Genetic analysis of dopamine signaling that regulates avoidance behavior in the nematode C. elegans
Project/Area Number |
21570187
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Molecular biology
|
Research Institution | Osaka University |
Principal Investigator |
KIMURA Kotaro 大阪大学, 大学院・理学研究科, 特任准教授 (20370116)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 分子間相互作用 / 神経機能の可塑性 / 線虫C.elegans / ドーパミン / ノルアドレナリン / 神経機能 / 可塑性 / 分子遺伝学的解析 |
Research Abstract |
Avoidance behavior of the nematode C. elegans to 2-nonanone is significantly enhanced, rather than reduced, after 1 hr-preexposure to the odor. In this project, we found that the D2-like dopamine receptor DOP-3 is required in a couple of interneurons RIC to regulate the enhancement to repulsive odor 2-nonanone in the animals. Our result may shed light on molecular mechanism of dopamine signaling that plays significant roles in regulating locomotion, emotion and learning in mammalian brain.
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Report
(4 results)
Research Products
(20 results)