High accuracy numerical methods for estimation pharmacokinetics parameters from one-point concentration data.
| Project/Area Number |
21590163
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | The University of Tokushima |
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Principal Investigator |
TAKEUCHI Toshiki 徳島大学, 大学院・ソシオテクノサイエンス研究部, 教授 (30264964)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 高精度数値計算 / 非線形最適化 / 最小2乗法 / ベイズ推定 / 薬物動態解析 / 母集団パラメータ / コンパートメントモデル / ベイジアン最小2乗法 / 薬物動態 / MM消失 / PPK / 非線形最小2乗法 / TDM / 最適化 |
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| Research Abstract |
Pharmacokinetics plays an important role in efficacy and safety pharmacotherapy. The estimation of pharmacokinetics parameters from one-point concentration data is desirable. In this study, i developed a stable numerical method for nonlinear optimization in pharmacokinetics. Moreover, I applied it to the least square methods to calculate the population parameters.
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Report
(4 results)
Research Products
(20 results)
