urata N, Takahashi Y, Muneoka A Sukamoto T, Fukuzaki K, Shoji S
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Journal Title
J. Immunol
Pages: 6061-6070
Related Report
Peer Reviewed
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[Journal Article] Targeted delivery of immunogen to primate M-cells with tetragalloyl lysine dendrimer2009
Author(s)
Misumi S, Masuyama M, Takamune N, Nakayama D, Mitsumata R, Matsumoto H, Urata N, Takahashi Y, Muneoka A, Sukamoto T, Fukuzaki K, Shoji S.
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Journal Title
J.Immunol. 182
Pages: 6061-6070
Related Report
Peer Reviewed
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[Presentation] HIV感染防止粘膜ワクチンの創製-Absolute rejection vaccineを目指して2010
Author(s)
三隅将吾, 大坪靖治, 野崎清輝, 八城勢造, 高橋義博, 増山光明, 宗岡篤信, 洲加本孝幸, 福崎好一郎, 杉本幸彦, 高宗暢暁, 庄司省三
Organizer
日本エイズ学会
Place of Presentation
グランドプリンスホテル高輪(東京)
Year and Date
2010-11-24
Related Report
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[Presentation] HIV感染防止粘膜ワクチンの創製-Absolute rejection vaccineを目指して2010
Author(s)
三隅将吾, 大坪靖治, 野崎清輝, 八城勢造, 高橋義博, 増山光明, 宗岡篤信, 洲加本孝幸, 福崎好一郎, 杉本幸彦, 高宗暢, 庄司省三
Organizer
日本エイズ学会
Place of Presentation
東京(グランドプリンスホテル高輪)
Year and Date
2010-11-24
Related Report
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