A comprehensive transcriptome analysis of humanized mouse liver using ultra high density cDNA micro array

• Project/Area Number: 21390229
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Hiroshima University
• Principal Investigator: CHAYAMA Kazuaki 広島大学, 大学院・医歯薬学総合研究科, 教授 (00211376)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2009: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
• Keywords: 肝臓学 / 転写 / 発現抑制 / 発現亢進 / cDNA micro array / interferon / IFN誘導遺伝子 / GS EA

Research Abstract

We investigated a mechanism of continuous infection of hepatitis B and hepatitis C virus with high density microarray using human hepatocyte chimeric mice. Induction of interferon stimulated genes were partially inhibited by each of the two viruses suggesting that these viruses inhibit induction of interferon stimulated genes with different mechanisms

Research Products

• [Journal Article] Severe necroinflammatory reaction caused by natural killer by Fas/ FasL interaction and dendritic cells in human hepatocyte chimeric mouse (2012)
  • Author(s): Okazaki A, Hiraga N, Imamura M, NelsonHayes C, Tsuge M, Takahashi S, AikataH, Abe H, Miki D, Ochi H, Tateno C, Yoshizato K, Ohdan H, Chayama K
  • Journal Title: Hepatology Volume: (in press) Issue: 2 Pages: 25651-25651
  • DOI: 10.1002/hep.25651
  • Peer Reviewed
• [Journal Article] Toward the establishment of a prediction system for thepersonalized treatment of chronic hepatitis C (2012)
  • Author(s): Ochi H, Hayes CN, Abe H, Hayashida Y, Uchiyama T, Kamatani N, Nakamura Y, Chayama K
  • Journal Title: J Infect Dis Volume: 205 Issue: 2 Pages: 204-210
  • DOI: 10.1093/infdis/jir726
  • Peer Reviewed
• [Journal Article] Telaprevir with peginterferon and ribavirin for treatment-naive patients chronically infected with HCV of genotype 1 inJapan (2012)
  • Author(s): Kumada H, Toyota J, Okanoue T, ChayamaK, Tsubouchi H, Hayashi N
  • Journal Title: J Hepatol Volume: 56 Issue: 1 Pages: 78-84
  • DOI: 10.1016/j.jhep.2011.07.016
  • Peer Reviewed
• [Journal Article] Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, inhepatitis C virus genotype1b-infected null responders (2012)
  • Author(s): Chayama K, Takahashi S, Toyota J, Karino Y, Ikeda K, Ishikawa H, Watanabe H, McPhee F, Hughes E, KumadaH
  • Journal Title: Hepatology Volume: 55 Issue: 3 Pages: 742-748
  • DOI: 10.1002/hep.24724
  • Peer Reviewed
• [Journal Article] Impact of pegylated interferon therapy on outcomes of patients with hepatitis C virus-related hepatocellular carcinoma after curative hepatic resection (2012)
  • Author(s): Tanimoto Y, Tashiro H, Aikata H, Amano H, Oshita A, Kobayashi T, Kuroda S, Tazawa H, Takahashi S, Itamoto T, Chayama K, Ohdan H
  • Journal Title: Ann Surg Oncol Volume: 19 Issue: 2 Pages: 418-425
  • DOI: 10.1245/s10434-011-1866-1
  • Peer Reviewed
• [Journal Article] IL28B polymorphism is associated with fatty change in the liver of chronic hepatitis C patients (2012)
  • Author(s): Ohnishi M, Tsuge M, Kohno T, Zhang Y, Abe H, Hyogo H, Kimura Y, Miki D, Hiraga N, Imamura M, Takahashi S, Ochi H, Hayes CN, Tanaka S, Arihiro K, Chayama K
  • Journal Title: J Gastroenterol Volume: (in press) Issue: 7 Pages: 834-844
  • DOI: 10.1007/s00535-012-0550-y
  • NAID: 10030962375
  • Peer Reviewed
• [Journal Article] Serum PAI-1 is a novel predictor for response to pegylated interferon-al pha-2b plus ribavirin therapy in chronic hepatitis C virus infection (2012)
  • Author(s): Miki D, Ohishi W, Ochi H, Hayes CN, Abe H, Tsuge M, Imamura M, Kamatani N, Nakamura Y, Chayama K
  • Journal Title: J Viral Hepat Volume: 19 Issue: 2 Pages: 126-133
  • DOI: 10.1111/j.1365-2893.2011.01516.x
  • Peer Reviewed
• [Journal Article] Hepatocellular carcinoma : towards personalized medicine (2012)
  • Author(s): Miki D, Ochi H, Nelson Hayes C, Aikata H, Chayama K
  • Journal Title: Cancer Sci Volume: (in press) Issue: 5 Pages: 846-850
  • DOI: 10.1111/j.1349-7006.2012.02242.x
  • Peer Reviewed
• [Journal Article] Combination of hepatitis B viral antigens and DNA for prediction of relapse after discontinuation of nucleos(t)ide analogs in patients with chronic hepatitis B (2012)
  • Author(s): Matsumoto A, Tanaka E, Suzuki Y, Kobayashi M, Tanaka Y, Shinkai N, Hige S, Yatsuhashi H, Nagaoka S, Chayama K, Tsuge M, Yokosuka O, Imazeki F, Nishiguchi S, Saito M, Fujiwara K, Torii N, Hiramatsu N, Karino Y, Kumada H
  • Journal Title: Hepatol Res Volume: 42 Issue: 2 Pages: 139-149
  • DOI: 10.1111/j.1872-034x.2011.00910.x
  • NAID: 10031144221
  • Peer Reviewed
• [Journal Article] Efficacy and safety of telaprevir, a new protease inhibitor, for difficult-to-treat patients with genotype 1 chronic hepatitis C (2012)
  • Author(s): Hayashi N, Okanoue T, Tsubouchi H, Toyota J, Chayama K, Kumada H
  • Journal Title: J Viral Hepat Volume: 19 Issue: 2 Pages: 134-42
  • DOI: 10.1111/j.1365-2893.2011.01528.x
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• [Journal Article] Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan : a multicenter large retrospective study (2012)
  • Author(s): Eguchi Y, Hyogo H, Ono M, Mizuta T, Ono N, Fujimoto K, Chayama K, Saibara T, Jsg N
  • Journal Title: J Gastroenterol Volume: (in press) Issue: 5 Pages: 586-595
  • DOI: 10.1007/s00535-012-0533-z
  • NAID: 10030650741
  • Peer Reviewed
• [Journal Article] Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population (2012)
  • Author(s): Sumida Y, Yoneda M, Hyogo H, Itoh Y, Ono M, Fujii H, Eguchi Y, Suzuki Y, Aoki N, Kanemasa K, Fujita K, Chayama K, Saibara T, Kawada N, Fujimoto K, Kohgo Y, Yoshikawa T, Okanoue T, Jsg-Nafld JS
  • Journal Title: BMC Gastroenterol Volume: (Epub) Issue: 1 Pages: 2-2
  • DOI: 10.1186/1471-230x-12-2
  • NAID: 120005122663
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• [Journal Article] Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor (2012)
  • Author(s): Sainz B, Jr., Barretto N, Martin DN, Hiraga N, Imamura M, Hussain S, Marsh KA, Yu X, Chayama K, Alrefai WA, Uprichard SL
  • Journal Title: Nat Med Volume: 18 Issue: 2 Pages: 281-285
  • DOI: 10.1038/nm.2581
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• [Journal Article] Atorvastatin improves disease activity of nonalcoholic steatohepatitis partly through its tumour necrosis factor-alpha-lowering property (2012)
  • Author(s): Hyogo H, Yamagishi SI, Maeda S, Kimura Y, Ishitobi T, Chayama K
  • Journal Title: Dig Liver Dis Volume: (in press) Issue: 6 Pages: 482-486
  • DOI: 10.1016/j.dld.2011.12.013
  • NAID: 120005308251
  • Peer Reviewed
• [Journal Article] Amino Acid Substitution in HCV Core/NS5A Region and Genetic Variati on Near IL28B Gene Affect Treatment Efficacy to Interferon plus Ribavirin Combination Therapy (2012)
  • Author(s): Akuta N, Suzuki F, Hirakawa M, Kawamura Y, Sezaki H, Suzuki Y, Hosaka T, Kobayashi M, Kobayashi M, Saitoh S, Arase Y, Ikeda K, Chayama K, Nakamura Y, Kumada H
  • Journal Title: Intervirology Volume: 55 Issue: 3 Pages: 231-41
  • DOI: 10.1159/000328327
  • Peer Reviewed
• [Journal Article] Will there be an HCV meeting in 2020? Summary of the 17th international meeting on hepatitis C virus and related viruses (2011)
  • Author(s): Wakita T, Suzuki T, Evans MJ, Shimotohno K, Chayama K, Matsuura Y, Hijikata M, Moriishi K, Seya T, Enomoto N, Koike K, Kato N, Kanto T, Hotta H
  • Journal Title: Gastroenterology Volume: 141 Issue: 1 Pages: 1-5
  • DOI: 10.1053/j.gastro.2011.05.027
  • Peer Reviewed
• [Journal Article] Effects of hepatitis B virus infection on the interferon response in immunodeficient human hepatocyte chimeric mice (2011)
  • Author(s): Tsuge M, Takahashi S, Hiraga N, Fujimoto Y, Zhang Y, Mitsui F, Abe H, Kawaoka T, Imamura M, Ochi H, Hayes CN, Chayama K
  • Journal Title: J Infect Dis Volume: 204 Issue: 2 Pages: 224-228
  • DOI: 10.1093/infdis/jir247
  • Peer Reviewed
• [Journal Article] Hepatitis C virus infectionsuppresses the interferon response inthe liver of the human hepatocytechimeric mouse (2011)
  • Author(s): Tsuge M, Fujimoto Y, Hiraga N, ZhangY, Ohnishi M, Kohno T, Abe H, Miki D, Imamura M, Takahashi S, Ochi H, HayesCN, Miya F, Tsunoda T, Chayama K
  • Journal Title: PLoS One Volume: 6 Issue: 8 Pages: 23856-23856
  • DOI: 10.1371/journal.pone.0023856
  • Peer Reviewed
• [Journal Article] Influence of ITPA polymorphisms on decreases of hemoglobin during treatment with pegylated interferon, ribavirin, and telaprevir (2011)
  • Author(s): Suzuki F, Suzuki Y, Akuta N, Sezaki H, Hirakawa M, Kawamura Y, Hosaka T, Kobayashi M, Saito S, Arase Y, IkedaK, Kobayashi M, Chayama K, Kamatani N, Nakamura Y, Miyakawa Y, Kumada H
  • Journal Title: Hepatology Volume: 53 Issue: 2 Pages: 415-421
  • DOI: 10.1002/hep.24058
  • Peer Reviewed
• [Journal Article] In vivo adaptation of hepatitis C virus in chimpanzees for efficient virus production and evasion of apoptosis (2011)
  • Author(s): Saeed M, Shiina M, Date T, Akazawa D, Watanabe N, Murayama A, Suzuki T, Watanabe H, Hiraga N, Imamura M, Chayama K, Choi Y, Krawczynski K, Liang TJ, Wakita T, Kato T
  • Journal Title: Hepatology Volume: 54 Issue: 2 Pages: 425-433
  • DOI: 10.1002/hep.24399
  • Peer Reviewed
• [Journal Article] Impact of radiation and hepatitis virus infection on risk of hepatocellular carcinoma (2011)
  • Author(s): Ohishi W, Fujiwara S, Cologne JB, Suzuki G, Akahoshi M, Nishi N, TsugeM, Chayama K
  • Journal Title: Hepatology Volume: 53 Issue: 4 Pages: 1237-1245
  • DOI: 10.1002/hep.24207
  • Peer Reviewed
• [Journal Article] Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice (2011)
  • Author(s): Ohara E, Hiraga N, Imamura M, Iwao E, Kamiya N, Yamada I, Kono T, Onishi M, Hirata D, Mitsui F, Kawaoka T, TsugeM, Takahashi S, Abe H, Hayes CN, OchiH, Tateno C, Yoshizato K, Tanaka S, Chayama K
  • Journal Title: JHepatol Volume: 54 Issue: 5 Pages: 872-878
  • DOI: 10.1016/j.jhep.2010.08.033
  • Peer Reviewed
• [Journal Article] IL-28B predicts response to chronic hepatitis Ctherapy-fine-mapping and replication study in Asian populations (2011)
  • Author(s): Ochi H, Maekawa T, Abe H, Hayashida Y, Nakano R, Imamura M, Hiraga N, Kawakami Y, Aimitsu S, Kao JH, Kubo M, Tsunoda T, Kumada H, Nakamura Y, HayesCN, Chayama K
  • Journal Title: J Gen Virol Volume: 92 Issue: 5 Pages: 1071-1081
  • DOI: 10.1099/vir.0.029124-0
  • Peer Reviewed
• [Journal Article] Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers (2011)
  • Author(s): Miki D, Ochi H, Hayes CN, Abe H, Yoshima T, Aikata H, Ikeda K, KumadaH, Toyota J, Morizono T, Tsunoda T, Kubo M, Nakamura Y, Kamatani N, Chayama K
  • Journal Title: Nat Genet Volume: 43 Issue: 8 Pages: 797-800
  • DOI: 10.1038/ng.876
  • Peer Reviewed
• [Journal Article] A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population (2011)
  • Author(s): Mbarek H, Ochi H, Urabe Y, Kumar V, Kubo M, Hosono N, Takahashi A, Kamatani Y, Miki D, Abe H, Tsunoda T, Kamatani N, Chayama K, Nakamura Y, Matsuda K
  • Journal Title: Hum Mol Genet Volume: 20 Issue: 19 Pages: 3884-3892
  • DOI: 10.1093/hmg/ddr301
  • Peer Reviewed
• [Journal Article] Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b (2011)
  • Author(s): Kawaoka T, Hayes CN, Ohishi W, Ochi H, Maekawa T, Abe H, Tsuge M, Mitsui F, Hiraga N, Imamura M, Takahashi S, KuboM, Tsunoda T, Nakamura Y, Kumada H, Chayama K
  • Journal Title: J Hepatol Volume: 54 Issue: 3 Pages: 408-414
  • DOI: 10.1016/j.jhep.2010.07.032
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• [Journal Article] Rapidemergence of telaprevir resistanthepatitis C virus strain from wildtypeclone in vivo (2011)
  • Author(s): Hiraga N, Imamura M, Abe H, Hayes CN, Kono T, Onishi M, Tsuge M, TakahashiS, Ochi H, Iwao E, Kamiya N, Yamada I, Tateno C, Yoshizato K, Matsui H, KanaiA, Inaba T, Tanaka S, Chayama K
  • Journal Title: Hepatology Volume: 54 Issue: 3 Pages: 781-788
  • DOI: 10.1002/hep.24460
  • Peer Reviewed
• [Journal Article] Impact of viral aminoacid substitutions and hostinterleukin-28b polymorphism on replication and susceptibility tointerferon of hepatitis C virus (2011)
  • Author(s): Hiraga N, Abe H, Imamura M, Tsuge M, Takahashi S, Hayes CN, Ochi H, TatenoC, Yoshizato K, Nakamura Y, KamataniN, Chayama K
  • Journal Title: Hepatology Volume: 54 Issue: 3 Pages: 764-711
  • DOI: 10.1002/hep.24453
  • Peer Reviewed
• [Journal Article] HCV substitutions and IL28B polymorphisms on outcome ofpeg-interferon plus ribavirincombination therapy (2011)
  • Author(s): Hayes CN, Kobayashi M, Akuta N, SuzukiF, Kumada H, Abe H, Miki D, Imamura M, Ochi H, Kamatani N, Nakamura Y, Chayama K
  • Journal Title: Gut Volume: 60 Issue: 2 Pages: 261-267
  • DOI: 10.1136/gut.2010.223495
  • Peer Reviewed
• [Journal Article] A single nucleotidepoly morphism in activated Cdc42 associated tyrosine kinase 1influences the interferon therapy in hepatitis C patients (2011)
  • Author(s): Fujimoto Y, Ochi H, Maekawa T, Abe H, Hayes CN, Kumada H, Nakamura Y, Chayama K
  • Journal Title: J Hepatol Volume: 54 Issue: 4 Pages: 629-639
  • DOI: 10.1016/j.jhep.2010.07.021
  • Peer Reviewed
• [Journal Article] IL28B butnot ITPA polymorphism is predictive ofresponse to pegylated interferon, ribavirin, and telaprevir tripletherapy in patients with genotype 1hepatitis C (2011)
  • Author(s): Chayama K, Hayes CN, Abe H, Miki D, Ochi H, Karino Y, Toyota J, NakamuraY, Kamatani N, Sezaki H, Kobayashi M, Akuta N, Suzuki F, Kumada H
  • Journal Title: J Infect Dis Volume: 204 Issue: 1 Pages: 84-93
  • DOI: 10.1093/infdis/jir210
  • Peer Reviewed
• [Journal Article] ME3738 enhances the effect of interferon andinhibits hepatitis C virusreplication both in vitro and in vivo (2011)
  • Author(s): Abe H, Imamura M, Hiraga N, Tsuge M, Mitsui F, Kawaoka T, Takahashi S, OchiH, Maekawa T, Hayes CN, Tateno C, Yoshizato K, Murakami S, Yamashita N, Matsuhira T, Asai K, Chayama K
  • Journal Title: J Hepatol Volume: 55 Issue: 1 Pages: 11-18
  • DOI: 10.1016/j.jhep.2010.10.017
  • Peer Reviewed
• [Journal Article] IL28 variationaffects expression of interferonstimulated genes and peg-interferonand ribavirin the rapy (2011)
  • Author(s): Abe H, Hayes CN, Ochi H, Maekawa T, Tsuge M, Miki D, Mitsui F, Hiraga N, Imamura M, Takahashi S, Kubo M, Nakamura Y, Chayama K
  • Journal Title: J Hepatol Volume: 54 Issue: 6 Pages: 1094-1101
  • DOI: 10.1016/j.jhep.2010.09.019
  • Peer Reviewed
• [Journal Article] A randomized phase II trial of intra-arterial chemotherapy using SM-11355 (Miriplatin) for hepatocellular carcinoma (2011)
  • Author(s): Okusaka T, Kasugai H, Ishii H, Kudo M, Sata M, Tanaka K, Shioyama Y, Chayama K, Kumada H, Yoshikawa M, Seki T, Saito H, Hayashi N, Shiratori K, Okita K, Sakaida I, Honda M, Kusumoto Y, Tsutsumi T, Sakata K
  • Journal Title: Invest New Drugs (Epub 21 Dec.) Volume: (E-pub) Issue: 5 Pages: 2015-2025
  • DOI: 10.1007/s10637-011-9776-4
  • Peer Reviewed
• [Journal Article] Treatment of chronic hepatitis B with nuoleos(t)ide analogues (2011)
  • Author(s): Ohishi W, Chayama K
  • Journal Title: Hepatol Ees Volume: 42 Issue: 3 Pages: 219-25
  • DOI: 10.1111/j.1872-034x.2011.00921.x
  • Peer Reviewed
• [Journal Article] Recent trend of clinical features in patients with hepatocellular carcinoma (2011)
  • Author(s): Nagaoki Y, Hyogo H, Aikata H, Tanaka M, Naeshiro N, Nakahara T, Honda Y, Miyaki D, Kawaoka T, Takaki S, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Takahashi S, Chayama K
  • Journal Title: Hepatol Res (Epub 13 Dec.) Volume: (Epub) Issue: 4 Pages: 368-375
  • DOI: 10.1111/j.1872-034x.2011.00929.x
  • NAID: 10031144249
  • Peer Reviewed
• [Journal Article] Platelet count for predicting fibrosis in nonalcoholic fatty liver disease (2011)
  • Author(s): Yoneda M, Fujii H, Sumida Y, Hyogo H, Itoh Y, Ono M, Eguchi Y, Suzuki Y, Aoki N, Kanemasa K, Imajo K, Chayama K, Saibara T, Kawada N, Fujimoto K, Kohgo Y, Yoshikawa T, Okanoue T, Japan Study Group of Nonal coholic Fatty Liver D
  • Journal Title: J Gastroenterol Volume: 46 Issue: 11 Pages: 1300-1306
  • DOI: 10.1007/s00535-011-0436-4
  • NAID: 10030294888
  • Peer Reviewed
• [Journal Article] Clinical outcome of esophageal varices after hepatic arterial infusion chemotlierapy for advanced hepatocellular carcinoma with major portal vein tumor thrombus (2011)
  • Author(s): Kodama H, Aikata H, Murakami E, Miyaki D, Nagaoki Y, Hashimoto Y, Azakami T, Katamura Y, Kawaoka T, Takaki S, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Takahashi S, Ishikawa M, Kakizawa H, Awai K, Kenio M, Nagata Y, Chayama K
  • Journal Title: Hepatol Res Volume: 41 Issue: 11 Pages: 1046-1056
  • DOI: 10.1111/j.1872-034x.2011.00857.x
  • Peer Reviewed
• [Journal Article] Eradication of hepatitis C virus genotype 1 after liver transplantation by interferon therapy before surgery : Report of three patients with analysis of interleukin-28 polymorphism, hepatitis C virus core region and interferon-sensitivity determining region (2011)
  • Author(s): Kawaoka T, Aikata H, Miyaki D, Murakami E, Azakami T, Takaki S, Nagaoki Y, Hashimoto Y, Katamura Y, Hiramatsu A, Waki K, Hiraga N, Miki D, TsugeM, Imamura M, Kawakami Y, Takahashi S, Ochi H, Tashiro H, Ohdan H, Chayama K
  • Journal Title: Hepatol Res Volume: 41 Issue: 11 Pages: 1126-1131
  • DOI: 10.1111/j.1872-034x.2011.00853.x
  • NAID: 10031144190
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• [Journal Article] A huge metastatic liver tumor from leiomyosarcoma of the inferior vena cava : report of a case (2011)
  • Author(s): Hashimoto M, Kobayashi T, Tashiro H, Amano H, Oshita A, Tanimoto Y, Kuroda S, Tazawa H, Aikata H, Chayama K, Fujii M, Arihiro K, Ohdan H
  • Journal Title: Surg Today (Epub 30 Nov.) Volume: (Epub) Issue: 5 Pages: 505-508
  • DOI: 10.1007/s00595-011-0070-z
  • NAID: 10030621850
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• [Journal Article] Lymphocyte subset characterization associated with persistent hepatitis C virus infection and subsequent progression of liver fibrosis (2011)
  • Author(s): Yoshida K, Ohishi W, Nakashima E, Fujiwara S, Akahoshi M, Kasagi F, Chayama K, Hakoda M, Kyoizumi S, Nakachi K, Hayashi T, Kusunoki Y
  • Journal Title: Hum Immunol Volume: 72 Issue: 10 Pages: 821-826
  • DOI: 10.1016/j.humimm.2011.05.029
  • NAID: 120006547414
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• [Journal Article] Prevention of hepatitis B virus reactivation in immunosuppressive therapy or chemotherapy (2011)
  • Author(s): Ohishi W, Chayama K
  • Journal Title: Clin Exp Nephrol Volume: 15 Issue: 5 Pages: 634-640
  • DOI: 10.1007/s10157-011-0464-7
  • NAID: 10030340714
  • Peer Reviewed
• [Journal Article] IL28B polymorphism may guide pegylated interferon plus ribavirin therapy even after curative treatment for hepatitis C virus-related hepatooellular carcinoma (2011)
  • Author(s): Kawaoka T, Aikata H, Takaki S, Hiramatsu A, Waki K, Hiraga N, Miki D, Tsuge M, Imamura M, Kawakami Y, Takahashi S, Ochi H, Tashiro H, Ohdan H, Chayama K
  • Journal Title: J Viral Hepat Volume: 18 Issue: 10 Pages: e550-e560
  • DOI: 10.1111/j.1365-2893.2011.01468.x
  • Peer Reviewed
• [Journal Article] Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state (2011)
  • Author(s): Abe H, Hayes CN, Ochi H, Tsuge M, Miki D, Hiraga N, Imamura M, Takahashi S, Kubo M, Nakamura Y, Kamatani N, Chayama K
  • Journal Title: J Med Virol Volume: 83 Issue: 9 Pages: 1597-1607
  • DOI: 10.1002/jmv.22158
  • Peer Reviewed
• [Journal Article] Achievement of Sustained Viral Response after Switching Treatment from Pegylated Interferon alpha-2b to alpha-2a and Ribavirin in Patients with Recurrence of Hepatitis C Virus Genotype 1 Infection after Liver Transplantation : A Case Report (2011)
  • Author(s): Kawaoka T, Hiraga N, Takahashi S, Takaki S, Tsuge M, Nagaoki Y, Hashimoto Y, Katamura Y, Muki D, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Aikata H, Ochi H, Tashiro H, Ohdan H, Chayama K
  • Journal Title: Intervirology (Elpub 25 Aug.) Volume: (Epub) Issue: 4 Pages: 306-310
  • DOI: 10.1159/000328661
  • Peer Reviewed
• [Journal Article] Treatment strategy for early hepatocellular carcinomas : comparison of radiofrequency ablation with or without transcatheter arterial chemoembolization and surgical resection (2011)
  • Author(s): Tashiro H, Aikata H, Waki K, Amano H, Oshita A, Kobayashi T, Tanimoto Y, Kuroda S, Tazawa H, Chayama K, Asahara T, Ohdan H
  • Journal Title: J Surg Oncol Volume: 104 Issue: 1 Pages: 3-9
  • DOI: 10.1002/jso.21745
  • Peer Reviewed
• [Journal Article] Antiviral effects of peginterferon alpha-2b and ribavirin following 24-week monotherapy of telaprevir in Japanese hepatitis C patients (2011)
  • Author(s): Ozeki I, Akaike J, Karino Y, Arakawa T, Kuwata Y, Ohmura T, Sato T, Kamiya N, Yamada I, Chayama K, Kumada H, Toyota J
  • Journal Title: J Gastroenterol Volume: 46 Issue: 7 Pages: 929-937
  • DOI: 10.1007/s00535-011-0411-0
  • NAID: 10029313367
  • Peer Reviewed
• [Journal Article] Impact of ribavirin dose reduction on the efficacy of pegylated interferon plus ribavirin combination therapy for elderly patients infected with genotype 1b and high viral loads (2011)
  • Author(s): Kohno H, Kouno H, Aimitsu S, Aisaka Y, Kitamoto M, Kawakami H, Chayama K
  • Journal Title: Hepatol Ees Volume: 41 Issue: 7 Pages: 626-634
  • DOI: 10.1111/j.1872-034x.2011.00811.x
  • Peer Reviewed
• [Journal Article] Clinical features and prognosis in patients with hepatocellular carcinom a that developed after hepatitis C virus eradication with interferon therapy (2011)
  • Author(s): Nagaoki Y, Aikata H, Miyaki D, Murakami E, Hashimoto Y, Katamura Y, Azakami T, Kawaoka T, Takaki S, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Takahashi S, Chayama K
  • Journal Title: J Gastroenterol Volume: 46 Issue: 6 Pages: 799-808
  • DOI: 10.1007/s00535-011-0384-z
  • Peer Reviewed
• [Journal Article] Significant regression of a cavernous hepatic hemangioma to a sclerosed hemangioma over 12 years :a case study (2011)
  • Author(s): Miyaki D, Aikata H, Waki K, Murakami E, Hashimoto Y, Nagaoki Y, Katamura Y, Kawaoka T, Takaki S, Hiramatsu A, Imamura M, Takahashi S, Ohya T, Sakimoto H, Arihiro K, Chayama K
  • Journal Title: Nihon Shokakibyo Gakkai Zasshi Volume: 108 Pages: 954-961
  • NAID: 10031122114
  • Peer Reviewed
• [Journal Article] Cutaneous complications after transcatheter arterial treatment for hepat ocellular carcinoma via the internal mammary artery : how to avoid this complication (2011)
  • Author(s): Kajiwara K, Kakizawa H, Takeuchi N, Toyota N, Hieda M, Ishikawa M, Tanitame K, Tani G, Suzuki T, Fujikawa K, Aikata H, Chayama K, Awai K
  • Journal Title: Jpn J Radiol Volume: 29 Issue: 5 Pages: 307-315
  • DOI: 10.1007/s11604-011-0559-9
  • NAID: 50008099049
  • Peer Reviewed
• [Journal Article] Prediction of response to peginterferon-alfa-2b plus ribavirin therapy in Japanese patients infected with hepatitis C virus genotype 1b (2011)
  • Author(s): Hashimoto Y, Ochi H, Abe H, Hayashida Y, Tsuge M, Mitsui F, Hiraga N, Imamura M, Takahashi S, Nelson Hayes C, Ohishi W, Kubo M, Tsunoda T, Kamatani N, Nakamura Y, Chayama K
  • Journal Title: J Med Virol Volume: 83 Issue: 6 Pages: 981-988
  • DOI: 10.1002/jmv.22028
  • Peer Reviewed
• [Journal Article] Common genetic polymorphism of ITPA gene affects ribavirin-induced anemia and effect of peg-interferon plus ribavirin therapy (2011)
  • Author(s): Azakami T, Hayes CN, Sezaki H, Kobayashi M, Akuta N, Suzuki F, Kumada H, Abe H, Miki D, Tsuge M, Imamura M, Kawakami Y, Takahashi S, Ochi H, Nakamura Y, Kamatani N, Chayama K
  • Journal Title: J Med Virol Volume: 83 Issue: 6 Pages: 1048-1057
  • DOI: 10.1002/jmv.22069
  • Peer Reviewed
• [Journal Article] HCV replication animal model (2011)
  • Author(s): Imamura M, Hiraga N, Chayama K
  • Journal Title: Nihon Rinsho Volume: 69 Suppl 4 Pages: 75-79
  • NAID: 40018838443
  • Peer Reviewed
• [Journal Article] Factors predictive of sustained virological response following 72 weeks of combination therapy for genotype 1b hepatitis C (2011)
  • Author(s): Chayama K, Hayes CN, Yoshioka K, Moriwaki H, Okanoue T, Sakisaka S, Takehara T, Oketani M, Toyota J, Izumi N, Hiasa Y, Matsumoto A, Nomura H, Seike M, Ueno Y, Yotsuyanagi H, Kumada H
  • Journal Title: J Gastroenterol Volume: 46 Issue: 4 Pages: 545-555
  • DOI: 10.1007/s00535-010-0358-6
  • NAID: 10029028821
  • Peer Reviewed
• [Journal Article] Long-term use ofentecavir in nucleoside-naiveJapanese patients with chronichepatitis B infection (2010)
  • Author(s): Yokosuka O, Takaguchi K, Fujioka S, Shindo M, Chayama K, Kobashi H, Hayashi N, Sato C, Kiyosawa K, Tanikawa K, Ishikawa H, Masaki N, Seriu T, Omata M
  • Journal Title: J Hepatol Volume: 52 Issue: 6 Pages: 791-799
  • DOI: 10.1016/j.jhep.2009.12.036
  • Peer Reviewed
• [Journal Article] HBx protein is indispensable for development of viraemia in human hepatocyte chimericmice (2010)
  • Author(s): Tsuge M, Hiraga N, Akiyama R, TanakaS, Matsushita M, Mitsui F, Abe H, Kitamura S, Hatakeyama T, Kimura T, Miki D, Mori N, Imamura M, TakahashiS, Hayes CN, Chayama K
  • Journal Title: J Gen Virol Volume: 91 Issue: 7 Pages: 1854-1864
  • DOI: 10.1099/vir.0.019224-0
  • Peer Reviewed
• [Journal Article] IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/ 2b chimeric clones (2010)
  • Author(s): Suda G, Sakamoto N, Itsui Y, NakagawaM, Tasaka-Fujita M, Funaoka Y, Watanabe T, Nitta S, Kiyohashi K, Azuma S, Kakinuma S, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Watanabe M
  • Journal Title: Virology Volume: 407 Issue: 1 Pages: 80-90
  • DOI: 10.1016/j.virol.2010.07.041
  • Peer Reviewed
• [Journal Article] ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy-a genome-wide study ofJapanese HCV virus patients (2010)
  • Author(s): Ochi H, Maekawa T, Abe H, Hayashida Y, Nakano R, Kubo M, Tsunoda T, Hayes CN, Kumada H, Nakamura Y, Chayama K
  • Journal Title: Gastroenterology Volume: 139 Issue: 4 Pages: 1190-1197
  • DOI: 10.1053/j.gastro.2010.06.071
  • Peer Reviewed
• [Journal Article] Cellculture and in vivo analyses of cytopathic hepatitis C virus mutants (2010)
  • Author(s): Mishima K, Sakamoto N, Sekine-OsajimaY, Nakagawa M, Itsui Y, Azuma S, Kakinuma S, Kiyohashi K, Kitazume A, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Wakita T, Watanabe M
  • Journal Title: Virology Volume: 405 Issue: 2 Pages: 361-369
  • DOI: 10.1016/j.virol.2010.06.020
  • Peer Reviewed
• [Journal Article] Practical evaluation of a mouse with chimeric human liver model for hepatitis C virus infection using an NS3-4A protease inhibitor (2010)
  • Author(s): Kamiya N, Iwao E, Hiraga N, Tsuge M, Imamura M, Takahashi S, Miyoshi S, Tateno C, Yoshizato K, Chayama K
  • Journal Title: J Gen Virol Volume: 91 Issue: 7 Pages: 1668-1677
  • DOI: 10.1099/vir.0.019315-0
  • Peer Reviewed
• [Journal Article] Amino acidsubstitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin (2010)
  • Author(s): Akuta N, Suzuki F, Hirakawa M, Kawamura Y, Yatsuji H, Sezaki H, Suzuki Y, Hosaka T, Kobayashi M, Saitoh S, Arase Y, Ikeda K, Chayama K, Nakamura Y, Kumada H
  • Journal Title: Hepatology Volume: 52 Issue: 2 Pages: 421-4293
  • DOI: 10.1002/hep.23690
  • Peer Reviewed
• [Journal Article] Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients (2010)
  • Author(s): Abe H, Ochi H, Maekawa T, Hayes CN, Tsuge M, Miki D, Mitsui F, Hiraga N, Imamura M, Takahashi S, Ohishi W, Arihiro K, Kubo M, Nakamura Y, ChayamaK
  • Journal Title: J Hepatol Volume: 53 Issue: 3 Pages: 439-443
  • DOI: 10.1016/j.jhep.2010.03.022
  • NAID: 120002577227
  • Peer Reviewed
• [Journal Article] Amino acid substitutions in core and NS5A regions of the HCV genome can predict virological decrease with pegylated interferon plus ribavirin therapy. (2010)
  • Author(s): Kitamura S, Tsuge M, Hatakeyama T, Abe H, Imamura M, Mori N, Saneto H, Kawaoka T, Mitsui F, Hiraga N, Takaki S, Kawakami Y, Aikata H, Takahashi S, Ohishi W, Ochi H, Hayes CN, Chayama K
  • Journal Title: Antivir Ther Volume: 15(8) Pages: 1087-1097
  • Peer Reviewed
• [Journal Article] Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b. (2010)
  • Author(s): Kawaoka T, Hayes CN, Ohishi W, Ochi H, Maekawa T, Abe H, Tsuge M, Mitsui F, Hiraga N, Imamura M, Takahashi S, Kubo M, Tsunoda T, Nakamura Y, Kumada H, Chayama K.
  • Journal Title: J Hepatol Volume: 54(3) Pages: 408-414
  • Peer Reviewed
• [Journal Article] HCV substitutions and IL28B polymorphisms on outcome of peg-interferon plus ribavirin combination therapy. (2010)
  • Author(s): Hayes CN, Kobayashi M, Akuta N, Suzuki F, Kumada H, Abe H, Miki D, Imamura M, Ochi H, Kamatani N, Nakamura Y, Chayama K.
  • Journal Title: Gut Volume: 60(2) Pages: 261-267
  • Peer Reviewed
• [Journal Article] Accumulation of refractory factors for pegylated interferon plus ribavirin therapy in older female patients with chronic hepatitis C (2010)
  • Author(s): Chayama K, Hayes CN, Yoshioka K, Moriwaki H, Okanoue T, Sakisaka S, Takehara T, Oketani M, Toyota J, Izumi N, Hiasa Y, Matsumoto A, Nomura H, Seike M, Ueno Y, Yotsuyanagi H, Kumada H.
  • Journal Title: Hepatol Res. Volume: 12 Pages: 1155-1167
  • NAID: 10028172403
  • Peer Reviewed
• [Journal Article] IL-6-mediated intersubgenotypic variation of interfer on sensitivity in hepatitis C virus genotype 2a/2b chimeric clones (2010)
  • Author(s): Suda G, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Funaoka Y, Watanabe T, Nitta S, Kiyohashi K, Azuma S, Kakinuma S, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Watanabe M.
  • Journal Title: Virology. Volume: 407(1) Pages: 80-90
  • Peer Reviewed
• [Journal Article] Prolongation of interferon therapy for recurrent hepatitis C after living donor liver transplantation : analysis of predictive factors of sustained virological response, including amino acid sequence of the core and NS5A regions of hepatitis C virus (2010)
  • Author(s): Kawaoka T, Hiraga N, Takahashi S, Takaki S, Mitsui F, Tsuge M, Nagaoki Y, Kimura Y, Hashimoto Y, Katamura Y, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Aikata H, Tashiro H, Ohdan H, Chayama K.
  • Journal Title: Scand J Gastroenterol Volume: 45(12) Pages: 1488-1496
  • Peer Reviewed
• [Journal Article] Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginter feron and ribavirin. (2010)
  • Author(s): Akuta N, Suzuki F, Hirakawa M, Kawamura Y, Yatsuji H, Sezaki H, Suzuki Y, Hosaka T, Kobayashi M, Kobayashi M, Saitoh S, Arase Y, Ikeda K, Chayama K, Nakamura Y, Kumada H.
  • Journal Title: Hepatology Volume: 52(2) Pages: 421-429
  • Peer Reviewed
• [Journal Article] ITPA Polymorphism Affects Ribavirin-induced Anemia and Outcome of Therapy-a Genome-wide Study of Japanese HCV Patients. (2010)
  • Author(s): Ochi H, Maekawa T, Abe H, Hayashida Y, Nakano R, Kubo M, Tsunoda T, Hayes CN, Kumada H, Nakamura Y, Chayama K
  • Journal Title: Gastroenterology. Volume: 139(4) Pages: 1190-1197
  • Peer Reviewed
• [Journal Article] Cell culture and in vivo analyses of cytopathic hepatitis C virus mutants. (2010)
  • Author(s): Mishima K, Sakamoto N, Sekine-Osajima Y, Nakagawa M, Itsui Y, Azuma S, Kakinuma S, Kiyohashi K, Kitazume A, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Wakita T, Watanabe M
  • Journal Title: Virology. Volume: 30;405(2) Pages: 361-369
  • Peer Reviewed
• [Journal Article] common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients. (2010)
  • Author(s): Abe H, Ochi H, Maekawa T, Hayes CN, Tsuge M, Miki D, Mitsui F, Hiraga N, Imamura M, Takahashi S, Ohishi W, Arihiro K, Kubo M, Nakamura Y, Chayama K.
  • Journal Title: J Hepatol. Volume: 53(3) Pages: 439-443
  • NAID: 120002577227
  • Peer Reviewed
• [Journal Article] Importance of serum concentration of adefovir for Lamivudine-adefovir combination therapy in patients with lamivudine-resistant chronic hepatitis B. (2010)
  • Author(s): Mitsui F, Tsuge M, Kimura T, Kitamura S, Abe H, Saneto H, Kawaoka T, Miki D, Hatakeyama T, Hiraga N, Imamura M, Kawakami Y, Aikata H, Takahashi S, Hayes CN, Igarashi H, Morimoto K, Shimizu M, Chayama K.
  • Journal Title: Antimicrob Agents Chemother Volume: 54(8) Pages: 3205-3211
  • Peer Reviewed
• [Journal Article] Long-term use of entecavir in nucleoside-naive Japanese patients with chronic hepatitis B infection. (2010)
  • Author(s): Yokosuka O, Takaguchi K, Fujioka S, Shindo M, Chayama K, Kobashi H, Hayashi N, Sato C, Kiyosawa K, Tanikawa K, Ishikawa H, Masaki N, Seriu T, Omata M.
  • Journal Title: J Hepatol Volume: 52(6) Pages: 791-799
  • Peer Reviewed
• [Journal Article] Differential effects of interferon and lamivudine on serum HBV RNA inhibition in patients with chronic hepatitis B. (2010)
  • Author(s): Huang YW, Chayama K, Tsuge M, Takahashi S, Hatakeyama T, Abe H, Hu JT, Liu CJ, Lai MY, Chen DS, Yang SS, Kao JH.
  • Journal Title: Antivir Ther Volume: 15(2) Pages: 177-184
  • Peer Reviewed
• [Journal Article] HBx protein is indispensable for development of viremia in human hepatocyte chimeric mice. (2010)
  • Author(s): Tsuge M, Hiraga N, Akiyama R, Tanaka S, Matsushita M, Mitsui F, Abe H, Kitamura S, Hatakeyama T, Kimura T, Miki D, Mori N, Imamura M, Takahashi S, Hayes CN, Chayama K.
  • Journal Title: J Gen Virol Volume: 91(pt7) Pages: 1854-1864
  • Peer Reviewed
• [Journal Article] Practical Evaluation of a Mouse with Chimeric Human Liver Model for Hepatitis C Virus Infection Using an NS3-4A Protease Inhibitor. (2010)
  • Author(s): Kamiya N, Iwao E, Hiraga N, Tsuge M, Imamura M, Takahashi S, Miyoshi S, Tateno C, Yoshizato K, Chayama K.
  • Journal Title: J Gen Virol Volume: 91 Pages: 1668-1677
  • Peer Reviewed
• [Journal Article] Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis B virus infection for the fiscal year 2008 in Japan. (2010)
  • Author(s): Kumada H, Okanoue T, Onji M, Moriwaki H, Izumi N, Tanaka E, Chayama K, Sakisaka S, Takehara T, Oketani M, Suzuki F, Toyota J, Nomura H, Yoshioka K, Seike M, Yotsuyanagi H, Ueno Y ; The Study Group for the Standardization of Treatment of Viral Hepatitis Including Cirrhosis, inistry of Health, Labor, Welfare of Japan.
  • Journal Title: Hepatol Res Volume: 40(1) Pages: 1-7
  • NAID: 10027406161
  • Peer Reviewed
• [Journal Article] G to A hypermutation of TT virus. (2010)
  • Author(s): Tsuge M, Noguchi C, Akiyama R, Matsushita M, Kunihiro K, Tanaka S, Abe H, Mitsui F, Kitamura S, Hatakeyama T, Kimura T, Miki D, Hiraga N, Imamura M, Takahashi S, Hayses CN, Chayama K
  • Journal Title: Virus Res Volume: 149(2) Pages: 211-216
  • Peer Reviewed
• [Journal Article] A polymorphism in MAPKAPK3 affects response to interferon therapy for chronic hepatitis C (2009)
  • Author(s): Tsukada H, Ochi H, Maekawa T, Abe H, Fujimoto Y, Tsuge M, Takahashi H, Kumada H, Kamatani N, Nakamura Y, Chayama K
  • Journal Title: Gastroenterology Volume: 136 Issue: 5 Pages: 1796-1805.e6
  • DOI: 10.1053/j.gastro.2009.01.061
  • NAID: 120001700405
  • Peer Reviewed
• [Journal Article] Adoptive immunotherapy with liver allograft-derived lymphocytes induces anti-HCV activity after liver transplantation in humans and humanized mice (2009)
  • Author(s): Ohira M, Ishiyama K, Tanaka Y, DoskaliM, Igarashi Y, Tashiro H, Hiraga N, Imamura M, Sakamoto N, Asahara T, Chayama K, Ohdan H
  • Journal Title: J Clin Invest Volume: 119 Pages: 3226-3235
  • DOI: 10.1172/jci38374
  • Peer Reviewed
• [Journal Article] G-to-A hypermutation in hepatitis B virus(HBV) and clinical course of patients with chronic HBV infection (2009)
  • Author(s): Noguchi C, Imamura M, Tsuge M, HiragaN, Mori N, Miki D, Kimura T, TakahashiS, Fujimoto Y, Ochi H, Abe H, MaekawaT, Tateno C, Yoshizato K, Chayama K
  • Journal Title: J Infect Dis Volume: 199 Issue: 11 Pages: 1599-1607
  • DOI: 10.1086/598951
  • Peer Reviewed
• [Journal Article] Deletion of angiotensin II type I receptor reduces hepatic steatosis (2009)
  • Author(s): Nabeshima Y, Tazuma S, Kanno K, HyogoH, Chayama K
  • Journal Title: J Hepatol Volume: 50 Issue: 6 Pages: 1226-1235
  • DOI: 10.1016/j.jhep.2009.01.018
  • NAID: 120001700483
  • Peer Reviewed
• [Journal Article] Amphipathic DNA polymers inhibit hepatitis C virus infection by blocking viral entry (2009)
  • Author(s): Matsumura T, Hu Z, Kato T, Dreux M, Zhang YY, Imamura M, Hiraga N, JuteauJM, Cosset FL, Chayama K, Vaillant A, Liang TJ
  • Journal Title: Gastroenterology Volume: 137 Issue: 2 Pages: 673-681
  • DOI: 10.1053/j.gastro.2009.04.048
  • Peer Reviewed
• [Journal Article] Amphipathic DNA polymers inhibit hepatitis C virus infection by blocking viral entry (2009)
  • Author(s): Kamatani Y, Wattanapokayakit S, OchiH, Kawaguchi T, Takahashi A, Hosono N, Kubo M, Tsunoda T, Kamatani N, KumadaH, Puseenam A, Sura T, Daigo Y, ChayamaK, Chantratita W, Nakamura Y, MatsudaK
  • Journal Title: Nat Genet Volume: 41 Issue: 5 Pages: 591-595
  • DOI: 10.1038/ng.348
  • Peer Reviewed
• [Journal Article] Absence of viral interference and different susceptibility to interferon between hepatitis B virus and hepatitis C virus in human hepatocyte chimeric mice (2009)
  • Author(s): Hiraga N, Imamura M, Hatakeyama T, Kitamura S, Mitsui F, Tanaka S, TsugeM, Takahashi S, Abe H, Maekawa T, OchiH, Tateno C, Yoshizato K, Wakita T, Chayama K
  • Journal Title: J Hepatol Volume: 51 Issue: 6 Pages: 1045-1054
  • DOI: 10.1016/j.jhep.2009.09.002
  • NAID: 120002036688
  • Peer Reviewed
• [Journal Article] Regular surveillance by imaging for early detection and better prognosis of hepatocellular carcinoma in patients infected with hepatitis C virus (2009)
  • Author(s): Noda I, Kitamoto M, Nakahara H, Hayashi R, Okimoto T, Monzen Y, Yamada H, Imagawa M, Hiraga N, Tanaka J, Chayama K
  • Journal Title: J Gastroenterol 45 Pages: 105-112
  • NAID: 10027214070
  • Peer Reviewed
• [Journal Article] Absence of viral interference and different susceptibility to interferon between hepatitis B virus and hepatitis C virus in human hepatocyte chimeric mice (2009)
  • Author(s): Hiraga N, Imamura M, Hatakeyama T, Kitamura S, Mitsui F, Tanaka S, Tsuge M, Takahashi S, Abe H, Maekawa T, Ochi H, Tateno C, Yoshizato K, Wakita T, Chayama K.
  • Journal Title: J Hepatol 51(6) Pages: 1046-1054
  • NAID: 120002036688
  • Peer Reviewed
• [Journal Article] Adoptive immunotherapy with liver allograft-derived lymphocytes induces anti-HCV activity after liver transplantation in humans and humanized mice (2009)
  • Author(s): Ohira M, Ishiyama K, Tanaka Y, Doskali M, Igarashi Y, Tashiro H, Hiraga N, Imamura M, Sakamoto N, Asahara T, Chayama K.
  • Journal Title: J Clin Invest 119(11) Pages: 3226-3235
  • Peer Reviewed
• [Journal Article] Adoptive immunotherapy with liver allograft-derived lymphocytes induces anti-HCV activity after liver transplantation in humans and humanized mice (2009)
  • Author(s): Abe H, Ochi H, Maekawa T, Hatakeyama T, Tsuge M, Kitamura S, Kimura T, Miki D, Mitsui F, Hiraga N, Imamura M, Fujimoto Y, Takahashi S, Nakamura Y, Kumada H, Chayama K.
  • Journal Title: Hepatol Res 39 Pages: 1159-1168
  • Peer Reviewed
• [Journal Article] Antiviral activity, dose-response relationship, and safety of entecavir following 24-week oral dosing in nucleoside-naive Japanese adult patients with chronic hepatitis B : a randomized, double-blind, phase II clinical trial (2009)
  • Author(s): Shindo M, Chayama K, Mochida S, Toyota J, Tomita E, Kumada H, Yokosuka O, Sata M, Hayashi N, Suzuki K, Okanoue T, Tsubouchi H, Ishikawa H, Seriu T, Omata M.
  • Journal Title: Hepatol Int 3 Pages: 445-452
  • Peer Reviewed
• [Journal Article] Evaluation of portosystemic collaterals by MDCT-MPR imaging for management of hemorrhagic esophageal varices (2009)
  • Author(s): Kodama H, Aikata H, Takaki S, Azakami T, Katamura Y, Kawaoka T, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Takahashi S, Toyota N, Ito K, Chayama K.
  • Journal Title: Eur J Radiol (In press)
  • Peer Reviewed
• [Journal Article] Predictive values of amino acid sequences of the core and NS5A regions in antiviral therapy for hepatitis C : a Japanese multi-center study (2009)
  • Author(s): Okanoue T, Itch Y, Hashimoto H, Yasui K, Minami M, Takehara T, Tanaka E, Onji M, Toyota J, Chayama K, Yoshioka K, Izumi N, Akuta N, Kumada H.
  • Journal Title: J Gastroenterol 44(9) Pages: 952-963
  • NAID: 10025581408
  • Peer Reviewed
• [Journal Article] Successful hepatitis B vaccination in liver transplant recipients with donor-specific hyporesponsiveness (2009)
  • Author(s): Tahara H, Tanaka Y, Ishiyama K, Ide K, Shishida M, Irei T, Ushitora Y, Ohira M, Banshodani M, Tashiro H, Itamoto T, Asahara T, Imamura M, Takahashi S, Chayama K, Ohdan H.
  • Journal Title: Transpl Int. 22(8) Pages: 805-813
  • Peer Reviewed
• [Journal Article] Chronic hepatitis C in patients co-infected with human immunodeficiency virus in Japan : a retrospective multicenter analysis (2009)
  • Author(s): Yotsuyanagi H, Kikuchi Y, Tsukada K, Nishida K, Kato M, Sakai H, Takamatsu J, Hige S, Chayama K, Moriya K, Koike K.
  • Journal Title: Hepatol Res 39(7) Pages: 657-663
  • NAID: 10025326580
  • Peer Reviewed
• [Journal Article] Transarterial infusion chemotherapy using cisplatin-lipiodol suspensior with or without embolization for unresectable hepatocellular carcinoma (2009)
  • Author(s): Kawaoka T, Aikata H, Takaki S, Katamura Y, Hiramatsu A, Waki K, Takahashi S, Hieda M, Toyota N, Ito K, Chayama K.
  • Journal Title: Cardiovasc Intervent Radiol 32(4) Pages: 687-694
  • Peer Reviewed
• [Journal Article] G-to-A hypermutation in hepatitis B virus (HBV) and clinical course of patients with chronic HBV infection (2009)
  • Author(s): Noguchi C, Imamura M, Tsuge M, Hiraga N, Mori N, Miki D, Kimura T, Takahashi S, Fujimoto Y, Ochi H, Abe H, Maekawa T, Tateno C, Yoshizato K, Chayama K.
  • Journal Title: J Infect Dis 199(11) Pages: 1599-1607
  • Peer Reviewed
• [Journal Article] Deletion of angiotensin II type I receptor reduces hepatic steatosis (2009)
  • Author(s): Nabeshima Y, Tazuma S, Kanno K, Hyogo H.Chayama K.
  • Journal Title: J Hepatol 50(6) Pages: 1226-1235
  • NAID: 120001700483
  • Peer Reviewed
• [Journal Article] Amphipathic DNA Polymers Inhibit Hepatitis C Virus Infection by Blocking Viral Entry (2009)
  • Author(s): Matsumura T, Hu Z, Kato T, Dreux M, Zhang YY, Imamura M, Hiraga N, Juteau JM, Cosset FL, Chayama K, Vaillant A, Liang TJ.
  • Journal Title: Gastroenterolog 137(2) Pages: 673-681
  • Peer Reviewed
• [Journal Article] A genome-wide association study identifies variants in the HLA-DP Iocus associated with chronic hepatitis B in Asians (2009)
  • Author(s): Kamatani Y, Wattanapokayakit S, Ochi H, Kawaguchi T, Takahashi A, Hosono N, Kubo M, Tsunoda T, Kamatani N, Kumada H, Puseenam A, Sura T, Daigo Y, Chayama K, Chantratita W, Nakamura Y, Matsuda K.
  • Journal Title: Nat Ganet 41(5) Pages: 591-595
  • Peer Reviewed
• [Journal Article] Intra-arterial 5-fluorouracil/interferon combination therapy for advanced hepatocellular carcinoma with or without three-dimensional conformal radiotherapy for portal vein tumor thrombosis (2009)
  • Author(s): Katamura Y, Aikata H, Takaki S, Azakami T, Kawaoka T, Waki K, Hiramatsu A, Kawakami Y, Takahashi S, Kenjo M, Toyota N, Ito K, Chayama K.
  • Journal Title: J Gastroenterol 44(5) Pages: 492-502
  • NAID: 10025175131
  • Peer Reviewed
• [Journal Article] The first, Japanese case of COACH syndrome (2009)
  • Author(s): Mitsui F, Aikata H, Azakami T, Katamura Y, Kimura T, Kawaoka T, Saneto H, Takaki S, Hiraga N, Tsuge M, Waki K, Hiramatsu A, Imamura M, Kawakami Y, Takahashi S, Arihiro K, Chayama K.
  • Journal Title: Hepatol Res. 39(3) Pages: 318-323
  • NAID: 10025325115
  • Peer Reviewed
• [Journal Article] Predicting the response to 48-week combination therapy with peginterferon alpha-2b plus ribavirin from the estimated HCV RNA load index after negative serum change in genotype 1b hepatitis C patients (2009)
  • Author(s): Tsuji K, Kawakami Y, Aimitsu S, Kohno H, Aisaka Y, Kimura S, Nagata S, Ohgoshi H, Kitamoto M, Hidaka T, Kawakami H, Nakanishi T, Chayama K.
  • Journal Title: Hepatol Res. 39(6) Pages: 531-538
  • Peer Reviewed
• [Journal Article] Randomized trial of high-dose interferon-alpha-2b combined with ribavirin in patients with chronic hepatitis C : Correlation between amino acid substitutions in the core/NS5A region and virological response to interferon therapy (2009)
  • Author(s): Mori N, Imamura M, Kawakami Y, Saneto H, Kawaoka T, Takaki S, Aikata H, Takahashi S, Chayama K, Hiroshima Liver Study Group
  • Journal Title: J Med Virol 81(4) Pages: 640-649
  • Peer Reviewed
• [Journal Article] A Polymorphism in MAPKAPK3 Affects Response to Interferon Therapy for Chronic Hepatitis C (2009)
  • Author(s): Tsukada H, Ochi H, Maekawa T, Abe H, Fujimoto Y, Tsuge M, Takahashi H, Kumada H, Kamatani N, Nakamura Y, Chayama K, the Hiroshima Liver Study Group, Toranomon Hospital
  • Journal Title: Gastroenterology 136(5) Pages: 1796-1805
  • NAID: 120001700405
  • Peer Reviewed
• [Journal Article] FDG positron emission tomography/computed tomography for the detection of extrahepatic metastases from hepatocellular carcinoma (2009)
  • Author(s): Kawaoka T, Aikata H, Takaki S, Uka K, Azakami T, Saneto H, Jeong SC, Kawakami Y, Takahashi S, Toyota N, Ito K, Hirokawa Y, Chayama K.
  • Journal Title: Hepatol Res 39(2) Pages: 134-142
  • NAID: 10025324381
  • Peer Reviewed
• [Journal Article] Successful treatment of pulmonary metastases associated with advanced hepatocellular carcinoma by systemic 5-fluorouracil combined with interferon-alpha in a hemodialysis patient (2009)
  • Author(s): Katamura Y, Aikata H, Kimura Y, Azakami T, Kawaoka T, Takaki S, Waki K, Hiramatsu A, Kawakami Y, Takahashi S, Chayama K.
  • Journal Title: Hepatol Res 39(4) Pages: 415-420
  • Peer Reviewed
• [Journal Article] Significant correlation between spleen volume and thrombocytopenia in liver transplant patients : a concept for predicting persistent thrombocytopenia (2009)
  • Author(s): Ohira M, Ishifuro M, Ide K, Irei T, Tashiro H, Itamoto T, Ito K, Chayama K, Asahara T, Ohdan H.
  • Journal Title: Liver Transpl 15(2) Pages: 208-215
  • Peer Reviewed
• [Journal Article] Evaluation of patients with esophageal varices after endoscopic injection sclerotherapy using multiplanar reconstruction MDCT images (2009)
  • Author(s): Kodama H, Aikata H, Takaki S, Takahashi S, Toyota N, Ito K, Chayama K.
  • Journal Title: AJR Am J Roentgenol 192(1) Pages: 122-130
  • Peer Reviewed
• [Presentation] Biological analysis of hepatitis C virus using human hepatocyte chimeric mouse (2012)
  • Author(s): 茶山一彰
  • Organizer: アジア太平洋肝臓病学会議(APASL)
  • Place of Presentation: 台北、台湾(招待講演)
  • Year and Date: 2012-02-19
• [Presentation] Dual Oral Combination Therapy with the NS5A Inhibitor BMS-790052 and the NS3 Protease Inhibitor BMS-650032 Achieved 90% Sustained Virologic Response(SVR12) in HCV Genotype 1b-Infected Null Responders (2011)
  • Author(s): Chayama Kazuaki
  • Organizer: The 62nd Annual Meeting ofAmerican Association for the Study ofLiver Diseases(AASLD)
  • Place of Presentation: SanFrancisco U. S. A
  • Year and Date: 2011-11-07
• [Presentation] Dual Oral Combination Therapy with the NS5A Inhibitor BMS-790052 and the NS3 Protease Inhibitor BMS-650032 Achieved 90% Sustained Virologic Response (SVR12) in HCV Genotype 1b-Infected Null Responders (2011)
  • Author(s): 茶山一彰
  • Organizer: The 62nd Annual Meeting of American Association for the study of Liver Diseases(AASLD)
  • Place of Presentation: アメリカサンフランシスコ(招待講演)
  • Year and Date: 2011-11-07
• [Presentation] Biological analysis of hepatitis viruses using human hepatocyte chimeric mouse (2011)
  • Author(s): 茶山一彰
  • Organizer: 第59回国際歯科研究学会日本部会総会・学術大会(JADR2011)
  • Place of Presentation: 広島(招待講演)
  • Year and Date: 2011-10-09
• [Presentation] Hepatitis C Virus Replication and Response to Anti-viral Drugs in Human Hepatocyte Chimeric Mice (2010)
  • Author(s): 茶山一彰
  • Organizer: 第7回アジア太平洋肝臓病学会議(APASL)シングルトピックカンファレンス
  • Place of Presentation: 千葉市(招待講演)
  • Year and Date: 2010-12-17
• [Presentation] Personalized Medicine in Chronic Hepatitis B (2010)
  • Author(s): Chayama K
  • Organizer: TASL 2020 Single Topic Conference
  • Place of Presentation: 台北(招待講演)
  • Year and Date: 2010-08-22
• [Presentation] IL28の多型とC型慢性肝炎の炎症、繊維化、γGTPとの関連 (2010)
  • Author(s): 阿部弘美, 越智秀典, 柘植雅貴, 三木大樹, 光井富貴子, 平賀伸彦, 今村道雄, 高橋祥一, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-28
• [Presentation] C型慢性肝炎患者に対するPegIFN/RBV療法の治療効果とIL28 locusのSNPおよび肝内IFN誘導遺伝子発現量の関連 (2010)
  • Author(s): 阿部弘美, 越智秀典, 柘植雅貴, 三木大樹, 光井富貴子, 平賀伸彦, 今村道雄, 高橋祥一, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-28
• [Presentation] HCV関連ミラノ基準内肝細胞癌に対する根治治療後の予後 IFN効果とミラノ基準逸脱時期の検討を含めて (2010)
  • Author(s): 相方浩, 片村嘉男, 橋本義政, 長沖祐子, 河岡友和, 高木慎太郎, 平松憲, 脇浩司, 川上由育, 高橋祥一, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-28
• [Presentation] 骨転移合併肝細胞癌に対するゾレドロン酸の効果 (2010)
  • Author(s): 片村嘉男, 相方浩, 長沖祐子, 石田友希, 橋本義政, 河岡友和, 高木慎太郎, 脇浩司, 平松憲, 高橋祥一, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-28
• [Presentation] Angio-CTでは指摘されずGd-EOB DTPA造影MRI肝細胞相でのみ指摘される結節についての検討 (2010)
  • Author(s): 高木慎太郎, 橋本義政, 長沖祐子, 石田友希, 片村嘉男, 河岡友和, 柘植雅貴, 平松憲, 脇浩司, 今村道雄, 川上由育, 兵庫秀幸, 相方浩, 高橋祥一, 柿沢秀明, 福田浩, 堀口純, 永田靖, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-28
• [Presentation] HBV RT領域の変異と核酸アナログ耐性への影響 (2010)
  • Author(s): 柘植雅貴, 今村道雄, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-28
• [Presentation] HCV感染マウスを用いたプロテアーゼ阻害剤およびRNAポリメラーゼ阻害剤の抗ウイルス効果の検討 (2010)
  • Author(s): 平賀伸彦, 今村道雄, 岩尾英治, 柘植雅貴, 光井富貴子, 河岡友和, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-28
• [Presentation] HBV感染ヒト肝細胞キメラマウスの血清中及び肝臓中cccDNA量の解析 (2010)
  • Author(s): 石田雄二, 眞田春美, 加国雅和, 島田卓, 茶山一彰, 立野知世
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-27
• [Presentation] C型肝炎ウイルス感染におけるHLA DRB1とNKG2D遺伝子多型の影響 (2010)
  • Author(s): 大石和佳, 吉田健吾, 林奉権, 楠洋一郎, 藤原佐枝子, 柘植雅貴, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-27
• [Presentation] 肝細胞癌に対するCDDP/LPDを用いた経カテーテル的化学塞栓術反復療法とステージングシステムについての検討 (2010)
  • Author(s): 河岡友和, 相方浩, 長沖祐子, 橋本義政, 石田友希, 片村嘉男, 光井富貴子, 石飛朋和, 高木慎太郎, 平賀伸彦, 柘植雅貴, 平松憲, 脇浩司, 今村道雄, 川上由育, 兵庫秀幸, 高橋祥一, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-27
• [Presentation] 3cm以下単発、Child A肝細胞癌に対する肝切除とラジオ波焼灼療法の比較 (2010)
  • Author(s): 脇浩司, 相方浩, 長沖祐子, 石田友希, 橋本義政, 片村嘉男, 河岡友和, 高木慎太郎, 平松憲, 今村道雄, 川上由育, 高橋祥一, 田代裕尊, 大段秀樹, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-27
• [Presentation] Genotype1b・高ウイルス量以外のC型慢性肝炎に対するResponse-guided therapy (2010)
  • Author(s): 北本幹也, 井川敦, 松本陽子, 山田博康, 川上由育, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-27
• [Presentation] 慢性肝疾患に対する脾臓摘出術の効果と合併症 (2010)
  • Author(s): 田代裕尊, 艮雄一郎, 天野尋暢, 大下彰彦, 小林剛, 谷本新学, 黒田慎太郎, 田澤宏文, 相方浩, 高橋祥一, 茶山一彰, 浅原利正, 板本敏行, 大段秀樹
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-27
• [Presentation] 非アルコール性脂肪性肝炎(NASH)における肝線維化と糖代謝異常の関連性について (2010)
  • Author(s): 石田友希, 兵庫秀幸, 石飛朋和, 鍋島由宝, 長沖祐子, 橋本義政, 片村嘉男, 河岡友和, 高木慎太郎, 脇浩司, 平松憲, 川上由育, 相方浩, 高橋祥一, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-27
• [Presentation] NAFLDの肝線維化と血小板数の関係について (2010)
  • Author(s): 石飛朋和, 兵庫秀幸, 鍋島由宝, 石田友希,茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-27
• [Presentation] 肝移植後C型肝炎再燃に対するIFN治療の現況とSVR率改善のための検討 (2010)
  • Author(s): 河岡友和, 高橋祥一, 田代裕尊, 大段秀樹, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-27
• [Presentation] C型慢性肝炎患者におけるILB28多型とウイルス側および宿主側因子との関連 (2010)
  • Author(s): 今村道雄, 越智秀典, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-27
• [Presentation] B型慢性肝炎の治療 (2010)
  • Author(s): 茶山一彰
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟市
  • Year and Date: 2010-04-24
• [Presentation] MRIによる肝線維化の評価 (2010)
  • Author(s): 橋本義政, 高木慎太郎, 石井康隆, 川瀬理恵, 小酒慶一, 寺崎元美, 永井健太, 中土井鋼一, 野田育江, 村上英介, 宮木大輔, 長沖祐子, 石田友希, 片村嘉男, 平松憲, 脇浩司, 相方浩, 高橋祥一, 茶山一彰, 福田浩
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟市
  • Year and Date: 2010-04-24
• [Presentation] ミラノ基準内Child A、B肝細胞癌症例に対する肝切除、ラジオ波治療後の予後から見た肝移植適応時期の検討 (2010)
  • Author(s): 片村嘉男, 高橋祥一, 茶山一彰
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟市
  • Year and Date: 2010-04-24
• [Presentation] 当院における生体肝移植ドナーの術後経過および診療の現況 (2010)
  • Author(s): 高木慎太郎, 大段秀樹, 茶山一彰
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟市
  • Year and Date: 2010-04-23
• [Presentation] C型慢性肝炎に対するインターフェロン治療におけるILB28多型とCore領域変異の影響 (2010)
  • Author(s): 今村道雄, 越智秀典, 茶山一彰
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟市
  • Year and Date: 2010-04-23
• [Presentation] 肝外転移合併肝細胞癌に対するS1 based全身化学療法の検討 (2010)
  • Author(s): 相方浩, 片村嘉男, 橋本義政, 長沖祐子, 河岡友和, 高木慎太郎, 平松憲, 脇浩司, 川上由育, 高橋祥一, 茶山一彰
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟市
  • Year and Date: 2010-04-22
• [Presentation] in vitro,in vivoモデルを用いた多剤耐性HBVに対する抗ウイルス効果の検討 (2010)
  • Author(s): 柘植雅貴, 平賀伸彦, 茶山一彰
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟市
  • Year and Date: 2010-04-22
• [Presentation] B型・C型肝炎合併CKD患者におけるステロイド薬、免疫抑制薬使用に関する考え方 (2010)
  • Author(s): 茶山一彰
  • Organizer: 第40回日本腎臓学会西部学術大会
  • Place of Presentation: 広島市(招待講演)
• [Presentation] Professor of Research, BCLC Group.Liver Unit, IDIBAPS, Barcelona Josep M Llovet (2009)
  • Author(s): 茶山一彰
  • Organizer: MDHCC update Seminar
  • Place of Presentation: Boston, USA
  • Year and Date: 2009-11-01
• [Presentation] C型慢性肝炎治療の最前線～次世代の治療薬を見据えて～ (2009)
  • Author(s): 茶山一彰
  • Organizer: JDDW 2009
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-10-14
• [Presentation] ヒト肝細胞キメラマウスを用いた治療抵抗性の肝炎に関する研究 (2009)
  • Author(s): 茶山一彰
  • Organizer: 第27回 犬山シンポジウム
  • Place of Presentation: 愛知
  • Year and Date: 2009-08-06
• [Presentation] C型肝癌根治後のPegIFN α2a 少量長期投与の可能性 (2009)
  • Author(s): 橋本義政, 川上由育, 長沖祐子, 石田友希, 横山聡栄, 片村嘉男, 光井富貴子, 河岡友和, 實藤宏美, 石飛朋和, 鍋島由宝, 平賀伸彦, 相方浩, 高橋祥一, 茶山一彰
  • Organizer: 第91回日本消化器病学会中国支部例会
  • Place of Presentation: 岡山市
  • Year and Date: 2009-06-13
• [Presentation] 肝細胞癌長期生存例の検討 (2009)
  • Author(s): 平松憲, 相方浩, 茶山一彰
  • Organizer: 第91回日本消化器病学会中国支部例会
  • Place of Presentation: 岡山市
  • Year and Date: 2009-06-13
• [Presentation] INTRAARTERIAL 5-FLUOROURACIL/INTERFERON COMBINATION THERAPY FOR HEPATOCELLULAR CARCINOMA WITH PORTAL VEIN TUMOR THROMBOSIS AND EXTRAHEPATIC METASTASES (2009)
  • Author(s): Katamura Y, Aikata H, Kimura Y, Kawaoka T, Takaki S, Waki K, Hiramatsu A, Kawakami Y, Takahashi S, Chayama K.
  • Organizer: 3rd International Kobe Liver Symposium on HCC with a JSH-ILCA Joint Scientific Session
  • Place of Presentation: 神戸市
  • Year and Date: 2009-06-06
• [Presentation] PERCUTANEOUS RADIOFREQUENCY ABLATION FOR RECURRENT HEPATOCELLULAR CARCINOMA AFTER CURATIVE TREATMENT : RESULTS AND PROGNOSTIC FACTORS ON LONG-TERM FOLLOW-UP (2009)
  • Author(s): Waki K, Aikata H, Nagaoki Y, Kimura Y, Hashimoto Y, Katamura Y, Kawaoka T, Takaki S, Hiramatsu A, Takahashi S, Chayama K.
  • Organizer: 3rd International Kobe Liver Symposium on HCC with a JSH-ILCA Joint Scientific Session
  • Place of Presentation: 神戸
  • Year and Date: 2009-06-06
• [Presentation] THE USEFULNESS OF SONAZOID CONTRAST-ENHANCEDULTRASONOGRAPHY FOR GROSS CLASSIFICATION OF HEPATOCELLULAR CARCINOMA (2009)
  • Author(s): Takaki S, Aikata H, Nagaoki Y, Kimura Y, Hashimoto Y, Katamura Y, Kawaoka T, Hiramatsu A, Waki K, Takahashi S, Chayama K.
  • Organizer: 3rd International Kobe Liver Symposium on HCC with a JSH-ILCA Joint Scientific Session
  • Place of Presentation: 神戸市
  • Year and Date: 2009-06-06
• [Presentation] ANALYSIS OF CLINICAL FEATURES OF PATIENTS WITH HEPATOCELLULAR CARCINOMA SURVIVING MORE THAN 10 YEARS (2009)
  • Author(s): Hiramatsu A, Aikata H, Nagaoki Y, Kimura Y, Hashimoto Y, Katamura Y, Kawaoka T, Takaki S, Waki K, Takahashi S, Chayama K
  • Organizer: 3rd International Kobe Liver Symposium on HCC with a JSH-ILCA Joint Scientific Session
  • Place of Presentation: 神戸市
  • Year and Date: 2009-06-06
• [Presentation] 当院で治療した急性肝不全患者50例の成因と予後 (2009)
  • Author(s): 平松憲, 高橋祥一, 石田友希, 片村嘉男, 河岡友和, 高木慎太郎, 柘植雅貴, 脇浩司, 今村道雄, 川上由育, 兵庫秀幸, 相方浩, 田代裕尊, 板本敏行, 大段秀樹, 茶山一彰
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2009-06-04
• [Presentation] 肝細胞癌根治療法後の初回再発癌に対するRFA の治療成績 (2009)
  • Author(s): 脇浩司, 相方浩, 石田友希, 片村嘉男, 阿座上隆広, 河岡友和, 高木慎太郎, 平松憲, 今村道雄, 川上由育, 高橋祥一, 茶山一彰
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2009-06-04
• [Presentation] 非アルコール性脂肪性肝炎の臨床病態とAGE-RAGE axis の関連性 (2009)
  • Author(s): 石飛朋和, 兵庫秀幸, 山岸昌一, 竹内正義, 石田友希, 鍋島由宝, 茶山一彰
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2009-06-04
• [Presentation] B型慢性肝疾患における Lamivudine, Adefovir 併用療法の治療効果と薬剤血中濃度との関連性の検討 (2009)
  • Author(s): 光井富貴子, 柘植雅貴, 河岡友和, 實藤宏美, 畠山剛, 北村正輔, 平賀伸彦, 今村道雄, 川上由育, 相方浩, 高橋祥一, 茶山一彰
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2009-06-04
• [Presentation] 肝外転移合併肝細胞癌に対するTS-1/CDDP併用療法 (2009)
  • Author(s): 片村嘉男, 相方浩, 石田友希, 阿座上隆広, 河岡友和, 高木慎太郎, 脇浩司, 平松憲, 川上由育, 高橋祥一, 茶山一彰
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2009-06-04
• [Presentation] 肝細胞癌に対するシスプラチン/リピオドールを用いた経カテーテル的肝動脈化学塞栓術において, アナフィラキシー症状を起こした症例の検討 (2009)
  • Author(s): 河岡友和, 相方浩, 石田友希, 片村嘉男, 阿座上隆広, 高木慎太郎, 平松憲, 脇浩司, 今村道雄, 川上由育, 高橋祥一, 茶山一彰
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2009-06-04
• [Presentation] C型肝炎ウイルスのクリアランスと感染持続における HLA-DRB1 対立遺伝子の影響 (2009)
  • Author(s): 大石和佳, 林奉権, 楠洋一郎, 藤原佐枝子, 茶山一彰
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2009-06-04
• [Presentation] C型慢性肝委患者血清中の欠損型 HCV ゲノムの同定とその臨床的意義の解析 (2009)
  • Author(s): 畠山剛, 柘植雅貴, 阿部弘美, 北村正輔, 光井富貴子, 平賀伸彦, 今村道雄, 川上由育, 相方浩, 高橋祥一, 茶山一彰
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2009-06-04
• [Presentation] 肝癌組織における fluorouracil 関連遺伝子の検討 (2009)
  • Author(s): 阿座上隆広, 川上由育, 石田友希, 片村嘉男, 河岡友和, 實藤宏美, 平松憲, 脇浩司, 相方浩, 高橋祥一, 有広光司, 大段秀樹, 茶山一彰
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2009-06-04
• [Presentation] HCV感染マウスを用いた Telaprevir の抗ウイルス効果の検討 (2009)
  • Author(s): 平賀伸彦, 今村道雄, 岩尾英治, 柘植雅貴, 光井富貴子, 河岡友和, 實藤宏美, 高橋祥一, 茶山一彰
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2009-06-04
• [Presentation] 食道静脈瘤患者のマネージメントにおけるMDCTによる門脈系再構築画像の有用性 (2009)
  • Author(s): 相方浩, 児玉英章, 片村嘉男, 河岡友和, 阿座上隆広, 高木慎太郎, 平松憲, 脇浩司, 今村道雄, 川上由育, 高橋祥一, 茶山一彰
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2009-06-04
• [Presentation] 慢性肝疾患に対する生体肝移植後の効果的な抗ウイルス療法と術後胆管狭窄に対する対策 (2009)
  • Author(s): 高橋祥一, 河岡友和, 茶山一彰
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2009-06-04
• [Presentation] HBs抗体に対する escape mutant の出現とその解析 (2009)
  • Author(s): 柘植雅貴, 高橋祥一, 高木慎太郎, 石田友希, 片村嘉男, 阿座上隆広, 河岡友和, 實藤宏美, 光井富貴子, 平賀伸彦, 平松憲, 脇浩司, 今村道雄, 川上由育, 兵庫秀幸, 相方浩, 茶山一彰
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2009-06-04
• [Presentation] APOBEC3B遺伝子の欠失多型がB型肝炎ウイルスの持続感染と病態に及ぼす影響 (2009)
  • Author(s): 阿部弘美, 越智秀典, 前川敏郎, 藤本佳史, 柘植雅貴, 今村道雄, 平賀伸彦, 高橋祥一, 茶山一彰
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2009-06-04
• [Presentation] 治療方針のコンセンサス (2009)
  • Author(s): 茶山一彰, 今村道雄, 高橋祥一
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2009-06-04
• [Presentation] HCVCOre, ISDRのアミノ酸変異とPEG-IFN+リバビリン療法の治療成績およびHCV感染モデルマウスを用いたウイルス学的検討 (2009)
  • Author(s): 今村道雄, 平賀伸彦, 茶山一彰
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2009-06-04
• [Presentation] Evaluation of long-term entecavir (ETV) treatment in chronic hepatitis B (CHB) patients swiched from 24 weeks lamivudine (LVD) therapy (2009)
  • Author(s): Tsuge M, Chayama K, Shindo M, Toyota J, Mochida S, Tomita E, Kumada H, Yamada G, Yatsuhashi H, Sata M, Yokosuka O, Hayashi N, Ishikawa H, Seriu T, Omata M.
  • Organizer: APASL
  • Place of Presentation: 香港
  • Year and Date: 2009-06-04
• [Presentation] 当科における食道静脈瘤破裂の治療成績と標準化に向けた治療方針 (2009)
  • Author(s): 児玉英章, 相方浩, 阿座上隆広, 片村嘉男, 河岡友和, 高木慎太郎, 平松憲, 脇浩司, 今村道雄, 川上由育, 高橋祥一, 茶山一彰
  • Organizer: 第77回 日本消化器内視鏡学会総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2009-05-21
• [Presentation] 非アルコール性脂肪性肝炎(NASH)の診断・経時的変化に終末糖化産物が有用である可能性について (2009)
  • Author(s): 兵庫秀幸, 田妻進, 茶山一彰
  • Organizer: 第95回日本消化器病学会総会
  • Place of Presentation: 札幌市
  • Year and Date: 2009-05-07
• [Presentation] 生体肝移植後のウイルス肝炎に対する治療 (2009)
  • Author(s): 河岡友和, 高橋祥一, 茶山一彰
  • Organizer: 第95回日本消化器病学会総会
  • Place of Presentation: 札幌市
  • Year and Date: 2009-05-07
• [Presentation] B型肝癌根治治療後の核酸アナログ投与による肝癌再発抑制効果の検討 (2009)
  • Author(s): 平松憲, 相方浩, 茶山一彰
  • Organizer: 第95回日本消化器病学会総会
  • Place of Presentation: 札幌市
  • Year and Date: 2009-05-07
• [Presentation] PEG-I FNα-2b/Ribavirin 併用療法におけるHCVcore 抗体価比を指標とした治療期間の設定 (2009)
  • Author(s): 川上由育, 高橋祥一, 茶山一彰
  • Organizer: 第95回日本消化器病学会総会
  • Place of Presentation: 札幌市
  • Year and Date: 2009-05-07
• [Presentation] in vitro, in vivo モデルを用いた核酸アナログに対するHBVの抗ウイルス効果の検討 (2009)
  • Author(s): 柘植雅貴, 今村道雄, 茶山一彰
  • Organizer: 第95回日本消化器病学会総会
  • Place of Presentation: 札幌市
  • Year and Date: 2009-05-07
• [Presentation] 進行肝細胞癌に対するIFN併用5FU肝動注療法における、門脈腫瘍栓への3次元体放射線照射併用の意義 (2009)
  • Author(s): 相方浩, 片村嘉男, 茶山二彰
  • Organizer: 第95回日本消化器病学会総会
  • Place of Presentation: 札幌市
  • Year and Date: 2009-05-07
• [Presentation] 非アルコール性脂肪性肝炎(NASH)の拾い上げに糖代謝異常が重要である可能性について (2009)
  • Author(s): 石田友希, 兵庫秀幸, 鍋島肉宝, 石飛朋和, 長沖祐子, 橋本義政, 片村嘉男, 高木慎太郎, 脇浩司, 平松憲, 相方浩, 高橋祥一, 茶山一彰
  • Organizer: 第91回日本消化器病学会中国支部例会
  • Place of Presentation: 岡山市
• [Remarks] ホームページ
  • URL: http://home.hiroshima-u.ac.jp/naika1/
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/naika1/
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/naika1/
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/nbard/biom/saisei.htm
• [Remarks]
  • URL: http://www.src.riken.go.jp/group/liver/index.html
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/naikal/
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/nbard/biom/saisei.htm
• [Remarks]
  • URL: http://www.src.riken.go.jp/group/liver/index.html