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Mechanism and physiological role for generation of the carboxyl terminal fragment of the P/Q-type calcium channel

Research Project

Project/Area Number 21590228
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General physiology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

SAEGUSA Hironao  東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (90261205)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsCav2. 1,カルボキシ末端 / プロテアーゼ / 脊髄小脳変性症6型 / SCA6 / Cav2.1 / カルボキシ末端
Research Abstract

Generation of Cav2. 1 carboxyl terminal tail(Cav2. 1CT) is thought to be causally related to spinocerebellar ataxia type 6, a hereditary neurological disease. Cav2. 1CT is generated by cleavage of the full-length Cav2. 1 protein. But the exact mechanism underlying the generation of Cav2. 1CT and the function of this CT fragment remain to be clarified. In the present study, I have tried to clarify the mechanism to generate the Cav2. 1CT from full-length Cav2. 1 protein. Also, I have studied the functional role of the Cav2. 1CT in some in vitro systems. As a result, the following molecules are candidates for the protease responsible for the Cav2. 1CT generation : caspase 6, cathepsin L, and calpain small subunit 1, but further studies are necessary to conclude this. Cav2. 1CT was found to be toxic to cells and it is possible that Cav2. 1CT possess transcription repressing activity

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (13 results)

All 2011 2009 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Upregulation of casein kinase 1epsilon in dorsal root ganglia and spinal cord after mouse spinal nerve injury contributes to neuropathic pain2009

    • Author(s)
      Sakurai, E., Kurihara, T., Kouchi, K., Saegusa, H., Zong, S. and Tanabe, T
    • Journal Title

      Molecular Pain

      Volume: 5 Pages: 74-74

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deficit of heat shock transcription factor 1-heat shock 70 kDa protein 1A axis determines the cell death vulnerability in a model of spinocerebellar ataxia type 62009

    • Author(s)
      Li, L., Saegusa, H. and Tanabe, T
    • Journal Title

      Genes to Cells

      Volume: 14 Pages: 1253-1269

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peripheral-type benzodiazepine receptor antagonist is effective in relieving neuropathic pain in mice2009

    • Author(s)
      Kondo, D., Saegusa, H., Yabe, R., Takasaki, I., Kurihara, T., Zong, S. and Tanabe, T
    • Journal Title

      Journal of Pharmacological Science

      Volume: 110 Pages: 55-63

    • NAID

      10025736602

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of casein kinase 1 epsilon in dorsal root ganglia and spinal cord after mouse spinal nerve injury contributes to neuropathic pain2009

    • Author(s)
      Sakurai, E.
    • Journal Title

      Molecular Pain 5

      Pages: 74-74

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficit of heat shock transcription factor 1-heat shock 70kDa protein 1A axis determines the cell death vulnerability in a model of spinocerebellar ataxia type 62009

    • Author(s)
      Li, L.
    • Journal Title

      Genes to Cells 14

      Pages: 1253-1269

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peripheral-type benzodiazepine receptor antagonist is effective in relieving neuropathic pain in mice2009

    • Author(s)
      Kondo, D.
    • Journal Title

      Journal of Pharmacological Science 110

      Pages: 55-63

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Down regulation of particular miRNAs is responsible for the cell death vulnerability of Spinocerebellar ataxia type 6(SCA6)2011

    • Author(s)
      Tanabe, T, et al.
    • Organizer
      The 41st annual meeting of the Society for Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Involvement of miRNA in the pathogenesis of Spinocerebellar ataxia type 6(SCA6)2011

    • Author(s)
      Tanabe T, et al.
    • Organizer
      8th IBRO World Congress of Neuroscience
    • Place of Presentation
      Florence, Italy
    • Related Report
      2011 Final Research Report
  • [Presentation] Involvement of miRNA in the pathogenesis of spinocerebellar ataxiatype 6 (SCA6)2011

    • Author(s)
      Tsutomu Tanabe(代表)
    • Organizer
      8^<th> IBRO World Congress of Neuroscience
    • Place of Presentation
      Florence, Italy
    • Related Report
      2011 Annual Research Report
  • [Presentation] Down regulation of particular miRNAs is responsible for the cell death vulnerability of spinocerebellar ataxia type 6 (SCA6)2011

    • Author(s)
      Tsutomu Tanabe(代表)
    • Organizer
      The 41^<st> annuarl meeting of the Society for Neuroscience
    • Place of Presentation
      Wasington DC, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] Down-regulation of heat shock transcription factor 1-heat shock 70kDa protein 1A axis and increased caspase-dependent apoptosis in a cell model of spinocerebellar ataxia type 6(SCA6)2009

    • Author(s)
      Li L, et al.
    • Organizer
      日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-12-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Down-regulation of heat shock transcription factor 1-heat shock 70kDa protein 1 A axis and increased caspase-dependent apoptosis in a cell model of spinocerebellar ataxia type 6 (SCA6)2009

    • Author(s)
      Li, L.
    • Organizer
      日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/med/mphm/Yakuri.HTM

    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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