| Project/Area Number |
21390434
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Osaka University |
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Principal Investigator |
MASHIMO Takashi 大阪大学, 大学院・医学系研究科, 教授 (10110785)
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| Co-Investigator(Kenkyū-buntansha) |
SHIBATA Masahiko 大阪大学, 大学院・医学系研究科, 寄附講座教授 (50216016)
INOUE Takaya 大阪大学, 大学院・医学系研究科, 助教 (00335358)
SAKAUE Gaku 大阪大学, 大学院・医学系研究科, 助教 (70379254)
NAKAE Aya 大阪大学, 大学院・医学系研究科, 特任准教授(常勤) (60379170)
MATSUDA Yoichi 大阪大学, 大学院・医学系研究科, 助教 (00397754)
SUMITANI Masahiko 東京大学, 医学部附属病院, 助教 (80420420)
KITA Shinichi 神戸大学, 大学院・人文学研究科, 准教授 (10224940)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2009: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | 神経障害性疼痛 / 情動異常 / α2Aアドレノ受容体 / モルヒネ耐性 / セロトニン2C受容体 / RNA編集 / CRPS / 注意 / 錯視 / 共感 / 催眠 / 情動行動異常 / α2アドレナリン受容体 / アドレナリン受容体サブタイズ / 脊髄損傷 / 5-HT受容体 / うつ / 筋肉痛 / fMRI / 帯状回 / 脳ペインマトリックス |
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| Research Abstract |
Nerve injury triggered affective disturbances such as depression and anxiety that appeared much later than sensory hypersensitivity in mice. The alpha-2A adrenergic receptor may play a role in the neural mechanism of affective disturbances. Systemic daily morphine enhanced the analgesic effect of intrathecal dexmedetomidine via up-regulation of the alpha-2A,-2B and-2C adrenergic receptors in lumber dorsal root ganglion and dorsal horn in mice. In the trigeminal neuropathic pain model rats, intrathecal serotonin 2C receptor agonists produced antiallodynic effect. This effect was attenuated by intrathecal pretreatment with the serotonin 2C receptor antagonist. These results indicate that the serotonin 2C receptor plays a role in spinal inhibition of trigeminal neuropathic pain
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