| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
The pollution caused by the military use of depleted uranium and renewed interests in nuclear energy have raised increasing concern about uranium toxicity. The dose-response relationship between uranium accumulation and tissue damage, however, has not been demonstrated, primarily due to a lack of suitable analytical methodologies for measuring trace levels of uranium in tissues. In the present study, a method of analysis to reveal uranium localization in tissues was established using nano-beam elemental analysis and applied for uranium induced renal toxicity. Uranium selectively concentrated in the down stream of the proximal tubules more than 500-fold higher than the dose and caused renal apoptosis and lesions in the site.
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