| Project/Area Number |
21510226
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUEYOSHI Noriyuki 香川大学, 農学部, 准教授 (90346635)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 生体機能関連物質 / プロテオミクス / プロテインキナーゼ / シグナル伝達 / 網羅的解析 / バイオテクノロジー / モノクローナル抗体 / キノコ / ゼブラフィッシュ / 胚発生 / インスリン分泌 / 糖尿病 / 二次元電気泳動 |
|---|
| Research Abstract |
We attempted to apply the Multi-PK antibodies for the analysis of various protein kinases. By expression screening of protein kinases using the Multi-PK antibodies, we obtained various novel protein kinases from mushroom, plant, and zebrafish, and characterized them. We also developed a new technology to identify protein kinases using the Multi-PK antibodies, and identified a protein kinase responsible for glucotoxicity in diabetis. Our present study revealed that the Multi-PK antibodies can be used as the useful tools for the analysis of various protein kinases.
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