| Budget Amount *help |
¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2009: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Research Abstract |
Disruption of the blood-labyrinthine barrier was evaluated by the degree of Gd contrast enhancement of the inner ear in suddensensorineural hearing loss. There were ears with significant Gd enhancenment but there were also ears without Gd enhancement. Disruption of the blood-labyrinthine barrier may be associated with impairment of the blood vessels, inflammation and oxidative stress. The relevant gene polymorphisms were investigated in patients with sudden sensorineural hearing loss and in controls. Polymorphisms of interleukin-1A (rs1800587), interleukin-6 (rs1061170), complement factor H (rs1061170), aquaporin5 (rs3736309) and NO synthase 3 (rs1799983) seemed to be related to onset of sudden sensorineural hearing loss.交付決定額
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