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Translational research of hard tissue regeneration using physiologically active substances

Research Project

Project/Area Number 21390533
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionKyoto University

Principal Investigator

BESSHO Kazuhisa  京都大学, 医学研究科, 教授 (90229138)

Co-Investigator(Kenkyū-buntansha) FUJIMURA Kazuma  京都大学, 医学研究科, 准教授 (30252399)
OKUBO Yasunori  京都大学, 医学研究科, 講師 (50378618)
SONOBE Junya  京都大学, 医学研究科, 講師 (50464219)
KOYAMA Noriaki  京都大学, 医学研究科, 助教 (30599931)
NAKAO Kazumasa  京都大学, 医学研究科, 医員 (40599932)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Keywords軟骨 / C型ナトリウム利尿ペプチド / 骨形成 / 間葉系幹細胞 / アドレノメデュリン / 軟骨形成 / CNP
Research Abstract

C-type natriuretic peptide(CNP) promotes endchondral bone growth by acting chondrocytes directly to increase the size of chondrocytes and the space extracellular space. In addition, CNP affects bone formation by acting osteoblasts directly.
Adult dental pulp and exfoliated deciduous teeth pulp-derived mesenchymal stem cells compared with bone marrow-derived mesenchymal stem cells, osteogenic differentiation potentials were high.
Adrenomedullin didn' t affect on osteodifferentiation.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (50 results)

All 2012 2011 2010 2009 Other

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (26 results) Book (2 results) Remarks (4 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Innovative Collagen Nano-Hydroxyapatite Scaffolds Offer a Highly Efficient Non-Viral Gene Delivery Platform for Stem Cell-Mediated Bone Formation.2012

    • Author(s)
      C. M. Curtin, G. M. Cunniffe, F. G. Lyons, K. Bessho, G. R. Dickson, G. P. Duffy, F. J. O' Brien
    • Journal Title

      Advanced Materials

      Volume: 24 Issue: 6 Pages: 749-754

    • DOI

      10.1002/adma.201103828

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Id2 controls chondrogenesis acting downstream of BMP signaling during maxillary morphogenesis2012

    • Author(s)
      Sakata-Goto T
    • Journal Title

      Bone

      Volume: 50 Issue: 1 Pages: 69-78

    • DOI

      10.1016/j.bone.2011.09.049

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 筋突起に生じた骨軟骨種の1例2012

    • Author(s)
      高藤洋之、藤村和磨、高橋克、家森正志、大久保康則、別所和久
    • Journal Title

      日本口腔外科学会雑誌

      Volume: 57 Pages: 25-29

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] BMP-2 Gene Transfer under Various Conditions with in vivo Electroporation and Bone Induction2012

    • Author(s)
      H.Yamamoto, M.Kawai, N.Shiotsu, M.Watanabe, Y.Yoshida, M.Suzuki, H.Maruyama, J.Miyazaki, M.Ikegami, K.Bessho, T.Yamamoto
    • Journal Title

      Asian Jornal of Oral and Maxillofacial Surgery

      Volume: (IN PRESS)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bessho Experimental Study of Osteoinduction Using a New Material as a Carrier for Bone Morphogenetic Protein-22011

    • Author(s)
      N. Koyama, Y. Okubo, K. Nakao, K. Osawa, K.
    • Journal Title

      Br J Oral Maxillofac Surg

      Volume: 49(4) Issue: 4 Pages: 314-8

    • DOI

      10.1016/j.bjoms.2010.05.010

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pluripotency of Mesenchymal Cells Derived from Synovial Fluid in Patients with Temporomandibula Joint Disordar2011

    • Author(s)
      N. Koyama, Y. Okubo, K. Nakao, K. Osawa, K. Bessho
    • Journal Title

      Life Science

      Volume: 89 Issue: 19-20 Pages: 741-5

    • DOI

      10.1016/j.lfs.2011.09.005

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Social Nicotine Dependence in Australian Dental Undergraduate Students2011

    • Author(s)
      B. Huang, K. Inagaki, C. Yoshii, M. Kano, P. V. Abbott, T. Noguchi, K. Takahashi, K. Bessho
    • Journal Title

      International Dental Journal

      Volume: 61 Issue: 3 Pages: 152-6

    • DOI

      10.1111/j.1875-595x.2011.00032.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of Different Surgery Modalities to Correct Class III Jaw Deformities on the Pharyngeal Airway Space2011

    • Author(s)
      T. F. Abdelrahman, K. Takahashi, K. Tamura, K. Nakao, K. M. Hassanein, A. Alsuity, H. Maher, K. Bessho
    • Journal Title

      The Journal of Craniofacial Surgery

      Volume: 22 Issue: 5 Pages: 1598-1601

    • DOI

      10.1097/scs.0b013e31822e5fc2

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation Tongue Sensary Disturbance by Somatosensory Evoked Magnetic Fields Following Tongue Stimulation2011

    • Author(s)
      H. Maezawa, K. Yoshida, M. Matsuhashi, Y. Yokoyama, T. Mima, K. Bessho, S. Fujita, T. Nagamine, H. Fukuyama
    • Journal Title

      Neuroscience Research

      Volume: 71 Issue: 3 Pages: 244-250

    • DOI

      10.1016/j.neures.2011.07.1831

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypertension, periodontal disease, and potassium intake in nonsmoking, nondrinker African women on no medication2011

    • Author(s)
      Yamori Y.
    • Journal Title

      International Journal of Hypertension

      Volume: 2011 Pages: 1-6

    • DOI

      10.4061/2011/695719

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rigid Fixation of Intraoral Vertico-Sagittal Ramus Osteotomy for Mandibular Prognathism2011

    • Author(s)
      K. Fujimura, K. Bessho
    • Journal Title

      J Oral Maxillofac Surg

      Volume: 70 Issue: 5 Pages: 1170-3

    • DOI

      10.1016/j.joms.2011.03.010

    • NAID

      120004108330

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Osteoinduction by Repeat Plasmid Injection of Human Bone Borphogenetic Protein-22010

    • Author(s)
      K. Osawa, Y. Okubo, K. Nakao, N. Koyama, K. Bessho
    • Journal Title

      J Gene Med

      Volume: 12(12) Issue: 12 Pages: 937-44

    • DOI

      10.1002/jgm.1515

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Osteoinduction by repeat plasmid injection of human bone morp hogenetic protein-2.2010

    • Author(s)
      Osawa Kenji
    • Journal Title

      The Journal of Gene Medicine

      Volume: 12 Pages: 937-944

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Experimental study of osteoinduction using a new material as a carrier for bone morphogenetic protein-2.2010

    • Author(s)
      Koyama Noriaki
    • Journal Title

      British Journal of Oral and Maxillofacial Surgery

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteoinduction by microbable-enhanced transcutaneous sononoration by human morphogenetic protein-22009

    • Author(s)
      Osawa K, Okubo Y, Nakao K, Koyama N, Bessho K
    • Journal Title

      J Gene Med

      Volume: 11 Pages: 633-41

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Pluripotency in Human Dental Pulp Cells2009

    • Author(s)
      Koyama N, Okubo Y, Nakao K, Bessho K
    • Journal Title

      J Oral Maxillofaic Surg

      Volume: 67 Pages: 501-506

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BMP-2 Gene Transfer under Various Conditions with in vivo Electrop oration and Bone Induction

    • Author(s)
      H. Yamamoto, M. Kawai, N. Shiotsu, M. Watanabe, Y. Yoshida, M. Suzuki, H. Maruyama, J. Miyazaki, M. Ikegami, K. Bessho, T. Yamamot
    • Journal Title

      Asian Jornal of Oral and Maxillofacial Surgery

      Volume: (IN PRESS)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 喫煙・ニコチンの歯槽骨再生治療に対する影響2011

    • Author(s)
      別所和久
    • Organizer
      第26回喫煙科学研究財団助成研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-07-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 喫煙・ニコチンの歯槽骨再生治療に対する影響2011

    • Author(s)
      別所和久
    • Organizer
      第26回喫煙科学研究財団助成研究会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2011-07-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] ビスフォスフォネート製剤投与患者に発症する顎骨壊死・顎骨骨髄炎2011

    • Author(s)
      別所和久
    • Organizer
      久留米骨粗鬆症研究会
    • Place of Presentation
      久留米歯科医師会館(久留米市)(招待講演)
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 再建から美容治療へ:歯科インプラントを利用した顎顔面矯正・再建手術と口腔顎顔面再生医療2011

    • Author(s)
      別所和久
    • Organizer
      香川県保険医協会医科歯科合同セミナー
    • Place of Presentation
      高松市
    • Year and Date
      2011-03-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Osteoinduction by Ultrasound-mediated Gene Transfer of Bone Morphogenetic Protein-2.2011

    • Author(s)
      Kenji Osawa
    • Organizer
      89th General Session and Exibition of the International Association of Dental Research
    • Place of Presentation
      サンディエゴ, アメリカ
    • Year and Date
      2011-03-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Morphological analysis of maxillary deformity in Id2 KO mice2011

    • Author(s)
      Tomoko Sakata
    • Organizer
      89th General Session and Exibition of the International Association of Dental Research
    • Place of Presentation
      サンディエゴ, アメリカ
    • Year and Date
      2011-03-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Morphogenetical Analysis of Maxillary Deformity in Id2 KO mice2011

    • Author(s)
      T. Sakata-Goto, K. Takahashi, H. Kiso, B. Huang, H. Tukamoto, K. Bessho
    • Organizer
      I. A. D. R
    • Place of Presentation
      USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Osteoinduction by Ultrasound-mediated Gene Transfer of Bone Morphogenetic Protein-22011

    • Author(s)
      K. Osawa, K. Nakao, N. Koyama, K. Bessho
    • Organizer
      I. A. D. R
    • Place of Presentation
      USA
    • Related Report
      2011 Final Research Report
  • [Presentation] 医療安全管理・歯科インプラントを利用した口腔外科手術2010

    • Author(s)
      別所和久
    • Organizer
      西京歯科医師会学術講演会
    • Place of Presentation
      京都市
    • Year and Date
      2010-12-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 医療安全管理・歯科インプラントを利用した口腔外科手術2010

    • Author(s)
      別所和久
    • Organizer
      西京歯科医師会学術講演会
    • Place of Presentation
      京都市(招待講演)
    • Year and Date
      2010-12-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 抗血栓薬・ビスフォスフォネート製剤投与患者に対する歯科治療と歯科再生医療2010

    • Author(s)
      別所和久
    • Organizer
      第14回「空穂の会」学術講演会
    • Place of Presentation
      新潟市
    • Year and Date
      2010-11-13
    • Related Report
      2011 Final Research Report
  • [Presentation] 抗血栓薬・ビスフォスフォネート製剤投与患者に対する歯科治療と歯科再生医療2010

    • Author(s)
      別所和久
    • Organizer
      第14回「空穂の会」学術講演会
    • Place of Presentation
      新潟市(招待講演)
    • Year and Date
      2010-11-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] 再生医療の現状と歯科領域への応用2010

    • Author(s)
      別所和久
    • Organizer
      第40回日本口腔インプラント学会学術大会
    • Place of Presentation
      札幌市
    • Year and Date
      2010-09-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 再生医療の現状と歯科領域への応用2010

    • Author(s)
      別所和久
    • Organizer
      第40回日本口腔インプラント学会学術大会
    • Place of Presentation
      札幌市(招待講演)
    • Year and Date
      2010-09-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 歯科インプラントを利用した口腔外科手術と歯科再生医療2010

    • Author(s)
      別所和久
    • Organizer
      KIDS研究会学術講演会
    • Place of Presentation
      京都市
    • Year and Date
      2010-08-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 歯科インプラントを利用した口腔外科手術と歯科再生医療2010

    • Author(s)
      別所和久
    • Organizer
      KIDS研究会学術講演会
    • Place of Presentation
      京都市(招待講演)
    • Year and Date
      2010-08-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] ビスフォスフォネート製剤投与患者に発症する顎骨壊死・顎骨骨髄炎2010

    • Author(s)
      別所和久
    • Organizer
      久留米骨粗鬆症研究会
    • Place of Presentation
      久留米市
    • Year and Date
      2010-07-02
    • Related Report
      2011 Final Research Report
  • [Presentation] 硬組織再生医療を目指して2010

    • Author(s)
      別所和久
    • Organizer
      松本歯科大学学会特別講演会
    • Place of Presentation
      塩尻市
    • Year and Date
      2010-05-28
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 硬組織再生医療を目指して2010

    • Author(s)
      別所和久
    • Organizer
      松本歯科大学学会特別講演会
    • Place of Presentation
      塩尻市(招待講演)
    • Year and Date
      2010-05-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] ビスフォスフォネート製剤投与患者に対する歯科治療・歯科領域の再生医療の可能性2010

    • Author(s)
      別所和久
    • Organizer
      南口腔ケアセンター記念講演会
    • Place of Presentation
      京都市
    • Year and Date
      2010-04-24
    • Related Report
      2011 Final Research Report
  • [Presentation] ビスフォスフォネート製剤投与患者に対する歯科治療・歯科領域の再生医療の可能性2010

    • Author(s)
      別所和久
    • Organizer
      南口腔ケアセンター記念講演会
    • Place of Presentation
      京都市(招待講演)
    • Year and Date
      2010-04-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 抗血栓療法中患者の歯科治療・医療安全管理・歯科再生医療2010

    • Author(s)
      別所和久
    • Organizer
      福井県歯科医師学術講演
    • Place of Presentation
      福井市
    • Year and Date
      2010-04-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 抗血栓療法中患者の歯科治療・医療安全管理・歯科再生医療2010

    • Author(s)
      別所和久
    • Organizer
      福井県歯科医師学術講演
    • Place of Presentation
      福井市(招待講演)
    • Year and Date
      2010-04-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] オーラルケア・マネジメントとオーラルヘルス・マネジメント2010

    • Author(s)
      別所和久
    • Organizer
      京都西部化学療法研究会
    • Place of Presentation
      京都市
    • Year and Date
      2010-03-12
    • Related Report
      2011 Final Research Report
  • [Presentation] 硬組織再生医療の現状と臨床応用への展望2009

    • Author(s)
      別所和久
    • Organizer
      日本外傷歯学会 認定医セミナー
    • Place of Presentation
      広島市
    • Year and Date
      2009-12-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] 硬組織再生医療を目指して2009

    • Author(s)
      別所和久
    • Organizer
      第130回日本歯科保存学会2009年春期学術大会
    • Place of Presentation
      札幌市(特別講演)
    • Year and Date
      2009-06-11
    • Related Report
      2009 Annual Research Report
  • [Book] Targets in Gene Therapy2011

    • Author(s)
      Osawa K, Okubo Y, Nakao K, Koyama N, Bessho K
    • Total Pages
      8
    • Publisher
      Feasibility of BMP-2 Gene Therapy Using an Ultra-Fine Needle
    • Related Report
      2011 Annual Research Report
  • [Book] Feasibility of BMP-2 Gene Therapy Using an Ultra-Fine Needle

    • Author(s)
      K. Osawa, Y. Okubo, K. Nakao, N. Koyama, K. Bessho
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.kuhp.kyoto-u.ac.jp/%7Eoral_surg/Oral_Surg_index.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.kuhp.kyoto-u.ac.jp/%7Eoral_surg/Oral_Surg_index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.kuhp.kyoto-u.ac.jp/%7Eoral_surg/Oral_Surg_index.html

    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 歯の切削方法及び装置2011

    • Inventor(s)
      別所和久、松久寛、高橋克、東郷由弥子
    • Industrial Property Rights Holder
      別所和久、松久寛、高橋克、東郷由弥子
    • Industrial Property Number
      2011-060967
    • Filing Date
      2011-03-18
    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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