Development of a novel prophylaxis for the post-cardiopulmonary bypass lung injury by a pharmacological leukocyte control

• Project/Area Number: 21390384
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: University of Tsukuba
• Principal Investigator: GOTO Yukinobu 筑波大学, 医学医療系, 講師 (20451700)
• Co-Investigator(Kenkyū-buntansha): HIRAMATSU Yuji 筑波大学, 医学医療系, 准教授 (30302417) ; AGEYAMA Naohide 独立行政法人医薬基盤研究所, 霊長類研究所, 研究員 (50399458) ; SAKAKIBARA Yuzuru 筑波大学, 医学医療系, 教授 (60192085) ; TOKUNAGA Chiho 筑波大学, 医学医療系, 講師 (30451701)
• Project Period (FY): 2009 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 呼吸器外科 / 心臓血管外科 / 病態生理学 / 体外循環 / 肺傷害 / 白血球 / 骨髄 / 肺障害

Research Abstract

We have applied a well-established method to assess the BM reactionin vivo in monkeys. This method proved to be a model relevant for humans by showing the release of PMN and monocytes from the BM to be quantified and their T_<1/2> in the circulation pool to be estimated. Using this technique, we confirmed that CPB accelerates the release of leukocytes (PMN and monocytes) from the BM and showed their delayed recruitment to the lungs. We postulate that the behavior of BM-derived leukocytes following CPB, rather than of circulating leukocytes, plays an important role in the pathogenesis of post-CPB lung injury as a part of a whole-body inflammatory reaction.

Research Products

• [Presentation] Cardiopulmonary Bypass Accelerates Bone-marrow Leukocyte Release And Recruitment Into The Lung In Primate Model. (2012)
  • Author(s): Goto Y, Hiramatsu Y, Ageyama N, Sato S, Kobayashi N, Suzuki H, Sakai M, Kanemoto S, Onizuka M., Sato Y., Sakakibara Y
  • Organizer: American Thoracic Society International Conference. 2012;169:K83
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2012-05-20
• [Presentation] Bone-marrow-derived Leukocyte Induced by Cardiopulmonary Bypass Recruit into the Lung in Our Established Primate Model (2011)
  • Author(s): Goto Y, Hiramatsu Y, Ageyama N, Kobayashi N, Sakai M, Onizuka M, Sato Y, Kanemoto S, Sakakibara Y
  • Organizer: General Thoracic and Cardiovascular Surgery 2011;59:171 (Outstasnding Works).
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-10
• [Presentation] Bone-marrow-derived Leukocytes Induced by Cardiopulmonary Bypass Recruit into the Lung in Our Established Primate Model (2011)
  • Author(s): 後藤行延
  • Organizer: 第64回日本胸部外科学会定期学術集会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-10
• [Presentation] A novel primate model to study bone-marrow-derived leukocyte kinetics induced by cardiopulmonary bypass (2010)
  • Author(s): Goto Y., Hiramatsu Y., Ageyama N., Sato S., Sakai M., Onizuka M., Sato Y., Sakakibara Y
  • Organizer: Chest. 2010; 138: 580A.
  • Place of Presentation: VANCOUVER,BC,CANADA
  • Year and Date: 2010-11-03
• [Presentation] A Novel Primate Model to Study Bone-marrow-derived Leukocyte Kinetics Induced by Cardiopulmonary Bypass (2010)
  • Author(s): 後藤行延
  • Organizer: CHEST2010
  • Place of Presentation: VANCOUVER, BC, CANADA
  • Year and Date: 2010-11-03
• [Presentation] Cardiopulmonary Bypass Accelerates Bone-marrow Leukocyte Release And Recruitment Into The Lung In Primate Model
  • Author(s): 後藤行延
  • Organizer: American Thoracic Society International Conference. 2012
  • Place of Presentation: San Francisco, USA
• [Remarks]
  • URL: http://www.md.tsukuba.ac.jp/clinical-med/respiratory/
• [Remarks] 筑波大学呼吸器外科ホームページ
  • URL: http://www.md.tsukuba.ac.jp/clinical-med/respiratory/
• [Remarks]
  • URL: http://www.md.tsukuba.ac.jp/clinical-med/respiratory/
• [Remarks]
  • URL: http://www.md.tsukuba.ac.jp/clinical-med/respiratory/