Impacts of Congenital Infections : A Birth Cohort Study in a Mid Southern Region in Vietnam

• Project/Area Number: 21406028
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Nagasaki University
• Principal Investigator: MORIUCHI Hiroyuki 長崎大学, 大学院・医歯薬学総合研究科, 教授 (90315234)
• Co-Investigator(Kenkyū-buntansha): ARIYOSHI Koya 長崎大学, 熱帯医学研究所, 教授 (30311400) ; OHSAWA Kazutaka 長崎大学, 先導生命科学研究支援センター, 教授 (90244756)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2009: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
• Keywords: 感染症 / 社会医学 / 微生物 / ウイルス / 脳神経疾患

Research Abstract

Mother-to-child infections in a mid-southern region in Vietnam were investigated in a birth cohort study. A total of 2222 pairs of mothers and their babies were enrolled. Incidences of congenital cytomegalovirus infection and congenital rubella were 0. 54% and 0. 13%, respectively. 12. 5% of mothers were hepatitis B virus(HBV) carriers, and 58. 8% of them showed evidence of current or past HBV infection. Rubella outbreak in early 2011 led to the occurrence of congenital rubella syndrome(CRS), and a total of 36 CRS babies have been investigated in their epidemiological and clinical aspects up to now.

Research Products

• [Journal Article] Maternal body mass index and gestational weight gain and their association with perinatal outcomes in Viet Nam (2011)
  • Author(s): Ota E, Haruna M, Suzuki M, Anh DD, Tho LH, Tam NTT, Thiem VD, Hien Anh NT, Isozaki M, Shibuya K, Ariyoshi K, Murashima S, Moriuchi H, Yanai H.
  • Journal Title: Bull WHO Volume: 89 Pages: 127-136
  • Peer Reviewed
• [Journal Article] Japanese Congenital Cytomegalovirus Study Group. Screening for congenital cytomegalovirus infection using newborn urine samples collected on filter paper : feasibility and outcomes from a multicenter study (2011)
  • Author(s): Koyano S, Inoue N, Oka A, Moriuchi H, Asano K, Ito Y, Yamada H, Yoshikawa T, Suzutani T
  • Journal Title: BMJ Open Volume: 1
  • Peer Reviewed
• [Journal Article] 先天性CMV感染症治療プロトコール (2011)
  • Author(s): 森内浩幸
  • Journal Title: 小児感染免疫 Volume: 22 Pages: 385-389
  • Peer Reviewed
• [Journal Article] Maternal body mass index and gestational weight gain and their association with perinatal outcomes in Viet Nam (2011)
  • Author(s): Ota E, Haruna M, Suzuki M, Anh DD, Tho LH, Tam NTT, Thiem VD, Anh HNT, Isozaki M, Shibuya K, Ariyoshi K, Murashima S, Moriuchi H, Yanai H
  • Journal Title: Bulletin of World Heath Organization Volume: 89 Pages: 127-136
  • Peer Reviewed
• [Journal Article] Screening for congenital cytomegalovirus infection using newborn urine samples collected on filter paper : feasibility and outcomes from a multicenter study (2011)
  • Author(s): Koyano S, Inoue N, Oka A, Moriuchi H, Asano K, Ito Y, Yamada H, Yoshikawa T, Suzutani T; Japanese Congenital Cytomegalovirus Study Group
  • Journal Title: BMJ Open Volume: 1
  • Peer Reviewed
• [Journal Article] 先天性CMV感染治療プロトコール (2011)
  • Author(s): 森内浩幸
  • Journal Title: 小児感染免疫 Volume: 22 Pages: 385-389
  • NAID: 10027865171
• [Journal Article] Maternal body mass index and gestational weight gain and their association with perinatal outcomes in Viet Nam. (2011)
  • Author(s): Ota E, Haruna M, Suzuki M, Anh DD, Tho LH, Tam NTT, Thiem VD, Hien Anh NT, Isozaki M, Shibuya K, Ariyoshi K, Murashima S, Moriuchi H, Yanai H.
  • Journal Title: Bull WHO Volume: 89 Pages: 127-136
  • Peer Reviewed
• [Journal Article] Seroepidemiological Survey of Cytomegalovirus Infection among Pregnant Women in Nagasaki (2010)
  • Author(s): Tagawa M, Minematsu T, Masuzaki H, Ishimaru T, Moriuchi H.
  • Journal Title: Japan. Pediatr Int Volume: 52 Pages: 459-462
  • Peer Reviewed
• [Journal Article] Detection of cytomegalovirus in preserved umbilical cord from a boy with autistic disorder (2010)
  • Author(s): Kawatani M, Nakai A, Okuno T, Kobata R, Moriuchi M, Moriuchi H, et al.
  • Journal Title: Pediatr Int Volume: 52 Pages: 304-307
  • NAID: 10028182222
  • Peer Reviewed
• [Journal Article] Seroepidemiological Survey of Cytomegalovirus Infection among Pregnant Women in Nagasaki, Japan. (2010)
  • Author(s): Tagawa M, Minematsu T, Masuzaki H, Ishimaru T, Moriuchi H.
  • Journal Title: Pediatr Int Volume: 52 Pages: 459-462
  • NAID: 10028182884
  • Peer Reviewed
• [Journal Article] Detection of cytomegalovirus in preserved umbilical cord from a boy with autistic disorder. (2010)
  • Author(s): Kawatani M, Nakai A, Okuno T, Kobata R, Moriuchi M, Moriuchi H, et al.
  • Journal Title: Pediatr Int Volume: 52 Pages: 304-307
  • NAID: 10028182222
  • Peer Reviewed
• [Journal Article] Retrospective diagnosis of congenital cytomegalovirus infection at a school for the deaf by using preserved umbilical cord (2009)
  • Author(s): Tagawa M, Tanaka H, Moriuchi M, Moriuchi H
  • Journal Title: Journal of Pediatrics 115 Pages: 749-751
  • Peer Reviewed
• [Journal Article] 免疫異常のない非低出生体重児に発症した後天性サイトメガロウイルス腸炎 (2009)
  • Author(s): 佐藤尚、永山善久、山崎肇、森内浩幸
  • Journal Title: 日本周産期・新生児医学会雑誌 45 Pages: 872-875
  • NAID: 10029090272
  • Peer Reviewed
• [Journal Article] 先天性サイトメガロウイルス感染(総説) (2009)
  • Author(s): 森内昌子、森内浩幸
  • Journal Title: 小児科 50 Pages: 103-112
• [Journal Article] サイトメガロウイルス感染症(総説) (2009)
  • Author(s): 森内昌子、森内浩幸
  • Journal Title: 診断と治療 97 Pages: 530-539
• [Presentation] A Birth Cohort Study on Congenital Cytomegalovirus Infection in Khanh HoaProvince, Vietnam (2011)
  • Author(s): Motomura H, Miyakawa M, Moriuchi M, Yoshino H, Yoshida LM, Minematsu T, Tho LH, Ariyoshi K, Anh DD, Moriuchi H.
  • Organizer: Pediatric Academic Societies(PAS)/ ASPRJoint Meeting
  • Place of Presentation: デンバー(米国)
• [Presentation] Mother-to-child transmission of cytomegalovirus and human T-cell leukemia virus (2011)
  • Author(s): Moriuchi H, Moriuchi M.
  • Organizer: PAS/ ASPR Joint Meeting
  • Place of Presentation: デンバー(米国)
• [Presentation] Emerging Pediatric Pathogens : A Symposium of Experience and Perspective Across Cultures and Continents" The View from Asia" (2011)
  • Author(s): Moriuchi H.
  • Organizer: PAS/ ASPR Joint Meeting
  • Place of Presentation: デンバー(米国)
• [Presentation] A Birth Cohort Study on Congenital Cytomegalovirus Infection in Khanh Hoa Province, Vietnam (2011)
  • Author(s): Motomura H, Miyakawa M, Moriuchi M, Yoshino H, Yoshida LM, Minematsu T, Tho LH, Ariyoshi K, Anh DD, Moriuchi H
  • Organizer: Pediatric Academic Societies/Asian Society for Pediatric Research Joint Meeting
  • Place of Presentation: デンバー(USA)
• [Presentation] Mother-to-child transmission of cytomegalovirus and human T-cell leukemia virus (2011)
  • Author(s): Moriuchi H, Moriuchi M
  • Organizer: Pediatric Academic Societies/Asian Society for Pediatric Research Joint Meeting
  • Place of Presentation: デンバー(USA)
• [Presentation] Emerging Pediatric Pathogens : A Symposium of Experience and Perspective Across Cultures and Continents "The View from Asia" (2011)
  • Author(s): Moriuchi H
  • Organizer: Pediatric Academic Societies/Asian Society for Pediatric Research Joint Meeting
  • Place of Presentation: デンバー(USA)
• [Presentation] The Incidence and Prognosis of Congenital Cytomegalovirus infection in Japan and Vietnam (2010)
  • Author(s): Miyakawa M, Doi M, Motomura H, Moriuchi M, Yoshino H, Yoshida L, Ariyoshi K, Tho LH, Anh DD, Inoue N, Moriuchi H.
  • Organizer: Asian Society for Pediatric Research(ASPR) Annual Meeting
  • Place of Presentation: 台北(台湾)
• [Presentation] A multi-center study on the treatment of congenital CMV infection in Japan (2010)
  • Author(s): Moriuchi H, Morioka I, Yamada H, Imamura T, Asano K, Oka A, et al.
  • Organizer: 3^<rd> Congenital CMV Conference
  • Place of Presentation: パリ(フランス)
• [Presentation] The Incidence and Prognosis of Congenital Cytomegalovirus infection in Japan and Vietnam. (2010)
  • Author(s): Miyakawa M, Doi M, Motomura H, Moriuchi M, Yoshino H, Yoshida L, Ariyoshi K, Tho LH, Anh DD, Inoue N, Moriuchi H.
  • Organizer: Asian Society for Pediatric Research Annual Meeting.
  • Place of Presentation: 台北(台湾)
• [Presentation] A multi-center study on the treatment of congenital CMV infection in Japan. (2010)
  • Author(s): Moriuchi H, Morioka I, Yamada H, Imamura T, Asano K, Oka A, Itoh Y, et al.
  • Organizer: 3^<rd> Congenital CMV Conference 2010
  • Place of Presentation: パリ(フランス)
• [Presentation] 全新生児を対象とした先天性サイトメガロウイルス感染スクリーニング体制の構築に向けたパイロット調査 : 長崎県における中間成績報告 (2009)
  • Author(s): 土居美智子、森内浩幸
  • Organizer: 第54回日本未熟児新生児学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-01
• [Presentation] CMV胎内感染の制御 : 診断 (2009)
  • Author(s): 森内浩幸
  • Organizer: 第16回 Japan Herpesvirus Infection Forum
  • Place of Presentation: 札幌
  • Year and Date: 2009-08-21
• [Presentation] Estimated impacts of congenital infections on children in Khanh Hoa Province, Vietnam : a pilot study (2009)
  • Author(s): Motomura H, Moriuchi M, 他
  • Organizer: Asian Society for Pediatric Research 5^<th>Congress
  • Place of Presentation: 中国 杭州
  • Year and Date: 2009-05-22
• [Presentation] ベトナム中南部における先天性トキソプラズマ・風疹・CMV感染の疫学 (2009)
  • Author(s): 森内浩幸、有吉紅也
  • Organizer: 第83回日本感染症学会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-24