Analysis of molecular mechanisms and large-scale epidemiological study for tobacco smoke-related skin aging and diseases
| Project/Area Number |
21390326
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Nagoya City University |
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Principal Investigator |
MORITA Akimichi 名古屋市立大学, 大学院・医学研究科, 教授 (30264732)
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Akira 名古屋市立大学, 大学院・医学研究科, 講師 (00319708)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | 環境因子 / 喫煙 / 紫外線 / 皮膚老化 / 乾癬 / 掌蹠膿疱症 |
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| Research Abstract |
The JAGE study(study of the extrinsic skin aging of JApanese and GErman women) is a cross-sectional study to investigate the possible reasons for differences in the manifestation of extrinsic skin aging between Asian and Caucasian European women. Japanese women had significantly more pigment spots on their cheeks than German women. In contrast, Japanese women had fewer wrinkles. The pigmentation was related to smoking and air pollution. Tobacco smoking increases the risk of psoriasis, but the mechanisms are not clear. We evaluated the percentage of circulating Th17.More smokers than nonsmokers had high Th17 levels. Tobacco smoke extract induced Th17 generation from central memory T cells in vitro. Epidemiologic studies suggest a link between smoking and extrinsic skin aging, and we previously reported that matrix metalloproteinases(MMPs) mediate connective tissue damage in skin exposed to tobacco smoke extracts. Tobacco smoke contains more than 3800 constituents, including numerous wat
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er insoluble polycyclic aromatic hydrocarbons that trigger the aryl hydrocarbon receptor(AhR ; also called the dioxin receptor) signaling pathway. To analyze the molecular mechanisms involved in tobacco smoke. induced skin aging, we exposed primary human fibroblasts and keratinocytes to tobacco smoke extracts. Hexane-and water-soluble tobacco extracts significantly induced MMP-1 mRNA in both human cultured fibroblasts and keratinocytes in a dose-dependent manner. To clarify the involvement of the AhR pathway, we used stable knockdown cell lines for AhR in HaCaT cells. AhR knockdown abolished the increase in transcription of the AhR-dependent gene CYP1A1/CYP1B1 and MMP-1 upon treatment with either tobacco smoke extract. Likewise, treating fibroblasts with AhR pathway inhibitors blocked the induction of CYP1B1 and MMP-1.These findings suggest that the tobacco smoke extracts induced MMP-1 expression in human fibroblasts and keratinocytes via activation of the AhR pathway. Thus, the AhR pathway may be pathogenetically involved in extrinsic skin aging. Less
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Report
(4 results)
Research Products
(70 results)
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[Journal Article] Lack of promoting effect of titanium dioxide particles on chemically-induced skin carcinogenesis in rats and mice2012
Author(s)
Yoko Sagawa1, 2, Mitsuru Futakuchi2, Jiegou Xu2, 3, Katsumi Fukamachi2, Yuto Sakai2, 4, Yoshiaki Ikarashi5, Tetsuji Nishimura5, Masumi Suzui2, Hiroyuki Tsuda3, and Akimichi Morita1
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Journal Title
J Toxicological Science
Volume: 37
Pages: 317-327
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[Journal Article] Lack of promoting effect of titanium dioxide particles on ultraviolet B-initiated skin carcinogenesis in rats2011
Author(s)
J Xu, Y Sagawa, M Futakuchi, K Fukamachim, DB Alexander, F Furukawa, Y Ikarashi, T Uchino, T Nishimura, A Morita, M Suzui, H Tsuda
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Journal Title
Food and Chemical Toxicology
Volume: 49
Pages: 1298-1302
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[Journal Article] Association between sun-exposure, smoking behaviour and plasma antioxidant levels with the different manifestation of skin ageing signs between Japanese and German women-a pilot study2011
Author(s)
Dany Perner, Andrea Vierkootter, Dorothea Sugiri, Mary Matsui, Ulrich Ranft, Charlotte Esser, Stephane Etheeve, Regina Goralczyk, Natsumi Kaneko, Ai Yamamoto, Akimichi Morita, Ursula Kraamer and Jean Krutmann
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Journal Title
J Dermatol Sci
Volume: 62
Pages: 138-140
Related Report
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[Journal Article] Lack of promoting effect of titanium dioxide particles on ultraviolet B-initiated skin carcinogenesis in rats2011
Author(s)
J Xu, Y Sagawa, M Futakuchi, K Fukamachim, DB Alexander, F Furukawa, Y Ikarashi, T Uchino, T Nishimura, A Morita, M Suzzui, H Tsuda
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Journal Title
Food and chemical Toxicology
Volume: 49
Pages: 1298-1302
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Peer Reviewed
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[Journal Article] The development of a filter to enhance the efficacy and safety of excimer light(308 nm) therapy2009
Author(s)
Keiko Kobayashi, Yoko Yasuda, Yoichi Shintani, Taku Sumitomo, Takashi Saga, Makoto Kimura, Aya Yamamoto, Toshio Mori, Akira Maeda, Yuji Yamaguchi, Akimichi Morita
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Journal Title
Photoderm Photoimmunol Photomedicin
Volume: 25
Pages: 30-36
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[Journal Article] The development of a filter to enhance the efficacy and safety of excimer light(308nm)therapy2009
Author(s)
Keiko Kobayashi, Yoko Yasuda, Yoichi Shintani, Taku Sumitomo, Takashi Saga, Makoto Kimura, Aya Yamamoto, Toshio Mori, Akira Maeda, Yuji Yamaguchi, Akimichi Morita
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Journal Title
Photoderm Photoimmunol Photomedicin 25
Pages: 30-36
Related Report
Peer Reviewed
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[Presentation] Ethnic differences in skin ageing between Japanese versus Caucasian women : The JAGE study2009
Author(s)
Akimichi Morita, Vierkotter, A. Kramer, U. Ranft, U. Sugiri, D. Momna, T. Kaneko, N. Yamamoto, A. Matusi, M. Krutmann, J.
Organizer
15th International Congress of Photobiology
Place of Presentation
Dusseldorf, Germany
Related Report
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[Presentation] Ethnic differences in skin ageing between Japanese versus Caucasian women : The JAGE study2009
Author(s)
Akimichi Morita, Vierkotter, A.Kramer, U.Ranft, U.Sugiri, D.Momna, T.Kaneko, N.Yamamoto, A.Matusi, M.Krutmann, J.
Organizer
15th International Congress of Photobiology
Place of Presentation
Dinseldorf, Germany
Related Report
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