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Studies on gastrointestinal mucosa-maintaining factors produced during digestion of foods

Research Project

Project/Area Number 21580141
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionThe University of Tokushima

Principal Investigator

TANAKA Tamotsu  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (90258301)

Co-Investigator(Kenkyū-buntansha) TOKUMURA Akira  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (00035560)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords食品 / 消化管粘膜保護 / ホスファチジン酸 / 抗潰瘍 / リン脂質 / セラミド1-リン酸 / 消化管 / 粘膜上皮細胞 / 創傷治癒 / リゾボスファチジン酸 / 抗消化性潰瘍 / 粘膜上皮組織 / 細胞遊走
Research Abstract

Studies on gastrointestinal mucosa-maintaining factors in foods and digested foods were conducted. We found that phosphatidic acid(PA), a characteristic phospholipid in plant foodstuffs, effectively ameliorates aspirin-induced stomach ulcer. The lysophosphatidic acid produced by the hydrolysis of the PA was involved in the ulcer-ameliorating activity of PA. We also identified phytoceramide-1-phsphate as a novel sphingophospholipid with anti-apoptotic activity in cabbage leaves.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (31 results)

All 2012 2011 2010 2009 Other

All Journal Article (9 results) (of which Peer Reviewed: 8 results) Presentation (19 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Quantification of phosphatidic acid in foodstuffs using TLC-imaging technique2012

    • Author(s)
      T. Tanaka, A. Kassai, M. Ohmoto, K. Morito, Y. Kashiwada, Y. Takaishi, M. Urikura, J. Morishige, K. Satouchi & A. Tokumura
    • Journal Title

      J. Agric. Food Chem

      Volume: (in press) Issue: 16 Pages: 4156-4161

    • DOI

      10.1021/jf300147y

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phos-tagを用いた活性リン脂質の質量分析2012

    • Author(s)
      田中保, 他4名
    • Journal Title

      生物物理化学

      Volume: 56 s1

    • NAID

      130004809454

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intragastrically administrered lysophospatidic acid protect against gastric ulcer in rats under water-immersion restraint stress2011

    • Author(s)
      M. Adachi, G. Horiuchi, N. Ikematsu, T. Tanaka, J. Terao, K. Satouchi, A. Tokumura Dig.
    • Journal Title

      Dis. Sci

      Volume: 56 Issue: 8 Pages: 2252-2261

    • DOI

      10.1007/s10620-011-1595-0

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 胃腸障害に効く野菜のリン脂質2011

    • Author(s)
      田中保
    • Journal Title

      化学と生物

      Volume: 49 Pages: 187-192

    • NAID

      10027898722

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Intragastrically administrered lysophospatidic acid protect against gastric ulcer in rats under water-immersion restraint stress2011

    • Author(s)
      Mika Adachi, et al
    • Journal Title

      Digestive Diseases and Sciences

      Volume: 56 Pages: 2252-2261

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A clean-up technology for the simultaneous determination of lysophosphatidic acid and sphingosine-1-phosphate by matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry using a phosphate-capture molecule, Phos-tag2010

    • Author(s)
      J. Morishige, M. Urikura, H. Takagi, K. Hirano, T. Koike, T. Tanaka & K.
    • Journal Title

      Satouchi Rapid Commun. Mass Spectrom

      Volume: 24 Issue: 7 Pages: 1075-1084

    • DOI

      10.1002/rcm.4484

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A clean-up technology for the simultaneous determination of lysophosphatidic acid and sphingosine-1-phosphate by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using a phosphate-capture molecule, Phos-tag2010

    • Author(s)
      盛重純一, 他6名
    • Journal Title

      Rapid Commun.Mass Spectrom.

      Volume: 24 Pages: 1075-1084

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Formation of lysophosphatidic acid, a wound-healing lipid, during digestion ofcabbage leaves2009

    • Author(s)
      T. Tanaka, G. Horiuchi, M. Matsuoka, K. Hirano, A. Tokumura, T. Koike & K. Satouchi
    • Journal Title

      Biosci. Biotech. Biochem

      Volume: 73 Pages: 1293-1300

    • URL

      http://dx.doi.org/10.1271/bbb.80813

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Formation of lysophosphatidic acid, a wound-healing lipid, during digestion of cabbage leaves2009

    • Author(s)
      田中保, 他6名
    • Journal Title

      Biosci.Biotechnol.Biochem. 73

      Pages: 1293-1300

    • NAID

      10027542114

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ホスフグァチジン酸によるアスピリン潰瘍抑制2012

    • Author(s)
      森戸克弥
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都市(京都女子大学)
    • Year and Date
      2012-03-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] キャベツ葉中に見出されたフィトセラミド-1-リン酸の生物活性2011

    • Author(s)
      安藤千恵
    • Organizer
      第50回日本薬学会日本薬剤師会日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      高松市(サンポートホール高松)
    • Year and Date
      2011-11-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] キャベツ葉中に見出されたフィトセラミド-1-リン酸の生合成経路と生理作用2011

    • Author(s)
      田中保, 喜田孝史, 盛重純一, 安藤千恵, 山下量平、里内清, 今井博之, 長野稔, 西迫寛隆, 川添和義, 徳村彰
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都(京都国際会館)
    • Year and Date
      2011-09-22
    • Related Report
      2011 Final Research Report
  • [Presentation] キャベツ葉中に見出されたフィトセラミド-1-リン酸の生合成経路と生理作用2011

    • Author(s)
      田中保
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都市(京都国際会館)
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 種々の食材のホスファチジン酸含量と胃における消化2011

    • Author(s)
      田中保
    • Organizer
      日本脂質栄養学第20回大会
    • Place of Presentation
      坂戸市(女子栄養大学)
    • Year and Date
      2011-09-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] キャベツ葉中に見出されたフィトセラミド-1-リン酸2011

    • Author(s)
      喜田孝史
    • Organizer
      第52回日本生化学会中国・四国支部例会
    • Place of Presentation
      広島市(広島大学廣仁会館)
    • Year and Date
      2011-05-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 種々の食材中の創傷治癒性リン脂質含量2011

    • Author(s)
      葛西彩香, 木下正文, 足立美佳, 盛重純一, 瓜倉真衣, 里内清, 柏田良樹, 今林潔, 高石喜久, 田中保, 徳村彰
    • Organizer
      日本農芸化学会中四国支部第29回講演会
    • Place of Presentation
      徳島・徳島大学薬学部
    • Year and Date
      2011-01-22
    • Related Report
      2011 Final Research Report
  • [Presentation] リン酸捕獲試薬を用いた簡易リゾホスファチジン酸分析法の食品への適用2011

    • Author(s)
      盛重純一, 他6名
    • Organizer
      日本農芸化学会中四国支部第29回講演会
    • Place of Presentation
      徳島大学薬学部
    • Year and Date
      2011-01-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] メディエーターリン脂質による抗消化性潰瘍効果2011

    • Author(s)
      木下正文, 他9名
    • Organizer
      日本農芸化学会中四国支部第29回講演会
    • Place of Presentation
      徳島大学薬学部
    • Year and Date
      2011-01-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 種々の食材中の創傷治癒性リン脂質含量2011

    • Author(s)
      葛西彩香, 他10名
    • Organizer
      日本農芸化学会中四国支部第29回講演会
    • Place of Presentation
      徳島大学薬学部
    • Year and Date
      2011-01-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] キャベツ葉中に見出されたフィトセラミド-1-リン酸2010

    • Author(s)
      田中保, 他9名
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] キャベツ葉中に見出されたフィトセラミド-1-リン酸2010

    • Author(s)
      田中保, 他9名
    • Organizer
      第28回 日本農芸化学会中四国支部講演会
    • Place of Presentation
      香川大学農学部
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 抗潰瘍作用を目的とするホスホリパーゼD活性の高い野菜の有効な摂取法2010

    • Author(s)
      瓜倉真衣, 他7名
    • Organizer
      日本脂質栄養学会 第19回大会
    • Place of Presentation
      愛知県犬山市
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] キャベツ葉中に見出されたフィトセラミド-1-リン酸2010

    • Author(s)
      田中保, 他9名
    • Organizer
      第52回 日本脂質生化学会
    • Place of Presentation
      渋川市(伊香保温泉森秋旅館)
    • Year and Date
      2010-06-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] Formation of lysophosphatidic acid, a wound-healing lipid, during digestion of cabbage leaves2010

    • Author(s)
      Tamotsu Tanaka, Jun-ichi Morishige, Hiroki Kondo, Masafumi Kinoshita, Mika Adachi, Mai Urikura, Kiyoshi Satouchi, Akira Tokumura
    • Organizer
      Keystone Symposia, Bioactive lipis : Biochemistry and Diseases
    • Place of Presentation
      京都(ウエスティン都ホテル京都)
    • Year and Date
      2010-06-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Formation of lysophosphatidic acid, a wound-healing lipid, during digestion of cabbage leaves2010

    • Author(s)
      田中保, 他7名
    • Organizer
      Keystone Symposia, Bioactive lipis : Biochemistry and Diseases
    • Place of Presentation
      京都(ウエスティン都ホテル 京都)
    • Year and Date
      2010-06-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] キャベツの摂取によって胃の中で生じる創傷治癒因子としてのリゾホスファチジン酸2010

    • Author(s)
      木下正文, 他7名
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      就実大学
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 消化管で生じるリゾホスファチジン酸の胃粘膜への作用2010

    • Author(s)
      近藤宏樹, 他7名
    • Organizer
      日本農芸化学会中四国支部第26回講演会
    • Place of Presentation
      愛媛大学農学部
    • Year and Date
      2010-01-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 野菜の消化で生じるリゾホスファチジン酸2009

    • Author(s)
      田中保, 他7名
    • Organizer
      日本脂質栄養学会第18回大会
    • Place of Presentation
      東京(コクヨホール)
    • Year and Date
      2009-09-05
    • Related Report
      2009 Annual Research Report
  • [Book] Methods in Molecular Biology (S-1-P Signaling Methods and Protocols)2012

    • Author(s)
      J.Morishige, et al
    • Publisher
      Springer(in press)
    • Related Report
      2011 Annual Research Report
  • [Book] 胃腸障害に効く野菜のリン脂質2011

    • Author(s)
      田中保
    • Publisher
      社団法人日本農芸化学会
    • URL

      http://dx.doi.org/10.1271/kagakutoseibutsu.49.187

    • Related Report
      2011 Final Research Report
  • [Remarks] 今晩はこの食材できまり"キャベツ"日経ヘルスNo.146, p128-131(2010)日経BP

    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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