Medium chain fatty acid regulates uncoupling protein 3 expression in skeletal muscle
| Project/Area Number |
21590257
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | The University of Tokushima |
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Principal Investigator |
NIKAWA Takeshi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (20263824)
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| Co-Investigator(Kenkyū-buntansha) |
OKUMURA Yuushi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (70294725)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 栄養生理学 / 中鎖脂肪酸 / 骨格筋 / UCP / PDK4 / 肥満 |
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| Research Abstract |
Long chain fatty acids are incorporated into chylomicrons and transported trough lymph, whereas medium chain fatty acids which are transported in the portal blood directly to the liver and are consumed as energy immediately. However, the role of medium chain fatty acids on energy expenditure in skeletal muscle was unclear. In the present study, we found that the expression of uncoupling protein 3(UCP3) and pyruvate dehydrogenase kinase 4(PDK4) was increased in medium chain fatty acid-treated muscle cells. The uptake of medium chain fatty acids in FATP1-transfected cells significantly increased, compared with that in mock-transfected cells. Furthermore, the expression of UCP3 induced by medium chain fatty acid was blocked with GSK0660, a selective PPAR-δantagonist, in muscle cells. These findings suggest that medium chain fatty acids protect the obesity by a mechanism that may involve in the expression of UCP3 in skeletal muscle, resulting in increased thermoregulation.
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] Polyphenols prevent clinorotation-induced expression of atrogenes in mouse C2C12 skeletal myotubes2009
Author(s)
Hemdan DI, Hirasaka K, Nakao R, Kohno S, Kagawa S, Abe T, Harada-Sukeno A, Okumura Y, Nakaya Y, Terao J, Nikawa T
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Journal Title
J Med Invest
Volume: 56(1-2)
Pages: 26-32
NAID
URL
Related Report
Peer Reviewed
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[Journal Article] Awa(Tokushima) lactate-fermented tea as well as green tea enhance the effect of diet restriction on obesity in rats2009
Author(s)
Sogawa M, Seura T, Kohno S, Hirasaka K, Yamaguchi Y, Takagaki R, Harada A, Okumura Y, Yamamoto S, Kishi K, Nikawa T
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Journal Title
J Med Invest
Volume: 56(1-2)
Pages: 42-48
NAID
URL
Related Report
Peer Reviewed
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[Journal Article] Ubiquitin ligase Cbl-b is a negative regulator for insulin-like growth factor 1 signaling during muscle atrophy caused by unloading2009
Author(s)
Nakao R, Hirasaka K, Goto J, Ishidoh K, Yamada C, Ohno A, Okumura Y, Nonaka I, Yasutomo K, Baldwin KM, Kominami E, Higashibata A, Nagano K, Tanaka K, Yasui N, Mills EM, Takeda S, Nikawa T
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Journal Title
Mol Cell Biol
Volume: 29(17)
Pages: 4798-4811
URL
Related Report
Peer Reviewed
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