Translational research of hard tissue regeneration using physiologically active substances
| Project/Area Number |
21390533
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
FUJIMURA Kazuma 京都大学, 医学研究科, 准教授 (30252399)
OKUBO Yasunori 京都大学, 医学研究科, 講師 (50378618)
SONOBE Junya 京都大学, 医学研究科, 講師 (50464219)
KOYAMA Noriaki 京都大学, 医学研究科, 助教 (30599931)
NAKAO Kazumasa 京都大学, 医学研究科, 医員 (40599932)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
|
|---|
| Keywords | 軟骨 / C型ナトリウム利尿ペプチド / 骨形成 / 間葉系幹細胞 / アドレノメデュリン / 軟骨形成 / CNP |
|---|
| Research Abstract |
C-type natriuretic peptide(CNP) promotes endchondral bone growth by acting chondrocytes directly to increase the size of chondrocytes and the space extracellular space. In addition, CNP affects bone formation by acting osteoblasts directly.
Adult dental pulp and exfoliated deciduous teeth pulp-derived mesenchymal stem cells compared with bone marrow-derived mesenchymal stem cells, osteogenic differentiation potentials were high.
Adrenomedullin didn' t affect on osteodifferentiation.
|
Report
(4 results)
Research Products
(42 results)
-
-
-
-
[Journal Article] BMP-2 Gene Transfer under Various Conditions with in vivo Electroporation and Bone Induction2012
Author(s)
H.Yamamoto, M.Kawai, N.Shiotsu, M.Watanabe, Y.Yoshida, M.Suzuki, H.Maruyama, J.Miyazaki, M.Ikegami, K.Bessho, T.Yamamoto
-
Journal Title
Asian Jornal of Oral and Maxillofacial Surgery
Volume: (IN PRESS)
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] BMP-2 Gene Transfer under Various Conditions with in vivo Electrop oration and Bone Induction
Author(s)
H. Yamamoto, M. Kawai, N. Shiotsu, M. Watanabe, Y. Yoshida, M. Suzuki, H. Maruyama, J. Miyazaki, M. Ikegami, K. Bessho, T. Yamamot
-
Journal Title
Asian Jornal of Oral and Maxillofacial Surgery
Volume: (IN PRESS)
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Book] Targets in Gene Therapy2011
Author(s)
Osawa K, Okubo Y, Nakao K, Koyama N, Bessho K
Total Pages
8
Publisher
Feasibility of BMP-2 Gene Therapy Using an Ultra-Fine Needle
Related Report
-
-
-
-
-
-
