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The specific SM molecular species that these endogenous SM species interacted with HCV nonstructural 5B polymerase to enhance viral replication

Research Project

Project/Area Number 21390145
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Virology
Research Institution財団法人東京都医学総合研究所 (2011)
Tokyo Metropolitan Organization for Medical Research (2009-2010)

Principal Investigator

KOHARA Michinori  財団法人東京都医学総合研究所, ゲノム医科学研究分野, 副参事研究員 (10250218)

Co-Investigator(Kenkyū-buntansha) HIRATA Yuuichi  財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員 (50439452)
MUNAKATA Tsubasa  財団法人東京都医学総合研究所, ゲノム医科学研究分野, 主席研究員 (50420237)
TOKUNAGA Yuuko  財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員 (80555011)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywords細胞 / スフィンゴ脂質 / HCV複製 / 脂質ラフト / RdRp / C型肝炎ウイルス / SPT / 細胞内逆輸送 / 遺伝子複製 / スフィンゴ肪質
Research Abstract

Lipids are key components in the viral life cycle that affect host-pathogen interactions. In this study, we investigated the effect of HCV infection on sphingolipid metabolism, especially on endogenous SM levels, and the relationship between HCV replication and endogenous SM molecular species. We demonstrated that HCV induces the expression of the genes encoding sphingomyelin(SM) synthases. We observed associated increases of both total and individual sphingolipid molecular species, as assessed in human hepatocytes and in the detergent-resistant membrane(DRM) fraction in which HCV replicates. SGMS-1 expression had a strong correlation with HCV replication. Inhibition of sphingolipid biosynthesis with a hepatotropic serine palmitoyltransferase inhibitor, NA808, suppressed HCV-RNA production while also interfering with sphingolipid metabolism. Further, we identified the specific SM molecular species that comprise the DRM fraction and demonstrated that these endogenous SM species interacted with HCV nonstructural 5B polymerase to enhance viral replication. Our results reveal that HCV alters sphingolipid metabolism to promote viral replication, providing new insights into the formation of the HCV replication complex and the involvement of host lipids in the HCV life cycle.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (158 results)

All 2012 2011 2010 2009 Other

All Journal Article (54 results) (of which Peer Reviewed: 54 results) Presentation (82 results) Book (16 results) Remarks (4 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] An orally available, small-molecule interferon inhibits hepatitis C virus replication2012

    • Author(s)
      Konoishi H., Okamoto K., Ohmori Y., Yoshino H., Ohmori H., Ashiara M., Hirata Y., Ohta A., Sakamoto H., Hada N., Katsume A., Kohara M., MOrikawa K., Tsukuda T., Shimma N., Foster G., Alazawi W., Aoki Y., Arisawa M., Sudoh M.
    • Journal Title

      Sci. Comm

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detergent-induced activation of the hepatitis C virus genotype 1b RNA polymerase2012

    • Author(s)
      Weng L., Kohara M., Wakita T., Shimotohno K., Toyoda T.
    • Journal Title

      Gene

      Volume: 469 Pages: 79-87

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis C virus induces overexpression of 3β-hydroxysterolΔ24-reductase through Sp12012

    • Author(s)
      Saito M., Kohara M., Kasama Y., Tsukiyama-Kohara K.
    • Journal Title

      J. Med. Virol

      Volume: 84 Pages: 733-746

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Translocase of outer mitochondrial membrane 70 induces interferon response and is impaired by hepatitis C virus NS32012

    • Author(s)
      Kasama Y., Saito M., Takano T., Nishimura T., Satoh M., Wang Z., Elwy N., Harada S., Kohara M., Tsukiyama-Kohara K.
    • Journal Title

      Virus Res

      Volume: 163 Pages: 405-409

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Translocase of outer mitochondrial membrane 70 induces interferon response and is impaired by hepatitis C virus NS32012

    • Author(s)
      Kasama Y.
    • Journal Title

      Virus.Res.

      Volume: 163 Pages: 405-409

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detergent-induced activation of the hepatitis C virus genotype 1b RNA polymerase2012

    • Author(s)
      Leiyun Weng
    • Journal Title

      Gene

      Volume: 496 Pages: 79-87

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An orally available, small-molecule interferon inhibits hepatitis C virus replication2012

    • Author(s)
      Konishi H.
    • Journal Title

      Sci.Comm.

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis C virus-related lymphomagenesis in a mouse model2011

    • Author(s)
      Tsukiyama-Kohara K., Sekiguchi S., Kasama Y., Salem N. E., Machida K., Kohara M.
    • Journal Title

      Hematology

      Volume: 2011 Pages: 167501-167501

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Conditional hepatitis C virus gene expression without induction of severe inflammatory responses through the use of a Cre-expressing recombinant adenovirus in mice2011

    • Author(s)
      Ciyo T., Sekiguchi S., Hayashi M., Tobita Y., Kanegae Y., Saito I., Kohara M.
    • Journal Title

      Virus Research

      Volume: 160(1-2) Pages: 89-97

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Monoclonal antibody 2-152a suppresses hepatitis C virus infection thorough betaine/GABA transporter-12011

    • Author(s)
      Satoh M., Saito M., Takano T., Kasama Y., Nishimura T., Nishito Y., Hirata Y., Arai M., Sudoh M., Kai C., Kohara M., Tsukiyama-Kohara K.
    • Journal Title

      J. Infectious Disease

      Volume: 204(8) Pages: 1172-1180

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes2011

    • Author(s)
      Takano T., Tsukiyama-Kohara K., Hayashi M., Hirata Y., Satoh M., Tateno C., Hayashi Y., Hishima T., Funata N., Sudo M., Kohara M.
    • Journal Title

      J. Hepatology

      Volume: 55 Pages: 512-521

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Frontiers of Model Animals for Human Diseases2011

    • Author(s)
      Kimura K., Kohara M
    • Journal Title

      Exp. Anim

      Volume: 60(2) Pages: 93-100

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Translocase of outer mitochondrial membrane 70 is induced by hepatitis C virus and is related to the apoptotic response2011

    • Author(s)
      Takano T., Kohara M., Kasama Y., Nishimura T., Saito M., Kai C., Tsukiyama-Kohara K.
    • Journal Title

      J. Med. Virol

      Volume: 83 Pages: 801-809

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of interleukin-18 in intrahepatic inflammatory cell recruitment in acute liver injury2011

    • Author(s)
      Kimura K., Sekiguchi S., Hayashi S., Hayashi Y., Hishima T., Nagaki M., Kohara M.
    • Journal Title

      J. Leukocyte Biology

      Volume: 89 Pages: 433-442

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of infectious HCV virion-producing cells with newly designed full-genome replicon RNA2011

    • Author(s)
      Arai M., Suzuki H., Tobita Y., Takagi A., Okamoto K., Ohta A., Sudoh M., Kohara M.
    • Journal Title

      Arch. Virol

      Volume: 156 Pages: 295-304

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Incorporation of biaryl units into the 5 and 3 ends of sense and antisense strands of siRNA duplexes improves strand selectivity and nuclease resistance2011

    • Author(s)
      Yoshikawa K., Ogata A., Matsuda C., Kohara M., Iba H., Kitade Y., Ueno Y.
    • Journal Title

      Bioconjugate Chemistry

      Volume: 22 Pages: 42-49

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Incorporation of biaryl uniys into the 5' and 3' ends of sense and antisense strands of siRNA duplexes improves strand selectivity and nuclease2011

    • Author(s)
      Yoshikawa k.
    • Journal Title

      Bioconjugate Chemistry

      Volume: 22 Pages: 42-49

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of infectious HCV virion-producing cells with newly designed full-genome replicon RNA2011

    • Author(s)
      Arai M.
    • Journal Title

      Arch.Virol.

      Volume: 156 Pages: 295-304

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of interleukin-18 in intrahepatic inflammatory cell recruitment in acute liver injury2011

    • Author(s)
      Kimura K.
    • Journal Title

      Journal of Leukocyte Biology

      Volume: 89 Pages: 433-442

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Translocase of outer mitochondrial membranze 70 is induced by hepatitis C virus and is related to the apoptotic response2011

    • Author(s)
      Takano T.
    • Journal Title

      Journal of Med.Virol.

      Volume: 83 Pages: 801-809

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frontiers of Model Animals for Human Diseases2011

    • Author(s)
      Kimura K.
    • Journal Title

      Experimental Animals

      Volume: 60 Pages: 93-100

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes2011

    • Author(s)
      Takano T.
    • Journal Title

      Journal of Hepatology

      Volume: 55 Pages: 512-21

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conditional hepatitis C virus gene expression without induction of severe inflammatory responses through the use of a Cre-expressing recombinant adenovirus in mice2011

    • Author(s)
      Chiyo T.
    • Journal Title

      Virus.Res.

      Volume: 160 Pages: 89-97

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monoclonal antibody 2-152a suppresses hepatitis C virus infection through betaine/GABA transporter-12011

    • Author(s)
      Satoh M.
    • Journal Title

      Journal of Infec.Dis.

      Volume: 204 Pages: 1172-1180

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis C virus induces overexpression of 3β-hydroxysterol Δ24-reductase through Spl2011

    • Author(s)
      Saito M.
    • Journal Title

      Journal of Med.Virol.

      Volume: 84 Pages: 733-746

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of infectious HCV virion -producing cells with newly designed full-genome replicon RNA.2011

    • Author(s)
      Arai M.
    • Journal Title

      Arch.Virol.

      Volume: 156 Pages: 295-304

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of interleukin-18 in intrahepatic inflammatory cell recruitment in acute liver injur.2011

    • Author(s)
      Kimura K.
    • Journal Title

      J.Leukocyte Biology

      Volume: 89 Pages: 433-442

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Incorporation of biaryl units into the 5, and 3, ends of sense and antisense strands of siRNA duplexes improves strand selectivity and nuclease resistance.2011

    • Author(s)
      Yoshikawa K.
    • Journal Title

      Bioconjugate Chemistry

      Volume: 22 Pages: 42-49

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Translocase of outer mitochondrial membrane 70 is induced by hepatitis C virus and is related to the apoptotic response.2011

    • Author(s)
      Takano T.
    • Journal Title

      J.Med.Virol.

      Volume: 83 Pages: 801-809

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Persistent expression of the full genome of hepatitis C virus in B cells induces spontaneous development of B-cell lymphomas in vivo2010

    • Author(s)
      Kasama Y., Sekiguchi S., Saito M., Tanaka K., Satoh M., Kuwahara K., Sakaguchi N., Takeya M., Hiasa Y., Kohara M. Tsukiyama-Kohara K.
    • Journal Title

      Blood

      Volume: 116(23) Pages: 4926-4933

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of a recombinant measles virus expressing hepatitis C virus envelope proteins by infection of human PBL-NOD/Scid/Jak3null mouse2010

    • Author(s)
      Satoh M., Saito M., Tanaka K., Iwanaga S., Salem N E., Seki T., Okada S., Kohara M., Harada S., Kai C., Tsukiyama-Kohara K.
    • Journal Title

      Comp Immunol Microbiol Infect Dis

      Volume: 33(6) Pages: 81-88

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sphingomyelin activates hepatitis C virus RNA polymerease in a genotype specific manner2010

    • Author(s)
      Weng L., Hirata Y., Arai M., Kohara M., Wakita T., Watashi K., Shimotohno K., He Y., Zhong J., Toyoda T.
    • Journal Title

      J. Virol

      Volume: 84(22) Pages: 11761-70

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of hepatitis B and C viruses in almost all hepatocytes by modified PCR-based in situ hybridization2010

    • Author(s)
      Nuriya H., Inoue K., Tanaka T., Hayashi Y., Hishima T., Funata N., Kaji K., Hayashi S., Kaneko S., Kohara M.
    • Journal Title

      J. Clinical Microbiology

      Volume: 48(11) Pages: 3843-3851

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pathogenesis of hepatitis C virus infection in Tupaia belangeri2010

    • Author(s)
      Amako Y., Tsukiyama-Kohara K., Katsume A., Hirata Y., Sekiguchi S., Tobita Y., Hayashi Y., Hishima T., Funata N., Yonekawa H., Kohara M.
    • Journal Title

      J. Virology

      Volume: 84(1) Pages: 303-311

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Natural killer cells target HCV core proteins during the innate immune response in HCV transgenic miceQ12010

    • Author(s)
      Satoh K., Takahashi H., Matsuda C., Umehara T., Tanaka T., Miyasaka M., Zeniya M., Kohara M.
    • Journal Title

      J. Medical Virology

      Volume: 82(9) Pages: 1545-1553

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Natural killer cells target HCV core proteins during the innate immune response in HCV transgenic mice^Q1.2010

    • Author(s)
      Satoh K.
    • Journal Title

      J.Medical Virology

      Volume: 82(9) Pages: 1545-1553

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathogenesis of hepatitis C virus infection in Tupaia belangeri.2010

    • Author(s)
      Amako Y.
    • Journal Title

      J.Virology

      Volume: 84(1) Pages: 303-311

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of hepatitis B and C viruses in almost all hepatocytes by modified PCR-based in situ hybridization.2010

    • Author(s)
      Nuriya H.
    • Journal Title

      J.Clinical Microbiology

      Volume: 48(11) Pages: 3843-3851

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sphingomyelin activates hepatitis C virus RNA polymerease in a genotype specific manner.2010

    • Author(s)
      Weng L.
    • Journal Title

      J.Virol.

      Volume: 84(22) Pages: 11761-11770

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of a recombinant measles virus expressing hepatitis C virus envelope proteins by infection of human PBL-NOD/Scid/Jak3null mouse.2010

    • Author(s)
      Satoh M.
    • Journal Title

      Comp Immunol Microbiol Infect Dis.

      Volume: 33(6) Pages: 81-88

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Persistent expression of the full genome of hepatitis C virus in B cells induces spontaneous development of B -cell lymphomas in vivo.2010

    • Author(s)
      Kasama Y.
    • Journal Title

      Blood

      Volume: 116(23) Pages: 4926-4933

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of SARS-COV spike protein-derived and HLA-A2-restricted human CTL epitopes by using a new muramyl dipeptide derivative adjuvant.2010

    • Author(s)
      Chen Y-Z.
    • Journal Title

      International Journal of Immunopathology and Pharmacology

      Volume: 23(1) Pages: 165-177

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathogenesis of hepatitis C virus infection in Tupaia belanger2010

    • Author(s)
      Amako Y.
    • Journal Title

      J.Virology 84(1)

      Pages: 303-311

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis C virus impairs P53 via persistent over-expression of 3β-hydroxysterolΔ24-reductase2009

    • Author(s)
      Nishimura T., Kohara M., Izumi K., Kasama Y., Hirata Y., Huang Y., Shuda M., Nuriya H., Tokunaga Y., Sato M., Saito M., Kai C. and Tsukiyama-Kohara K.
    • Journal Title

      J. Biol. Chem

      Volume: 284(52) Pages: 36442-36452

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased rate of death related to presence of viremia among hepatitis C virus antibody-positive subjects in a community-based cohort study2009

    • Author(s)
      Uto H., Stuver S. O., Hayashi K., Kumagai K., Sasaki F., Kanmura S., Numata M., Moriuchi A., Hasegawa S., Oketani M., Ido A., Kusumoto K., Hasuike S., Nagata K., Kohara M. and Tsubouchi H.
    • Journal Title

      Hepatology

      Volume: 50(2) Pages: 393-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Disruption of IFN signaling and HCV synergistically enhance lymphoproliferation through type II CD95 and interleukins2009

    • Author(s)
      Machida K., Tsukiyama-Kohara K., Sekiguchi S., Seike E., Tone S., Hayashi Y., Kasama Y., Shimizu M., Takahashi H., Taya C., Yonekawa H., Tanaka N. and Kohara M.
    • Journal Title

      Gastroenterology

      Volume: 137(1) Pages: 285-296

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Modification of hepatitis C virus 1b RNA polymerase to make a highly active JFH1-type polymerase by mutation of the thumb domain2009

    • Author(s)
      Weng L., Du J., Zhou J., Ding J., Wakita T., Kohara M. and Toyoda T.
    • Journal Title

      Arch Virol

      Volume: 154(5) Pages: 765-773

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of nuclease-resistant siRNAs possessing universal overhangs2009

    • Author(s)
      Ueno Y., Watanabe Y., Shibata A., Yoshikawa K., Takano T., Kohara M. and Kitade Y.
    • Journal Title

      Bioorganic & Medicinal chemistry

      Volume: 17(5) Pages: 1974-81

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of nuclease-resistant siRNAs possessing universal overhangs2009

    • Author(s)
      Ueno Y
    • Journal Title

      Bioorganic & Medicinal chemistry 17(5)

      Pages: 1974-1981

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modification of hepatitis C virus 1b RNA polymerase to make a highly active JFH1-type polymerase by mutation of the thumb domain2009

    • Author(s)
      Weng L
    • Journal Title

      Arch Virol. 154(5)

      Pages: 765-773

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disruption of IFN signaling and HCV synergistically enhance lym-phoproliferation through type II CD95 and interleukins2009

    • Author(s)
      Machida K
    • Journal Title

      Gastroenterology 137(1)

      Pages: 285-296

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased rate of death related to presence of viremia among hepatitis C virus antibody-positive subjects in a community-based cohort study2009

    • Author(s)
      Uto H
    • Journal Title

      Hepatology 50(2)

      Pages: 393-399

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis C virus impairs P53 via persistent over-expression of 3β-hydroxysterol Δ24-reductase2009

    • Author(s)
      Nishimura T
    • Journal Title

      J.Biol.Chem. 284(52)

      Pages: 36442-36452

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes.

    • Author(s)
      Takano T.
    • Journal Title

      J.Hepatology

      Volume: in press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] French marine bark extract pycnogenol is a new candidate of Heoatitis C virus therapeutic material2011

    • Author(s)
      Nishimura T.
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Interferon-lambda plays a critical role in antiviral response in human hepatocytes2011

    • Author(s)
      Hirata Y.
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Evaluation of the therapeutic effect of DNA vaccines in the mouse model of chronic HCV infection2011

    • Author(s)
      Wada T.
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-28
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Recombinant vaccinia virus encoding hepatitis C virus nonstructural protein modulates host immune response and ameliorates chronic hepatitis in mouse model2011

    • Author(s)
      Kimura K.
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-28
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Suppression of sphingomyelin augmented by hepatitis C virus has robust anti-vitral effects in human livers2011

    • Author(s)
      Hirata Y.
    • Organizer
      The American Association for the Study of Liver Diseasea
    • Place of Presentation
      San Francisco
    • Year and Date
      2011-11-08
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Recombinant vaccinia virus encoding hepatitis C virus nonstructural protein modulates host immune response and ameliorates chronic hepatitis in mouse model2011

    • Author(s)
      Kimura K.
    • Organizer
      The American Association for the Study of Liver Diseasea
    • Place of Presentation
      San Francisco
    • Year and Date
      2011-11-08
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] HCV持続発現マウスを用いたHCVワクチンの開発2011

    • Author(s)
      木村公則
    • Organizer
      第15回日本肝臓学会大会
    • Place of Presentation
      福岡サンパレス
    • Year and Date
      2011-10-20
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ヒト肝細胞での自然免疫応答におけるIFN-λの重要性とその誘導メカニズム2011

    • Author(s)
      平田雄一
    • Organizer
      第15回日本肝臓学会大会
    • Place of Presentation
      福岡サンパレス
    • Year and Date
      2011-10-20
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] C型肝炎ウイルスの複製におけるDHCR24の役割2011

    • Author(s)
      高野貴士
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] C型肝炎発症におけるウイルス蛋白質と炎症サイトカイン2011

    • Author(s)
      小原道法
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Suppression of sphingomyelin augmented by hepatitis C virus has robust anti-viral effects in human livers2011

    • Author(s)
      Hirata Y.
    • Organizer
      International Union of Microbiological Societies
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2011-09-13
    • Related Report
      2011 Final Research Report
  • [Presentation] Suppression of sphingomyelin augmented by hepatitis C virus has robust anti-viral effects in human livers2011

    • Author(s)
      Hirata Y.
    • Organizer
      International Union of Microbiological Societies
    • Place of Presentation
      Sapporo Convention Center
    • Year and Date
      2011-09-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Persistent expression of the full genome of hepatitis C virus in B cells induces spontaneous development of B-cell lymphomas in mice2011

    • Author(s)
      Kasama Y.
    • Organizer
      18th International Symposium Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Seattle(米国)
    • Year and Date
      2011-09-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes2011

    • Author(s)
      Takano T.
    • Organizer
      18th International Symposium Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Seattle(米国)
    • Year and Date
      2011-09-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Novel infectious clone of HCV 1a strain HCV-RMT efficiently replicate in vitro and in vivo using adaptive mutations2011

    • Author(s)
      Tokunaga Y.
    • Organizer
      18th International Symposium Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Seattle(米国)
    • Year and Date
      2011-09-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Regulation of HCV replication by fatty acid synthase2011

    • Author(s)
      Munakata T.
    • Organizer
      18th International Symposium Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Seattle(米国)
    • Year and Date
      2011-09-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Regulation of HCV replication by fatty acid synthase2011

    • Author(s)
      Munakata T.
    • Organizer
      18^<th> International Symposium Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Seattle(米国)
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Novel infectious clone of HCV 1a strain HCV-RMT efficiently replicate in vitro and in vivo using adaptive mutations2011

    • Author(s)
      Tokunaga Y.
    • Organizer
      18^<th> International Symposium Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Seattle(米国)
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes2011

    • Author(s)
      Takano T.
    • Organizer
      18^<th> International Symposium Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Seattle(米国)
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Persistent expression of the full genome of hepatitis C virus in B cells induces spontaneous development of B-cell lymphomas in mice2011

    • Author(s)
      Kasama Y.
    • Organizer
      18^<th> International Symposium Hepatitis C virus and Related Viruses
    • Place of Presentation
      Seattle(米国)
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] HCV持続発現マウスを用いたHCV治療ワクチンの開発2011

    • Author(s)
      小原道法
    • Organizer
      第10回CBSM
    • Place of Presentation
      軽井沢プリンスホテル(長野)
    • Year and Date
      2011-06-24
    • Related Report
      2011 Final Research Report
  • [Presentation] HCV持続発現マウスを用いたHCV治療ワクチンの開発2011

    • Author(s)
      小原道法
    • Organizer
      第10回CBSM2011
    • Place of Presentation
      軽井沢プリンスホテル(長野)
    • Year and Date
      2011-06-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] PCRとin situ hybridizationを組み合わせたHCVとHBVのウイルスゲノム存在様式可視化の試み2011

    • Author(s)
      井上和明
    • Organizer
      47回日本肝臓学会総会
    • Place of Presentation
      ホテルグランパシフィック(東京)
    • Year and Date
      2011-06-02
    • Related Report
      2011 Final Research Report
  • [Presentation] HCV感染による慢性肝炎の病態形成と炎症性サイトカインの関与2011

    • Author(s)
      木村公則
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      第ホテルグランパシフィック(東京)
    • Year and Date
      2011-06-02
    • Related Report
      2011 Final Research Report
  • [Presentation] HCV感染による慢性肝炎の病態形成と炎症性サイトカインの関与2011

    • Author(s)
      木村公則
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      ホテルグランパシフィック(東京)
    • Year and Date
      2011-06-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] PCRとin situ hybridizationを組み合わせたHCVとHBVのウイルスゲノム存在様式可視化の試み2011

    • Author(s)
      井上和明
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      ホテルグランパシフィック(東京)
    • Year and Date
      2011-06-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規C型慢性肝炎モデルマウスを用いたC型慢性肝炎の病態解析2011

    • Author(s)
      大槻貴博
    • Organizer
      第58回日本実験動物学会総会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2011-05-25
    • Related Report
      2011 Final Research Report
  • [Presentation] 新規C型慢性肝炎モデルマウスを用いたC型慢性肝炎の病態解析2011

    • Author(s)
      大槻貴博
    • Organizer
      第58回日本実験動物学会総会
    • Place of Presentation
      タワーホール船橋(東京)
    • Year and Date
      2011-05-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Spontaneous development of B-cell lymphomas by persistent expression of the full genome of hepatitis C virus in B cells in mics2011

    • Author(s)
      Tsukiyama-Kohara K.
    • Organizer
      2011ASBMB
    • Place of Presentation
      広州(中国)
    • Related Report
      2011 Final Research Report
  • [Presentation] Spontaneous development of B-cell lymphomas by persistent expression of the full genome of hepatitis C virus in B cells in mics2011

    • Author(s)
      Tsukiyama-Kohara K.
    • Organizer
      2011 ASBMB
    • Place of Presentation
      広州(中国)
    • Related Report
      2011 Annual Research Report
  • [Presentation] IFN-lambda plays a critical role in the sustained antiviral response in human hepatocytes2010

    • Author(s)
      Nakagawa S.
    • Organizer
      第33回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド(兵庫)
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 全長HCVのB細胞発現によるリンパ腫誘導2010

    • Author(s)
      笠間由里
    • Organizer
      第33回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド(兵庫)
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] C型肝炎ウイルス複製におけるBetaine/GABA transporter-1(BGT-1)の役割2010

    • Author(s)
      佐藤正明
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島県郷土文化会館(徳島)
    • Year and Date
      2010-11-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脂肪酸合成酵素を介したパルミチン酸によるC型肝炎ウイルスの複製制御2010

    • Author(s)
      棟方翼
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島県郷土文化会館(徳島)
    • Year and Date
      2010-11-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウスモデルを用いたC型肝炎ウイルス誘発性Bリンパ腫発生機序の解析2010

    • Author(s)
      笠間由里
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島県郷土文化会館(徳島)
    • Year and Date
      2010-11-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 感染性粒子を放出するHCV遺伝子型1aクローン(HCV-RMT)の樹立2010

    • Author(s)
      徳永優子
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島県郷土文化会館(徳島)
    • Year and Date
      2010-11-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hepatitis C virus-mediated pathogenesis is dependent on inflammatory cytokines IRRE-spective of the HCV protein level.2010

    • Author(s)
      Kimura K.
    • Organizer
      American Association for the Study of Liver Diseases
    • Place of Presentation
      ボストン(アメリカ)
    • Year and Date
      2010-11-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Critical Role of interleukin-18 for intrahepatic inflammatory cell recruitment in activated macrophage-mediated liver injury.2010

    • Author(s)
      Kimura K.
    • Organizer
      American Association for the Study of Liver Diseases
    • Place of Presentation
      ボストン(アメリカ)
    • Year and Date
      2010-11-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Interferon lambda plays a critical role on antiviral response by hepatotropic inducer of innate immunity in human hepatocyte.2010

    • Author(s)
      Hirata Y.
    • Organizer
      American Association for the Study of Liver Diseases
    • Place of Presentation
      ボストン(アメリカ)
    • Year and Date
      2010-11-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規SPT阻害剤NA808の抗HCV効果2010

    • Author(s)
      平田雄一
    • Organizer
      第18回日本消化器関連学会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2010-10-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] IFNλを強力に誘導する核酸/リポソーム製剤の同定とその抗HCV効果2010

    • Author(s)
      平田雄一
    • Organizer
      第18回日本消化器関連学会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2010-10-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] C型慢性肝炎に対するHCV遺伝子組換えワクチニアウイルスによる新たな治療戦略2010

    • Author(s)
      木村公則
    • Organizer
      第18回日本消化器関連学会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2010-10-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hepatitis C virus impairs p53 activity by persistent over-expression of DHCR24.2010

    • Author(s)
      Tsukiyama-Kohara K.
    • Organizer
      Cell Symposia Inflammation and Disease
    • Place of Presentation
      リスボン(ポルトガル)
    • Year and Date
      2010-09-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Immunotherapy using recombinant Vaccinia vir us cures chronic hepatitis C.2010

    • Author(s)
      Kimura K.
    • Organizer
      Cell Symposia : Inflammation and Disease
    • Place of Presentation
      リスボン(ポルトガル)
    • Year and Date
      2010-09-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] IFN-lambda mediated antiviral effects of poly IC/hepatotropic liposome complex on HCV and HBV2010

    • Author(s)
      小原道法
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Persistent expression of the full genome of hepatitis C virus in B cells induces spontaneous B-cell lymphomas2010

    • Author(s)
      笠間由里
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synthetic lipophilic antioxidant BO-653 suppresses HCV replication.2010

    • Author(s)
      Yasui F.
    • Organizer
      17^<th> International Meeting on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2010-09-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Interferon lambda plays a critical role on antiviral effect in human hepatocyte.2010

    • Author(s)
      Nakagawa S.
    • Organizer
      17^<th> International Meeting on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2010-09-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hepatitis C virus mediated pathogenesis is dependent on inflammatory cytokines with irrespective of HCV protein level.2010

    • Author(s)
      Sekiguchi S.
    • Organizer
      17^<th> International Meeting on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2010-09-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hepatitis C virus imnpairs p53 via persistent overexpression of 3beta-hydroxysterol delta24-reductase2010

    • Author(s)
      Nishimura T.
    • Organizer
      17^<th> International Meeting on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2010-09-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Application of DHCR24 for the diagnosis of hepatocellular carcinoma(HCC).2010

    • Author(s)
      Salem N.
    • Organizer
      17^<th> International Meeting on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2010-09-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] A newly synthesized serine palmytoiltransferase inhibitor, NA808, has a robust antiviral effect to hepatitis C virus via hindering host-virus interactions.2010

    • Author(s)
      Hirata Y.
    • Organizer
      17^<th> International Meeting on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2010-09-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Palmitate regulates HCV replication.2010

    • Author(s)
      Munakata T.
    • Organizer
      17^<th> International Meeting on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2010-09-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] HCV遺伝子組換えワクチニアウイルスによる免疫治療2010

    • Author(s)
      関口敏
    • Organizer
      第10回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      あわじ夢舞台国際会議揚(兵庫)
    • Year and Date
      2010-09-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hepatitis C virus altered the sphingolipids metabolism for better environment its replication.2010

    • Author(s)
      Hirata Y.
    • Organizer
      Keystone Symposia
    • Place of Presentation
      ウエスティン都ホテル(京都)
    • Year and Date
      2010-06-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Pathogenesis of hepatitis C virus in vitro and in vivo2010

    • Author(s)
      Tsukiyama-Kohara K.
    • Organizer
      Infection-associated Cancers
    • Place of Presentation
      札幌
    • Year and Date
      2010-03-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] C型肝炎のワクチン療法をめざして2009

    • Author(s)
      小原道法
    • Organizer
      第7回桜山感染症研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-12-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] A newly synthesized serine palmytoiltransferase inhibitor, NA808, has a robust antiviral effect to hepatitis C virus viahindering host-virus interactions2009

    • Author(s)
      平田雄一
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Hepatitis C virus impairs p53 via persistent overexpression of 3β-hydroxysterol δ24-reductase2009

    • Author(s)
      西村知裕
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Disruption of IFN Signaling and HCV Synergistically Enhance Lymphoproliferation through Type II CD95 and Interleukins2009

    • Author(s)
      Tsukiyama-Kohara K.
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Liver targeted Cationic Liposome, (plC/LIC)has robust antiviral effects on HCV or HBV Replication in chimeric mice2009

    • Author(s)
      中川慎一郎
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Interphase cyclin-dependent kinases regulate hepatitis C virus replication2009

    • Author(s)
      棟方翼
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] A newly synthesized serine palmytoiltransferase inhibitor, NA808, has a robust antiviral effect to hepatitis C virus via hindering host-virus interactions2009

    • Author(s)
      平田雄一
    • Organizer
      The 60^<th> Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      Boston、USA
    • Year and Date
      2009-11-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Resolution of HCV chronic hepatitis with immunotherapy using Hepatitis C virus recombinant vaccinia virus in persistent infection model mice2009

    • Author(s)
      関口敏
    • Organizer
      The 60^<th> Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      Boston、USA
    • Year and Date
      2009-11-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] C型肝炎ウイルスとBリンパ腫2009

    • Author(s)
      小原恭子
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] polyICリポソーム製剤によるキメラマウス感染HCVの排除及びその機序の解析2009

    • Author(s)
      中川慎一郎
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] サイクリン依存性リン酸化酵素阻害剤によるC型肝炎ウイルスの複製制御2009

    • Author(s)
      棟方翼
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] HCV遺伝子組換えワクチニアウイルスによる免疫治療2009

    • Author(s)
      関口敏
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高い抗HCV・RNAi活性をもつ Dicer 認識型siRNA配列の同定と動物への導入2009

    • Author(s)
      松田千穂
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Betaine/GABA transporter-1(BGT-1)のC型肝炎ウイルス複製における役割2009

    • Author(s)
      佐藤正明
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新規セリンパルミトイルトランスフェラーゼ阻害剤NA808の抗HCV効果2009

    • Author(s)
      平田雄一
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] C型肝炎ウイルス(HCV)が誘導するDHCR24(3β hydroxysterol Δ24 reductase)過剰発現によるp53機能抑制2009

    • Author(s)
      西村知裕
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Analysis of the mechanism by which BALB/c mice having prior immunization with nucleocapsid protein of SARS-CoV developsevere pneumonia after SARS-CoV infection2009

    • Author(s)
      安井文彦
    • Organizer
      3^<rd> Global Vaccine Congress
    • Place of Presentation
      Singapore、シンガポール
    • Year and Date
      2009-10-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] C型肝炎ウイルスの持続感染機序の解析2009

    • Author(s)
      関口敏
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] HCV誘導性3β-Hydroxysterol δ-24 reductase 持続発現によるp53転写因子機能の抑制2009

    • Author(s)
      西村知裕
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] SARS-CoVのヌクレオキャプシドタンパク質を前免疫したマウスへのSRAS-CoV感染により惹起される肺炎重症化機序の解析2009

    • Author(s)
      安井文彦
    • Organizer
      第13回日本ワクチン学会
    • Place of Presentation
      札幌
    • Year and Date
      2009-09-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Prior immunization with SARS-CoV nucleocapsid proyein causes severe pneumonia in mice infected with SARS -CoV2009

    • Author(s)
      安井文彦
    • Organizer
      第9回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      兵庫
    • Year and Date
      2009-09-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高いRNAi活性をもつ Dicer 認識型siRNA配列の同定と動物へのデリバリー2009

    • Author(s)
      小原道法
    • Organizer
      第8回国際バイオEXPO
    • Place of Presentation
      東京
    • Year and Date
      2009-07-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] A newly synthesized serine palmitoyltransferase inhibitor, NA808, has the strong effect to hepatitis C virus in vitro and in vivo2009

    • Author(s)
      平田雄一
    • Organizer
      44^<th> Annual Meeting of the EUROPEAN ASSOCIATION FOR THE STUDY OF THE LIVER
    • Place of Presentation
      Copenhagen、デンマーク
    • Year and Date
      2009-04-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] SARS-CoVのヌクレオキャップシドタンパク質を前免疫したマウスへのSARS-CoV感染により惹起される肺炎重症化機序の解析2009

    • Author(s)
      安井文彦
    • Organizer
      第4回中国バイオメディカルフォーラム
    • Place of Presentation
      大連、中国
    • Related Report
      2009 Annual Research Report
  • [Presentation] NA 808 has the strong effect to hepatitis C virus and in vivo2009

    • Author(s)
      平田雄一
    • Organizer
      16^<th> Internationl Symposium on Hepatitis C Virus & Related Viruses
    • Place of Presentation
      Nice、フランス
    • Related Report
      2009 Annual Research Report
  • [Presentation] Anti-hepatitis C virus activity of cyclin -dependent kinase inhibitors2009

    • Author(s)
      棟方翼
    • Organizer
      16^<th> Internationl Symposium on Hepatitis C Virus & Related Viruses
    • Place of Presentation
      Nice、フランス
    • Related Report
      2009 Annual Research Report
  • [Book] 日本臨床、新時代のウイルス性肝炎学ー「HCVの病原性発現に関与するウイルス因子とその機能」2011

    • Author(s)
      小原恭子, 他
    • Related Report
      2011 Final Research Report
  • [Book] BIO Clinica、C型肝炎ウイルスによる免疫攪乱と炎症発がん2011

    • Author(s)
      小原恭子, 他
    • Related Report
      2011 Final Research Report
  • [Book] BIO Clinica、細胞膜成分を標的としたC型肝炎治療薬2011

    • Author(s)
      須藤正幸, 他
    • Related Report
      2011 Final Research Report
  • [Book] 肝胆膵、スフィンゴ脂質合成阻害薬のC型肝炎ウイルスに対する薬理作用2011

    • Author(s)
      平田雄一, 他
    • Related Report
      2011 Final Research Report
  • [Book] 新時代のウイルス性肝炎学-「HCVの病原性発現に関与するウイルス因子とその機能」2011

    • Author(s)
      小原恭子
    • Total Pages
      6
    • Publisher
      日本臨床
    • Related Report
      2011 Annual Research Report
  • [Book] C型肝炎ウイルスによる免疫攪乱と炎症発がん2011

    • Author(s)
      小原恭子
    • Total Pages
      7
    • Publisher
      BIO Clinica
    • Related Report
      2011 Annual Research Report
  • [Book] 細胞膜成分を標的としたC型肝炎治療薬2011

    • Author(s)
      須藤正幸
    • Total Pages
      5
    • Publisher
      BIO Clinica
    • Related Report
      2011 Annual Research Report
  • [Book] 薬学雑誌、SPT阻害剤によるC型肝炎ウイルス(HCV)複製阻害機序の解析2010

    • Author(s)
      平田雄一, 他
    • Related Report
      2011 Final Research Report
  • [Book] YAKUGAKU ZASSHI、SPT阻害剤によるC型肝炎ウイルス(HCV)複製阻害機序の解析2010

    • Author(s)
      平田雄一, 他
    • Related Report
      2011 Final Research Report
  • [Book] SPT阻害剤によるC型肝炎ウイルス(HCV)複製阻害機序の解析2010

    • Author(s)
      平田雄一
    • Total Pages
      4
    • Publisher
      薬学雑誌
    • Related Report
      2010 Annual Research Report
  • [Book] スフィンゴ脂質合成阻害薬のC型肝炎ウイルスに対する薬理作用2010

    • Author(s)
      平田雄一
    • Total Pages
      6
    • Publisher
      肝胆膵
    • Related Report
      2010 Annual Research Report
  • [Book] SPT阻害剤によるC型肝炎ウイルス(HCV)複製阻害機序の解析2010

    • Author(s)
      平田雄一
    • Total Pages
      5
    • Publisher
      YAKUGAKU ZASSHI
    • Related Report
      2009 Annual Research Report
  • [Book] Summer、C型肝炎ウイルスとBリンパ腫2009

    • Author(s)
      小原恭子, 他
    • Related Report
      2011 Final Research Report
  • [Book] メディカル・サイエンス・ダイジェスト、C型肝炎ウイルスの持続感染機構と病原性2009

    • Author(s)
      関口敏, 他
    • Related Report
      2011 Final Research Report
  • [Book] C型肝炎ウイルスとBリンパ腫2009

    • Author(s)
      小原恭子
    • Total Pages
      4
    • Publisher
      Summer
    • Related Report
      2009 Annual Research Report
  • [Book] C型肝炎ウイルスの持続感染機構と病原性2009

    • Author(s)
      関口敏
    • Total Pages
      4
    • Publisher
      メディカル・サイエンス・ダイジェスト
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.igakuken.or.jp

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.igakuken.or.jp

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.igakuken.or.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.rinshoken.or.jp/

    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗C型肝炎ウイルス効果を有するベンゾフラン誘導体2009

    • Inventor(s)
      小原道法、安井文彦、須藤正幸
    • Industrial Property Rights Holder
      財団法人東京都医学研究機構、中外製薬株式会社
    • Industrial Property Number
      2009-093608
    • Filing Date
      2009-04-08
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] C型肝炎ウイルスの新規株由来のポリヌクレオチド及びその利用2009

    • Inventor(s)
      小原道法、新井正明、向谷知世
    • Industrial Property Rights Holder
      財団法人東京都医学研究機構、田辺三菱製薬株式会社、株式会社フェニックスバイオ
    • Industrial Property Number
      2009-197923
    • Filing Date
      2009-08-28
    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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