Molecular identification and physiological role of brain-type prostaglandin transporter
| Project/Area Number |
21390042
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | University of Toyama |
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Principal Investigator |
HOSOYA Ken-ichi 富山大学, 大学院・医学薬学研究部(薬学), 教授 (70301033)
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| Co-Investigator(Kenkyū-buntansha) |
AKANUMA Shin-ichi 富山大学, 大学院・医学薬学研究部(薬学), 助教 (30467089)
SAKAI Hideki 富山大学, 大学院・医学薬学研究部(薬学), 教授 (60242509)
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| Co-Investigator(Renkei-kenkyūsha) |
TACHIKAWA Masanori 東北大学, 大学院・薬学研究科, 准教授 (00401810)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2009: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | クリアランス / トランスポーター / プロスタグランジン / 有機アニオン輸送担体 / 脳・神経 / 脳脊髄液 / 脳関門 / 血液脳脊髄液関門 |
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| Research Abstract |
Our in vivo and in vitro studies revealed that PGD_2 and PGE_2, which are major prostaglandins in the brain, were eliminated from rat cerebroventricle across the blood-cerebrospinal fluid barrier(BCSFB). To examine the involvement of brain-type prostaglandin transporter(PGT-Br) in this elimination process, PGT-Br-expressing Xenopus Laevis oocytes were established. The PGD_2 uptake activity into PGT-Br-expressing oocytes was high, but not significantly altered, compared with water-injected oocytes
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Amyloid-βpeptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier2011
Author(s)
Fujiyoshi M., Tachikawa M., Ohtsuki S., Ito S., Uchida Y., Akanuma S., Kamiie J., Hashimoto T., Hosoya K., Iwatsubo T., Terasaki T.
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Journal Title
J. Neurochem.
Volume: 118
Issue: 3
Pages: 407-15
DOI
Related Report
Peer Reviewed
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