| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
The objective of this research was to find when, where, and how the G proteins(RagA, B/C, D) regulate mTOR signal transduction pathway. Moreover, we tried to identify roles of interacting proteins of the G proteins in mTOR pathway.
We elucidated significance of Gtrlp and Gtr2p complex formation and interaction to other proteins(Ego3 and Egol) by using G protein mutant proteins.
We found that Gtrlp interacted to Torl complex proteins Kogl and Tco89 in a specific manner. Interaction between Gtrlp and Tco89p was important.
We showed that human RagA, C regulate mTOR and AMPK. It was shown that AMPK regulates mTOR. Here we found that RagA, C could be bridge proteins for mTOR and AMPK.
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