| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
We found in the developing rat adenohypophysis that primordial cells co-expressed E-and N-cadherins, but endocrine cells lost E-cadherin to possess only N-cadherin in the process of cell differentiation. This change of cadherin type, cadherin switching, was shown to play important roles in the regulated secretion of hormones by affecting cortical actin network and in the Notch signaling-mediated proliferation/differentiation of progenitor cells through differential cell adhesion.
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