| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
Neuronal circuits are formed by axons that have elongated and reached their targets. The tip of each axon, called the growth cone, explores extracellular guidance cues and can turn in the appropriate direction. In this project, we found that repulsive cues cause asymmetric endocytosis across the growth cone via cytosolic Ca^<2+> signals and that this asymmetric endocytosis is both necessary and sufficient for repulsive guidance. We also showed that a localized imbalance between endocytosis and exocytosis drives growth cone turning.
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