• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Prediction of the genetic risk associated with lifestyle-related diseases in a population based cohort study

Research Project

Project/Area Number 21390209
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionAichi Gakuin University

Principal Investigator

YOKOTA Mitsuhiro  愛知学院大学, 歯学部, 教授 (50201851)

Co-Investigator(Renkei-kenkyūsha) MATSUBARA Tatsuaki  愛知学院大学, 歯学部, 教授 (30209598)
NARUSE Keiko  愛知学院大学, 歯学部, 准教授 (30387576)
HIRASHIKI Akihiro  名古屋大学, 医学部・付属病院, 助教 (10418741)
NODA Akiko  中部大学, 生命健康科学部, 教授 (80252287)
IZAWA Hideo  藤田保健衛生大学, 医学部, 教授 (80402569)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywords前向きコホート / 地域住民 / 遺伝子 / 生活習慣病 / ゲノム疫学
Research Abstract

The discovery of genetic risk factors for many common diseases in the past couple of years has been enormously exciting. But we are still in the early stages of this revolution. We know, from studies of families and identical twins, that most diseases like diabetes are highly heritable, with, on average, about 50 percent of the risk attributable to genetics. Yet our genetic analysis has so far discovered less than 10 percent of that hereditary component.
Therefore, the identification of new genomic variations that are associated with common diseases including coronary artery diseases(CADs), type 2 diabetes mellitus, and hypertension have to be made future efforts.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (45 results)

All 2012 2011 2010 2009

All Journal Article (32 results) (of which Peer Reviewed: 32 results) Presentation (2 results) Patent(Industrial Property Rights) (11 results) (of which Overseas: 6 results)

  • [Journal Article] Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians2012

    • Author(s)
      Li H, Kilpelainen TO, Liu C, et al.
    • Journal Title

      Diabetologia

      Volume: 55 Issue: 4 Pages: 981

    • DOI

      10.1007/s00125-011-2370-7

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Meta-analysis identifies common variants associated with body mass index in east Asians2012

    • Author(s)
      Wen W, et al
    • Journal Title

      Nat Genet

      Volume: 44 Issue: 3 Pages: 307

    • DOI

      10.1038/ng.1087

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study of coronary artery disease in the Japanese2012

    • Author(s)
      Fumihiko Takeuchi, Mitsuhiro Yokota, et al.(他23名、3番目)
    • Journal Title

      Eur J Hum Genet

      Volume: 20 Issue: 3 Pages: 333

    • DOI

      10.1038/ejhg.2011.184

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians2011

    • Author(s)
      Cho YS, Yamauchi T, Hara K, Kadowaki T
    • Journal Title

      Nature Genatics

      Volume: 44 Issue: 1 Pages: 67

    • DOI

      10.1038/ng.1019

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The ratio of adiponectin to homeostasis model assessment of insulin resistance is a powerful index of each component of metabolic syndrome in an aged Japanese population : results from the KING Study2011

    • Author(s)
      Masahiro Nakatochi, Mitsuhiro Yokota, et al.(他10名、12番目)
    • Journal Title

      Diabetes Res Clin Pr

      Volume: 92 Issue: 3 Pages: e61-e65

    • DOI

      10.1016/j.diabres.2011.02.029

    • Related Report
      2011 Annual Research Report 2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese population2011

    • Author(s)
      Daisuke Tanimura, Mitsuhiro Yokota, et al.(他13名、15番目)
    • Journal Title

      Eur J Hum Genet

      Volume: 19(3) Issue: 3 Pages: 262-269

    • DOI

      10.1038/ejhg.2010.201

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians2011

    • Author(s)
      Yamori Y
    • Journal Title

      Nat Genetics

      Volume: 43 Issue: 6 Pages: 531

    • DOI

      10.1038/ng.834

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Meta-analysis of genome-wide association studies identifies five novel loci associated with blood pressure in East Asians2011

    • Author(s)
      Norihiro Kato
    • Journal Title

      Nature Genetics

      Volume: (in print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Meta-analysis of genome-wide association studies in Asians identifies novel genetic variants associated with body mass index2011

    • Author(s)
      Wen Wanqing
    • Journal Title

      Nature Genetics

      Volume: (in print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MuRF1 negatively regulates pathological cardiac hypertrophy through downregulation of calcineurin2011

    • Author(s)
      Soichiro Usui
    • Journal Title

      Circulation Research

      Volume: (in print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese population2011

    • Author(s)
      Daisuke Tanimura
    • Journal Title

      European Journal of Human Genetics

      Volume: 19 Pages: 262-269

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Beneficial Effects of Growth Hormone-Releasing Peptide on Myocardial Oxidative Stress and Left Ventricular Dysfunction in Dilated Cardiomyopathic Hamsters2010

    • Author(s)
      Yosuke Kato, Mitsuhiro Yokota, et al.(他7名、9番目)
    • Journal Title

      Circulation Journal

      Volume: 74 Issue: 1 Pages: 163-170

    • DOI

      10.1253/circj.CJ-09-0378

    • NAID

      10025941641

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutation of ARHGAP9 in patients with coronary spastic angina2010

    • Author(s)
      Mikito Takefuji, Mitsuhiro Yokota, et al.(他16名、17番目)
    • Journal Title

      J Hum Genet

      Volume: 55(1) Issue: 1 Pages: 42-49

    • DOI

      10.1038/jhg.2009.120

    • NAID

      10030733231

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasma resistin concentration determined by common variants in the resistin gene and associated with metabolic traits in an aged Japanese population2010

    • Author(s)
      Hiroyuki Asano, Mitsuhiro Yokota, et al.(他10名、12番目)
    • Journal Title

      Diabetologia

      Volume: 53(2) Issue: 2 Pages: 234-246

    • DOI

      10.1007/s00125-009-1517-2

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blood Pressure and hypertension are associated with 7 loci in the japanese population2010

    • Author(s)
      Yamori Y.
    • Journal Title

      Circulation

      Volume: 121 Issue: 21 Pages: 2302

    • DOI

      10.1161/circulationaha.109.904664

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutation of ARHGAP9 in patients with coronary spastic angina2010

    • Author(s)
      Mikito Takefuji
    • Journal Title

      Journal of Human Genetics 55

      Pages: 42-49

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frequency, Predictors and Outcome of Stent Fracture After Sirolimus-Eluting Stent Implantation2009

    • Author(s)
      Hisashi Umeda, Mitsuhiro Yokota, et al.(他8名、9番目)
    • Journal Title

      Int J Cardiol

      Volume: 133(3) Issue: 3 Pages: 321-326

    • DOI

      10.1016/j.ijcard.2007.12.067

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Safety and efficacy of 2.5-mm sirolimus-eluting stent implantation at lower deployment pressure in very small vessels(<2.5mm)2009

    • Author(s)
      Hisashi Umeda, Mitsuhiro Yokota, et al.(他7名、8番目)
    • Journal Title

      Coron Artery Dis

      Volume: 20(2) Issue: 2 Pages: 163-168

    • DOI

      10.1097/mca.0b013e328329dc20

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exercise training alters left ventricular geometry and attenuates heart failure in dahl salt-sensitive hypertensive rats2009

    • Author(s)
      Masaaki Miyachi, Mitsuhiro Yokota, et al.(他12名、11番目)
    • Journal Title

      Hypertension

      Volume: 53 Issue: 4 Pages: 701-707

    • DOI

      10.1161/hypertensionaha.108.127290

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Xanthine oxidase inhibition improves left ventricular dysfunction in dilated cardiomyopathic hamsters2009

    • Author(s)
      Keiko Hayashi, Mitsuhiro Yokota, et al.(他9名、10番目)
    • Journal Title

      J Card Fail

      Volume: 14(3) Issue: 3 Pages: 238-244

    • DOI

      10.1016/j.cardfail.2007.11.001

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relation of functional and morphological changes in mitochondria to myocardial contractile and relaxation reserves in asymptomatic to mildly symptomatic patients with hypertrophic cardiomyopathy2009

    • Author(s)
      Kazumasa Unno, Mitsuhiro Yokota, et al.(他12名、13番目)
    • Journal Title

      Eur Heart J

      Volume: 30(15) Issue: 15 Pages: 1853-1862

    • DOI

      10.1093/eurheartj/ehp184

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of diastolic stiffening of the failing myocardium and its prevention by angiotensin receptor and calcium channel blockers2009

    • Author(s)
      Xian Wu Cheng, Mitsuhiro Yokota, et al.(他12名、13番目)
    • Journal Title

      J Cardiovasc Pharmacol

      Volume: 54(1) Issue: 1 Pages: 47-56

    • DOI

      10.1097/fjc.0b013e3181ab371d

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Beneficial effects of torasemide on systolic wall stress and sympathetic nervous activity in asymptomatic or mildly symptomatic patients with heart failure : Comparison with azosemide2009

    • Author(s)
      Ken Harada, Mitsuhiro Yokota, et al.(他10名、11番目)
    • Journal Title

      J Cardiovasc Pharmacol

      Volume: 53 Issue: 6 Pages: 468-473

    • DOI

      10.1097/fjc.0b013e3181a717f7

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term administration of nifedipine attenuates cardiac remodeling and diastolic heart failure in hypertensive rats2009

    • Author(s)
      Takashi Yamada, Mitsuhiro Yokota, et al.(他10名、12番目)
    • Journal Title

      Eur J Pharmacol

      Volume: 615 Issue: 1-3 Pages: 163-170

    • DOI

      10.1016/j.ejphar.2009.05.028

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic inhibition of calcineurin induces diastolic dysfunction in mice with chronic pressure overload2009

    • Author(s)
      Ricardo Gelpi, Mitsuhiro Yokota, et al.(他11名、10番目)
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 297(5) Issue: 5 Pages: 1814-1819

    • DOI

      10.1152/ajpheart.00449.2009

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relation of functional and morphological changes in mitochondria to myocardial contractile and relaxation reserves in asymptomatic to mildly symptomatic patients with hypertrophic cardiomyopathy2009

    • Author(s)
      Kazumasa Unno
    • Journal Title

      European Heart Journal 30

      Pages: 1853-1862

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasma resistin concentration determined by common variants in the resistin gene and associated with metabolic traits in an aged Japanese population2009

    • Author(s)
      Hiroyuki Asano
    • Journal Title

      Diabetologia 53

      Pages: 234-246

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Xanthine oxidase inhibition improves left ventricular dysfunction in dilated cardiomyopathic hamsters2009

    • Author(s)
      Keiko Hayashi
    • Journal Title

      Journal of Cardiac Failure 14

      Pages: 238-244

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic inhibition of calcineurin induces diastolic dysfunction in mice with chronic pressure overload2009

    • Author(s)
      Ricardo Gelpi
    • Journal Title

      American Journal of Physiology-Heart and Circulatory Physiology 297

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term administration of nifedipine attenuates cardiac remodeling and diastolic heart failure in hypertensive rats2009

    • Author(s)
      Takashi Yamada
    • Journal Title

      European Journal of Pharmacology 615

      Pages: 163-170

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of diastolic stiffening of the failing myocardium and its prevention by angiotensin receptor and calcium channel blockers2009

    • Author(s)
      Xian Wu Cheng
    • Journal Title

      Journal of Cardiovascular Pharmacology 54

      Pages: 47-56

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Beneficial effects of torasemide on systolic wall stress and sympathetic nervous activity in asymptomatic or mildly symptomatic patients with heart failure : Comparison with azosemide2009

    • Author(s)
      Ken Harada
    • Journal Title

      Journal of Cardiovascular Pharmacology 53

      Pages: 468-473

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] The ratio of serum adiponectin level to homeostasis model assessment of insulin resistance is a powerful index of metabolic syndrome in an aged Japanese population : results from the KING Study international academy of carkiology2010

    • Author(s)
      Mitsuhiro Yokota
    • Organizer
      15th world dongress on heart desease
    • Place of Presentation
      VANCOUVER, BC, CANADA
    • Year and Date
      2010-07-26
    • Related Report
      2011 Final Research Report
  • [Presentation] THE RATIO OF SERUM ADIPONECTIN LEVEL TO HOMEOSTASIS MODEL ASSESSMENT OF INSULIN RESISTANCE IS A POWERFUL INDEX OF METABOLIC SYNDROME IN AN AGED JAPANESE POPULATION : RESULTS FROM THE KING STUDY2010

    • Author(s)
      Mitsuhiro YOKOTA
    • Organizer
      INTERNATIONAL ACADEMY OF CARKIOLOGY 15th WORLD DONGRESS ON HEART DISEASE
    • Place of Presentation
      VANCOUVER, BC, CANADA
    • Year and Date
      2010-07-26
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 心筋梗塞のリスク検査法2011

    • Inventor(s)
      横田充弘
    • Industrial Property Rights Holder
      横田充弘
    • Filing Date
      2011-11-19
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] メタボリック症候群又はその構成疾患の評価2011

    • Inventor(s)
      横田充弘、谷村大輔
    • Industrial Property Rights Holder
      横田充弘
    • Industrial Property Number
      2011-503572
    • Filing Date
      2011-05-30
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] メタボリック症候群又はその構成疾患の評価2011

    • Inventor(s)
      横田充弘, 谷村大輔
    • Industrial Property Rights Holder
      横田充弘
    • Industrial Property Number
      2011-503572
    • Filing Date
      2011-05-30
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 心筋梗塞のリスク検査法2011

    • Inventor(s)
      横田充弘
    • Industrial Property Rights Holder
      横田充弘
    • Filing Date
      2011-11-19
    • Related Report
      2011 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] メタボリック症候群又は心血管疾患のリスク検査法及びリスク検査用キット2010

    • Inventor(s)
      横田充弘、谷村大輔
    • Industrial Property Rights Holder
      横田充弘
    • Industrial Property Number
      2010-525575
    • Filing Date
      2010-12-10
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 心筋梗塞のリスク検査法2010

    • Inventor(s)
      横田充弘
    • Industrial Property Rights Holder
      横田充弘
    • Industrial Property Number
      2010-259925
    • Filing Date
      2010-11-22
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 心筋梗塞のリスク検査法2010

    • Inventor(s)
      横田充弘、浅野展行
    • Industrial Property Rights Holder
      横田充弘
    • Industrial Property Number
      2010-521603
    • Filing Date
      2010-11-22
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 心筋梗塞のリスク診断方法2010

    • Inventor(s)
      山田芳司、横田充弘
    • Industrial Property Rights Holder
      財)名古屋産業科学研究所
    • Filing Date
      2010-05-07
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] メタボリック症候群又はその構成疾患の評価2009

    • Inventor(s)
      横田充弘、谷村大輔
    • Industrial Property Rights Holder
      横田充弘
    • Filing Date
      2009-10-21
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] メタボリック症候群又は心血管疾患のリスク検査法及びリスク検査用キット2009

    • Inventor(s)
      横田充弘、谷村大輔
    • Industrial Property Rights Holder
      横田充弘
    • Filing Date
      2009-07-30
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 心筋梗塞のリスク検査法2009

    • Inventor(s)
      横田充弘、浅野展行
    • Industrial Property Rights Holder
      横田充弘
    • Filing Date
      2009-07-22
    • Related Report
      2011 Final Research Report
    • Overseas

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi