| Project/Area Number |
21390052
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General anatomy (including Histology/Embryology)
|
|---|
| Research Institution | University of Fukui |
|---|
Principal Investigator |
SATO Makoto 福井大学, 医学部, 教授 (10222019)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YAGI Hideshi 兵庫医科大学, 医学部, 准教授 (10303372)
XIE Min-jue 福井大学, 医学部, 助教 (40444210)
IGUCHI Tokuichi 福井大学, 医学部, 特命助教 (60509305)
IKEDA Hiroshi 福井大学, 工学研究科, 教授 (80377473)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
|
|---|
| Keywords | 細胞分化 / 細胞形成 / 細胞骨格 / 解剖学 / 細胞・組織 / 神経科学 / 脳・神経 / 脂質 / アクチン / スパイン / 細胞移動 |
|---|
| Research Abstract |
It has been demonstrated that LL5beta and FILIP bind to filamin A, one of well-known actin-binding molecules, and exert their important activities over cell migration, especially radial migration that is essential for the neocortex development. In the present study, we further pursued the possible roles of LL5beta and FILIP in the adult brain and found that LL5beta plays an important role for spine development and that FILIP for synaptic transmission through modulating the morphology of spines and subcellular localization of glutamate receptors. In addition, we observed that some actin-binding molecules, other than filamin A, are involved in their activities.
|
