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nvestigation of the neuroendocrinological basis involved in the human paternal and maternal behaviors

Research Project

Project/Area Number 21590259
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionNagasaki University

Principal Investigator

SHINOHARA Kazuyuki  長崎大学, 大学院・医歯薬学総合研究科, 教授 (30226154)

Co-Investigator(Kenkyū-buntansha) NISHITANI Shota  長崎大学, 大学院・医歯薬学総合研究科, 助教 (50448495)
DOI Hirokaz  長崎大学, 大学院・医歯薬学総合研究科, 助教 (40437827)
Co-Investigator(Renkei-kenkyūsha) ONAKA Tat  自治医科大学, 医学部, 教授 (90177254)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsヒト / ホルモン / 前頭前野 / 母性行動 / 父性行動 / 神経内分泌学 / 脳 / 近赤外分光法(NIRS) / 神経内分泌
Research Abstract

The purpose of the present study is to determine the biological basis for paternal and maternal behavior and to clarify the characteristics of their specific brain and hormone functions. We examined whether the brain activation patterns in response to infant facial stimuli are different between parents and non-parents and between the groups divided by the oxytocin receptor gene polymorphisms in parents. First, we found that father seemed to show the brain activation different from non-fathers. Second, from our data for the time-dependent effect from pregnancy to motherhood on the maternal brain activities, we have shown the possibility that both the post partum hormones and experiences to take care of their infant contribute to the change of their brain function from nulliparous females to mothers. Finally, we have shown that the oxytocin receptor genetic polymorphisms would modulate the maternal affections.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (55 results)

All 2012 2011 2010 2009 Other

All Journal Article (23 results) (of which Peer Reviewed: 23 results) Presentation (30 results) Remarks (2 results)

  • [Journal Article] Differential prefrontal response to infant facial emotions in mothers compared with non-mothers2011

    • Author(s)
      Shota Nishitani, Hirokazu Doi, Atsuko Koyama, Kazuyuki Shinohara
    • Journal Title

      Neuroscience Research

      Volume: 70(2) Pages: 183-188

    • NAID

      120006985147

    • URL

      http://naosite.lb.nagasaki-u.ac.jp/dspace/handle/10069/25162

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neural correlates of maternal love, paternal love and children' s love for their parents2011

    • Author(s)
      Shinohara K
    • Journal Title

      Neuroscience Research(Supplement)

      Volume: 71

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 近赤外分光法(NIRS)による養育の絆に関わる神経基盤の性差2011

    • Author(s)
      西谷正太、高村恒人、藤澤隆史、篠原一之
    • Journal Title

      日本生理学雑誌

      Volume: 73(1) Pages: 22-22

    • Related Report
      2011 Annual Research Report 2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] オキシトシン受容体遺伝子多型と乳児の泣き声刺激呈示に対する反応性の違い2011

    • Author(s)
      西谷正太, 荒木萌, 井上貴雄, 藤澤隆史, 高村恒人, 篠原一之
    • Journal Title

      日本生物学的精神医学会誌

      Volume: 22 Pages: 104-104

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 近赤外分光法(NIRS)による養育の絆に関わる神経基盤の性差2011

    • Author(s)
      西谷正太, 高村恒人, 藤澤隆史, 篠原一之
    • Journal Title

      日本生理学雑誌

      Volume: 73(1) Pages: 22-22

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neural correlates of maternal love, paternal love and children's love for their parents2011

    • Author(s)
      Shinohara K
    • Journal Title

      Neuroscience Research (Supplement)

      Volume: 71

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] オキシトシン受容体遺伝子多型と乳児の泣き声刺激呈示に対する反応性の違い2011

    • Author(s)
      西谷正太、荒木萌、井上貴雄、藤澤隆史、高村恒人、篠原一之
    • Journal Title

      日本生物学的精神医学会誌

      Volume: 22 Pages: 104-104

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neural correlates of maternal love, paternal love and children' s love for their parents2010

    • Author(s)
      Kazuyuki Shinohara, Shota Nishitani
    • Journal Title

      Clin Neurophysiol(abstract)

      Volume: 121

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 近赤外分光法によるヒト養育の絆に関わる神経基盤の性差の解明2010

    • Author(s)
      西谷正太, 高村恒人, 山下翔, 藤澤隆史, 篠原一之
    • Journal Title

      日本生物学的精神医学会誌

      Volume: 21(S1) Pages: 110-110

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ヒト養育の絆に関わる神経基盤の性差2010

    • Author(s)
      西谷正太, 高村恒人, 藤澤隆史, 篠原一之
    • Journal Title

      第51回日本児童青年精神医学会総会抄録集

      Pages: 277-277

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neural correlates of maternal love, paternal love and children's love for their parents2010

    • Author(s)
      Kazuyuki Shinohara, Shota Nishitani
    • Journal Title

      Clin Neurophysiol (abstract)

      Volume: 121

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 近赤外分光法によるヒト養育の絆に関わる神経基盤の性差の解明2010

    • Author(s)
      西谷正太、高村恒人、山下翔、藤澤隆史、篠原一之
    • Journal Title

      日本生物学的精神医学会誌

      Volume: 21(S1) Pages: 110-110

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ヒト養育の絆に関わる神経基盤の性差2010

    • Author(s)
      西谷正太、高村恒人、藤澤隆史、篠原一之
    • Journal Title

      第51回日本児童青年精神医学会総会抄録集

      Pages: 277-277

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The prefrontal cortex was activated in mothers during the odor detection task of the newborn infant2009

    • Author(s)
      Shota Nishitani, Saori Kuwamoto, Asuka Takahira, Kazuyuki Shin ohara
    • Journal Title

      The Journal of Physiological Sciences(supplement)

      Volume: 59 Pages: 192-192

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 近赤外分光法によるヒト母性行動に関わる脳基盤の解明2009

    • Author(s)
      西谷正太, 馬場遥子, 吉元崇文, 大森淳子, 木佐貫芳恵, 池田英二, 土居裕和, 高村恒人, 尾仲達史, 篠原一之
    • Journal Title

      日本生気象学会雑誌(supplement)

      Volume: 46(3)

    • NAID

      10025589345

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ヒト母親の母性行動に関与する神経基盤の解明-新生児の匂い検出課題を用いた検討2009

    • Author(s)
      西谷正太, 桑本沙織, 高比良飛香, 篠原一之
    • Journal Title

      日本生理学雑誌(supplement)

      Volume: 71(3) Pages: 152-152

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 気質と前頭葉の反応性の関連における母親と未経産女性の相違:近赤外線分光法を用いた検討2009

    • Author(s)
      池田英二, 西谷正太, 大森淳子, 木佐貫芳恵, 土居裕和, 篠原一之
    • Journal Title

      日本生理学雑誌(supplement)

      Volume: 71(3) Pages: 151-151

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The prefrontal cortex was activated in mothers during the odor detection task of the newborn infant2009

    • Author(s)
      Nishitani S, Kuwamoto S, Takahira A, Shinohara K
    • Journal Title

      The Journal of Physiological Sciences(supplement) 59

      Pages: 192-192

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neural responses to emotional faces of own and others infants in human mothers2009

    • Author(s)
      Doi H, Hirase E, Arimura A, Kitamura W, Shinohara K
    • Journal Title

      Neuroscience Research(supplement) 65

      Pages: 195-195

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 近赤外分光法によるヒト母性行動に関わる脳基盤の解明2009

    • Author(s)
      西谷正太, 馬場遥子, 吉元崇文, 大森淳子, 木佐貫芳恵, 池田英二, 土居裕和, 高村恒人, 尾仲達史, 篠原一之
    • Journal Title

      日本生気象学会雑誌(supplement) 46(3)

    • NAID

      10025589345

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ヒト母親の母性行動に関与する神経基盤の解明-新生児の匂い検出課題を用いた検討2009

    • Author(s)
      西谷正太, 桑本沙織, 高比良飛香, 篠原一之
    • Journal Title

      日本生理学雑誌(supplement) 71(3)

      Pages: 152-152

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 気質と前頭葉の反応性の関連における母親と未経産女性の相違 : 近赤外線分光法を用いた検討2009

    • Author(s)
      池田英二, 西谷正太, 大森淳子, 木佐貫芳恵, 土居裕和, 篠原一之
    • Journal Title

      日本生理学雑誌(supplement) 71(3)

      Pages: 151-151

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential prefrontal response to infant facial emotions in mothers compared with non-mothers

    • Author(s)
      Shota Nishitani, Hirokazu Doi, Atsuko Koyama, Kazuyuki Shinohara
    • Journal Title

      Neuroscience Research

      Volume: (in press)

    • NAID

      120006985147

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ヒト養育に関わる前頭前野賦活に対するオキシトシン受容体遺伝子多型の影響2012

    • Author(s)
      西谷正太, 池松和哉, 篠原一之
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野
    • Year and Date
      2012-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒト養育に関わる前頭前野賦活に対するオキシトシン受容体遺伝子多型の影響2012

    • Author(s)
      西谷正太、池松和哉、篠原一之
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野・松本
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 愛着の神経基盤2011

    • Author(s)
      篠原一之, 母性愛、父性愛
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      神奈川
    • Year and Date
      2011-09-15
    • Related Report
      2011 Final Research Report
  • [Presentation] 母性愛、父性愛、愛着の神経基盤2011

    • Author(s)
      篠原一之
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      神奈川・横浜
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] オキシトシン受容体遺伝子多型と乳児の泣き声刺激呈示に対する反応性の違い2011

    • Author(s)
      西谷正太, 荒木萌, 井上貴雄, 藤澤隆史, 高村恒人, 篠原一之
    • Organizer
      第33回日本生物学的精神医学会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-21
    • Related Report
      2011 Final Research Report
  • [Presentation] オキシトシン受容体遺伝子多型と乳児の泣き声刺激呈示に対する反応性の違い2011

    • Author(s)
      西谷正太、荒木萌、井上貴雄、藤澤隆史、高村恒人、篠原一之
    • Organizer
      第33回日本生物学的精神医学会
    • Place of Presentation
      東京・港区台場
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Neural correlates of maternal love, paternal love and children' s love for their parents2010

    • Author(s)
      Kazuyuki Shinohara, Shota Nishitani
    • Organizer
      the 29th International Congress of Clinical Neurophysiology(ICCN)
    • Place of Presentation
      兵庫
    • Year and Date
      2010-11-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Neural correlates of maternal love, paternal love and children's love for their parents2010

    • Author(s)
      Kazuyuki Shinohara, Shota Nishitani
    • Organizer
      the 29th International Congress of Clinical Neurophysiology (ICCN)
    • Place of Presentation
      兵庫
    • Year and Date
      2010-11-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 母・父と子の間に築かれる絆の神経学的基盤2010

    • Author(s)
      篠原一之
    • Organizer
      第51回日本児童青年精神医学会総会
    • Place of Presentation
      群馬
    • Year and Date
      2010-10-30
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] ヒト養育の絆に関わる神経基盤の性差2010

    • Author(s)
      西谷正太, 高村恒人, 藤澤隆史, 篠原一之
    • Organizer
      第51回日本児童青年精神医学会総会
    • Place of Presentation
      群馬
    • Year and Date
      2010-10-30
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 近赤外分光法(NIRS)による養育の絆に関わる神経基盤の性差2010

    • Author(s)
      西谷正太、高村恒人、山下翔、藤澤隆史、篠原一之
    • Organizer
      第61回西日本生理学会
    • Place of Presentation
      長崎
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 近赤外分光法(NIRS)による養育の絆に関わる神経基盤の性差2010

    • Author(s)
      西谷正太, 高村恒人, 山下翔, 藤澤隆史, 篠原一之
    • Organizer
      第61回西日本生理学会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 近赤外分光法によるヒト養育の絆に関わる神経基盤の性差の解明2010

    • Author(s)
      西谷正太、高村恒人、山下翔、藤澤隆史、篠原一之
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Sex difference in the neural basis of parental bonding2010

    • Author(s)
      Shota Nishitani, Tsunehiko Takamura, Sho Yamashita, Kazuyuki Shinohara
    • Organizer
      Neuro2010
    • Place of Presentation
      兵庫
    • Year and Date
      2010-09-02
    • Related Report
      2011 Final Research Report
  • [Presentation] Sex difference in the neural basis of parental bonding2010

    • Author(s)
      Shota Nishitani, Tsunehiko Takamura, Sho Yamashita, Kazuyuki Shinohara
    • Organizer
      Neuro 2010
    • Place of Presentation
      兵庫
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト養育的絆に関わる神経基盤の性差2010

    • Author(s)
      西谷正太, 高村恒人, 山下翔, 篠原一之
    • Organizer
      第13回日本光脳機能イメージング研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-24
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Sex difference of the neural basis of the maternal and paternal attachment in humans2010

    • Author(s)
      Shota Nishitani, Tsunehiko Takamura, Sho Yamashita, Moe Araki, Kazuyuki Shinohara
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      岩手
    • Year and Date
      2010-05-21
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] The neural basis of the maternal attachment in human grandmothers2010

    • Author(s)
      Masanori Tanaka, Shota Nishitani, Tsunehiko Takamura, Masashi Sugawara, Kazuyuki Shinohara
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      岩手
    • Year and Date
      2010-05-19
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 泣き声刺激への反応性とOXTR遺伝子多型性との関連性の解明2010

    • Author(s)
      西谷正太, 荒木萌, 井上貴雄, 藤澤隆史, 高村恒人, 池松和哉, 篠原一之
    • Organizer
      第87回日本生理学会大会サテライト企画第5回環境生理学プレコングレス
    • Place of Presentation
      岩手
    • Year and Date
      2010-05-18
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] ヒト母性行動に関わる脳基盤の解明2009

    • Author(s)
      西谷正太, 馬場遥子, 吉元崇文, 大森淳子, 木佐貫芳恵, 池田英二, 土居裕和, 高村恒人, 尾仲達史, 篠原一之
    • Organizer
      第12回光脳機能イメージング研究会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-05
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] ヒト高齢者女性を対象とした養育における絆を司る脳基盤の解明2009

    • Author(s)
      田中勝則, 西谷正太, 高村恒人, 管原正志, 篠原一之
    • Organizer
      第12回光脳機能イメージング研究会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-05
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 近赤外分光法によるヒト母性行動に関わる脳基盤の解明2009

    • Author(s)
      西谷正太、馬場遥子、吉元崇文、大森淳子、木佐貫芳恵、池田英二、土居裕和、高村恒人、尾仲達史、篠原一之
    • Organizer
      第60回西日本生理学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-11-07
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 近赤外分光法(NIRS)による養育における絆に関わる脳基盤の探索2009

    • Author(s)
      田中勝則、西谷正太、高村恒人、管原正志、篠原一之
    • Organizer
      第60回西日本生理学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-11-07
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 近赤外分光法によるヒト母性行動に関わる脳基盤の解明2009

    • Author(s)
      西谷正太, 馬場遥子, 吉元崇文, 大森淳子, 木佐貫芳恵, 池田英二, 土居裕和, 高村恒人, 尾仲達史, 篠原一之
    • Organizer
      第48回日本生気象学会
    • Place of Presentation
      茨城
    • Year and Date
      2009-10-30
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] A comparative NIRS study of the prefrontal activity between mothers, non-mother nursery nurses and other non-mother females2009

    • Author(s)
      Shota Nishitani, Yoko Baba, Takefumi Yoshimoto, Atsuko Omori, Yoshie Kisanuki, Hirokazu Doi, Eiji Ikeda, Tsunehiko Takamura, Tatsushi Onaka, Kazuyuki Shinohara
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      愛知
    • Year and Date
      2009-09-18
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] ヒト母性行動の脳基盤2009

    • Author(s)
      西谷正太
    • Organizer
      第73回日本心理学会
    • Place of Presentation
      京都
    • Year and Date
      2009-08-26
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] The prefrontal cortex was activated in mothers during the odor detection task of the newborn infant2009

    • Author(s)
      Shota Nishitani, Saori Kuwamoto, Asuka Takahira, Kazuyuki Shinohara
    • Organizer
      IUPS2009
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-07-28
    • Related Report
      2011 Final Research Report
  • [Presentation] The prefrontal cortex was activated in mothers during the odor detection task of the newborn infant2009

    • Author(s)
      Nishitani S, Kuwamoto S, Takahira A, Shinohara K
    • Organizer
      IUPS2009
    • Place of Presentation
      京都
    • Year and Date
      2009-07-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト母性行動に関する脳機能の母親および未産婦の女性保育士との比較研究2009

    • Author(s)
      西谷正太, 馬場遥子, 吉元崇文, 篠原一之
    • Organizer
      第31回生物学的精神医学会
    • Place of Presentation
      京都
    • Year and Date
      2009-04-24
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 乳児の泣き声から情動を識別するときの脳活動における母親と未経産婦との差異2009

    • Author(s)
      池田英二、井上貴雄、西谷正太、土居裕和、加藤美香子、篠原一之
    • Organizer
      第31回生物学的精神医学会
    • Place of Presentation
      京都
    • Year and Date
      2009-04-24
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Remarks] 平成22年度ひらめきときめきサイエンス「頭を使うってなんだろう?光をつかって脳のはたらきを測ってみよう(HT22192)」採択・開催アウトリーチ活動情報

    • Related Report
      2011 Final Research Report
  • [Remarks] 平成23年度ひらめきときめきサイエンス「脳とホルモンのはたらきを実験で調べてみよう(HT23191)」採択・開催アウトリーチ活動情報

    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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