Chronic stress and depressive disorder : Research on preventive effect of odorant and its mechanism
| Project/Area Number |
21590255
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Tottori University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATO Shinsuke 鳥取大学, 医学部, 准教授 (60194817)
MICHIO Miyoshi 鳥取大学, 医学部, 助教 (20093627)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | ストレス / うつ病 / 前頭前皮質 / 海馬 / 神経新生 / doublecortin / c-fos / Zif268 / 酪酸 / 緑の香り / 強制水泳試験 / 学習性無力試験 / immobility time / failure / ラット / 視床下部 / 下垂体 / 副腎 |
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| Research Abstract |
We investigated whether inhalation of green odor(a mixture of equal amounts of trans-2-hexenal and cis-3-hexenal) cures and/or prevents the depressive disorders induced in rats. To this end, we used two behavioral models of depression, forced swim test and learned helplessness paradigms. The present results suggest that green odor has not only a therapeutic, but also a preventive effect on depressive-like states in rats.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Green odor and depressive-like state in rats : Toward an evidence-based alternative medicine?2011
Author(s)
Watanabe, T., Fujihara, M., Murakami, E., Miyoshi, M., Tanaka, Y., Koba, S. & Tachibana, H.
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Journal Title
Behavioural Brain Research
Volume: 224(2)
Pages: 290-296
Related Report
Peer Reviewed
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[Journal Article] Protective effects of ginger against aspirin-induced gastric ulcers in rats Yonago Acta medica2011
Author(s)
Wang, Z., Hasegawa, J., Wang, X., Matsuda, A., Tokuda, T., Miura, N. & Watanabe, T.
Volume
54
Pages
11-19
Related Report
Peer Reviewed
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[Journal Article] "Green odor" inhalation by rats down-regulates stress-induced increases in Fos expression in stress-related forebrain regions2009
Author(s)
Ito, A., Miyoshi, M., Ueki, S., Fukada, M., Komaki, R. and Watanabe, T.
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Journal Title
Neuroscience Research
Volume: 65(2)
Pages: 166-174
Related Report
Peer Reviewed
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