Gastric tumorigenesis through cooperation of COX-2/PGE2 pathway and inflammatory responses
| Project/Area Number |
21390118
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Kanazawa University |
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Principal Investigator |
OSHIMA Masanobu 金沢大学, がん進展制御研究所, 教授 (40324610)
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| Co-Investigator(Renkei-kenkyūsha) |
OSHIMA Hiroko 金沢大学, がん進展制御研究所, 助教 (80362515)
ISHIKAWA Tomoo 金沢大学, がん進展制御研究所, 助教 (70322162)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | 胃がん / 炎症 / COX-2 / PGE_2 / マウスモデル / PGE2 / TGF-beta |
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| Research Abstract |
To generate a novel mouse model in which TGF-βsignaling is blocked and COX-2/PGE_2 pathway is activated, we tried construction of transgenic mice expressing Cre in gastric epithelial cells using K19 gene promoter. However, we found that K19 promoter is active in whole body during embryogenesis and its expression efficiency is very low in adult stomach, indicating that other promoter than K19 is required for future construction of stomach specific Cre mice.
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Report
(4 results)
Research Products
(98 results)
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[Journal Article] Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells2012
Author(s)
Kong D, Piao YS, Yamashita S, Oshima H, Oguma K, Fushida S, Fujimura T, Minamoto T, Seno H, Yamada Y, Satou K, Ushijima T, Ishikawa T, and Oshima M.
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Journal Title
Oncogene
Volume: (in press)
Issue: 35
Pages: 3949-60
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Induction and downregulation of Sox17 and its roles during the course of gastrointestinal tumorigenesis2009
Author(s)
Du Y-C, Oshima H, Kitamura T, Itadani H, Fujimura T, Piao YS, Yoshimoto T, Minamoto T, Taketo, MM, and Oshima M.
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Journal Title
Gastroenterology
Volume: 137
Issue: 4
Pages: 1346-1357
DOI
Related Report
Peer Reviewed
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[Journal Article]2009
Author(s)
小熊圭祐, 大島正伸
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Journal Title
分子細胞治療 特集「炎症反応と消化器発がん」(先端医学社)
Pages: 188-193
Related Report
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