| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Research Abstract |
Spin-labeled nucleic acids, which have N-tert-butylaminoxyl group at nucleobase, were synthesized and investigated with respect to how they can monitor the structure of nucleic acids. Adjacent and opposing nucleobases affected EPR spectra of deuplex ODN containing adenine derivative, A*. EPR spectra of B-and Z-form DNA containing A* were investigated. Synthetic studies of spin-labeled C-nucleoside were also carried out with the aim of development of a novel probe which forms base pair with adenine at aminoxyl group.
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