Studies on inhibitory effects of the monoclonal antibodies to NHA2 on alveolar bone resorption
| Project/Area Number |
21390516
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Kyushu University (2010-2011)
Hiroshima University (2009) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NIKAWA Hiroki 広島大学, 大学院・医歯薬学総合研究科, 教授 (10228140)
SATODA Takahiro 広島大学, 大学院・医歯薬学総合研究科, 教授 (80170801)
YUGE Lois 広島大学, 大学院・保健学研究科, 教授 (20263676)
TERADA Yoshihiro 九州大学, 大学院・歯学研究院, 教授 (30038898)
SHINOHARA Yoshinori 九州大学, 大学院・歯学研究院, 助教 (00423533)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | 骨吸収 / 破骨細胞 / 補綴処置 / NHA2 / メカニカルストレス / NHE10 / RANKL / モノクローナル抗体 |
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| Research Abstract |
The functions of NHA2 during osteoclast differentiation were investigated using the monoclonal antibodies(anti-NHA2 mAb). The data suggest that NHA2 is involved in cell-cell fusion during osteoclast differentiation. On the other hand, mechanical loading conditions result in alveolar bone resorption. Therefore, we investigated the effects of anti-NHA2 mAb on osteoblast and osteoclast differentiation under mechanical loading. However, the data was not enough for conclusion.。
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Report
(4 results)
Research Products
(60 results)
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[Journal Article] Fumio Suehiro Evaluation of trabecular bone formation in a canine model surrounding a dental implant fixture immobilized with an antimicrobial peptide derived from histatin. Journal of Materials Science2011
Author(s)
Seicho Makihira, Hiroki Nikawa, Takahiro Shuto, Masahiro Nishimura, Yuichi Mine, Koichiro Tsuji, Keishi Okamoto, Yuhiro Sakai, Masanori Sakai, Naoya Imari, Satoshi Iwata, Mika Takeda
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Journal Title
Materials in Medicine
Volume: 22
Pages: 2765-2772
Related Report
Peer Reviewed
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[Presentation] 口腔インプラントに固定化した新規塩基性抗菌ペプチド(JH8194)の骨増生効果Part II in vivo解析2010
Author(s)
竹田美佳,坂井将典,牧平清超,西村正宏,坂井裕大,首藤崇裕,峯裕一,岩田慧,今利直也,末廣史雄,二川浩樹,辻紘一郎
Organizer
第32回日本バイオマテリアル学会大会
Place of Presentation
広島
Related Report
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[Presentation] Amilorideが破骨細胞の分化に与える影響2009
Author(s)
宮井良介,牧平清超,二川浩樹,岡崎昌太,峯裕一,山口裕,河原和子,野宗万喜,原久美子,松本厚枝,仁井谷善恵
Organizer
第60回中国地区歯科医学大会
Place of Presentation
広島
Year and Date
2009-10-25
Related Report
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[Presentation] 天野秀昭新規抗菌ペプチドJH8194がヒト間葉系幹細胞の増殖に与える影響2009
Author(s)
河村卓,牧平清超,二川浩樹,河原和子,西村正宏,下江宰司,玉本光弘,村山長,里田隆博,竹本俊伸,杉山勝
Organizer
第60回中国地区歯科医学大会
Place of Presentation
広島
Year and Date
2009-10-25
Related Report
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