| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Research Abstract |
In renal cortex, prostaglandin E_2(PGE_2) is released from the macula densa of distal tubules and functions as an autacoid responsible for the regulation of tubuloglomerular feedback and renin release from the juxtaglomerular apparatus. However, the molecular mechanisms through which released PGE_2 is removed and PGE_2 signal is turned off have not been understood. By using knockout mice in which the gene for the novel prostaglandin-specific transporter OAT-PG is disrupted, this study has addressed the questions. The results in this study indicate that OAT-PG is the transporter responsible for the local prostaglandin clearance in renal cortex.
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