Clarification of the genes involved in the hyperlipidemia and the application to the preventive medicine
| Project/Area Number |
21390188
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
DOUMAE Sumiko 名古屋市立大学, 大学院・医学研究科, 准教授 (70227700)
EBOSHIDA Akira 広島大学, 大学院・医歯(薬)学総合研究科, 教授 (50168811)
FUJIMOTO Nariaki 広島大学, 原爆放射線医科学研究所, 准教授 (40243612)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2009: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Keywords | 衛生 / 予防医学 / 脂質 / 高脂血症 / レステロール / ゲノム / 遺伝子 / ジーントラップ / コレステロール代謝・輸送 / ゲノム機能学 / 細胞機能遺伝学 / ジーントラップ挿入変異 / 候補遺伝子解析 / 分子疫学 / 脂質代謝 / 脂質輸送 |
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| Research Abstract |
To clarify the genes involved in hypelipidemia (hypercholesterolemia), we conducted a functional genetic screening of the genes that play an important role in intra-cellular cholesterol transport and/or metabolism. So far we succeeded to isolate 188 mutants that defected the LDL-cholesterol uptake, intracellular cholesterol transport and/or metabolism from the large-scale gene-trap insertional mutants library of CHO cells, and to identify the 49 known genes and 32 genes of unidentified function.
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Report
(4 results)
Research Products
(68 results)
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[Journal Article] The differences in the involvements of loci of promoter region and Ile50Val in interleukin-4 receptor αchain gene between atopic dermatitis and Japanese cedar pollinosis2012
Author(s)
Tanaka T, Hitomi Y, Kambayashi Y, Hibino Y, Fukutomi Y, Shibata S, SugimotoS, Hatta K, Eboshida A, Konoshita T, Nakamura H
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Journal Title
Allergol Int
Volume: 61巻
Pages: 57-63
NAID
Related Report
Peer Reviewed
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[Journal Article] The differences in the involvements of loci of promoter region and Ile50Val in interleukin-4 receptor α chain gene between atopic dermatitis and Japanese cedar pollinosis2012
Author(s)
Tanaka T, Hitomi Y, Kambayashi Y, Hibino Y, Fukutomi Y, Shibata S, Sugimoto S, Hatta K, Eboshida A, Konoshita T, Nakamura H
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Journal Title
Allergol Int
Volume: 61
Pages: 57-63
NAID
Related Report
Peer Reviewed
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[Journal Article] Pharmacological inhibition of ABC A1 degradation increases HDL biogenesis and exhibits antiatherogenesis2009
Author(s)
Arakawa R, Tsujita M, Iwamoto N, Ito-Ohsumi C, Lu R, Wu CA, Shimizu K, Aotsuka T, Kanazawa H, Abe-Dohmae S, Yokoyama S.
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Journal Title
J Lipid Res.
Volume: 50巻
Issue: 11
Pages: 2299-2305
DOI
Related Report
Peer Reviewed
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[Journal Article] Pharmacological inhibition of ABCA1 degradation increases HDL biogenesis and exhibits antiatherogenesis.2009
Author(s)
Arakawa R, Tsujita M, Iwamoto N, Ito-Ohsumi C, Lu R, Wu CA, Shimizu K, Aotsuka T, Kanazawa H, Abe-Dohmae S, Yokoyama S.
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Journal Title
J Lipid Res. 50
Pages: 2299-2305
Related Report
Peer Reviewed
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