| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
Amyloid β proteins(Aβ) extracted from the amyloid cores of neutritic plaques are considerably isomerized at their Asp residues. To asseses the impact of D-Asp on Aβ conformation. and on initiation of amyloid fibril formation, I used wild type Aβ and D-Asp-containing Aβ which D-Asp. was substituted for L-Asp at residues 1, 7, 23. Amyloid fibril formation was enhanced by D-Asp23. Moreover, I demonstrated that D-Asp containing Aβ showed no effect on fibril formation of wild-type Aβ. Lastly, I showed that A. fragment 1-23 promoted formation of fibrils and aggregates of wild-type Aβ.
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