Regulation of the ubiquitin system by checkpoint kinases in response to stalled replication forks

• Project/Area Number: 21390094
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Kyoto University
• Principal Investigator: TAKATA Minoru 京都大学, 放射線生物研究センター, 教授 (30281728)
• Co-Investigator(Kenkyū-buntansha): ITAYA Akiko 京都大学, 放射線生物研究センター, 研究員 (50535812) ; TOMIDA Junya 京都大学, 放射線生物研究センター, 研究員 (50511367)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000); Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
• Keywords: ファンコニ貧血 / チェックポイントキナーゼ / リン酸化 / モノユビキチン化 / FANCD2 / FANC1 / FANCL / FANCI / コア複合体

Research Abstract

Faconi anemia(FA) is a hereditary disorder characterized by progressive bone marrow failure, increased incidence of cancer, and deficiency of DNA repair driven by the ubiquitin system. In this study, we have clarified a role of checkpoint kinase ATR in triggering DNA damage-induced activation of theFA DNA repair pathway. Furthermore, we have discovered that some FA proteins promote association of essential ATR interacter ATRIP to chromatin.

Research Products

• [Journal Article] DNA robustly stimulates FANCD2 monoubiquitylation in the complex with FANCI (2012)
  • Author(s): Koichi Sato. Kazue Toda, Masamichi Ishiai, Minora Takata, Hitoshi Kurumizaka
  • Journal Title: Nucleic Acids Research Volume: 40 Issue: 10 Pages: 4553-4561
  • DOI: 10.1093/nar/gks053
  • Peer Reviewed
• [Journal Article] ATR-Chkl signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity (2012)
  • Author(s): Fujinaka Y, Matsuoka K, Iimori M, Tuul M, Sakasai R, Yoshinaga K, Saeki H, Morita M, Kakeji Y, Gillespie DA, Yamamoto KI, Takata M, Kitao H, Maehara Y
  • Journal Title: DNA Repair Volume: 1(3) Issue: 3 Pages: 247-58
  • DOI: 10.1016/j.dnarep.2011.11.005
  • Peer Reviewed
• [Journal Article] ATR-ATRIP Kinase Complex Triggers Activation of the Fanconi Anemia DNA Repair Pathway (2012)
  • Author(s): Tomoko Shigechi, Junya Tomida, Koichi Sato, Masahiko Kobayashi, John K.Eykelenboom, Fabio Pessina, Yanbin Zhang, Emi Uchida, Masamichi Ishiai, Noel F.Lowndes, Kenichi Yamamoto, Hitoshi Kurumizaka, Yoshihiko Maehara, Minoru Takata
  • Journal Title: Cancer Research Volume: 72 Issue: 5 Pages: 1149-1156
  • DOI: 10.1158/0008-5472.can-11-2904
  • Peer Reviewed
• [Journal Article] Establishment of the DNA repair-defective mutants in DT40 cells (2012)
  • Author(s): Ishiai M, Uchida E, Takata M
  • Journal Title: Methods Mol Biol Volume: (in press)
  • NAID: 120004996387
  • Peer Reviewed
• [Journal Article] Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway (2011)
  • Author(s): Rosado IV, Langevin F, Crossan GP, Takata M, Patel KJ
  • Journal Title: Nat Struct Mol Biol Volume: 18(12) Issue: 12 Pages: 1432-4
  • DOI: 10.1038/nsmb.2173
  • Peer Reviewed
• [Journal Article] Predisposition to cancer caused by genetic and functional defects of Mammalian atad5 (2011)
  • Author(s): Bell DW, Sikdar N, Lee KY, Price J C, Chatterjee R, Park HD, Fox J, Ishiai M, Rudd ML, Pollock LM, Fogoros SK, Mohamed H, Hanigan CL ; NISC Comparative Sequencing Program, Zhang S, Cruz P, Renaud G, Hansen NF, Cherukuri PF, Borate B, McManus KJ, Stoepel J
  • Journal Title: PLoS Genet Volume: 7(8) Issue: 8 Pages: e1002245-e1002245
  • DOI: 10.1371/journal.pgen.1002245
  • Peer Reviewed
• [Journal Article] Direct Inhibition of TNF-α Promoter Activity by Fanconi Anemia Prote in FANCD2 (2011)
  • Author(s): Nobuko Matsushita, Yujiro Endo, Koichi Sato, Hitoshi Kurumizaka, Takayuki Yamashita, Minoru Takata, Shigeru Yanagi
  • Journal Title: PLoS One Volume: 6(電子媒体による発表) Issue: 8 Pages: e23324-e23324
  • DOI: 10.1371/journal.pone.0023324
  • Peer Reviewed
• [Journal Article] The role of SNM1 family nucleases in etoposide-induced apoptosis (2011)
  • Author(s): Hosono, Y., Abe, T., Ishiai, M., Takata, M., Enomoto, T., Seki, M.
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 410 Issue: 3 Pages: 568-573
  • DOI: 10.1016/j.bbrc.2011.06.027
  • Peer Reviewed
• [Journal Article] FancJ/Bripl helicase protects against genomic losses and gains in vertebrate cells (2011)
  • Author(s): Kitao H, Nanda I, Sugino RP, Kinomura A, Yamazoe M, Arakawa H, Schmid M, Innan H, Hiom K, Takata M
  • Journal Title: Genes to Cells Volume: 16(6) Pages: 714-27
  • Peer Reviewed
• [Journal Article] USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation (2011)
  • Author(s): Guervilly JH, Renaud E, Takata M, Rosselli F
  • Journal Title: Hum Mol Genet Volume: 20(11) Issue: 11 Pages: 2171-81
  • DOI: 10.1093/hmg/ddr103
  • Peer Reviewed
• [Journal Article] The involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway (2011)
  • Author(s): Yamamoto KN, Kobayashi S, Tsuda M, Kurumizaka H, Takata M, Kono K, Jiricny J, Takeda S, Hirota K
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 108 Issue: 16 Pages: 6492-6496
  • DOI: 10.1073/pnas.1018487108
  • NAID: 120003072120
  • Peer Reviewed
• [Journal Article] Fanconi anemia : a disorder defective in the DNA damage response (2011)
  • Author(s): Kitao H, Takata M
  • Journal Title: Int J Hematol Volume: 93(4) Issue: 4 Pages: 417-24
  • DOI: 10.1007/s12185-011-0832-9
  • NAID: 10029534160
  • Peer Reviewed
• [Journal Article] KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents (2010)
  • Author(s): azunori Yoshikiyo, Katja Kratz, Kouji Hirota, Kana Nishihara, Minoru Takata, Hitoshi Kurumizaka, Satoshi Horimoto, Shunichi Takeda and Josef Jiricny.
  • Journal Title: PNAS Volume: 107(50) Issue: 50 Pages: 21553-7
  • DOI: 10.1073/pnas.1011081107
  • Peer Reviewed
• [Journal Article] KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents. (2010)
  • Author(s): Yoshikiyo K, Kratz K, Hirota K, Nishihara K, Takata M, Kurumizaka H, Horimoto S, Takeda S, Jiricny J.
  • Journal Title: Proc.Natl.Acad.Sci.USA.2010 Volume: 107 Pages: 21553-21557
  • Peer Reviewed
• [Journal Article] Chemopreventive effects of gefitinib on nonsmoking-related lung tumorigenesis in activating epidermal growth factor receptor transgenic mice (2009)
  • Author(s): Ohashi K, Takigawa N, Osawa M, Ichihara E, Takeda H, Kubo T, Hirano S, Yoshino T, Takata M, Tanimoto M, Kiura K.
  • Journal Title: Cancer Res Volume: 69(17) Issue: 17 Pages: 7088-95
  • DOI: 10.1158/0008-5472.can-08-4205
  • Peer Reviewed
• [Journal Article] The Fanconi anemia pathway : Insights from somatic cell genetics using DT40 cell line (2009)
  • Author(s): Takata M, Ishiai M, Kitao H
  • Journal Title: Invited review Mutat Res Volume: 668(1-2) Issue: 1-2 Pages: 92-102
  • DOI: 10.1016/j.mrfmmm.2008.12.012
  • Peer Reviewed
• [Journal Article] The Fanconi anemia pathway : Insights from somatic cell genetics using DT40 cell line (2009)
  • Author(s): Takata M, Ishiai M, Kitao H
  • Journal Title: Mutat Res 668 Pages: 92-102
  • Peer Reviewed
• [Journal Article] Chemopreventive effects of gefitinib on nonsmoking-related lung tumorigenesis in activating epidermal growth factor receptor transgenic mice (2009)
  • Author(s): Ohashi K, Takigawa N, Osawa M, Ichihara E, Takeda H, Kubo T, Hirano S, Yoshino T, Takata M, Tanimoto M, Kiura K.
  • Journal Title: Can Res 69 Pages: 7088-95
  • Peer Reviewed
• [Journal Article] USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation.
  • Author(s): Guervilly JH, Renaud E, Takata M, Rosselli F.
  • Journal Title: Hum.Mol.Genet. Volume: (in press)
  • Peer Reviewed
• [Journal Article] The involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway.
  • Author(s): Yamamoto KY, Kobayashi S, Kurumizaka H, Takata M, Kono K, Jiricny J, Takeda S, Hirota K.
  • Journal Title: Proc.Natl Acad.Sci.USA. Volume: (in press)
  • NAID: 120003072120
  • Peer Reviewed
• [Journal Article] FancJ/Brip1 helicase protects against genomic losses and gains in vertebrate cells.
  • Author(s): Kitao H, Nanda I, Sugino RP, Kinomura A, Yamazoe M, Arakawa H, Schmid M, Innan H, Hiom K, Takata M.
  • Journal Title: Genes Cells Volume: (in press)
  • Peer Reviewed
• [Journal Article] Fanconi anemia : a disorder defective in the DNA damage response."Progress in Hematology review series"
  • Author(s): Kitao H, Takata M.
  • Journal Title: Int.J.Hematol. Volume: (in press)
  • Peer Reviewed
• [Presentation] DNA損傷への応答メカニズムと疾患 (2012)
  • Author(s): 高田穣
  • Organizer: 第ll回分子予防環境医学研究会シンポジウムオーガナイザー & 演者
  • Place of Presentation: 倉敷市
  • Year and Date: 2012-01-27
• [Presentation] DNA損傷への応答メカニズムと疾患 (2012)
  • Author(s): 高田穣
  • Organizer: 第11回分子予防環境医学研究会
  • Place of Presentation: 倉敷市市民会館(倉敷市)(招待講演)
  • Year and Date: 2012-01-27
• [Presentation] The Sugahara Memorial International Symposium on Prospective Topics and Charm of Radiation Biology (2012)
  • Author(s): Minoru Takata
  • Organizer: Fanconi anemia and the DNA damage response
  • Place of Presentation: Kyoto
• [Presentation] Fanconi anemia and the DNA damage response (2012)
  • Author(s): Minoru Takata
  • Organizer: The Sugahara Memorial International Symposium
  • Place of Presentation: 稲盛ホール(京都市)(招待講演)
• [Presentation] International session for DNA repair and related subjects (2011)
  • Author(s): Takata, M
  • Organizer: 日本放射線影響学会第54回大会
  • Place of Presentation: 神戸商工会議所会館(神戸市)(招待講演)
  • Year and Date: 2011-11-19
• [Presentation] 特別企画プログラム東京ビッグサイト (2011)
  • Author(s): 高田穣
  • Organizer: 第28回日本医学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-09-17
• [Presentation] 放射線被曝医療 (2011)
  • Author(s): 高田穣
  • Organizer: 第28回日本医学会総会講演会特別企画プログラム
  • Place of Presentation: 東京ビッグサイト(東京都)(招待講演)
  • Year and Date: 2011-09-17
• [Presentation] ファンコニ貧血DNA修復経路の中心タンパク質FANCD2はヌクレオソームアセンブリー活性を示す (2011)
  • Author(s): 石合正道、佐藤浩一、高田穣、胡桃坂仁志
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋市
• [Presentation] ファンコニ貧血コア複合体によるATR-ATRIPキナーゼのクロマチン動態制御 (2011)
  • Author(s): 高田穣、冨田純也、板谷(内田)亜希子、茂地智子、海野純也、前原善彦、石合正道
  • Organizer: 第70回日本癌学会学術総会シンポジウム
  • Place of Presentation: 名古屋市
• [Presentation] 複製ストレスによるFA経路の活性化には、ATRIP-ATRキナーゼが必須である (2011)
  • Author(s): 茂地智子、冨田純也、佐藤浩一、海野純也、小林昌彦、山本健一、石合正道、胡桃坂仁志、前原善彦、高田穣
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 古屋市
• [Presentation] An Absolute Requirement of ATRIP-ATR Kinase in Replication Stress-induced Triggering of the FA Pathway Activation (2011)
  • Author(s): T. Shigechi, J. Tomida, K. Sato, Y. Zhang, E. Uchida, J. Eykelenbo, N. Lowndes, H. Kurumizaka, Y. Maehara, M. Takata
  • Organizer: 23rd ANNUAL Fanconi Anemia Research Fund SCIENTIFIC SYMPOSIUM
  • Place of Presentation: Barcelona, Spain
• [Presentation] Inhibition of NHEJ Reveals Distinct Roles for FANCG in the Repair of Interstrand Crosslinks and DNA Strand Breaks (2011)
  • Author(s): J. B. Wilson, J. K. Lingley, F. A. Makki, A. M. Alandwani, K. Lee, Y. Xiao, M. Takata, G. M. Kupfer, N. J. Jones
  • Organizer: 23rd ANNUAL Fanconi Anemia Research Fund SCIENTIFIC SYMPOSIUM
  • Place of Presentation: Barcelona, Spain
• [Presentation] ファンコニ貧血蛋白質FANCD2/FANCI結合タンパク質のプロテオーム解析 (2011)
  • Author(s): 海野純也、板谷(内田)亜希子、冨田純也、井倉毅、高田穣
  • Organizer: 日本放射線影響学会第54回大会
  • Place of Presentation: 神戸市
• [Presentation] 複製ストレスによるファンコニ貧血経路の活性化には、ATR-ATRIPキナーゼ複合体が必須である (2011)
  • Author(s): 茂地智子、冨田純也、佐藤浩一、小林昌彦、内田恵美、山本健一、胡桃坂仁志、前原善彦、高田穣
  • Organizer: 日本放射線影響学会第54回大会
  • Place of Presentation: 神戸市
• [Presentation] ファンコニ貧血とDNA損傷シグナリン」ポジウム[Internationa session for DNA repair and related subjects (2011)
  • Author(s): Takata, M
  • Organizer: H放射線影響学会
  • Place of Presentation: 神戸市
• [Presentation] Genome Dynamics : molecular network in maintenance and conversion:molecularnetworkinmaintenanceandconversion (2011)
  • Author(s): 高田穣
  • Organizer: 日本分子生物学会第34回年会
  • Place of Presentation: 横浜市
• [Presentation] Molecular mechanisms of the Fanconi anemia pathway. (2011)
  • Author(s): Masamichi Ishiai, Junya Tomida, Tomoko Shigechi, Akiko Itaya, Emi Uchida, Junya Unno, Minoru Takata
  • Organizer: 日本分子生物学会第34回年会
  • Place of Presentation: 横浜市
• [Presentation] リン酸化プロテオミクスを用いた新規DNA損傷初期応答キナーゼの探索 (2011)
  • Author(s): 足立淳、鳴海良平、佐野聖三、久家貴寿、白水崇、松本雅記、中山敬一、井倉正枝、井倉毅、高田穣、朝長毅
  • Organizer: 日本分子生物学会第34回年会
  • Place of Presentation: 横浜市
• [Presentation] Mass spectrometric analysis identifiles factors associated with the Fanconi anemia proteins FANCD2 and FANCI (2011)
  • Author(s): unya Unno, Akiko Itaya, Junya Tomida, Tsuyoshi Ikura, Minoru Takata
  • Organizer: 日本分子生物学会
  • Place of Presentation: 横浜市
• [Presentation] Homologous recombinational repair and Chk1-mediated S-phase arrest protect cells from 5-FU cytotoxicity repair and Chkl-mediated S-phase arrest protect cells from (2011)
  • Author(s): Hiroyuki Kitao, Yoshihiko Fujinaka, Kazuaki Matsuoka, Makoto Iimori, Munkhbold Tuul, Ryo Sakasai, Ken-ichi Yamamoto, Minoru Takata, Yoshihiko Kakeji, Yoshihiko Maehara
  • Organizer: 日本分子生物学会第34回年会
  • Place of Presentation: 横浜市
• [Presentation] ファンコニ貧血蛋白FANCD2によるNF-kappaB転写制御機構の解析 (2011)
  • Author(s): 松下暢子、菊間啓太、太田莉英子、もたい龍介、徳山郷±、高田穣、胡桃坂仁志、山下孝之、稲留涼子、柳茂
  • Organizer: 日本分子生物学会第34回年会
  • Place of Presentation: 横浜市
• [Presentation] Histone chaperone activity of the FANCD2-FANCI complex and its importance in repair of interstrand DNA crosslinks by the Fanconi anemia pathway (2011)
  • Author(s): oichi Sato, Masamichi Ishiai, Kazue Toda, Satoshi Furukoshi, Akihisa Osakabe, Hiroaki Tachiwana, Yoshimasa Takizawa, Wataru Kagawa, Hiroyuki Kitao, Naoshi Dohmae, Chikashi Obuse, Hiroshi Kimura, Minoru Takata, Hitoshi Kurumizaka
  • Organizer: 日本分子生物学会第34回年会
  • Place of Presentation: 横浜市
• [Presentation] Robust stimulation of the FANCD2 monoubiquitination by three-way brached DNAs (2011)
  • Author(s): Kazue Toda, Koichi Sato, Masamichi Ishiai, Minoru Takata, Hitoshi Kurumizaka
  • Organizer: 日本生物学会第34回年会
  • Place of Presentation: 横浜市
• [Presentation] Mcm8 and Mcm9 form a novel complex involved in resistance to DNA crosslinking agents (2011)
  • Author(s): Kohei Nishimura, Masamichi Ishiai, Tatsuo Fukagawa, Minoru Takata, Haruhiko Takisawa, Masato Kanemaki
  • Organizer: 日本生物学会第34回年会
  • Place of Presentation: 横浜市
• [Presentation] ATR-ATRIP kinase complex is responsible for triggering of the FA pathway (2011)
  • Author(s): Tomoko Shigechi, Junya Tomida, Koichi Sato, Masahiko Kobayashi, John Eykelenboom, Pessina Fabio, Zhang Yanbin, Emi Uchida, Masamichi Ishiai, Noel Lowndes, Kenichi Yamamoto, Hitoshi Kurumizaka, Yoshihiko Maehara, Minoru Takata
  • Organizer: 日本生物学会第34回年会
  • Place of Presentation: 横浜市
• [Presentation] Fanconi anemia and the DNA damage signaling (2011)
  • Author(s): Minoru Takata
  • Organizer: 7th RBC-NIRS International Symposium
  • Place of Presentation: Kyoto
• [Presentation] Fanconi貧血原因遺伝子餌艦η2及びE郡01一の機能解析 (2011)
  • Author(s): 佐藤浩一, 石合正道, 戸田和江, 古越聡, 越坂部晃永, 立和名博昭, 堂前直, 小布施力史, 木村宏, 高田穣, 胡桃坂仁志
  • Organizer: 第9回核ダイナミクス研究会
  • Place of Presentation: 伊豆市
• [Presentation] ファンコニ貧血コア複合体によるATR-ATRIPキナーゼのクロマチン動態制御 (2011)
  • Author(s): 高田穣、冨田純也、板谷(内田)亜希子、茂地智子、海野純也、前原善彦、石合正道
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
• [Presentation] An Absolute Requirement of ATRIP-ATR Kinase in Replication stress-induced Triggering of the FA Pathway Activation (2011)
  • Author(s): T.Shigechi, J.Tomida, K.Sato, Y.Zhang, E.Uchida, J.Eykelenbo, N.Lowndes, H.Kurumizaka, Y.Maehara, M.Takata
  • Organizer: 23rd ANNUAL Fanconi Anemia Research Fund SCIENTIFIC SYMPOSIUM
  • Place of Presentation: Princesa Sofia Hotel(スペイン)
• [Presentation] Genome Dynamics : molecular network in maintenance and conversion (2011)
  • Author(s): 高田穣
  • Organizer: 日本分子生物学会第34回年会
  • Place of Presentation: パシフィコ横浜(横浜市)(招待講演)
• [Presentation] Molecular mechanisms of the Fanconi anemia pathway (2011)
  • Author(s): Masamicni Ishiai, Junya Tomida, Tomoko Shigechi, Akiko Itaya, Emi Uchida, Junya Unno, Minoru Takata
  • Organizer: 日本分子生物学会第34回年会
  • Place of Presentation: パシフィコ横浜(横浜市)
• [Presentation] DNA損傷応答シグナルにおけるクロマチン動態とエピジェネティクス制御 (2011)
  • Author(s): Minoru Takata
  • Organizer: 27th RBC-NIRS International Symposium
  • Place of Presentation: コープイン京都(京都市)(招待講演)
• [Presentation] 発がんとDNA損傷応答の分子メカニズム (2010)
  • Author(s): 高田穣
  • Organizer: 肺がん分子病態研究会
  • Year and Date: 2010-09-11
• [Presentation] Activation mechanisms of the Fanconi anemia pathway via ATR signaling (2010)
  • Author(s): 高田穣
  • Organizer: 放射線生物若手の会(原子炉実験所
  • Year and Date: 2010-09-10
• [Presentation] リン酸化・モノユビキチン化によるファンコニ貧血・DNA修復経路の活性化メカニズム (2010)
  • Author(s): 石合正道, 冨田純也, 茂地智子, 板谷亜希子, 高田穣
  • Organizer: 第9回核ダイナミクス研究会
  • Place of Presentation: 伊豆市
• [Presentation] FAAP20 is Required for Normal Activation of the Fanconi Anemia-associated DNA Damage Response Pathway (2010)
  • Author(s): Z. Yan, R. Guo, W. Shen, D. FoxIII, A. B. Oostra, M. Takata, D. Schindler, H. oatlin, J. de Winter, W. Wang.
  • Organizer: 22nd Fanconi Anemia Research Fund Scientific Symposium
  • Place of Presentation: Minnesota(USA)
• [Presentation] FANCG Functions Independently of the FA Core Complex in Homologous Recombination Repair of Phleomycin-induced DNA Damage (2010)
  • Author(s): N. J. Jones, A. Aladwani, Y. Xiao, V. S. Mysore, G. M. Kupfer, M. Takata, J. B. Wilson
  • Organizer: 22nd Fanconi Anemia Research Fund Scientific Symposium
  • Place of Presentation: Minnesota(USA)
• [Presentation] DNA損傷応答におけるファンコニ貧血経路の活性化メカニズム (2010)
  • Author(s): 冨田純也、板谷亜希子、内田恵美、茂地智子、井倉正枝、胡桃坂仁志、井倉毅、石合正道、高田穣
  • Organizer: 日本放射線影響学会第53回大会
  • Place of Presentation: ワークショップ京都
• [Presentation] Artemisの核内動態制御機構の解析 (2010)
  • Author(s): 石合正道、島弘季、田代聡、高田穣
  • Organizer: 日本放射線影響学会第53回大会
  • Place of Presentation: ワークショップ京都市
• [Presentation] FANCI phosphorylation by ATR kinase proceeds in a Rad17/TopBP1-independent manner (2010)
  • Author(s): Junya Tomida, Akiko Itaya, Emi Uchida, Tomoko Shigechi, Masahiko Kobayashi, Ken-ichi Yamamoto, Masae Ikura, Tsuyoshi Ikura, Agata Smogorzewska, Masamichi Ishiai, Minoru Takata
  • Organizer: 第33回年会日本生物学会年会
  • Place of Presentation: 神戸
• [Presentation] DNAダメージにおけるArtemisの核内動態制御 (2010)
  • Author(s): 石合正道、島弘季、田代聡、高田穣
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸市
• [Presentation] Gene targeting : vector design and construction EMBO practical course (2010)
  • Author(s): Minoru Takata
  • Organizer: EMBO practical course
• [Presentation] How we can achieve disruption of the genes essential for cell viability in DT40 cells? (2010)
  • Author(s): Minoru Takata
  • Organizer: EMBO practical course
  • Place of Presentation: Ireland
• [Presentation] Activation mechanisms of the Fanconi anemia pathway (2010)
  • Author(s): Minoru Takata
  • Organizer: Traute Schroeder-Kurth Symposium at the University of Wu rzburg
  • Place of Presentation: Gemmany
• [Presentation] The DT40 cell line as a model genetic system (2010)
  • Author(s): Takata M.
  • Organizer: EMBO Practical Course
  • Place of Presentation: Galway, Ireland(招待講演)
• [Presentation] Activation mechanisms of the Fanconi anemia pathway (2010)
  • Author(s): Takata M.
  • Organizer: Preventing genomic instability, neoplasia and premature ageing emerging role of the Fanconi anemia- BRCA caretaker network.Traute Schroeder-Kurth Symposium.
  • Place of Presentation: Wurburg, Germany(招待講演)
• [Presentation] A novel role of the FA core complex in FANCI phosphorylation, an important switch in the FA pathway (2009)
  • Author(s): Minom Takata, Junva Tomida, Tomoko Shigechi, Hiroyuki Kitao, Akiko Itava, Masamichi Ishiai
  • Organizer: Twenty-first Annual Fanconi Anemia Research Fund Scientific Symposium
• [Presentation] A novel role of the FA core complex in FANCI phosphorylation, an important switch in the FA pathway (2009)
  • Author(s): Minoru Takata, Junya Tomida, Tomoko Shigechi, Hiroyuki Kitao, Akiko Itaya, Masamichi Ishiai
  • Organizer: Twenty-first Annual Fanconi Anemia Research Fund Scientific Symposium
  • Place of Presentation: Baltimore, MA, USA
• [Presentation] REGULATION OF CROSS-LINK REPAIR THROUGH THE FANCONI ANEMIA PATHWAY (2009)
  • Author(s): Minoru Takata, Junya Tomida, Akiko Itaya, Tomoko Shigechi, Masamichi Ishiai
  • Organizer: The Fortieth International Symposium of the Princess Takamatsu Cancer Research Fund
  • Place of Presentation: Tokyo
• [Presentation] 高発がん遺伝病ファンコニ貧血の分子メカニズム (2009)
  • Author(s): 高田穣
  • Organizer: 第71回 日本血液学会学術集会 シンポジウム「小児血液腫瘍の発症リスクと先天異常」
  • Place of Presentation: 京都市 国際会館
• [Presentation] DNA damage signaling in the Fanconi anemia pathogenesis (2009)
  • Author(s): 高田穣
  • Organizer: 第51回 小児血液学会 血液プレジデンシャルシンポジウム「DNA damage response and hemato logical disorder」
  • Place of Presentation: 千葉 東京ベイホテル東急
• [Book] Evaluation of Homologous Recombinational Repair in Chicken B Lymphoma Cell Line, DT40. Methods Mol Biol (2011)
  • Author(s): Kitao H, Hirano S, Takata M
  • Total Pages: 745
• [Book] Establishment of the DNA repair-defective mutants in DT40 cells. Methods Mol Biol
  • Author(s): Ishiai M, Uchida E, and Takata M
• [Remarks]
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• [Remarks]
  • URL: http://www.rbc.kyoto-u.ac.jp/Late_Effect/Site_1/Welcome.html
• [Remarks]
  • URL: http://www.rbc.kyoto-u.ac.jp/Late_Effect/Site_1/Welcome.html