The role of histamine H4 receptor in the development of cancer-related fatigue

• Project/Area Number: 21590279
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Osaka University
• Principal Investigator: YAMATODANI Atsushi 大阪大学, 大学院・医学系研究科, 教授 (30116123)
• Co-Investigator(Kenkyū-buntansha): HARUSAWA Shinya 大阪薬科大学, 薬学部, 教授 (90167601) ; YAMAMOTO Kouichi 大阪大学, 大学院・医学系研究科, 助教 (40362694)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ヒスタミン / ヒスタミンH4受容体 / 腫瘍壊死因子(TNF)-α / がん治療関連倦怠感 / 抗悪性腫瘍薬 / マクロファージ / 腫瘍壊死因子(TNF) α / 細胞内情報伝達系MAPK / 活性酸素種(ROS) / 転写因子NF-κB / シスプラチン / がん関連倦怠感(Cancer-Related Fatigue : CRF) / がん関連倦怠感 / がん化学療法 / がん関連副作用 / 腫瘍壊死因子(TNF-α) / MAPK / 炎症性サイトカイン / がん関連疲労感

Research Abstract

We hypothesized excessive tumor necrosis factor(TNF)-αproduction via histamine H4 receptor(H4R) is concerned in cancer-therapy related fatigue. We found that cisplatin increased TNF-αmRNA expressions in macrophages. Histamine H4R agonists inhibited the cisplatin-induced TNF-αmRNA expression, but treatment with H4R antagonist aggravated the effect. These results suggest that activation of H4R attenuates cisplatin-induced TNF-αmRNA expression and that H4R agonists are expected to be useful for treatment of cancer-therapy related fatigue.

Research Products

• [Journal Article] Time-course analysis of pica in rats using an automatic feeding monitoring system (2011)
  • Author(s): Yamamoto K, Asano K, Matsukawa N, Imaizumi M, Yamatodani A
  • Journal Title: Journal of Pharmacological and Toxicological Methods Volume: 63 Pages: 30-34
  • URL: http://dx.doi.org/10.1016/j.vascn.2010.04.011
  • Peer Reviewed
• [Presentation] Synthesis and Evaluation of Potent Non-imidazole Histamine H_3 Antagonists Basedon S-Alkyl-N-alkylisothiourea Structure (2011)
  • Author(s): Hiroki Yoneyama, Takuji Magata, Yoshiheide Usami, Shinya Harusawa, Kouichi Sawada, Kouichi Yamamoto, Atsushi Yamatodani
  • Organizer: TIMECS11
  • Place of Presentation: 東京
  • Year and Date: 2011-11-29
• [Presentation] シスプラチン刺激によるRAW264細胞のTNF-αmRNA発現機序の解明 (2011)
  • Author(s): 金世洸、山本浩一、中村侑亮、大豊裕一、大和谷厚
  • Organizer: 第119回日本薬理学会近畿部会
  • Place of Presentation: 愛知
  • Year and Date: 2011-07-08
• [Presentation] シスプラチン刺激によるRAW264細胞のTNF-α mRNA発現機序の解明 (2011)
  • Author(s): 金世洸、山本浩一、中村侑亮、大豊裕一、大和谷厚
  • Organizer: 第119回日本薬理学会近畿部会
  • Place of Presentation: ウインクあいち(愛知県名古屋市)
  • Year and Date: 2011-07-08
• [Presentation] 摂餌量測定装置によるラットのシスプラチン誘発急性・遅発性パイカ行動の解析 (2011)
  • Author(s): 山本浩一、松川直樹、小倉由布子、今泉正洋、大和谷厚
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: 神奈川
  • Year and Date: 2011-03-24
• [Presentation] 摂餌量測定装置によるラットのシスプラチン誘発急性・遅発性パイカ行動の解析 (2010)
  • Author(s): 山本浩一
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: 日本神奈川県(パシフィコ横浜)
  • Year and Date: 2010-03-24
• [Presentation] Involvement of histamine in cisplatin-induced TNF-αexpression in RAW264 cells (2010)
  • Author(s): 大豊裕一、山本浩一、室谷知孝、中村侑亮、浅野景子、大和谷厚
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪
  • Year and Date: 2010-03-16
• [Presentation] Involvement of histamine in cisplatin-induced TNF-α expression in RAW264 cells (2010)
  • Author(s): 大豊裕一
  • Organizer: 第83回日本薬理学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-03-16
• [Remarks]
  • URL: http://sahswww.med.osaka-u.ac.jp/~pharmaco/index.html