Clarification of the genes involved in the hyperlipidemia and the application to the preventive medicine

• Project/Area Number: 21390188
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Hiroshima University
• Principal Investigator: NOBUKUNI Yoshitaka 広島大学, 原爆放射線医科学研究所, 准教授 (80295641)
• Co-Investigator(Kenkyū-buntansha): DOUMAE Sumiko 名古屋市立大学, 大学院・医学研究科, 准教授 (70227700) ; EBOSHIDA Akira 広島大学, 大学院・医歯(薬)学総合研究科, 教授 (50168811) ; FUJIMOTO Nariaki 広島大学, 原爆放射線医科学研究所, 准教授 (40243612)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000); Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2009: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
• Keywords: 衛生 / 予防医学 / 脂質 / 高脂血症 / レステロール / ゲノム / 遺伝子 / ジーントラップ / コレステロール代謝・輸送 / ゲノム機能学 / 細胞機能遺伝学 / ジーントラップ挿入変異 / 候補遺伝子解析 / 分子疫学 / 脂質代謝 / 脂質輸送

Research Abstract

To clarify the genes involved in hypelipidemia (hypercholesterolemia), we conducted a functional genetic screening of the genes that play an important role in intra-cellular cholesterol transport and/or metabolism. So far we succeeded to isolate 188 mutants that defected the LDL-cholesterol uptake, intracellular cholesterol transport and/or metabolism from the large-scale gene-trap insertional mutants library of CHO cells, and to identify the 49 known genes and 32 genes of unidentified function.

Research Products

• [Journal Article] The differences in the involvements of loci of promoter region and Ile50Val in interleukin-4 receptor αchain gene between atopic dermatitis and Japanese cedar pollinosis (2012)
  • Author(s): Tanaka T, Hitomi Y, Kambayashi Y, Hibino Y, Fukutomi Y, Shibata S, SugimotoS, Hatta K, Eboshida A, Konoshita T, Nakamura H
  • Journal Title: Allergol Int Volume: 61巻 Pages: 57-63
  • NAID: 130004873044
  • Peer Reviewed
• [Journal Article] The differences in the involvements of loci of promoter region and Ile50Val in interleukin-4 receptor α chain gene between atopic dermatitis and Japanese cedar pollinosis (2012)
  • Author(s): Tanaka T, Hitomi Y, Kambayashi Y, Hibino Y, Fukutomi Y, Shibata S, Sugimoto S, Hatta K, Eboshida A, Konoshita T, Nakamura H
  • Journal Title: Allergol Int Volume: 61 Pages: 57-63
  • NAID: 130004873044
  • Peer Reviewed
• [Journal Article] ApoA-I enhances generation of HDL-like lipoproteins through interaction between ABCA1 and phospholipase Cγ in rat astrocytes (2011)
  • Author(s): Ito J, Nagayasu Y, Kheirollah A, Abe-Dohmae S, Yokoyama S
  • Journal Title: Biochim Biophys Acta Volume: 1811巻 Issue: 12 Pages: 1062-1069
  • DOI: 10.1016/j.bbalip.2011.08.016
  • Peer Reviewed
• [Journal Article] Impact of self-association on function of apolipoprotein A-I (2011)
  • Author(s): Jayaraman S, Abe-Dohmae S, Yokoyama S, Cavigiolio G
  • Journal Title: J Biol Chem Volume: 286巻 Issue: 41 Pages: 35610-35623
  • DOI: 10.1074/jbc.m111.262485
  • Peer Reviewed
• [Journal Article] Calpain-mediated ABCA1 degradation: Post-translational regulation of ABCA1 for HDL biogenesis (2011)
  • Author(s): Yokoyama S, Arakawa R, Wu CA, Iwamoto N, Lu R, Tsujita M, Abe-Dohmae S
  • Journal Title: Biochim Biophys Acta.(Review) Volume: 1821巻 Pages: 547-551
  • Peer Reviewed
• [Journal Article] HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7 (2011)
  • Author(s): Tanaka N, Abe-Dohmae S, Iwamoto N, Fitzgerald ML, Yokoyama S
  • Journal Title: Atherosclerosis Volume: 216巻 Pages: 407-414
  • Peer Reviewed
• [Journal Article] Insulin down-regulates specific activity of ATP-binding cassette transporter A1 for high density lipoprotein biogenesis through its specificphosphorylation (2011)
  • Author(s): Nonomura K, Arai Y, Mitani H, Abe-Dohmae S, Yokoyama S
  • Journal Title: Atherosclerosis Volume: 216巻 Pages: 334-341
  • Peer Reviewed
• [Journal Article] Roles of ATP-Binding Cassette Transporter A7 in Cholesterol Homeostasis and Host Defense System (2011)
  • Author(s): Tanaka N, Abe-Dohmae S, Iwamoto N, Yokoyama S
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 18 Issue: 4 Pages: 274-281
  • DOI: 10.5551/jat.6726
  • NAID: 130004845365
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed
• [Journal Article] Insulin Down-Regulates Specific Activity Of ATP-Binding Cassette Transporter A1 For High Density Lipoprotein Biogenesis Through Its Specific Phosphorylation (2011)
  • Author(s): Nonomura K, Arai Y, Mitani H, Abe-Dohmae S, Yokoyama S
  • Journal Title: Atherosclerosis Volume: 216巻 Pages: 334-341
  • Peer Reviewed
• [Journal Article] Insulin down-regulates specific activity of ATP-binding cassette transporter A1 for high density lipoprotein biogenesis through its specific phosphorylation (2011)
  • Author(s): Nonomura K, Arai Y, Mitani H, Abe-Dohmae S, Yokoyama S
  • Journal Title: Atherosclerosis Volume: 216 Issue: 2 Pages: 334-341
  • DOI: 10.1016/j.atherosclerosis.2011.02.021
  • Peer Reviewed
• [Journal Article] Calpain-mediated ABCA1 degradation : Post-translational regulation of ABCA1 for HDL biogenesis (2011)
  • Author(s): Yokoyama S, Arakawa R, Wu CA, Iwamoto N, Lu R, Tsujita M, Abe-Dohmae S
  • Journal Title: Biochim Biophys Acta Volume: 1821 Pages: 547-551
  • Peer Reviewed
• [Journal Article] Roles of ATP-Binding Cassette Transporter A7 in Cholesterol Homeostasis and Host Defense System. (2011)
  • Author(s): Tanaka N, Abe-Dohmae S, Iwamoto N, Yokoyama S.
  • Journal Title: J Atheroscler Thromb.(Review) Volume: (in press)
  • Peer Reviewed
• [Journal Article] Insulin Down-Regulates Specific Activity Of ATP-Binding Cassette Transporter A1 For High Density Lipoprotein Biogenesis Through Its Specific Phosphorylation (2011)
  • Author(s): Kazuhiko N, Arai Y, Mitani H, Abe-Dohmae S, Yokoyama S.
  • Journal Title: Atherosclerosis Volume: (in press)
  • Peer Reviewed
• [Journal Article] Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7 (2010)
  • Author(s): Tanaka N, Abe-Dohmae S, Iwamoto N, Fitzgerald ML, Yokoyama S
  • Journal Title: J Lipid Res Volume: 51巻 Issue: 9 Pages: 2591-2599
  • DOI: 10.1194/jlr.m006049
  • Peer Reviewed
• [Journal Article] Calmodulin Interacts With ATP Binding Cassette Transporter A1 to Protect From Calpain-Mediated Degradation and Upregulates High-Density Lipoprotein Generation (2010)
  • Author(s): Iwamoto N, Lu R, Tanaka N, Abe-Dohmae S, Yokoyama S
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 30巻 Issue: 7 Pages: 1446-1452
  • DOI: 10.1161/atvbaha.110.203927
  • Peer Reviewed
• [Journal Article] Calmodulin Interacts With ATP Binding Cassette Transporter A1 to Protect From Calpain-Mediated Degradation and Upregulates High-Density Lipoprotein Generation. (2010)
  • Author(s): Iwamoto N, Lu R, Tanaka N, Abe-Dohmae S, Yokoyama S.
  • Journal Title: Arterioscler Thromb Vase Biol. Volume: 30 Pages: 1446-1452
  • Peer Reviewed
• [Journal Article] Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7. (2010)
  • Author(s): Tanaka N, Abe-Dohmae S, Iwamoto N, Fitzgerald ML, Yokoyama S.
  • Journal Title: J Lipid Res. Volume: 51 Pages: 2591-2599
  • Peer Reviewed
• [Journal Article] Pharmacological inhibition of ABC A1 degradation increases HDL biogenesis and exhibits antiatherogenesis (2009)
  • Author(s): Arakawa R, Tsujita M, Iwamoto N, Ito-Ohsumi C, Lu R, Wu CA, Shimizu K, Aotsuka T, Kanazawa H, Abe-Dohmae S, Yokoyama S.
  • Journal Title: J Lipid Res. Volume: 50巻 Issue: 11 Pages: 2299-2305
  • DOI: 10.1194/jlr.m900122-jlr200
  • Peer Reviewed
• [Journal Article] Pharmacological inhibition of ABCA1 degradation increases HDL biogenesis and exhibits antiatherogenesis. (2009)
  • Author(s): Arakawa R, Tsujita M, Iwamoto N, Ito-Ohsumi C, Lu R, Wu CA, Shimizu K, Aotsuka T, Kanazawa H, Abe-Dohmae S, Yokoyama S.
  • Journal Title: J Lipid Res. 50 Pages: 2299-2305
  • Peer Reviewed
• [Presentation] PI3 kinase negatively regulates apolipoprotein-dependent HDL generatio (2012)
  • Author(s): Sumiko Abe-Dohmae, Yoshitaka Nobukuni, Narehiko Hayashi, Yoshiaki Marumo, Junko Masumoto, Shinji Yokoyama
  • Organizer: HDL Satellite Symposium 2012
  • Place of Presentation: Cairns, Australia
  • Year and Date: 2012-03-31
• [Presentation] ABCA7 as a Link Between Cholesterol Metabolism and Host Defense System (2012)
  • Author(s): Shinji Yokoyama, Nobukiyo Tanaka, Sumiko Abe-Dohmae
  • Organizer: HDL Satellite Symposium 2012
  • Place of Presentation: Cairns, Australia(シンポジウム 招待講演)
  • Year and Date: 2012-03-31
• [Presentation] PI3 kinase negatively regulates apollpoprotein-dependent HDL generatio (2012)
  • Author(s): Sumiko Abe-Dohmae, Yoshitaka Nobukuni, Narehiko Hayashi, Yoshiaki Marurao, Jyunko Masumoto, Shinji Yokoyama
  • Organizer: HDL Satellite Symposium 2012
  • Place of Presentation: Cairns, Australia
  • Year and Date: 2012-03-31
• [Presentation] ABCA7 as a Link Between Cholesterol Metabolism and Host Defense System (2012)
  • Author(s): Shinji Yokoyama, Nobukiyo Tanaka, Sumiko Abe-Dohmae
  • Organizer: HDL Satellite Symposium 2012
  • Place of Presentation: Cairns, Australia(シンポジウム)(招待講演)
  • Year and Date: 2012-03-31
• [Presentation] PI3 kinase inhibits HDL generation through reducing protein levels of ABCA1 and ABCA7 (2012)
  • Author(s): Sumiko Abe-Dohmae, Yoshitaka Nobukuni, Narehiko Hayashi, Yoshiaki Marumo, Junko Masumoto, Shinji Yokoyama
  • Organizer: The 16th International Symposium on Atherosclerosis
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2012-03-28
• [Presentation] HMG-CoA Reductase Inhibitors Enhance Phagocytosis by Up-regulating ABCA7 (2012)
  • Author(s): Nobukiyo Tanaka, Sumiko Abe-Dohmae, Noriyuki Iwamoto, Michael L. Fitzgerald, Shinji Yokoyama
  • Organizer: The 16th International Symposium on Atherosclerosis
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2012-03-28
• [Presentation] Calpain-mediated ABCA1 degradation : Post-translational regulation of A BCA1 for HDL biogenesis (2012)
  • Author(s): Shinji Yokoyama, Reijiro Arakawa, Cheng-Ai Wu, Noriyuki Iwaraoto, Rui Lu, Maki Tsujita, Sumiko Abe-Dohmae
  • Organizer: The 16th International Symposium on Atherosclerosis
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2012-03-27
• [Presentation] 細胞内コレステロール代謝輸送関連遺伝子群の探索と予防医学への応用 (2012)
  • Author(s): 信國好俊、升本順子、堂前純子、林希彦、丸林義晃、横山信治
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 2012-03-25
• [Presentation] PI3キナーゼによるアポリポタンパク質依存性HDL新生反応の制御 Effect of PI3 kinase on apolipoprotein-mediated HDL generation (2011)
  • Author(s): 堂前純子、信國好俊、林希彦、丸茂義晃、升本順子、横山信治
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-23
• [Presentation] PI3キナーゼによるアポリポタンパク質依存性HDL新生反応の制御Effect of PI3 kinase on apolipoprotein-mediated HDL generation (2011)
  • Author(s): 堂前純子、信國好俊、林希彦、丸茂義晃、升本順子、横山信治
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-23
• [Presentation] A Molecular Ground for Enhancement of the Host-Defense System by Statins (2011)
  • Author(s): Nobukiyo Tanaka, Sumiko Abe-Dohmae, Noriyuki Iwamoto, Shinji Yokoyama
  • Organizer: 第75回日本循環器病学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-08-03
• [Presentation] PI3 kinase inhibits ABCA1- and ABCA7-mediated HDL generation through reducing their protein levels (2011)
  • Author(s): Sumiko Abe-Dohmae, Yoshitaka Nobukuni, Narehiko Hayashi, Yoshiaki Marumo, Junko Masumoto, Shinji Yokoyama
  • Organizer: 第43回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2011-07-15
• [Presentation] Statin enhances phagocytosis by up-regulating ABCA7 (2011)
  • Author(s): Nobukiyo Tanaka, Sumiko Abe-Dohmae, Noriyuki Iwamoto, Michael L. Fitzgerald, Shinji Yokoyama
  • Organizer: 第43回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2011-07-15
• [Presentation] PKD/AP-2によるABCA1とadiponectinの遺伝子発現の共通情報伝達系 (2011)
  • Author(s): 岩本紀之, 堂前純子, 横山信治
  • Organizer: 第53回日本脂質生化学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-13
• [Presentation] 細胞内コレステロール代謝輸送におけるPIK3CA機能の解析 (2011)
  • Author(s): 信國好俊、升本順子
  • Organizer: 第81回日本衛生学会学術総会
  • Place of Presentation: (東京での予定であったが地震災害のため総会中止、紙上発表)
  • Year and Date: 2011-03-26
• [Presentation] 細胞内コレステロール代謝輸送におけるPIK3CA機能の解析 (2011)
  • Author(s): 信國好俊、升本順子
  • Organizer: 第81回 日本衛生学会学術総会
  • Place of Presentation: (東京での予定であったが地震災害のため総会中止、紙上発表)
  • Year and Date: 2011-03-26
• [Presentation] ヒ素感受性に関与する遺伝子群の探索 (2011)
  • Author(s): 信國好俊、升本順子、安武章
  • Organizer: 第16回ヒ素シンポジウム
  • Place of Presentation: 旭川
  • Year and Date: 2011-02-06
• [Presentation] HMG-CoA reductase inhibitors enhance phagocytosis by up regulating ABCA7 (2010)
  • Author(s): Nobukiyo Tanaka, Sumiko Abe-Dohmae, Noriyuki Iwamoto, Michael L. Fitzgerald, and Shinji Yokoyama
  • Organizer: 第83回日本生化学会
  • Place of Presentation: 神戸(ワークショップ)
  • Year and Date: 2010-12-08
• [Presentation] HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ABCA7 (2010)
  • Author(s): Nobukiyo Tanaka, Sumiko Abe-Dohmae, Noriyuki Iwamoto, Michael L.Fitzgerald, Shinji Yokoyama
  • Organizer: 第83回 日本生化学会
  • Place of Presentation: 神戸(ワークショップ)
  • Year and Date: 2010-12-08
• [Presentation] HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ABCA7 (2010)
  • Author(s): Nobukiyo Tanaka, Sumiko Abe-Dohmae, Noriyuki Iwamoto, Michael L. Fitzgerald, and Shinji Yokoyama
  • Organizer: 第83回日本生化学会
  • Place of Presentation: 神戸(シンポジウム 招待講演)
  • Year and Date: 2010-12-07
• [Presentation] HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ABCA7 (2010)
  • Author(s): Nobukiyo Tanaka, Sumiko Abe-Dohmae, Noriyuki Iwamoto, Michael L.Fitzgerald, Shinji Yokoyama
  • Organizer: 第83回 日本生化学会
  • Place of Presentation: 神戸(シンポジウム 招待講演)
  • Year and Date: 2010-12-07
• [Presentation] 院内がん登録データによる治療の地域分析の検討 (2010)
  • Author(s): 村上玄樹、鹿嶋小緒里、烏帽子田彰
  • Organizer: 第70回日本公衆衛生学会総会
  • Place of Presentation: 秋田
  • Year and Date: 2010-10-16
• [Presentation] 公衆衛生の人材育成システムづくりを考える (2010)
  • Author(s): 曽根智史, 烏帽子田彰
  • Organizer: 第70回日本公衆衛生学会総会
  • Place of Presentation: 秋田
  • Year and Date: 2010-10-16
• [Presentation] Helical Apolipoproteins of High-Density Lipoprotein Enhance Phagocytosis by Stabilizing ATP-Binding Cassette Transporter A7 (2010)
  • Author(s): Nobukiyo Tanaka, Sumiko Abe-Dohmae, Noriyuki Iwamoto, Michael L. Fitzgerald, Shinji Yokoyama
  • Organizer: 第42回日本動脈硬化学会
  • Place of Presentation: 岐阜(シンポジウム 若手研究者奨励賞 招待講演)
  • Year and Date: 2010-07-16
• [Presentation] Mechanism of Lowering HDL Biosynthesis in Hyperinsulinemia States Through Direct Modulation of ATP-Binding Cassette Transporter A1 by Insulin Signaling (2010)
  • Author(s): Kazuhiko Nonomura, Yoshie Arai, Hironobu Mitani, Sumiko Abe-Dohmae, and Shinji Yokoyama
  • Organizer: 第42回日本動脈硬化学会
  • Place of Presentation: 岐阜
  • Year and Date: 2010-07-16
• [Presentation] A new insight of the relation between cholesterol homeostasis and host defense system (2010)
  • Author(s): Nobukiyo Tanaka, Sumiko Abe-Dohmae, Noriyuki Iwamoto, Michael L. Fitzgerald, and Shinji Yokoyama
  • Organizer: 第42回日本動脈硬化学会
  • Place of Presentation: 岐阜
  • Year and Date: 2010-07-16
• [Presentation] Helical Apolipoproteins of High-Density Lipoprotein Enhance Phagocytosis by Stabilizing ATP-Binding Cassette Transporter A7 (2010)
  • Author(s): Nobukiyo Tanaka, Sumiko Abe-Dohmae, Noriyuki Iwamoto, Michael L.Fitzgerald, Shinji Yokoyama
  • Organizer: 第42回 日本動脈硬化学会
  • Place of Presentation: 岐阜(若手研究者奨励賞 シンポジウム 招待講演)
  • Year and Date: 2010-07-16
• [Presentation] Mechanism of Lowering HDL Biosynthesis in Hyperinsulinemia States Through Direct Modulation of ATP-Binding Cassette Transporter A1 by Insulin Signaling (2010)
  • Author(s): Kazuhiko Nonomura, Yoshie Arai, Hironobu Mitani, Sumiko Abe-Dohmae, Shinji Yokoyama
  • Organizer: 第42回 日本動脈硬化学会
  • Place of Presentation: 岐阜
  • Year and Date: 2010-07-16
• [Presentation] A new insight of the relation between cholesterol homeostasis and host defense system (2010)
  • Author(s): Nobukiyo Tanaka, Sumiko Abe-Dohmae, Noriyuki Iwamoto, Michael L.Fitzgerald, Shinji Yokoyama
  • Organizer: 第42回 日本動脈硬化学会
  • Place of Presentation: 岐阜
  • Year and Date: 2010-07-16
• [Presentation] Functional genomics approach to identify the genes involved in hyperlipidemia (2010)
  • Author(s): Yoshitaka Nobukuni, Junko Masumoto
  • Organizer: 日本動脈硬化学会総会・学術集会
  • Place of Presentation: 岐阜
  • Year and Date: 2010-07-15
• [Presentation] ABCA1 and serum amyloid A during acute and chronic inflammation (2010)
  • Author(s): Sumiko Abe-Dohmae, Wei Hu, and Shinji Yokoyama
  • Organizer: 第42回日本動脈硬化学会
  • Place of Presentation: 岐阜(シンポジウム 招待講演)
  • Year and Date: 2010-07-15
• [Presentation] ABC transporter ABCA1 facilitates bidirectional sterol movement and modulates the regulatory sterol signals (2010)
  • Author(s): Yoshio Yamauchi, Sumiko Abe-Dohmae, Shinji Yokoyama, Koichi Furukawa, Ta-Yuan Chang
  • Organizer: 第42回日本動脈硬化学会
  • Place of Presentation: 岐阜
  • Year and Date: 2010-07-15
• [Presentation] ABCA1 and serum amyloid A during acute and chronic inflammation (2010)
  • Author(s): Sumiko Abe-Dohmae, Wei Hu, Shinji Yokoyama
  • Organizer: 第42回 日本動脈硬化学会
  • Place of Presentation: 岐阜(シンポジウム 招待講演)
  • Year and Date: 2010-07-15
• [Presentation] ABC transporter ABCA1 facilitates bidirectional sterol movement and modulates the regulatory sterol signals (2010)
  • Author(s): Yoshio Yamauchi, Sumiko Abe-Dohmae, Shinji Yokoyama, Koichi Furukawa, Ta-Yuan Chang
  • Organizer: 第42回 日本動脈硬化学会
  • Place of Presentation: 岐阜
  • Year and Date: 2010-07-15
• [Presentation] Helical Apolipoproteins of High-Density Lipoprotein Enhance Phagocytosis by Stabilizing ATP-Binding Cassette Transporter A7 (2010)
  • Author(s): Nobukiyo Tanaka, Sumiko Abe-Dohmae, Noriyuki Iwamoto, Michael L. Fitzgerald, and Shinji Yokoyama
  • Organizer: The 6th International Atherosclerosis Society-sponsored Workshop on High Density Lipoproteins
  • Place of Presentation: Wistler, Canada
  • Year and Date: 2010-05-19
• [Presentation] Amyloid A amyloidosis can be induced without SAA-HDL formation or substantial elevation of plasma SAA (2010)
  • Author(s): W Hu, S Abe-Dohmae, Y Kumon、 M Furihata, Y Hoshi, T Sugiura, O Ogikubo, T Otsuka, and S Yokoyama
  • Organizer: The 6th International Atherosclerosis Society-sponsored Workshop on High Density Lipoproteins
  • Place of Presentation: Wistler, Canada
  • Year and Date: 2010-05-18
• [Presentation] 高脂血症発症関連遺伝子群の解明と予防医学への応用 (2010)
  • Author(s): 信國好俊、升本順子、烏帽子田彰
  • Organizer: 第80回日本衛生学会学術総会
  • Place of Presentation: 仙台
  • Year and Date: 2010-05-10
• [Presentation] 高脂血症発症関連遺伝子群の解明と予防医学への応用 (2010)
  • Author(s): 信國好俊、升本順子、烏帽子田彰
  • Organizer: 第80回 日本衛生学会学術総会
  • Place of Presentation: 仙台
  • Year and Date: 2010-05-10
• [Presentation] ヒ素感受性に関与する遺伝子群解明への新たな試み (2010)
  • Author(s): 信國好俊
  • Organizer: 第80回日本衛生学会学術総会シンポジウム
  • Place of Presentation: 仙台(招待講演)
  • Year and Date: 2010-05-09
• [Presentation] ヒ素感受性に関与する遺伝子群解明への新たな試み (2010)
  • Author(s): 信國好俊
  • Organizer: 第80回 日本衛生学会学術総会シンポジウム
  • Place of Presentation: 仙台(招待講演)
  • Year and Date: 2010-05-09
• [Presentation] ヒ素感受性に関与する遺伝子群解明への取り組み (2009)
  • Author(s): 信國好俊, 升本順子, 安武章
  • Organizer: 第９回分子予防環境医学研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-12-11
• [Presentation] ヒ素感受性に関与する遺伝子群解明への取り組み (2009)
  • Author(s): 信國好俊, 升本順子, 安武章
  • Organizer: 第9回分子予防環境医学研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-12-11
• [Presentation] AAアミロイドーシスはSAA-HDL非存在下でも生じる (2009)
  • Author(s): 胡巍, 堂前純子, 公文義雄, 降幡睦夫, 星井嘉信, 杉浦哲朗, 大塚隆信, 横山信治
  • Organizer: 第82回日本生化学会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-22
• [Presentation] HDLと生体防衛作用apoA-IのABCA7安定化による食作用の促進 (2009)
  • Author(s): 田中伸享, 岩本紀之, 堂前純子, 横山信治
  • Organizer: 第82回日本生化学会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-22
• [Presentation] HDLと生体防衛作用 apoA-IのABCA7安定化による食作用の促進 (2009)
  • Author(s): 田中伸享, 岩本紀之, 堂前純子, 横山信治
  • Organizer: 第82回日本生化学会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-22
• [Presentation] アポリポタンパク質A-I(apoA-I)によるABCA7を介したファゴサイトーシスの正の制御 (2009)
  • Author(s): 田中伸享, 堂前純子, 横山信治
  • Organizer: 第51回日本脂質生化学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-07-31
• [Presentation] ABCA1ノックアウトマウス由来細胞に見られる脂質蓄積傾向 (2009)
  • Author(s): 堂前純子, 黒野智恵子, 西本静香, 横山信治
  • Organizer: 第51回日本脂質生化学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-07-31
• [Presentation] Calmodulin interacts with ABCA1 to protect it against calpain-mediated degrasation and up-regulates HDL generation (2009)
  • Author(s): Noriyuki Iwamoto, Lu Rui, Nobukiyo Tanaka, Sumiko Abe-Dohmae, and Shinji Yokoyama
  • Organizer: 第41回日本動脈硬化学会
  • Place of Presentation: 下関
  • Year and Date: 2009-07-17
• [Presentation] Characterization of fibroblast cell lines derived from ABCA1-Knock out mouse (2009)
  • Author(s): Sumiko Abe-Dohmae, Chieko Kurono, Shizuka Nishimoto, Shinji Yokoyama
  • Organizer: 第41回日本動脈硬化学会
  • Place of Presentation: 下関
  • Year and Date: 2009-07-17