Controlling of chronic inflammatory diseases via regulation of inflammation stroma cells

• Project/Area Number: 21390120
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Osaka University
• Principal Investigator: MURAKAMI Masaaki 大阪大学, 大学院・生命機能研究科, 准教授 (00250514)
• Co-Investigator(Kenkyū-buntansha): KAMIMURA Daisuke 大阪大学, 大学院・生命機能研究科, 助教 (20391922)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000); Fiscal Year 2011: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2009: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
• Keywords: 炎症 / 非免疫系細胞 / サイトカイン / IL-6 / IL-6アンプ / IL-17

Research Abstract

We defined the inflammation stroma cells as cells having excessive chenokine production after NFkB and STAT3 stimulation. The inflammation stroma cells have type 1 collagen molecules and include endothelial cells, fibroblasts, astrocytes, and epithelial cells. The main founding in this project is that excessive activation of the he inflammation stroma cells by an excessive neural activation particularly via sympathetic neuron' s creates a gateway for immune cells in blood vessels including autoreactive CD4+ T cells followed by the development of an autoimmune disease.

Research Products

• [Journal Article] Intestinal CX3C chemokine receptor 1high(CX3CRlhigh) myeloid cells prevent T-cell-dependent colitis (2012)
  • Author(s): Kayama H., Ueda, Y., Sawa, Y., Jeon, S. G., Ma, J. S. Okumura, R., Kubo, A., Ishii, M., Okazaki, T., Murakami, M., Yamamoto, M., Yagita, H., and Takeda, K
  • Journal Title: Natl. Acad. Sci. USA Volume: 109 Pages: 5010-5015
  • Peer Reviewed
• [Journal Article] Regional neural activation directly influences immune signals in the CNS (2012)
  • Author(s): Arima, Y, M. Harada, D. Kamimura, J.-H. Park, F. Kawano, F. E. Yull, T. Kawamoto Y. Iwakura, U. A. K. Betz, G. Marquez, T. S. Blackwell, Y. Ohira, T. Hirano, and M. Murakami
  • Journal Title: Cell Volume: 148 Pages: 447-457
  • Peer Reviewed
• [Journal Article] Intestinal CX3C chemokine receptor 1high (CX3CR1high) myeloid cells prevent T-cell-dependent colitis (2012)
  • Author(s): Kayama, H., M.Murakami, et al
  • Journal Title: PNAS Volume: (in press)
  • Peer Reviewed
• [Journal Article] Zinc in Allergy, Autoimmune, and Hard and Connective Tissue Diseases (2012)
  • Author(s): Nishida, K., M.Murakami, et al
  • Journal Title: Journal of Biological Inorganic Chemistry Volume: (in press)
  • Peer Reviewed
• [Journal Article] Zinc signaling in health and diseases (2012)
  • Author(s): Fukada, T., M.Murakami, et al
  • Journal Title: Metallomics Volume: (in press)
  • Peer Reviewed
• [Journal Article] SIRPalpha/ CD172a Regulates Eosinophil Homeostasis (2011)
  • Author(s): Garcia, N. V., Umemoto, E., Saito, Y., Yamasaki, M., Hata, E., Matozaki, T., Murakami, M., Jung, Y. J., Woo, S. Y., Seoh, JY., Jang, M. H., Aozasa, K., Miyasaka, M
  • Journal Title: J. Immunol Volume: 187(5) Pages: 2268-2277
  • Peer Reviewed
• [Journal Article] (equal contribution) Local microbleeding facilitates IL-6-and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells (2011)
  • Author(s): Murakami, M., Y. Okuyama, H. Ogura, S. Asano, Y. Arima, M. Tsuruoka, M. Harada, M. Kanamoto, Y. Sawa, Y. Iwakura, K. Takatsu, D. Kamimura, T. Hirano.
  • Journal Title: J. Exp. Med Volume: 208 Pages: 103-114
  • Peer Reviewed
• [Journal Article] A four step model for the IL-6 amplifier, a regulator of chromic inflammations in tissue specific MHC class II-associated autoimmune diseases (2011)
  • Author(s): Murakami, M. and T. Hirano
  • Journal Title: Front. Immun Volume: 2 Pages: 22-22
  • DOI: 10.3389/fimmu.2011.00022
  • Peer Reviewed
• [Journal Article] homeostasis and signaling in health and diseases : Zinc signaling (2011)
  • Author(s): Fukada, T., Nishida, K., Yamazaki, S., Murakami, M., and Hirano, T. Zinc
  • Journal Title: J Biol Inorg Chem Volume: 16 Pages: 1123-1134
  • Peer Reviewed
• [Journal Article] Zinc in Allergy, Autoimmune, and Hard and Connective Tissue Diseases (2011)
  • Author(s): Nishida, K., Fukada, T., Yamasaki, S., Murakami, M., and Hirano, T
  • Journal Title: Zinc in Human Health
• [Journal Article] SIRPalpha/CD172a Regulates Eosinophil Homeostasis (2011)
  • Author(s): Verjan Garcia, M.Murakami, et al
  • Journal Title: J.Immunol. Volume: 187 Pages: 2268-2277
  • Peer Reviewed
• [Journal Article] Local microbleeding facilitates IL-6- and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells (2011)
  • Author(s): Murakami, M., D.Kamimura, et al
  • Journal Title: J.Exp.Med. Volume: 208 Pages: 103-114
  • Peer Reviewed
• [Journal Article] Zinc in Allergy, Autoimmune, and Hard and Connective Tissue Diseases (2011)
  • Author(s): Fukada, T., M.Murakami, et al
  • Journal Title: Journal of Biological Inorganic Chemistry Volume: 16 Pages: 1123-1134
  • Peer Reviewed
• [Journal Article] Local microbleeding and IL-6/IL-7 dependent arthritis MHCクラス2にリンクした炎症性疾患の4ステップモデルとは? (2011)
  • Author(s): 村上正晃
  • Journal Title: 感染・炎症・免疫 Volume: 32 Pages: 72-74
  • Peer Reviewed
• [Journal Article] Local microbleeding facilitates IL-6- and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells. (2011)
  • Author(s): Murakami, M., D.Kamimura, T.Hirano, et al.
  • Journal Title: J.Exp.Med. Volume: 208 Pages: 103-114
  • Peer Reviewed
• [Journal Article] Zinc suppresses Th17 development viainhibition of STAT3 activation (2010)
  • Author(s): Kitabayashi C., T. Fukada, M. Kanamotol, W. Ohashi, S. Hojyo, T Atsumi, N. Ueda, I. Azuma, H. Hirota, M. Murakami, and T. Hirano
  • Journal Title: Int. Immunol Volume: 22(5) Pages: 375-386
  • Peer Reviewed
• [Journal Article] IL-6 positively regulates Foxp3+ CD8+ T cells in vivo (2010)
  • Author(s): Nakagawa T., Tsuruoka, M., Ogura, H., Okuyama, Y., Arima, Y., Hirano, T., and Murakami, M
  • Journal Title: Int. Immunol Volume: 22(2) Pages: 129-139
  • NAID: 10027391497
  • Peer Reviewed
• [Journal Article] IL-6 positively regulates Foxp3+CD8+ T cells in vivo. (2010)
  • Author(s): Nakagawa T., T.Hirano, M.Murakami, et al.
  • Journal Title: Int.Immunol. Volume: 22 Pages: 129-139
  • NAID: 10027391497
  • Peer Reviewed
• [Journal Article] Zinc suppresses Th17 development via inhibition of STAT3 activation. (2010)
  • Author(s): Kitabayashi C., M.Murakam, T.Hirano, et al.
  • Journal Title: Int.Immunol. Volume: 22 Pages: 375-386
  • Peer Reviewed
• [Journal Article] Zinc suppresses Th17 development via inhibition of STAT3 activation. (2010)
  • Author(s): Kitabayashi C., et al.
  • Journal Title: Int.Immunol. (in press)
  • Peer Reviewed
• [Journal Article] IL-6 positively regulates Foxp3+CD8+ T cells in vivo. (2010)
  • Author(s): Nakagawa T., et al.
  • Journal Title: Int.Immunol. 22 Pages: 129-139
  • Peer Reviewed
• [Journal Article] IFN-γexpression in CD8+ T cells regulated by IL-6 signal is involved in superantigen-mediated CD4+ T cell death (2009)
  • Author(s): Atsumi, T., Sato, M., Kamimura, D., Moroi, A., Iwakura, Y., Betz, U. A. K., Yoshimura, A., Nishihara, M., Hirano, T., and Murakami, M
  • Journal Title: Int. Immunol Volume: 21(1) Pages: 73-80
  • NAID: 10025383990
  • Peer Reviewed
• [Journal Article] Hepatic IL-7 expression regulates T cell Responses (2009)
  • Author(s): Sawa, Y., Y. Arima, H. Ogura, C. Kitabayashi, J. J. Jiang, T. Fukushima, D. Kamimura, T. Hirano, and M. Murakami
  • Journal Title: Immunity Volume: 30 Pages: 447-457
  • Peer Reviewed
• [Journal Article] Hepatic Interleukin-7 Expression Regulates T Cell Responses. (2009)
  • Author(s): Sawa Y., et al.
  • Journal Title: Immunity 30 Pages: 447-457
  • Peer Reviewed
• [Journal Article] IFN-γ expression in CD8+ T cells regulated by IL-6 signal is involved in superantigen-mediated CD4+ T cell death. (2009)
  • Author(s): Atsumi, T., et al.
  • Journal Title: Int.Immunol. 21 Pages: 73-80
  • Peer Reviewed
• [Presentation] Zinc finger motif containing protein A, ZFA regulates IL-6 amplifier activation via regulating NF-kB activity and promotes an autoimmune arthritis (2011)
  • Author(s): K, Katsunuma, D.Kamimura, M.Murakami, et al
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-29
• [Presentation] A zinc finger motif containing protein, ZFZ regulates IL-6 amplifier activation via regulating NF-kB activity and promotes an autoimmune arthritis (2011)
  • Author(s): H.Ogura, D.Kamimura, M.Murakami, et al
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-29
• [Presentation] Neural stimulation accelerates the IL-6 amplifier activation, which is critical for pathogenic CD4+ T cell accumulation in the central nervous system (2011)
  • Author(s): Y.Arima, D.Kamimura, M.Murakami, et al
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-29
• [Presentation] IL-6 amplifier activation in donors plays a role in allogenic rejections (2011)
  • Author(s): J.Lee, M.Murakami, et al
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-29
• [Presentation] The IL-6 amplifier activation, a key player of inflammation, in human diseases and disorders (2011)
  • Author(s): M.Murakami
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉)(招待講演)
  • Year and Date: 2011-11-29
• [Presentation] An ENU-mutant mouse, which increased a stress signaling in naive T cells (2011)
  • Author(s): D.Kamimura, M.Murakami, et al
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-28
• [Presentation] A Four-step Model for MHC Class II-Associated Autoimmune Diseases (2011)
  • Author(s): Y, Okuyama, D.Kamimura, M.Murakami, et al
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-28
• [Presentation] Enhancement of IL-6 amplifier activation by a soluble factor, SFX, which accelerates the development of autoimmune diseases (2011)
  • Author(s): M.Harda, D.Kamimura, M.Murakami, et al
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-28
• [Presentation] A Zinc finger protein, ZFX is critical for IL-6 amplifier activation via NF-kB activation (2011)
  • Author(s): R.Singh, Kamimura, M.Murakami, et al
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-28
• [Presentation] A MTF-1target, which regulates the IL-6 amplifier activation (2011)
  • Author(s): R.Otsubo, M.Murakami, et al
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-28
• [Presentation] The IL-6 amplifier activation, a key player of inflammation, in human diseases and disorders (2011)
  • Author(s): Masaaki Murakami
  • Organizer: 第40回日本免疫学会学術集会シンポジューム招待講演於
  • Place of Presentation: 幕張メッセ(千葉県)
  • Year and Date: 2011-11-27
• [Presentation] Identification of molecules, which move from the nuclear to cytoplasm by extracellular zinc treatment (2011)
  • Author(s): S.Kobayashi, M.Murakami, et al
  • Organizer: The 5^<th> International Conference on Metals and Genetics (ICMG2011)
  • Place of Presentation: 神戸国際カンファレンスセンター
  • Year and Date: 2011-09-06
• [Presentation] Identification of a critical MTF-1target gene for NFkB activation (2011)
  • Author(s): R.Otsubo, M.Murakami, et al
  • Organizer: The 5^<th> International Conference on Metals and Genetics (ICMG2011)
  • Place of Presentation: 神戸国際カンファレンスセンター
  • Year and Date: 2011-09-06
• [Presentation] Zinc signaling and Inflammation (2011)
  • Author(s): Masaaki Murakami
  • Organizer: The 5th International Conference on Metals and Genetics(ICMG2011)シンポジユーム招待講演
  • Place of Presentation: Kobe International Conference Center, Kobe, Japan
  • Year and Date: 2011-09-05
• [Presentation] Zinc signaling and Inflammation (2011)
  • Author(s): M.Murakami
  • Organizer: The 5^<th> International Conference on Metals and Genetics (ICMG2011)
  • Place of Presentation: 神戸国際カンファレンスセンター
  • Year and Date: 2011-09-05
• [Presentation] IL-17A-triggered positive-feedback for IL-6-signaling, a key player for inflammation, is associated with various human diseases (2011)
  • Author(s): M.Murakami
  • Organizer: RCAI-CGM Joint Meeting
  • Place of Presentation: 理化学研究所免疫アレルギー科学総合研究センター(横浜)(招待講演)
  • Year and Date: 2011-08-26
• [Presentation] IL-6 amplifier and human diseases (2011)
  • Author(s): Masaaki Murakami
  • Organizer: RCAI-CGM Joint Meeting,招待講演,理化学研究所免疫アレルギー科学総合研究センター
  • Place of Presentation: 神奈川県
  • Year and Date: 2011-06-17
• [Presentation] A 4 Step Model in MHC Class II-Associated Autoimmune Diseases (2011)
  • Author(s): 奥山祐子、上村大輔、平野俊夫、村上正晃, 他
  • Organizer: International Symposium "Towards Comprehensive Understanding of Immune Dynamism"
  • Place of Presentation: 千里阪急ホテル
  • Year and Date: 2011-03-01
• [Presentation] Zinc Prevents Th17 Cell-Mediated Autoitamune Disease by Directly Inhibiting STAT3 (2011)
  • Author(s): 北林知佳、村上正晃、平野俊夫, 他
  • Organizer: International Symposium "Towards Comprehensive Understanding of Immune Dynamism"
  • Place of Presentation: 千里阪急ホテル
  • Year and Date: 2011-03-01
• [Presentation] Foxp3^+CD8^+ T Cells Developed in an IL-6-Dependent Manner Control an Autoimmune Arthritis. (2011)
  • Author(s): 鶴岡峰子、平野俊夫、村上正晃, 他
  • Organizer: International Symposium "Towards Comprehensive Understanding of Immune Dynamism"
  • Place of Presentation: 千里阪急ホテル
  • Year and Date: 2011-03-01
• [Presentation] 亜鉛と亜鉛トランスポーター:サイトカイン/増殖因子の情報伝達と病態形成への関与 (2010)
  • Author(s): 深田俊幸、村上正晃、平野俊夫, 他
  • Organizer: 第75回インターフェロン・サイ.トカイン学会・学術集会
  • Place of Presentation: 北九州国際会議場(招待講演)
  • Year and Date: 2010-06-26
• [Presentation] 亜鉛と免疫・アレルギー・炎症:亜鉛はシグナル伝達分子である (2010)
  • Author(s): 平野俊夫、村上正晃, 他
  • Organizer: 第109回日本皮膚科学会
  • Place of Presentation: 大阪国際会議場(招待講演)
  • Year and Date: 2010-04-17
• [Presentation] Zinc and CD4+ T cell-mediated autoimmune diseases (2010)
  • Author(s): Masaaki Murakami, Chika Kitabayashi, Toshiyuki Fukada, Minoru Kanamoto, Wakana Ohashi, Shintaro Ho jyo, Toru Atsumi, Naoko Ueda, Ichiro Azuma, Hiroshi Hirota, and Toshio Hirano
  • Organizer: The 60th Fujihara Seminar Zinc Signaling and Cellular Functions
  • Place of Presentation: Osaka International Convention Center
• [Presentation] IL-6-mediated positive regulation of Foxp3+CD8+ T cells is critical for the development of autoimmune diseases. (2010)
  • Author(s): 鶴岡峰子、平野俊夫、村上正晃, 他
  • Organizer: 第14回国際免疫学会議
  • Place of Presentation: 神戸国際会議場他
• [Presentation] IFN-γ from CD8+ T cells, which is regulated by IL-6 signal, is involved in superantigen-mediated CD4+ T cell death. (2010)
  • Author(s): 熱海徹、平野俊夫、村上正晃, 他
  • Organizer: 第14回国際免疫学会議
  • Place of Presentation: 神戸国際会議場他
• [Presentation] Specific antigen recognition by CD4+ T cells is not required for a MHC class II-associated autoimmune arthritis. (2010)
  • Author(s): 奥山祐子、上村大輔、村上正晃、平野俊夫, 他
  • Organizer: 第14回国際免疫学会議
  • Place of Presentation: 神戸国際会議場他
• [Presentation] Hepatic IL-7, which is Induced by TLR-Type I IFN Signaling, Promotes T cell Responses. (2010)
  • Author(s): 澤幸久、上村大輔、平野俊夫、村上正晃, 他
  • Organizer: 第14回国際免疫学会議
  • Place of Presentation: 神戸国際会議場他
• [Presentation] Zinc-mediated STAT3 suppression is involved in inhibition of autoimmune disease development via regulating Th17 differentiation. (2010)
  • Author(s): 北林知佳、村上正晃、平野俊夫, 他
  • Organizer: 第14回国際免疫学会議
  • Place of Presentation: 神戸国際会議場他
• [Presentation] Homeostatic proliferation of CD4+ T cells is involved in the pathogenesis of a mouse model of Omenn syndrome. (2010)
  • Author(s): 上村大輔、平野俊夫、村上正晃, 他
  • Organizer: 第14回国際免疫学会議
  • Place of Presentation: 神戸国際会議場他
• [Presentation] IL-6 plays roles not only for developing Th17 but also for inducing an IL-6 amplifier in autoimmue diseases. (2010)
  • Author(s): 小椋英樹、村上正晃、平野俊夫, 他
  • Organizer: 第14回国際免疫学会議
  • Place of Presentation: 神戸国際会議場他
• [Presentation] IL-6-mediated STAT3 signaling in T cells directs the development of Th17 with a minimum effect on that of Treg in vivo. (2010)
  • Author(s): 原田誠也、村上正晃、平野俊夫, 他
  • Organizer: 第14回国際免疫学会議
  • Place of Presentation: 神戸国際会議場他
• [Presentation] Combination of IL-2 plus anti-IL-2 mAbs reduces cancer metastasis through activation of NK cells. (2010)
  • Author(s): 有馬康伸、平野俊夫、村上正晃, 他
  • Organizer: 第14回国際免疫学会議
  • Place of Presentation: 神戸国際会議場他
• [Presentation] Zinc and Th17-mediated autoimmune diseases (2010)
  • Author(s): 村上正晃、平野俊夫, 他
  • Organizer: The 60th Fujihara Seminar Zinc Signaling and Cellular Functions
  • Place of Presentation: 大阪国際会議場
• [Presentation] Regulation of T cell Activation via a Metal Transporter (2010)
  • Author(s): 諸井亜理沙、上村大輔、平野俊夫、村上正晃, 他
  • Organizer: The 60th Fujihara Seminar Zinc Signaling and Cellular Functions
  • Place of Presentation: 大阪国際会議場
• [Presentation] An attempt to identify molecules, which intracellular localizations are regulated by Zinc. (2010)
  • Author(s): 小林翔平、村上正晃、半野俊夫, 他
  • Organizer: The 60th Fujihara Seminar Zinc Signaling and Cellular Functions
  • Place of Presentation: 大阪国際会議場
• [Presentation] A zinc finger motif containing protein regulates the activation of the lL-6 amplifier, which is a critical for the development of an autoimmune arthritis. (2010)
  • Author(s): 小椋英樹、上村大輔、平野俊夫、村上正晃, 他
  • Organizer: The 60th Fujihara Seminar Zinc Signaling and Cellular Functions
  • Place of Presentation: 大阪国際会議場
• [Presentation] Zinc and CD4+ T cell-mediated autoimmune diseases (2010)
  • Author(s): 村上正晃、平野俊夫, 他
  • Organizer: The 60th Fujihara Seminar Zinc Signaling and Cellular Functions
  • Place of Presentation: 大阪国際会議場
• [Presentation] "Is the recognition of cognate antigens always required for the determination of the tissue specificity of autoimmune diseases associated with MHC II? Symposium 11" New Aspect of Effector T cell Functions2 (2009)
  • Author(s): Murakami M., and T. Hirano
  • Organizer: The 39t Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: Osaka I nternational Convention Center, Osaka, Japan
  • Year and Date: 2009-12-04
• [Presentation] The recognition of specific antigens is not always required for the development of tissue-specific autoimmune diseases associated with MHC II (2009)
  • Author(s): Masaaki Murakami, Hideki Ogura, Yuko Okuyama, Yoichiro Iwakura, Kiyoshi Takatsu, & Toshio Hirano
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-12-02
• [Presentation] How does IL-17 induce Autoimmune Diseases (2009)
  • Author(s): Murakami, M
  • Organizer: The 2md International Symposium of WPI-IFReC(世界トップレベル研究拠点大阪大学免疫学フロンティア研究センター第二回国際シンポジム)
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2009-02-12
• [Presentation] Liver as a regulator of T cells (2009)
  • Author(s): Murakami M., and T. Hirano
  • Organizer: The 5th International Workshop of Kyoto T Cell Conference 2009
  • Place of Presentation: Kyoto, Japan
• [Presentation] The recognition of specific antigens is not always required for the development of tissue-specific autoimmune diseases associated with MHC II. (2009)
  • Author(s): 村上正晃
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
• [Presentation] Impaired STAT activations in an ENU mutant mouse carrying excess memory T cells (2009)
  • Author(s): 上村大輔
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
• [Presentation] Hepatic IL-7 Regulates CD4+T Cell-mediated Autoimmune diseases. (2009)
  • Author(s): 澤幸久
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
• [Presentation] Specific antigen recognitions by activated CD4+ T cells are not necessary for the development of a MHC class II-associated arthritis. (2009)
  • Author(s): 小椋英樹
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
• [Presentation] Metallothionein I/II分子によるCD4+T細胞依存性の自己免疫疾患の抑制機序 (2009)
  • Author(s): 三田恵理
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
• [Presentation] Zinc prevents Th17 cell-mediated autoimmune disease by directly inhibiting STAT3. (2009)
  • Author(s): 北林知佳
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
• [Presentation] Foxp3^+CD8^+ T cells inhibit the development of F759 arthritis. (2009)
  • Author(s): 鶴岡峰子
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
• [Presentation] 亜鉛シグナルの標的分子の探索と解析 (2009)
  • Author(s): 小林翔平
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
• [Presentation] 関節局所でのIL-6 amplify loopの活性化がは759関節炎発症には重要である (2009)
  • Author(s): 浅野省吾
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
• [Book] 第5項 IL-16 (2011)
  • Author(s): 村上正晃・平野俊夫
  • Publisher: 免疫疾患-疾患モデルの作製と利用
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/molonc/www/index.htm1
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/molonc/www/index.html
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/molonc/www/index.html
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/molonc/www/index.html
• [Patent(Industrial Property Rights)] IL-6アンプの形成を正か負に制御して慢性炎症性疾患を制御する分子郡の発明 (2011)
  • Inventor(s): 平野俊夫、村上正晃
  • Industrial Property Rights Holder: 国立大学法人大阪大学
  • Filing Date: 2011
• [Patent(Industrial Property Rights)] IL-6アンプの形成を正か負に制御して慢性炎症性疾患を制御する分子郡の発明 (2011)
  • Inventor(s): 平野俊夫、村上正晃平野俊夫、村上正晃
  • Industrial Property Rights Holder: 国立大学法人大阪大学
  • Filing Date: 2011-09-14