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The therapeutic potentials of ghrelin in cardiovascular diseases-roles of the autonomic nervous system

Research Project

Project/Area Number 21390252
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

KISHIMOTO Ichiro  独立行政法人国立循環器病研究センター, 糖尿病・代謝内科, 医長 (80312221)

Co-Investigator(Kenkyū-buntansha) TOKUDOME Takeshi  独立行政法人国立循環器病研究センター, 生化学部, 室長 (00443474)
KANGAWA Kenji  独立行政法人国立循環器病研究センター, 研究所, 所長 (00112417)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2009: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywordsグレリン / 心臓保護 / 自律神経 / 心筋梗塞 / 心不全 / 交感神経 / 糖尿病 / 肥満 / 生理活性ペプチド / 迷走神経
Research Abstract

Ghrelin is an endogenous ligand for the growth-hormone secretagogues receptor(GHS-R). In addition to its role in the regulation of growth hormone(GH) release, the 28-amino acid peptide also stimulates food intake and induces adiposity. Since GHS-R is detected in the heart and blood vessels, the role of this peptide in the regulation of cardiovascular function has been suggested. Recently, we investigated the effect of daily peripheral ghrelin administration for 2 weeks in a rat model of myocardial infarction and found that ghrelin significantly attenuated cardiac dysfunction and remodeling induced by infarction. Interestingly, chronic administration of ghrelin dramatically suppressed the increase in heart rate and plasma noradrenaline concentration after infarction to the levels similar to sham-operated controls. The effects of ghrelin were accompanied by a decrease in the ratio of the low-to-high frequency spectra of heart rate variability. Moreover, we have also shown that one-shot subcutaneous administration of ghrelin in the very acute phase following infarction effectively rescues cardiac dysfunction/remodeling, prevents arrhythmias and significantly improves mortality. By the direct recoding of cardiac sympathetic nerve activity, it is demonstrated that early ghrelin administration suppresses cardiac sympathetic nerve activity excessively activated after infarction. Surprisingly, one-shot ghrelin administration in the acute phase of myocardial infarction improved cardiac dysfunction and sympathetic hyperactivity in the chronic phase. It is, therefore, suggested that ghrelin is potentially useful as a novel therapy for heart failure, arrhythmia and death in myocardial infarction, with its unique mechanism of action.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (52 results)

All 2012 2011 2010 2009 Other

All Journal Article (36 results) (of which Peer Reviewed: 21 results) Presentation (14 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Reduced ghrelin production induced anorexia after rat gastric ischemia and reperfusion2012

    • Author(s)
      Mogami S, Suzuki H, Fukuhara S, Matsuzaki J, Kangawa K, Hibi T
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol

      Volume: 302(3)

    • URL

      http://ajpgi.physiology.org/content/early/2011/11/18/ajpgi.00297.2011

    • Related Report
      2011 Final Research Report
  • [Journal Article] Ghrelin and cardiovascular diseases2012

    • Author(s)
      Kishimoto I, Tokudome T, Hosoda H, Miyazato M, Kangawa K
    • Journal Title

      J Cardiology

      Volume: 59 Issue: 1 Pages: 8-13

    • DOI

      10.1016/j.jjcc.2011.11.002

    • NAID

      10019807283

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transgenic overexpression of intraislet ghrelin does not affect insulin secretion or glucose metabolism in vivo2012

    • Author(s)
      Bando M, Nakao K, et al
    • Journal Title

      Am. J. Physiol. Endocrinol. Metab.

      Volume: 302 Issue: 4 Pages: 403-408

    • DOI

      10.1152/ajpendo.00341.2011

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induced pluripotent stem cells generated from diabetic patients with mitochondrial DNA A3243G mutation2012

    • Author(s)
      J.Fujikura, M.Sone, K.Hosoda, K.Nakao, et al
    • Journal Title

      Diabetologia

      Volume: (in press) Issue: 6 Pages: 1689-1698

    • DOI

      10.1007/s00125-012-2508-2

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Defining Patients at Extremely High Risk for Coronary Artery Disease in Heterozygous Familial Hypercholesterolemia2012

    • Author(s)
      Sugisawa T, Okamura T, Makino H, Watanabe M, Kishimoto I, Miyamoto Y, Iwamoto N, Yamamoto A, Yokoyama S, Harada-Shiba M
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 19 Issue: 4 Pages: 369-375

    • DOI

      10.5551/jat.11536

    • NAID

      130004444603

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Natriuretic peptide system : an overview of studies using genetically engineered animal models2011

    • Author(s)
      Kishimoto I, Tokudome T, Nakao K and Kangawa K
    • Journal Title

      FEBS Journal

      Volume: 278 Issue: 11 Pages: 1830-1841

    • DOI

      10.1111/j.1742-4658.2011.08116.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of guanylyl cyclase-A signaling in the cardiovascular system2011

    • Author(s)
      Saito Y, Kishimoto I, Nakao K
    • Journal Title

      Can J Physiol Pharmacol

      Volume: 89(8) Issue: 8 Pages: 551-556

    • DOI

      10.1139/y11-022

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] 摂食・エネルギー調節に関わる生理活性ペプチドの機能と糖尿病やメタボリックシンドロームを標的とした創薬展開2011

    • Author(s)
      岸本一郎
    • Journal Title

      実験医学増刊代謝・内分泌ネットワークと医薬応用

      Volume: 29(5)

    • URL

      http://www.yodosha.co.jp/jikkenigaku/book/9784758103138/

    • Related Report
      2011 Final Research Report
  • [Journal Article] 内因性ナトリウム利尿ペプチドの虚血組織血管新生促進作用2011

    • Author(s)
      徳留健,岸本一郎,寒川賢治
    • Journal Title

      治療

      Volume: 93 Pages: 686-688

    • NAID

      40018739233

    • URL

      http://jglobal.jst.go.jp/detail.php?JGLOBAL_ID=201102206638182146

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] ナトリウム利尿ペプチドと肥満・インスリン抵抗性2011

    • Author(s)
      岸本一郎, 槇野久士, 徳留健, 寒川賢治
    • Journal Title

      実験医学増刊代謝・内分泌ネットワークと医薬応用

      Volume: 29 Pages: 194-201

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 禁煙をはじめとする動脈硬化性因子の管理-ASOの診療は,血流障害だけではない!-脂質異常症専門医の立場から2011

    • Author(s)
      岩本紀之, 岸本一郎
    • Journal Title

      治療

      Volume: 93 Pages: 619-622

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 禁煙をはじめとする動脈硬化性因子の管理-ASOの診療は,血流障害だけではない!-糖尿病専門医の立場から-動脈硬化性因子の管理-2011

    • Author(s)
      泰江慎太郎, 岸本一郎
    • Journal Title

      治療

      Volume: 93 Pages: 616-618

    • Related Report
      2011 Annual Research Report
  • [Journal Article] メタボリックシンドロームの病態診断インスリン抵抗性の評価法高インスリン正常血糖クランプ法,SSPG法,ミニマルモデル法(メタボリックシンドローム(第2版)--基礎・臨床の最新知見)--(検査・診断)Approaches of assessing insulin resistance : euglycemic glucose clamp, steady state plasma glucose, and minimal model2011

    • Author(s)
      槇野久士, 宮本恵宏, 岸本一郎
    • Journal Title

      日本臨床

      Volume: 69 Pages: 473-477

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Association of plasma B-type natriuretic peptide levels with obesity in a general urban Japanese population: the Suita Study2010

    • Author(s)
      Sugisawa T, Kishimoto I, Kokubo Y, Makino H, Miyamoto Y, Yoshimasa Y
    • Journal Title

      Endocrine Journal

      Volume: 57 Issue: 8 Pages: 727-733

    • DOI

      10.1507/endocrj.K10E-067

    • NAID

      130004443639

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Visceral fat is negatively associated with B-type natriuretic peptide levels in patients with advanced type 2 diabetes2010

    • Author(s)
      Sugisawa T, Kishimoto I, Kokubo Y, Nagumo A, Makino H, Miyamoto Y, Yoshimasa Y
    • Journal Title

      Diabetes Research and Clinical Practice

      Volume: 89 Issue: 2 Pages: 174-180

    • DOI

      10.1016/j.diabres.2010.03.012

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vasodilator therapy with hydralazine induces angiotensin AT receptor-mediated cardiomyocyte growth in mice lacking guanylyl cyclase-A2010

    • Author(s)
      Li Y, Saito Y, Kuwahara K, Rong X, Kishimoto I, Harada M, Horiuchi M, Murray M, Nakao K
    • Journal Title

      Br J Pharmacol

      Volume: 159 Issue: 5 Pages: 1133-1142

    • DOI

      10.1111/j.1476-5381.2009.00619.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 内因性ナトリウム利尿ペプチドの虚血組織血管新生における役割2010

    • Author(s)
      徳留健,岸本一郎,寒川賢治
    • Journal Title

      The Journal of Japanese College of Angiology

      Volume: 50 Pages: 169-174

    • NAID

      10026911904

    • URL

      http://www.jc-angiology.org/journal/pdf/2010/169.pdf

    • Related Report
      2011 Final Research Report
  • [Journal Article] 内因性ANP・BNPによる血管新生,血管恒常性維持機構2010

    • Author(s)
      徳留健,岸本一郎,山原研一,新藤隆行,川上速人,白井幹康,寒川賢治
    • Journal Title

      血管

      Volume: 33 Pages: 75-80

    • NAID

      10027705041

    • URL

      http://pgx.medic.mie-u.ac.jp/upload/p4_zf20110201144112.pdf

    • Related Report
      2011 Final Research Report
  • [Journal Article] グレリンの心血管作用とその機序2010

    • Author(s)
      岸本一郎,徳留健,寒川賢治
    • Journal Title

      循環器内科

      Volume: 67 Pages: 171-177

    • URL

      http://www.kahyo.com/item/J201002-672

    • Related Report
      2011 Final Research Report
  • [Journal Article] SPring-8高輝度放射光を用いた小動物の心臓・血管機能の画像解析2010

    • Author(s)
      白井幹康, James Pearson, Daryl Schwenke,曽野部崇,藤井豊,吉本光佐,徳留健,清水壽一郎,寒川賢治,梅谷啓二,八木直人
    • Journal Title

      循環器研究の進歩

      Volume: 30(1) Pages: 70-82

    • URL

      http://jglobal.jst.go.jp/public/20090422/201002296524328312

    • Related Report
      2011 Final Research Report
  • [Journal Article] Association of plasma B-type natriuretic peptide levels with obesity in a general urban Japanese population : the Suita Study.2010

    • Author(s)
      Sugisawa T, Kishimoto I, Kokubo Y, Makino H, Miyamoto Y, Yoshimasa Y.
    • Journal Title

      Endocr J.

      Volume: 57(8) Pages: 727-33

    • NAID

      10029585994

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visceral fat is negatively associated with B-type natriuretic peptide levels in patients with advanced type 2 diabetes.2010

    • Author(s)
      Sugisawa T, Kishimoto I, Kokubo Y, Nagumo A, Makino H, Miyamoto Y, Yoshimasa Y.
    • Journal Title

      Diabetes Res Clin Pract.

      Volume: 89(2) Pages: 174-80

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vasodilator therapy with hydralazine induces angiotensin AT receptor-mediated cardiomyocyte growth in mice lacking guanylyl cyclase-A.2010

    • Author(s)
      Li Y, Saito Y, Kuwahara K, Rong X, Kishimoto I, Harada M, Horiuchi M, Murray M, Nakao K
    • Journal Title

      Br J Pharmacol. 5

      Pages: 45-51

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased circulating CD34+cells are associated with progression of diabetic nephropathy2009

    • Author(s)
      Makino H, Okada S, Nagumo A, Sugisawa T, Miyamoto Y, Kishimoto I, Kikuchi-Taura A, Soma T, Taguchi A, Yoshimasa Y
    • Journal Title

      Diabet Med

      Volume: 26(2) Issue: 2 Pages: 171-173

    • DOI

      10.1111/j.1464-5491.2008.02638.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Guanylyl cyclase-A inhibits angiotensin II type 2 receptor-mediated pro-hypertro phic signaling in the heart2009

    • Author(s)
      Li Y, Saito Y, Kuwahara K, Rong X, Kishimoto I, Harada M, Adachi Y, Nakanishi M, Kinoshita H, Horiuchi M, Murray M, Nakao K
    • Journal Title

      Endocrino logy

      Volume: 150(8) Issue: 8 Pages: 3759-3765

    • DOI

      10.1210/en.2008-1353

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Natriuretic peptides enhance the production of adiponectin in human adipo cytes and in patients with chronic heart failure2009

    • Author(s)
      Tsukamoto O, Fujita M, Kato M, Yamazaki S, Asano Y, Ogai A, Okazaki H, Asai M, Nagamachi Y, Maeda N, Shintani Y, Minamino T, Asakura M, Kishimoto I, Funahashi T, Tomoike H, Kitakaze M
    • Journal Title

      J Am Coll Cardiol

      Volume: 53(22) Issue: 22 Pages: 2070-2077

    • DOI

      10.1016/j.jacc.2009.02.038

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Natriuretic Peptide Signaling via Guanylyl Cyclase(GC)-A : An Endogenous Protective Mechanism of the Heart2009

    • Author(s)
      Kishimoto I, Tokudome T, Horio T, Garbers DL, Nakao K and Kangawa K
    • Journal Title

      Current Cardiology Reviews

      Volume: 5 Issue: 1 Pages: 45-51

    • DOI

      10.2174/157340309787048068

    • Related Report
      2011 Final Research Report
  • [Journal Article] Impaired recovery of blood flow after hind-limb ischemia in mice lacking guanylyl cyclase-a, a receptor for atrial and brain natriuretic peptides2009

    • Author(s)
      Tokudome T, Kishimoto I, Yamahara K, Osaki T, Minamino N, Horio T, Sawai K, Kawano Y, Miyazato M, Sata M, Kohno M, Nakao K, Kangawa K
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 29 Issue: 10 Pages: 1516

    • DOI

      10.1161/atvbaha.109.187526

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic potentials of ghrelin in cardiac diseases2009

    • Author(s)
      Kishimoto I, Tokudome T, Schwenke DO, Soeki T, Hosoda Y, Nagaya N and Kangawa K
    • Journal Title

      Expert Review of Endocrinology and Metabolism

      Volume: 4 Issue: 3 Pages: 283-289

    • DOI

      10.1586/eem.09.7

    • Related Report
      2011 Final Research Report
  • [Journal Article] グレリン2009

    • Author(s)
      宮里幹也,岸本一郎,寒川賢治
    • Journal Title

      Heart View

      Volume: 13(12) Pages: 99-104

    • URL

      http://www.medicalview.co.jp/catalog/MAGA17542-09-11-0.html

    • Related Report
      2011 Final Research Report
  • [Journal Article] Therapeutic potentials of ghrelin in cardiac diseases.2009

    • Author(s)
      Kishimoto I, Tokudome T, Schwenke DO, Soeki T, Hosoda Y, Nagaya N, Kangawa K
    • Journal Title

      Expert Review of Endocrinology and Metabolism 4(3)

      Pages: 283-289

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired Recovery of Blood Flow After Hind-Limb Ischemia in Mice Lacking Guanylyl Cyclase-A, a Receptor for Atrial and Brain Natriuretic Peptides.2009

    • Author(s)
      Tokudome T, Kishimoto I, Yamahara K, Osaki T, Minamino N, Horio T, Sawai K, Kawano Y, Miyazato M, Sata M, Kohno M, Nakao K, Kangawa K
    • Journal Title

      Arterioscler Thromb Vasc Biol. 29

      Pages: 1516-21

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Natriuretic Peptide Signaling via Guanylyl Cyclase(GC)-A : An Endogenous Protective Mechanism of the Heart.2009

    • Author(s)
      Kishimoto I, Tokudome T, Horio T, Garbers DL, Nakao K, Kangawa K
    • Journal Title

      Current Cardiology Reviews 5

      Pages: 45-51

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Natriuretic peptides enhance the production of adiponectin in human adipocytes and in patients with chronic heart failure.2009

    • Author(s)
      Tsukamoto O, Fujita M, Kato M, Yamazaki S, Asano Y, Ogai A, Okazaki H, Asai M, Nagamachi Y, Maeda N, Shintani Y, Minamino T, Asakura M, Kishimoto I, Funahashi T, Tomoike H, Kitakaze M
    • Journal Title

      J Am Coll Cardiol. 53

      Pages: 2070-7

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Guanylyl cyclase-A inhibits angiotensin II type 2 receptor-mediated pro-hypertrophic signaling in the heart.2009

    • Author(s)
      Li Y, Saito Y, Kuwahara K, Rong X, Kishimoto I, Harada M, Adachi Y, Nakanishi M, Kinoshita H, Horiuchi M, Murray M, Nakao K
    • Journal Title

      Endocrinology. 150

      Pages: 3759-65

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased circulating CD34+ cells are associated with progression of diabetic nephropathy.2009

    • Author(s)
      Makino H, Okada S, Nagumo A, Sugisawa T, Miyamoto Y, Kishimoto I, Kikuchi-Taura A, Soma T, Taguchi A, Yoshimasa Y
    • Journal Title

      Diabet Med. 26

      Pages: 171-3

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Cardiovascular Protective Roles of the Natriuretic Peptide System2012

    • Author(s)
      岸本一郎
    • Organizer
      第76回日本循環器学会学術集会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2012-03-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cardiovascular significance of the natriuretic peptide sytem2011

    • Author(s)
      岸本一郎
    • Organizer
      第16回世界心臓病学会議
    • Place of Presentation
      第16回世界心臓病学会議
    • Year and Date
      2011-07-26
    • Related Report
      2011 Final Research Report
  • [Presentation] Cardiovascular Significance of the Natriuretic Peptide System2011

    • Author(s)
      岸本一郎
    • Organizer
      第16回世界心臓病学会議
    • Place of Presentation
      Hyatt Regency Vancouver
    • Year and Date
      2011-07-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 2型糖尿病患者の血中B型ナトリウムペプチド(BNP)に及ぼす体格指数(BMI)と腹部脂肪面積の影響2010

    • Author(s)
      岸本一郎
    • Organizer
      第47回日本臨床分子医学会学術集会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2010-04-11
    • Related Report
      2011 Final Research Report
  • [Presentation] The role of natriuretic peptide/GC-A in obesity-related diseases2010

    • Author(s)
      岸本一郎
    • Organizer
      国際心血管内分泌代謝シンポジウム
    • Place of Presentation
      奈良県新公会堂
    • Year and Date
      2010-04-01
    • Related Report
      2011 Final Research Report
  • [Presentation] 肥満関連疾患におけるナトリウム利尿ペプチド/GC-Aの役割2010

    • Author(s)
      岸本一郎
    • Organizer
      第14回日本心血管内分泌代謝学会学術総会
    • Place of Presentation
      奈良県新公会堂
    • Year and Date
      2010-03-31
    • Related Report
      2011 Final Research Report
  • [Presentation] The cardiac natriuretic pept ides/guanylyl cyclase-A sign aling path way in cardiovasc ular/metabolic disease2010

    • Author(s)
      岸本一郎
    • Organizer
      第14回国際内分泌学会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2010-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] The cardiac natriuretic peptides/guanylyl cyclase-A signaling pathway in cardiovascular/metabolic diseases2010

    • Author(s)
      岸本一郎
    • Organizer
      第14回国際内分泌学会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] The therapeutic potentials of ghrelin in cardiovascular diseases2009

    • Author(s)
      岸本一郎
    • Organizer
      グレリン国際シンポジウム2009
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2009-11-20
    • Related Report
      2011 Final Research Report
  • [Presentation] The therapeutic potentials of ghrelin in cardiovascular diseases(心血管疾患におけるグレリンの治療可能性)2009

    • Author(s)
      岸本一郎
    • Organizer
      グレリン国際シンポジウム2009
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2009-11-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] メタボリックシンドロームとその関連腎症におけるナトリウム利尿ペプチド情報伝達系の関与2009

    • Author(s)
      岸本一郎
    • Organizer
      第45回高血圧関連疾患モデル学会学術総会
    • Place of Presentation
      東京ステーションコンファレンス
    • Year and Date
      2009-09-04
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] グレリンの心臓保護作用とその機序-自律神経系の関与2009

    • Author(s)
      岸本一郎
    • Organizer
      第6回GPCR研究会
    • Place of Presentation
      日本科学未来館
    • Year and Date
      2009-05-08
    • Related Report
      2011 Final Research Report
  • [Presentation] グレリンの心臓保護作用とその機序-自律神経系の関与2009

    • Author(s)
      岸本一郎
    • Organizer
      GPCR研究会
    • Place of Presentation
      日本科学未来館
    • Year and Date
      2009-05-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] 内因性ナトリウム利尿ペプチド系の血管形成における新たな意義とその機序2009

    • Author(s)
      岸本一郎、徳留健、寒川賢治
    • Organizer
      第82回日本内分泌学会学術総会
    • Place of Presentation
      群馬県民会館
    • Year and Date
      2009-04-23
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Book] メタボリックシンドロームの病態診断 インスリン抵抗性の評価法 高インスリン正常血糖クランプ法,SSPG法,ミニマルモデル法(メタボリックシンドローム(第2版)-基礎・臨床の最新知見)--(検査・診断)2011

    • Author(s)
      槇野久士, 宮本恵宏, 岸本一郎
    • Total Pages
      992
    • Publisher
      日本臨床社
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://hospital.ncvc.go.jp/section/department/c001/c001-basic-res.html

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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