| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
We have previously reported that chlorogenic acid, catechin and epicatechin were found to promote neuronal differentiation by using primary cultures of fetal rat hippocampal neurons in a serum-free medium. In this project, we evaluated brain absorption of these active compounds after oral administration to rat. Catechin was not detected in brain after catechin ingestion to rat, whereas its metabolite 3'-O-methylcatechin was observed by HPLC-ESI-MS/MS method. Our findings raise the possibility that studying the bioavailability of natural products is important to clarify the bioactive principles of their biological activities.
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