| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2009: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
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| Research Abstract |
To prove out hypothesis that cell-of-origin of synovial sarcomas(SS) is neural crest derived cells, we established transgenic mice in which the expression of SS-specific fusion gene, SYT-SSX was induced in neural crest cells using the P0 gene as a driver. The expression of fusion gene in utero inhibited the development of craniofacial bone and cartilage tissues causing stillbirth. Then we established inducible transgenic mice using tamoxifen-ER system. Treatment with tamoxifen successfully induced the expression of SYT-SSX and also its downstream gene in P0 positive cells, indicating that this mouse model is a useful tool to understand the development of synovial sarcomas.
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