| Project/Area Number |
21390079
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General medical chemistry
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OKA Kiyomasa 大阪大学, 産学連携本部, 特任准教授 (70314474)
FUKUTA Kazuhiro 大阪大学, 先端科学イノベーションセンター, 招聘准教授 (90379264)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
FUNAKOSHI Hiroshi 大阪大学, 医学系研究科, 准教授 (40273685)
MIZUNO Shinya 大阪大学, 医学系研究科, 助教 (10219644)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
|
|---|
| Keywords | 細胞内シグナル伝達 / 成熟幹細胞 / TDO / 細胞密度依存性 / プロリン / サイクリンD1 / サイクリンE1 / DNA合成 / 成熟肝細胞 / 最終分化 / c-Met / HGFレセプター / LAR |
|---|
| Research Abstract |
Growth and differentiated functions of mature hepatocytes are reciprocally regulated by cell density.
(1) We found that a furin-like protease activity is involved in HGF-mediated LAR activation under high-cell density conditions.
(2) Using TDO promoter-EGFP transgenic mice, we found that a conserved homologous region exists among the species. Furthermore, C/ EBP-αcan bind its site and activate promoter activity.
(3) Proline is an essential amino acid for hepatocyte growth. Proline increased accumulation of cyclin D and E proteins via newly synthesized collagen.
|
