Finding the novel anti-metabolic syndrome treatment by examining the mechanism of improvement for lipid metabolism with hyperbaric oxygen.
| Project/Area Number |
21500685
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Saitama Medical University (2011)
The University of Tokushima (2009-2010) |
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Principal Investigator |
HOSAKA Toshio 埼玉医科大学, 医学部, 講師 (60403698)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAYA Yutaka 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (50136222)
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| Research Collaborator |
INUAKI Kouichi 杏林大学, 大学院・医学研究科, 准教授 (20333007)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 生活習慣病 / 高圧酸素療法 / 脂質代謝 / 糖代謝 / アディポカイン / フディポカイン |
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| Research Abstract |
Serum levels of free fatty acid and triglyceride, but not glucose and insulin, were significantly decreased after chronic treatments with HBA(hyperbaric air). The mRNA expressions related to lipid metabolism were significantly up-regulated in the muscle and liver. Increases in adipocytokine mRNA, which impaired lipid metabolism, were also attenuated by HBA treatment. These results suggest that exposure of HBA could have beneficial effects on lipid metabolism in patients with obesity and metabolic syndrome and then, belong to the finding of new targets of treatment.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Long-term treatment with hyperbaric air improves hyperlipidemia of db/db mice2010
Author(s)
Kiyoshi Teshigawara, Toshio Hosaka, Miwa Yamaguchi, Eri Terada, Yuka kisyuku, Keiko Fukunaga, Yohko Hirata, Bayasgalan Jambaldorj, Nagakatsu Harada, Tohru Sakai and Yutaka Nakaya
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Journal Title
The journal of medical investigation
Volume: 57(3, 4)
Pages: 224-231
NAID
Related Report
Peer Reviewed
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