Mechanisms of cardiovascular-renal connection on life-style diseases
| Project/Area Number |
21390259
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
ITO Sadayoshi 東北大学, 大学院・医学系研究科, 教授 (40271613)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Takefumi 東北大学, 医学系研究科, 准教授 (40375001)
ABE Michiaki 東北大学, 病院, 助教 (40400246)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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|---|
| Keywords | メチルグリオキサール / 腎血行動態 / 酸化ストレス / インスリン抵抗性 / 高血圧 / 尿細管 / ミトコンドリア / カルボニル物質 / 糖尿病 |
|---|
| Research Abstract |
Present study determined the mechanisms of cardiovascular renal injury in CKD and the role of MG. 1%MG in drinking water was administered to Dahl salt sensitive rats exhibited increase in blood pressure associated with cardiovascular-renal injury. Cerebrovascular renal injury was observed in high salt fed stroke-prone spontaneously hypertensive rats, which was associated with blood pressure and oxidative stress. Glucose induced mitochondrial oxidative stress was observed in the tubules of juxtamedullary nephron, which was inhibited in glyoxalase 1 trangenic rats, indicating that carbonyl stress is responsible for glucose mediated renal injury
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Report
(4 results)
Research Products
(86 results)
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[Journal Article] 心腎連関2011
Author(s)
鳴海かほり、森建文、伊藤貞嘉
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Journal Title
Cardiovascular Frontier
Volume: 2(4)
Pages: 268-272
NAID
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[Presentation] 心腎連関と尿酸2011
Author(s)
伊藤貞嘉
Organizer
第34回日本高血圧学会(招待講演)
Place of Presentation
宇都宮
Year and Date
2011-10-22
Related Report
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[Presentation] 心腎連関と尿酸2011
Author(s)
伊藤貞嘉
Organizer
第34回日本高血圧学会
Place of Presentation
宇都宮(招待講演)
Year and Date
2011-10-22
Related Report
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[Presentation] 内分泌性高血圧2011
Author(s)
伊藤貞嘉
Organizer
日本内科学会生涯教育講演会
Place of Presentation
山形(招待講演)
Year and Date
2011-09-11
Related Report
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[Presentation] 進化と腎臓2011
Author(s)
伊藤貞嘉
Organizer
第20回日本小児泌尿器科学会教育講演
Place of Presentation
秋田(招待講演)
Year and Date
2011-07-15
Related Report
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[Presentation] CKDと高血圧2011
Author(s)
伊藤貞嘉
Organizer
日本内科学会信越支部第44回生涯教育講演会
Place of Presentation
長野(招待講演)
Year and Date
2011-06-26
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